| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donata Paternicò, Samantha Galluzzi, Valeria Drago, Luisella Bocchio-Chiavetto, Roberta Zanardini, Laura Pedrini, Manuela Baronio, Giovanni Amicucci, Giovanni B Frison. Cerebrospinal fluid markers for Alzheimer's disease in a cognitively healthy cohort of young and old adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 6. 2013-05-03. PMID:22677492. |
low amyloid β42 (aβ42) and high total tau and phosphorylated tau (p-tau) concentrations in the cerebrospinal fluid (csf) are biomarkers of alzheimer's disease (ad), reflecting brain deposition of amyloid plaques and tangles. |
2013-05-03 |
2023-08-12 |
Not clear |
| Erik S Musiek, David M Holtzma. Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23041958. |
origins of alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. |
2013-05-03 |
2023-08-12 |
Not clear |
| Erik S Musiek, David M Holtzma. Origins of Alzheimer's disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23041958. |
this review aims to address the temporal sequencing of involvement of amyloid-beta (aβ) and tau in the pathogenesis of alzheimer's disease and reconcile apparently conflicting neuropathologic and biomarker data. |
2013-05-03 |
2023-08-12 |
Not clear |
| Heiko Braak, Kelly Del Tredic. Where, when, and in what form does sporadic Alzheimer's disease begin? Current opinion in neurology. vol 25. issue 6. 2013-05-03. PMID:23160422. |
intraneuronal lesions consisting of abnormal tau protein are seen to develop from the beginning until the end-phase of the pathological process underlying alzheimer's disease. |
2013-05-03 |
2023-08-12 |
Not clear |
| Anna Urbania. [p75NTR receptor--role in cell growth and apoptosis]. Postepy higieny i medycyny doswiadczalnej (Online). vol 66. 2013-05-02. PMID:22706116. |
p75ntr can interact with the aggregated form of aβ peptides and by influencing protein tau hyperphosphorylation plays an important role in etiopathogenesis of alzheimer's disease. |
2013-05-02 |
2023-08-12 |
Not clear |
| Karelle Leroy, Kunie Ando, Vincent Laporte, Robert Dedecker, Valérie Suain, Michèle Authelet, Céline Héraud, Nathalie Pierrot, Zehra Yilmaz, Jean-Noël Octave, Jean-Pierre Brio. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice. The American journal of pathology. vol 181. issue 6. 2013-05-01. PMID:23026200. |
lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (app) identified in familial alzheimer disease. |
2013-05-01 |
2023-08-12 |
mouse |
| Xiyun Chai, Jeffrey L Dage, Martin Citro. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22668776. |
the microtubule-associated protein tau plays a critical role in the pathogenesis of alzheimer's disease and several related disorders. |
2013-04-30 |
2023-08-12 |
human |
| Xiyun Chai, Jeffrey L Dage, Martin Citro. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22668776. |
if previously postulated pathogenic extracellular tau intermediates are released by this route, low level constitutive tau secretion could play a role in the spread of tau pathology in alzheimer's disease and other human tauopathies. |
2013-04-30 |
2023-08-12 |
human |
| Gonzalo I Cancino, Freda D Miller, David R Kapla. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiology of aging. vol 34. issue 2. 2013-04-29. PMID:22592019. |
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and alzheimer's disease. |
2013-04-29 |
2023-08-12 |
mouse |
| Minghui Cao, Funing Liu, Fengtao Ji, Jianjun Liang, Ling Liu, Qiang Wu, Tinghuai Wan. Effect of c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (p38 MAPK) in morphine-induced tau protein hyperphosphorylation. Behavioural brain research. vol 237. 2013-04-26. PMID:23026374. |
hyperphosphorylation of tau is also a pathological feature of alzheimer's disease and other chronic neurodegenerative disorders. |
2013-04-26 |
2023-08-12 |
rat |
| Kristen M Henkins, Sophie Sokolow, Carol A Miller, Harry V Vinters, Wayne W Poon, Lindsey B Cornwell, Tommy Saing, Karen Hoppens Gyly. Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses. Brain pathology (Zurich, Switzerland). vol 22. issue 6. 2013-04-23. PMID:22486774. |
like amyloid beta (aβ) oligomers, tau aggregates are increasingly recognized as potential key toxic intermediates in alzheimer's disease (ad) and as therapeutic targets. |
2013-04-23 |
2023-08-12 |
Not clear |
| Heiko Braak, Dietmar Rudolf Thal, Jakob Matschke, Estifanos Ghebremedhin, Kelly Del Tredic. Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22503003. |
we identified p62-immunoreactive inclusions in dendrites of catecholaminergic brainstem projection neurons using antibodies against p62, ubiquitin, α-synuclein, hyperphosphorylated tau, and tyrosine hydroxylase in 100-μm sections through the brainstem dorsal vagal area, locus coeruleus, and substantia nigra of 149 autopsy cases staged for intraneuronal alzheimer's and parkinson's disease-associated lesions. |
2013-04-23 |
2023-08-12 |
human |
| Christopher M Acker, Stefanie K Forest, Ray Zinkowski, Peter Davies, Cristina d'Abram. Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22727277. |
transgenic mouse models have been an invaluable resource in elucidating the complex roles of β-amyloid and tau in alzheimer's disease. |
2013-04-23 |
2023-08-12 |
mouse |
| Christopher M Acker, Stefanie K Forest, Ray Zinkowski, Peter Davies, Cristina d'Abram. Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22727277. |
although many laboratories rely on qualitative or semiquantitative techniques when investigating tau pathology, we have developed 4 low-tau, sandwich enzyme-linked immunosorbent assays (elisas) that quantitatively assess different epitopes of tau relevant to alzheimer's disease: total tau, pser-202, pthr-231, and pser-396/404. |
2013-04-23 |
2023-08-12 |
mouse |
| Claudine L Bitel, Chinnaswamy Kasinathan, Rajesh H Kaswala, William L Klein, Peter H Frederiks. Amyloid-β and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model. Journal of Alzheimer's disease : JAD. vol 32. issue 2. 2013-04-23. PMID:22785400. |
amyloid-β and tau pathology of alzheimer's disease induced by diabetes in a rabbit animal model. |
2013-04-23 |
2023-08-12 |
mouse |
| Danijela Levacic, Leema Reddy Peddareddygari, David Nochlin, Leroy R Sharer, Raji P Grewa. Inclusion-body myositis associated with Alzheimer's disease. Case reports in medicine. vol 2013. 2013-04-23. PMID:23606855. |
in addition, similar to the pathology observed in the brains of patients with alzheimer's disease, the deposition of beta-amyloid and phosphorylated tau proteins in muscle fibers has been reported. |
2013-04-23 |
2023-08-12 |
Not clear |
| Haijun Wang, Hongyang Zhao, Youfan Ye, Nanxiang Xiong, Junhong Huang, Dongxiao Yao, Yin Shen, Xintong Zha. Focal cerebral ischemia induces Alzheimer's disease-like pathological change in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 1. 2013-04-12. PMID:20155452. |
the changes in the tau protein phosphorylation and expression of bcl-2, and bax in rat parietal cortex neurons after focal cerebral ischemia-reperfusion (i/r) were explored, and the relationship between the tau protein phosphorylation and the expression of bax or apoptosis was clarified in order to elucidate the relationship between cerebral infarction and alzheimer's disease. |
2013-04-12 |
2023-08-12 |
rat |
| Maria Manczak, P Hemachandra Redd. Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. Human molecular genetics. vol 21. issue 23. 2013-04-12. PMID:22926141. |
abnormal interaction of vdac1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in alzheimer's disease. |
2013-04-12 |
2023-08-12 |
mouse |
| Maria Manczak, P Hemachandra Redd. Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. Human molecular genetics. vol 21. issue 23. 2013-04-12. PMID:22926141. |
the purpose of our study was to determine the relationship between voltage-dependent anion channel 1 protein (vdac1) and amyloid beta (aβ) and phosphorylated tau in alzheimer's disease (ad). |
2013-04-12 |
2023-08-12 |
mouse |
| Guoxin Wu, Sethu Sankaranarayanan, Jacky Wong, Katherine Tugusheva, Maria S Michener, Xiaoping Shi, Jacquelynn J Cook, Adam J Simon, Mary J Savag. Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease. Journal of neuroscience research. vol 90. issue 12. 2013-04-11. PMID:22987781. |
reduction in cerebrospinal fluid (csf) amyloid β42 (aβ42) and elevation in total tau and phospho-thr181 tau consistently differentiate between alzheimer's disease (ad) and age-matched control subjects. |
2013-04-11 |
2023-08-12 |
mouse |