All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Carlos Cruchaga, John S K Kauwe, Oscar Harari, Sheng Chih Jin, Yefei Cai, Celeste M Karch, Bruno A Benitez, Amanda T Jeng, Tara Skorupa, David Carrell, Sarah Bertelsen, Matthew Bailey, David McKean, Joshua M Shulman, Philip L De Jager, Lori Chibnik, David A Bennett, Steve E Arnold, Denise Harold, Rebecca Sims, Amy Gerrish, Julie Williams, Vivianna M Van Deerlin, Virginia M-Y Lee, Leslie M Shaw, John Q Trojanowski, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Elaine R Peskind, Douglas Galasko, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. vol 78. issue 2. 2013-06-25. PMID:23562540. gwas of cerebrospinal fluid tau levels identifies risk variants for alzheimer's disease. 2013-06-25 2023-08-12 Not clear
Carlos Cruchaga, John S K Kauwe, Oscar Harari, Sheng Chih Jin, Yefei Cai, Celeste M Karch, Bruno A Benitez, Amanda T Jeng, Tara Skorupa, David Carrell, Sarah Bertelsen, Matthew Bailey, David McKean, Joshua M Shulman, Philip L De Jager, Lori Chibnik, David A Bennett, Steve E Arnold, Denise Harold, Rebecca Sims, Amy Gerrish, Julie Williams, Vivianna M Van Deerlin, Virginia M-Y Lee, Leslie M Shaw, John Q Trojanowski, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Elaine R Peskind, Douglas Galasko, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. vol 78. issue 2. 2013-06-25. PMID:23562540. cerebrospinal fluid (csf) tau, tau phosphorylated at threonine 181 (ptau), and aβ₄₂ are established biomarkers for alzheimer's disease (ad) and have been used as quantitative traits for genetic analyses. 2013-06-25 2023-08-12 Not clear
Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Luis Acero, Alfred Weber, Veronika Blinder, Alex Mably, Sebastian Bunk, Corinna Hermann, Michael A Farrell, Hartmut J Ehrlich, Hans P Schwarz, Dominic M Walsh, Alan Solomon, Brian O'Nuallai. Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide. PloS one. vol 7. issue 11. 2013-06-24. PMID:23209707. soluble non-fibrillar assemblies of amyloid-beta (aβ) and aggregated tau protein are the proximate synaptotoxic species associated with alzheimer's disease (ad). 2013-06-24 2023-08-12 human
Oliver B Villaflores, Ying-Ju Chen, Chih-Ping Chen, Jui-Ming Yeh, Tzong-Yuan W. Effects of curcumin and demethoxycurcumin on amyloid-β precursor and tau proteins through the internal ribosome entry sites: a potential therapeutic for Alzheimer's disease. Taiwanese journal of obstetrics & gynecology. vol 51. issue 4. 2013-06-24. PMID:23276558. effects of curcumin and demethoxycurcumin on amyloid-β precursor and tau proteins through the internal ribosome entry sites: a potential therapeutic for alzheimer's disease. 2013-06-24 2023-08-12 Not clear
Christian Schön, Nadine A Hoffmann, Simon M Ochs, Steffen Burgold, Severin Filser, Sonja Steinbach, Mathias W Seeliger, Thomas Arzberger, Michel Goedert, Hans A Kretzschmar, Boris Schmidt, Jochen Herm. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PloS one. vol 7. issue 12. 2013-06-24. PMID:23300938. in contradiction to previous studies, our observations do not support the notion that aβ or tau in the retina are of diagnostic value in alzheimer's disease. 2013-06-24 2023-08-12 mouse
Qian Huang, Hu Wang, Seth W Perry, Maria E Figueiredo-Pereir. Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons. The Journal of biological chemistry. vol 288. issue 17. 2013-06-24. PMID:23508964. in addition, calpain cleaved the microtubule-associated protein tau, a major component of neurofibrillary tangles in alzheimer disease and other tauopathies. 2013-06-24 2023-08-12 rat
Biljana Georgievska, Johan Sandin, James Doherty, Anette Mörtberg, Jan Neelissen, Anita Andersson, Susanne Gruber, Yvonne Nilsson, Pär Schött, Per I Arvidsson, Sven Hellberg, Gunilla Osswald, Stefan Berg, Johanna Fälting, Ratan V Bha. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. Journal of neurochemistry. vol 125. issue 3. 2013-06-20. PMID:23410232. abnormal tau phosphorylation resulting in detachment of tau from microtubules and aggregation are critical events in neuronal dysfunction, degeneration, and neurofibrillary pathology seen in alzheimer's disease. 2013-06-20 2023-08-12 mouse
Ines Moreno-Gonzalez, Lisbell D Estrada, Elisabeth Sanchez-Mejias, Claudio Sot. Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease. Nature communications. vol 4. 2013-06-20. PMID:23422663. our results showed that smoking increases the severity of some abnormalities typical of alzheimer's disease, including amyloidogenesis, neuroinflammation and tau phosphorylation. 2013-06-20 2023-08-12 mouse
Yu Luo, Yun-Juan Nie, Hai-Rong Shi, Zhong-Fei Ni, Qun Wang, Jian-Zhi Wang, Gong-Ping Li. PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. Biochimica et biophysica acta. vol 1833. issue 5. 2013-06-20. PMID:23428800. protein phosphatase-2a (pp2a), an important phosphatase in dephosphorylating tau and preserving synapse, is significantly suppressed in alzheimer's disease (ad), but the mechanism is not well understood. 2013-06-20 2023-08-12 mouse
Rodrigo A Quintanilla, Juan A Orellana, Rommy von Bernhard. Understanding risk factors for Alzheimer's disease: interplay of neuroinflammation, connexin-based communication and oxidative stress. Archives of medical research. vol 43. issue 8. 2013-06-18. PMID:23142264. alzheimer's disease (ad) is an age-related neurodegenerative disease characterized by dementia and the presence of amyloid plaques and anomalous tau aggregates. 2013-06-18 2023-08-12 Not clear
Ana M Cárdenas, Alvaro O Ardiles, Natalia Barraza, Ximena Baéz-Matus, Pablo Caviede. Role of tau protein in neuronal damage in Alzheimer's disease and Down syndrome. Archives of medical research. vol 43. issue 8. 2013-06-18. PMID:23142525. role of tau protein in neuronal damage in alzheimer's disease and down syndrome. 2013-06-18 2023-08-12 human
Jürgen Götz, Di Xia, Gerhard Leinenga, Yee Lian Chew, Hannah Nichola. What Renders TAU Toxic. Frontiers in neurology. vol 4. 2013-06-18. PMID:23772223. tau is a microtubule-associated protein that under pathological conditions such as alzheimer's disease (ad) forms insoluble, filamentous aggregates. 2013-06-18 2023-08-12 mouse
Umesh K Jinwal, Elias Akoury, Jose F Abisambra, John C O'Leary, Andrea D Thompson, Laura J Blair, Ying Jin, Justin Bacon, Bryce A Nordhues, Matthew Cockman, Juan Zhang, Pengfei Li, Bo Zhang, Sergiy Borysov, Vladimir N Uversky, Jacek Biernat, Eckhard Mandelkow, Jason E Gestwicki, Markus Zweckstetter, Chad A Dicke. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 4. 2013-06-17. PMID:23271055. despite its capacity to clear tau, hsp72 was not induced in the alzheimer's disease brain, suggesting a mechanism for age-associated onset of the disease. 2013-06-17 2023-08-12 mouse
Margareta Hinterberger, Peter Fische. Folate and Alzheimer: when time matters. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 1. 2013-06-14. PMID:22627695. it induces several alzheimer pathomechanisms like oxidative stress, ca(++) influx, accumulation of hyperphosphorylated tau and β-amyloid. 2013-06-14 2023-08-12 human
Jasmin Bartl, Andrea Meyer, Svenja Brendler, Peter Riederer, Edna Grünblat. Different effects of soluble and aggregated amyloid β42 on gene/protein expression and enzyme activity involved in insulin and APP pathways. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 1. 2013-06-14. PMID:22782687. although alzheimer's dementia (ad) is not characterised any longer simply as the accumulation and deposition of amyloid beta (aβ) peptides and hyperphosphorylation of tau proteins within the brain, excessive aβ(42) deposition is still considered to play a major role in this illness. 2013-06-14 2023-08-12 human
Alex Crowe, Michael J James, Virginia M-Y Lee, Amos B Smith, John Q Trojanowski, Carlo Ballatore, Kurt R Brunde. Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. The Journal of biological chemistry. vol 288. issue 16. 2013-06-13. PMID:23443659. alzheimer disease and several other neurodegenerative disorders are characterized by the accumulation of intraneuronal fibrils comprised of the protein tau. 2013-06-13 2023-08-12 Not clear
Alex Crowe, Michael J James, Virginia M-Y Lee, Amos B Smith, John Q Trojanowski, Carlo Ballatore, Kurt R Brunde. Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. The Journal of biological chemistry. vol 288. issue 16. 2013-06-13. PMID:23443659. interestingly, methylene blue, an inhibitor of tau fibrillization under evaluation in alzheimer disease clinical trials, caused a similar oxidation of cysteines in tau and other molecules. 2013-06-13 2023-08-12 Not clear
Juanfang Liu, Xiaodong Yan, Ling Li, Yi Zhu, Kefeng Qin, Linfu Zhou, Dong Sun, Xiaohui Zhang, Ruidong Ye, Gang Zha. Ginsennoside rd attenuates cognitive dysfunction in a rat model of Alzheimer's disease. Neurochemical research. vol 37. issue 12. 2013-06-11. PMID:22903450. alzheimer's disease is a neurodegenerative disease characterized by the production of β-amyloid proteins and hyperphosphorylation of tau protein. 2013-06-11 2023-08-12 rat
James K Chambers, Kazuyuki Uchida, Tomoyuki Harada, Masaya Tsuboi, Masumi Sato, Masahito Kubo, Hiroaki Kawaguchi, Noriaki Miyoshi, Hajime Tsujimoto, Hiroyuki Nakayam. Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats. PloS one. vol 7. issue 10. 2013-06-11. PMID:23056312. the distributions of hyperphosphorylated tau-positive cells and the two major isoforms of aggregated tau proteins were quite similar to those seen in alzheimer's disease. 2013-06-11 2023-08-12 human
Eunyoung Lee, Ji-Eun Eom, Hye-Lin Kim, Kyung Hye Baek, Kyu-Yeon Jun, Hwa-Jung Kim, Minyung Lee, Inhee Mook-Jung, Youngjoo Kwo. Effect of conjugated linoleic acid, μ-calpain inhibitor, on pathogenesis of Alzheimer's disease. Biochimica et biophysica acta. vol 1831. issue 4. 2013-06-11. PMID:23246577. hyper-activated μ-calpain enhances the accumulation of β-amyloid peptide by increasing the expression level of β-secretase (bace1) and induces hyper-phosphorylation of tau along with the formation of neurofibrillary tangle by mediating p35 cleavage into p25, both of which are the major mechanisms of neurodegeneration in alzheimer's disease (ad). 2013-06-11 2023-08-12 Not clear