| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abhinav Sharma, Lúcio Angnes, Naghmeh Sattarahmady, Masoud Negahdary, Hossein Hel. Electrochemical Immunosensors Developed for Amyloid-Beta and Tau Proteins, Leading Biomarkers of Alzheimer's Disease. Biosensors. vol 13. issue 7. 2023-07-28. PMID:37504140. |
electrochemical immunosensors developed for amyloid-beta and tau proteins, leading biomarkers of alzheimer's disease. |
2023-07-28 |
2023-08-14 |
human |
| Arzuhan Cetindag Ciltas, Sebahattin Karabulut, Bilal Sahin, Ahmet Kemal Filiz, Fatih Yulak, Mustafa Ozkaraca, Ozhan Karatas, Ali Ceti. FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer's disease. Neuropeptides. vol 101. 2023-07-28. PMID:37506425. |
alzheimer's disease (ad) is a multifactorial pathology marked by amyloid beta (aβ) accumulation, tau hyperphosphorylation, and progressive cognitive decline. |
2023-07-28 |
2023-08-14 |
rat |
| Sára Nemes, Paige E Logan, Mohit K Manchella, Nidhi S Mundada, Renaud La Joie, Angelina J Polsinelli, Dustin B Hammers, Robert A Koeppe, Tatiana M Foroud, Kelly N Nudelman, Ani Eloyan, Leonardo Iaccarino, Valérie Dorsant-Ardón, Alexander Taurone, Maryanne Thangarajah, Jeffery L Dage, Paul Aisen, Lea T Grinberg, Clifford R Jack, Joel Kramer, Walter A Kukull, Melissa E Murray, Malia Rumbaugh, David N Soleimani-Meigooni, Arthur Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario F Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J Sha, Raymond S Turner, Thomas S Wingo, Kyle B Womack, David A Wolk, Gil D Rabinovici, Maria C Carrillo, Bradford C Dickerson, Liana G Apostolov. Sex and APOE ε4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-07-27. PMID:37496307. |
sex and apoe ε4 carrier effects on atrophy, amyloid pet, and tau pet burden in early-onset alzheimer's disease. |
2023-07-27 |
2023-08-14 |
Not clear |
| Zi-Yang Zhang, Dilshan S Harischandra, Ruifang Wang, Shivani Ghaisas, Janet Y Zhao, Thomas P McMonagle, Guixin Zhu, Kenzo D Lacuarta, Jianing Song, John Q Trojanowski, Hong Xu, Virginia M-Y Lee, Xiaolu Yan. TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease. Science (New York, N.Y.). vol 381. issue 6656. 2023-07-27. PMID:37499037. |
aggregation of tau into filamentous inclusions underlies alzheimer's disease (ad) and numerous other neurodegenerative tauopathies. |
2023-07-27 |
2023-08-14 |
human |
| Jules Marien, Chantal Prévost, Sophie Sacquin-Mor. It Takes Tau to Tango: Investigating the Fuzzy Interaction between the R2-Repeat Domain and Tubulin C-Terminal Tails. Biochemistry. 2023-07-27. PMID:37499261. |
tau hyperphosphorylation affects its binding on the tubulin surface and has been shown to be involved in several pathologies such as alzheimer's disease. |
2023-07-27 |
2023-08-14 |
Not clear |
| Cecily G Swinford, Shannon L Risacher, Aaron Vosmeier, Rachael Deardorff, Evgeny J Chumin, Mario Dzemidzic, Yu-Chien Wu, Sujuan Gao, Brenna C McDonald, Karmen K Yoder, Frederick W Unverzagt, Sophia Wang, Martin R Farlow, Jared R Brosch, David G Clark, Liana G Apostolova, Justin Sims, Danny J Wang, Andrew J Sayki. Amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for Alzheimer's disease. Neurobiology of aging. vol 130. 2023-07-27. PMID:37499587. |
amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for alzheimer's disease. |
2023-07-27 |
2023-08-14 |
Not clear |
| Jiahui Zhu, Xingjun Jiang, Yanmin Chang, Yanqing Wu, Shangqi Sun, Cailin Wang, Siyi Zheng, Min Wang, Yi Yao, Gang Li, Rong M. Clemastine fumarate attenuates tauopathy and meliorates cognition in hTau mice via autophagy enhancement. International immunopharmacology. vol 123. 2023-07-26. PMID:37494840. |
based on these findings, we investigated the effect of clemastine fumarate in htau mice, a different alzheimer's disease model characterized by overexpression of human tau protein. |
2023-07-26 |
2023-08-14 |
mouse |
| Anika Finze, Gloria Biechele, Boris-Stephan Rauchmann, Nicolai Franzmeier, Carla Palleis, Sabrina Katzdobler, Endy Weidinger, Selim Guersel, Sebastian Schuster, Stefanie Harris, Julia Schmitt, Leonie Beyer, Johannes Gnörich, Simon Lindner, Nathalie L Albert, Christian H Wetzel, Rainer Rupprecht, Axel Rominger, Adrian Danek, Lena Burow, Carolin Kurz, Maia Tato, Julia Utecht, Boris Papazov, Mirlind Zaganjori, Lena-Katharina Trappmann, Oliver Goldhardt, Timo Grimmer, Jan Haeckert, Daniel Janowitz, Katharina Buerger, Daniel Keeser, Sophia Stoecklein, Olaf Dietrich, Estrella Morenas-Rodriguez, Henryk Barthel, Osama Sabri, Peter Bartenstein, Mikael Simons, Christian Haass, Günter U Höglinger, Johannes Levin, Robert Perneczky, Matthias Brende. Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies. Molecular psychiatry. 2023-07-26. PMID:37495886. |
β-amyloid (aβ) and tau aggregation as well as neuronal injury and atrophy (atn) are the major hallmarks of alzheimer's disease (ad), and biomarkers for these hallmarks have been linked to neuroinflammation. |
2023-07-26 |
2023-08-14 |
human |
| Noemi Sola-Sevilla, Elena Puert. SIRT2 as a potential new therapeutic target for Alzheimer's disease. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488853. |
this review summarizes and discusses the complex roles of sirtuin 2 in different molecular mechanisms involved in alzheimer's disease such as amyloid and tau pathology, microtubule stability, neuroinflammation, myelin formation, autophagy, and oxidative stress. |
2023-07-25 |
2023-08-14 |
Not clear |
| Aditi Halder, Eleanor Drummon. Strategies for translating proteomics discoveries into drug discovery for dementia. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488854. |
tauopathies, diseases characterized by neuropathological aggregates of tau including alzheimer's disease and subtypes of frontotemporal dementia, make up the vast majority of dementia cases. |
2023-07-25 |
2023-08-14 |
Not clear |
| Dina Medina-Vera, Antonio Jesús López-Gambero, Juan Antonio Navarro, Carlos Sanjuan, Elena Baixeras, Juan Decara, Fernando Rodríguez de Fonsec. Novel insights into D-Pinitol based therapies: a link between tau hyperphosphorylation and insulin resistance. Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488880. |
the pathogenesis of alzheimer's disease is mainly mediated by the phosphorylation and aggregation of tau protein. |
2023-07-25 |
2023-08-14 |
Not clear |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Róisín Winters, Michael S Perkinton, Andrew Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowa. Tau and Aß in patient-derived aqueous brain extracts act concomitantly to disrupt LTP The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-25. PMID:37491315. |
tau and aß in patient-derived aqueous brain extracts act concomitantly to disrupt ltp amyloid ß-protein (aß) and tau, the two main proteins implicated in causing alzheimer's disease (ad), are posited to trigger synaptic dysfunction long before significant synaptic loss occurs in vulnerable circuits. |
2023-07-25 |
2023-08-14 |
rat |
| Prokopis C Prokopiou, Nina Engels-Domínguez, Aaron P Schultz, Jorge Sepulcre, Elouise A Koops, Kathryn V Papp, Gad A Marshall, Marc D Normandin, Georges El Fakhri, Dorene Rentz, Reisa A Sperling, Keith A Johnson, Heidi I L Jacob. Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. Neurology. 2023-07-25. PMID:37491329. |
association of novelty-related locus coeruleus function with entorhinal tau deposition and memory decline in preclinical alzheimer disease. |
2023-07-25 |
2023-08-14 |
human |
| David López-Martos, Anna Brugulat-Serrat, Alba Cañas-Martínez, Lidia Canals-Gispert, Paula Marne, Nina Gramunt, Marc Suárez-Calvet, Marta Milà-Alomà, Carolina Minguillon, Karine Fauria, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, José Luis Molinuevo, Oriol Grau-Rivera, Gonzalo Sánchez-Benavide. Reference Data for Attentional, Executive, Linguistic, and Visual Processing Tests Obtained from Cognitively Healthy Individuals with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels. Journal of Alzheimer's disease : JAD. 2023-07-24. PMID:37483000. |
conventional neuropsychological norms likely include cognitively unimpaired (cu) individuals with preclinical alzheimer's disease (ad) pathology (amyloid-β, tau, and neurodegeneration) since they are based on cohorts without ad biomarkers data. |
2023-07-24 |
2023-08-14 |
Not clear |
| Daniel Lamontagne-Kam, Anosha Kiran Ulfat, Vincent Hervé, Tra-My Vu, Jonathan Brouillett. Implication of tau propagation on neurodegeneration in Alzheimer's disease. Frontiers in neuroscience. vol 17. 2023-07-24. PMID:37483337. |
implication of tau propagation on neurodegeneration in alzheimer's disease. |
2023-07-24 |
2023-08-14 |
human |
| Daniel Lamontagne-Kam, Anosha Kiran Ulfat, Vincent Hervé, Tra-My Vu, Jonathan Brouillett. Implication of tau propagation on neurodegeneration in Alzheimer's disease. Frontiers in neuroscience. vol 17. 2023-07-24. PMID:37483337. |
propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen during the progression of alzheimer's disease (ad). |
2023-07-24 |
2023-08-14 |
human |
| Irene Sintini, Jonathan Graff-Radford, Christopher G Schwarz, Mary M Machulda, Neha Atulkumar Singh, Arenn F Carlos, Matthew L Senjem, Clifford R Jack Jr, Val J Lowe, Keith A Josephs, Jennifer L Whitwel. Longitudinal rates of atrophy and tau accumulation differ between the visual and language variants of atypical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-07-24. PMID:37485642. |
longitudinal rates of atrophy and tau accumulation differ between the visual and language variants of atypical alzheimer's disease. |
2023-07-24 |
2023-08-14 |
Not clear |
| Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Igor Bryukhovetskiy, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharm. Nanowired Delivery of Cerebrolysin Together with Antibodies to Amyloid Beta Peptide, Phosphorylated Tau, and Tumor Necrosis Factor Alpha Induces Superior Neuroprotection in Alzheimer's Disease Brain Pathology Exacerbated by Sleep Deprivation. Advances in neurobiology. vol 32. 2023-07-22. PMID:37480458. |
nanowired delivery of cerebrolysin together with antibodies to amyloid beta peptide, phosphorylated tau, and tumor necrosis factor alpha induces superior neuroprotection in alzheimer's disease brain pathology exacerbated by sleep deprivation. |
2023-07-22 |
2023-08-14 |
Not clear |
| Avneet Kour, Virendra Tiwari, Nidhi Aggarwal, Himanshu Sekhar Panda, Ashwani Kumar, Siddharth Tiwari, Virander Singh Chauhan, Shubha Shukla, Jiban Jyoti Pand. Anti-amyloidogenic amphipathic arginine-dehydrophenylalanine spheres capped selenium nanoparticles as potent therapeutic moieties for Alzheimer's disease. Nanoscale. 2023-07-21. PMID:37477348. |
aggregation of both amyloid beta (aβ) peptide and hyperphosphorylated tau proteins is the major pathological hallmark of alzheimer's disease (ad). |
2023-07-21 |
2023-08-14 |
Not clear |
| Yingying Wang, Xing Ye, Bo Song, Yixin Yan, Wenyin Ma, Jingping Sh. Features of event-related potentials during retrieval of episodic memory in patients with mild cognitive impairment due to Alzheimer's disease. Frontiers in neuroscience. vol 17. 2023-07-20. PMID:37469837. |
to provide a rigorous comparison between patients with mild cognitive impairment due to alzheimer's disease (mci-ad) and healthy elderly, as well as to assess the value of electroencephalography (eeg) in terms of early diagnosis, we conducted a neutral image recognition memory task involving individuals with positive biomarkers including β amyloid deposition, pathologic tau or neurodegeneration. |
2023-07-20 |
2023-08-14 |
Not clear |