| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Larry Sparks, Richard J Kryscio, Marwan N Sabbagh, Chuck Ziolkowski, Yushun Lin, Lisa M Sparks, Carolyn Liebsack, Sherry Johnson-Trave. Tau is reduced in AD plasma and validation of employed ELISA methods. American journal of neurodegenerative disease. vol 1. issue 1. 2013-02-05. PMID:23383382. |
measure total tau levels in the circulation of living humans, validate the methods employed and determine if there are consistent differences in total tau levels between normal controls and individuals with mild cognitive impairment (mci) and/or alzheimer's disease (ad). |
2013-02-05 |
2023-08-12 |
Not clear |
| b' Megan Larson, Mathew A Sherman, Fatou Amar, Mario Nuvolone, Julie A Schneider, David A Bennett, Adriano Aguzzi, Sylvain E Lesn\\xc3\\xa. The complex PrP(c)-Fyn couples human oligomeric A\\xce\\xb2 with pathological tau changes in Alzheimer\'s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 47. 2013-02-01. PMID:23175838.' |
the complex prp(c)-fyn couples human oligomeric aβ with pathological tau changes in alzheimer's disease. |
2013-02-01 |
2023-08-12 |
mouse |
| b' Megan Larson, Mathew A Sherman, Fatou Amar, Mario Nuvolone, Julie A Schneider, David A Bennett, Adriano Aguzzi, Sylvain E Lesn\\xc3\\xa. The complex PrP(c)-Fyn couples human oligomeric A\\xce\\xb2 with pathological tau changes in Alzheimer\'s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 47. 2013-02-01. PMID:23175838.' |
together, our findings identify a complete signaling cascade linking one specific endogenous aβ oligomer, fyn alteration, and tau hyperphosphorylation in cellular and animal models modeling aspects of the molecular pathogenesis of alzheimer's disease. |
2013-02-01 |
2023-08-12 |
mouse |
| Thomas Arend. Cell cycle activation and aneuploid neurons in Alzheimer's disease. Molecular neurobiology. vol 46. issue 1. 2013-01-31. PMID:22528601. |
alzheimer's disease (ad) is a chronic neurodegenerative disorder, characterized by synaptic degeneration associated with fibrillar aggregates of the amyloid-ß peptide and the microtubule-associated protein tau. |
2013-01-31 |
2023-08-12 |
Not clear |
| Haruyuki Hongo, Takeshi Kihara, Toshiaki Kume, Yasuhiko Izumi, Tetsuhiro Niidome, Hachiro Sugimoto, Akinori Akaik. Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization. Biochemical and biophysical research communications. vol 426. issue 1. 2013-01-31. PMID:22922102. |
tau, a microtubule-associated protein and substrate for gsk3β, has been implicated in the pathogenesis of tauopathies such as alzheimer's disease. |
2013-01-31 |
2023-08-12 |
Not clear |
| Takayuki Nemoto, Toshihiko Yanagita, Shinya Satoh, Toyoaki Maruta, Tasuku Kanai, Manabu Murakami, Akihiko Wad. Insulin-induced neurite-like process outgrowth: acceleration of tau protein synthesis via a phosphoinositide 3-kinase~mammalian target of rapamycin pathway. Neurochemistry international. vol 59. issue 6. 2013-01-29. PMID:21854819. |
both insulin and tau, promoting neuronal differentiation (neurite outgrowth, neuronal polarity, and myelination) and cell survival, are associated with neurodegenerative disease (e.g., alzheimer's disease). |
2013-01-29 |
2023-08-12 |
cattle |
| Wing-Lau Ho, Yen Leung, Andrea Wing-Ting Tsang, Kwok-Fai So, Kin Chiu, Raymond Chuen-Chung Chan. Review: tauopathy in the retina and optic nerve: does it shadow pathological changes in the brain? Molecular vision. vol 18. 2013-01-29. PMID:23170062. |
similar pathological changes of tau protein can be found in alzheimer's disease, frontotemporal lobe dementia, and glaucoma. |
2013-01-29 |
2023-08-12 |
human |
| Gabriele Ciasca, Gaetano Campi, Anna Battisti, Giuseppina Rea, Marina Rodio, Massimiliano Papi, Petra Pernot, Alexander Tenenbaum, Antonio Biancon. Continuous thermal collapse of the intrinsically disordered protein tau is driven by its entropic flexible domain. Langmuir : the ACS journal of surfaces and colloids. vol 28. issue 37. 2013-01-24. PMID:22891813. |
tau is also involved in the genesis and in the development of the alzheimer disease when it detaches from mt surfaces and aggregates in paired helical filaments. |
2013-01-24 |
2023-08-12 |
Not clear |
| Hanna Rosenman. CSF biomarkers for amyloid and tau pathology in Alzheimer's disease. Journal of molecular neuroscience : MN. vol 47. issue 1. 2013-01-23. PMID:22058061. |
csf biomarkers for amyloid and tau pathology in alzheimer's disease. |
2013-01-23 |
2023-08-12 |
human |
| Markos Poulopoulos, Etty Cortes, Jean-Paul G Vonsattel, Stanley Fahn, Cheryl Waters, Lucien J Cote, Carol Moskowitz, Lawrence S Honig, Lorraine N Clark, Karen S Marder, Roy N Alcala. Clinical and pathological characteristics of LRRK2 G2019S patients with PD. Journal of molecular neuroscience : MN. vol 47. issue 1. 2013-01-23. PMID:22194196. |
cortical involvement varied significantly: one had diffuse lewy body (lb) pathology, tau inclusions, and amyloid pathology consistent with advanced alzheimer's disease; one had diffuse cortical lb; and one had only brainstem predominant lb pathology. |
2013-01-23 |
2023-08-12 |
human |
| Ulrike Krüger, Yipeng Wang, Satish Kumar, Eva-Maria Mandelko. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiology of aging. vol 33. issue 10. 2013-01-21. PMID:22169203. |
modulating the tau level may represent a therapeutic target for alzheimer's disease (ad), as accumulating evidence shows that abeta-induced neurodegeneration is mediated by tau. |
2013-01-21 |
2023-08-12 |
Not clear |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
chronic noise exposure (cne) has been associated with tau hyperphosphorylation and alzheimer's disease (ad)-like pathological changes. |
2013-01-21 |
2023-08-12 |
rat |
| Daniah Trabzuni, Selina Wray, Jana Vandrovcova, Adaikalavan Ramasamy, Robert Walker, Colin Smith, Connie Luk, J Raphael Gibbs, Allissa Dillman, Dena G Hernandez, Sampath Arepalli, Andrew B Singleton, Mark R Cookson, Alan M Pittman, Rohan de Silva, Michael E Weale, John Hardy, Mina Ryte. MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Human molecular genetics. vol 21. issue 18. 2013-01-17. PMID:22723018. |
the mapt (microtubule-associated protein tau) locus is one of the most remarkable in neurogenetics due not only to its involvement in multiple neurodegenerative disorders, including progressive supranuclear palsy, corticobasal degeneration, parksinson's disease and possibly alzheimer's disease, but also due its genetic evolution and complex alternative splicing features which are, to some extent, linked and so all the more intriguing. |
2013-01-17 |
2023-08-12 |
human |
| Gerhild van Echten-Deckert, Jochen Walte. Sphingolipids: critical players in Alzheimer's disease. Progress in lipid research. vol 51. issue 4. 2013-01-15. PMID:22835784. |
alzheimer's disease is characterized by the progressive accumulation of extracellular deposits of the amyloid β-peptide (aβ) and intraneuronal aggregates of the microtubule associated protein tau. |
2013-01-15 |
2023-08-12 |
Not clear |
| Vanessa Plouffe, Nguyen-Vi Mohamed, Jessica Rivest-McGraw, Johanne Bertrand, Michel Lauzon, Nicole Lecler. Hyperphosphorylation and cleavage at D421 enhance tau secretion. PloS one. vol 7. issue 5. 2013-01-08. PMID:22615831. |
it is well established that tau pathology propagates in a predictable manner in alzheimer's disease (ad). |
2013-01-08 |
2023-08-12 |
human |
| Venita Daebel, Subashchandrabose Chinnathambi, Jacek Biernat, Martin Schwalbe, Birgit Habenstein, Antoine Loquet, Elias Akoury, Katharina Tepper, Henrik Müller, Marc Baldus, Christian Griesinger, Markus Zweckstetter, Eckhard Mandelkow, Vinesh Vijayan, Adam Lang. β-Sheet core of tau paired helical filaments revealed by solid-state NMR. Journal of the American Chemical Society. vol 134. issue 34. 2013-01-07. PMID:22862303. |
one of the hallmarks of alzheimer's disease is the self-assembly of the microtubule-associated protein tau into fibers termed "paired helical filaments" (phfs). |
2013-01-07 |
2023-08-12 |
Not clear |
| Diana S Himmelstein, Sarah M Ward, Jody K Lancia, Kristina R Patterson, Lester I Binde. Tau as a therapeutic target in neurodegenerative disease. Pharmacology & therapeutics. vol 136. issue 1. 2013-01-04. PMID:22790092. |
in tauopathies, including alzheimer's disease and several frontotemporal dementias, tau is abnormally modified and misfolded resulting in its disassociation from microtubules and the generation of pathological lesions characteristic for each disease. |
2013-01-04 |
2023-08-12 |
Not clear |
| Kanae Iijima-Ando, Michiko Sekiya, Akiko Maruko-Otake, Yosuke Ohtake, Emiko Suzuki, Bingwei Lu, Koichi M Iijim. Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. PLoS genetics. vol 8. issue 8. 2013-01-04. PMID:22952452. |
loss of axonal mitochondria promotes tau-mediated neurodegeneration and alzheimer's disease-related tau phosphorylation via par-1. |
2013-01-04 |
2023-08-12 |
human |
| Kanae Iijima-Ando, Michiko Sekiya, Akiko Maruko-Otake, Yosuke Ohtake, Emiko Suzuki, Bingwei Lu, Koichi M Iijim. Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. PLoS genetics. vol 8. issue 8. 2013-01-04. PMID:22952452. |
abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of alzheimer's disease (ad); however, what pathological conditions trigger tau abnormality in ad is not fully understood. |
2013-01-04 |
2023-08-12 |
human |
| Lyzel S Elias-Sonnenschein, Lars Bertram, Pieter Jelle Visse. Relationship between genetic risk factors and markers for Alzheimer's disease pathology. Biomarkers in medicine. vol 6. issue 4. 2013-01-03. PMID:22917148. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by neuritic plaques (main constituent: β-amyloid [aβ]) and neurofibrillary tangles (hyperphosphorylated tau protein) in the brain. |
2013-01-03 |
2023-08-12 |
Not clear |