All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
J Lasierra-Cirujeda, P Coronel, Mj Aza, M Gimen. Beta-amyloidolysis and glutathione in Alzheimer's disease. Journal of blood medicine. vol 4. 2013-05-08. PMID:23650462. the histopathological characteristic hallmark that gives personality to the diagnosis of alzheimer's disease is the accumulation of neurofibroid tangles located intracellularly in the brain, such as the protein tau and extracellular senile plaques made primarily of amyloidal substance. 2013-05-08 2023-08-12 Not clear
Xiao-Hong Li, Jia-Zhao Xie, Xia Jiang, Bing-Ling Lv, Xiang-Shu Cheng, Lai-Ling Du, Jia-Yu Zhang, Jian-Zhi Wang, Xin-Wen Zho. Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation. Neuromolecular medicine. vol 14. issue 4. 2013-05-07. PMID:22798221. the hyperphosphorylated tau is a major protein component of neurofibrillary tangle, which is one of hallmarks of alzheimer's disease (ad). 2013-05-07 2023-08-12 Not clear
Hayk Davtyan, Anahit Ghochikyan, Irina Petrushina, Armine Hovakimyan, Arpine Davtyan, Anna Poghosyan, Annette M Marleau, Nina Movsesyan, Anatoly Kiyatkin, Suhail Rasool, Anna Kirstine Larsen, Peter Juul Madsen, Karen Malene Wegener, Dorte Kornerup Ditlevsen, David H Cribbs, Lars Ostergaard Pedersen, Michael G Agadjanya. Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486963. the alzheimer's disease (ad) process is understood to involve the accumulation of amyloid plaques and tau tangles in the brain. 2013-05-06 2023-08-12 mouse
Simantini Ghosh, Michael D Wu, Solomon S Shaftel, Stephanos Kyrkanides, Frank M LaFerla, John A Olschowka, M Kerry O'Banio. Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486975. sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an alzheimer's mouse model. 2013-05-06 2023-08-12 mouse
Donata Paternicò, Samantha Galluzzi, Valeria Drago, Luisella Bocchio-Chiavetto, Roberta Zanardini, Laura Pedrini, Manuela Baronio, Giovanni Amicucci, Giovanni B Frison. Cerebrospinal fluid markers for Alzheimer's disease in a cognitively healthy cohort of young and old adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 6. 2013-05-03. PMID:22677492. low amyloid β42 (aβ42) and high total tau and phosphorylated tau (p-tau) concentrations in the cerebrospinal fluid (csf) are biomarkers of alzheimer's disease (ad), reflecting brain deposition of amyloid plaques and tangles. 2013-05-03 2023-08-12 Not clear
Erik S Musiek, David M Holtzma. Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23041958. origins of alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. 2013-05-03 2023-08-12 Not clear
Erik S Musiek, David M Holtzma. Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23041958. this review aims to address the temporal sequencing of involvement of amyloid-beta (aβ) and tau in the pathogenesis of alzheimer's disease and reconcile apparently conflicting neuropathologic and biomarker data. 2013-05-03 2023-08-12 Not clear
Heiko Braak, Kelly Del Tredic. Where, when, and in what form does sporadic Alzheimer's disease begin? Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23160422. intraneuronal lesions consisting of abnormal tau protein are seen to develop from the beginning until the end-phase of the pathological process underlying alzheimer's disease. 2013-05-03 2023-08-12 Not clear
Anna Urbania. [p75NTR receptor--role in cell growth and apoptosis]. Postepy higieny i medycyny doswiadczalnej (Online). vol 66. 2013-05-02. PMID:22706116. p75ntr can interact with the aggregated form of aβ peptides and by influencing protein tau hyperphosphorylation plays an important role in etiopathogenesis of alzheimer's disease. 2013-05-02 2023-08-12 Not clear
Karelle Leroy, Kunie Ando, Vincent Laporte, Robert Dedecker, Valérie Suain, Michèle Authelet, Céline Héraud, Nathalie Pierrot, Zehra Yilmaz, Jean-Noël Octave, Jean-Pierre Brio. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice. The American journal of pathology. vol 181. issue 6. 2013-05-01. PMID:23026200. lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (app) identified in familial alzheimer disease. 2013-05-01 2023-08-12 mouse
Xiyun Chai, Jeffrey L Dage, Martin Citro. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22668776. the microtubule-associated protein tau plays a critical role in the pathogenesis of alzheimer's disease and several related disorders. 2013-04-30 2023-08-12 human
Xiyun Chai, Jeffrey L Dage, Martin Citro. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22668776. if previously postulated pathogenic extracellular tau intermediates are released by this route, low level constitutive tau secretion could play a role in the spread of tau pathology in alzheimer's disease and other human tauopathies. 2013-04-30 2023-08-12 human
Gonzalo I Cancino, Freda D Miller, David R Kapla. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiology of aging. vol 34. issue 2. 2013-04-29. PMID:22592019. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and alzheimer's disease. 2013-04-29 2023-08-12 mouse
Minghui Cao, Funing Liu, Fengtao Ji, Jianjun Liang, Ling Liu, Qiang Wu, Tinghuai Wan. Effect of c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (p38 MAPK) in morphine-induced tau protein hyperphosphorylation. Behavioural brain research. vol 237. 2013-04-26. PMID:23026374. hyperphosphorylation of tau is also a pathological feature of alzheimer's disease and other chronic neurodegenerative disorders. 2013-04-26 2023-08-12 rat
Kristen M Henkins, Sophie Sokolow, Carol A Miller, Harry V Vinters, Wayne W Poon, Lindsey B Cornwell, Tommy Saing, Karen Hoppens Gyly. Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses. Brain pathology (Zurich, Switzerland). vol 22. issue 6. 2013-04-23. PMID:22486774. like amyloid beta (aβ) oligomers, tau aggregates are increasingly recognized as potential key toxic intermediates in alzheimer's disease (ad) and as therapeutic targets. 2013-04-23 2023-08-12 Not clear
Heiko Braak, Dietmar Rudolf Thal, Jakob Matschke, Estifanos Ghebremedhin, Kelly Del Tredic. Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22503003. we identified p62-immunoreactive inclusions in dendrites of catecholaminergic brainstem projection neurons using antibodies against p62, ubiquitin, α-synuclein, hyperphosphorylated tau, and tyrosine hydroxylase in 100-μm sections through the brainstem dorsal vagal area, locus coeruleus, and substantia nigra of 149 autopsy cases staged for intraneuronal alzheimer's and parkinson's disease-associated lesions. 2013-04-23 2023-08-12 human
Christopher M Acker, Stefanie K Forest, Ray Zinkowski, Peter Davies, Cristina d'Abram. Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22727277. transgenic mouse models have been an invaluable resource in elucidating the complex roles of β-amyloid and tau in alzheimer's disease. 2013-04-23 2023-08-12 mouse
Christopher M Acker, Stefanie K Forest, Ray Zinkowski, Peter Davies, Cristina d'Abram. Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22727277. although many laboratories rely on qualitative or semiquantitative techniques when investigating tau pathology, we have developed 4 low-tau, sandwich enzyme-linked immunosorbent assays (elisas) that quantitatively assess different epitopes of tau relevant to alzheimer's disease: total tau, pser-202, pthr-231, and pser-396/404. 2013-04-23 2023-08-12 mouse
Claudine L Bitel, Chinnaswamy Kasinathan, Rajesh H Kaswala, William L Klein, Peter H Frederiks. Amyloid-β and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model. Journal of Alzheimer's disease : JAD. vol 32. issue 2. 2013-04-23. PMID:22785400. amyloid-β and tau pathology of alzheimer's disease induced by diabetes in a rabbit animal model. 2013-04-23 2023-08-12 mouse
Danijela Levacic, Leema Reddy Peddareddygari, David Nochlin, Leroy R Sharer, Raji P Grewa. Inclusion-body myositis associated with Alzheimer's disease. Case reports in medicine. vol 2013. 2013-04-23. PMID:23606855. in addition, similar to the pathology observed in the brains of patients with alzheimer's disease, the deposition of beta-amyloid and phosphorylated tau proteins in muscle fibers has been reported. 2013-04-23 2023-08-12 Not clear