| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takayoshi Tokutake, Kensaku Kasuga, Ryuji Yajima, Yumi Sekine, Toshiyuki Tezuka, Masatoyo Nishizawa, Takeshi Ikeuch. Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway. The Journal of biological chemistry. vol 287. issue 42. 2012-12-31. PMID:22910909. |
alzheimer disease (ad) is neuropathologically characterized by the formation of senile plaques from amyloid-β (aβ) and neurofibrillary tangles composed of phosphorylated tau. |
2012-12-31 |
2023-08-12 |
human |
| Ondrej Cehlar, Rostislav Skrabana, Andrej Kovac, Branislav Kovacech, Michal Nova. Crystallization and preliminary X-ray diffraction analysis of tau protein microtubule-binding motifs in complex with Tau5 and DC25 antibody Fab fragments. Acta crystallographica. Section F, Structural biology and crystallization communications. vol 68. issue Pt 10. 2012-12-26. PMID:23027743. |
the alzheimer's disease-associated protein tau is an intrinsically disordered protein with no preferred structure in solution. |
2012-12-26 |
2023-08-12 |
Not clear |
| Rostislav Skrabana, Ondrej Cehlar, Zuzana Flachbartova, Andrej Kovac, Jozef Sevcik, Michal Nova. Crystallization and preliminary X-ray diffraction analysis of two peptides from Alzheimer PHF in complex with the MN423 antibody Fab fragment. Acta crystallographica. Section F, Structural biology and crystallization communications. vol 68. issue Pt 10. 2012-12-26. PMID:23027744. |
the major constituent of the alzheimer's disease paired helical filaments (phf) core is the intrinsically disordered protein (idp) tau. |
2012-12-26 |
2023-08-12 |
Not clear |
| Daan van Abel, Omar Abdulhamid, Wiep Scheper, Marie van Dijk, Cees B M Oudejan. STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. Neuroscience letters. vol 528. issue 2. 2012-12-20. PMID:22995177. |
stox1a induces phosphorylation of tau proteins at epitopes hyperphosphorylated in alzheimer's disease. |
2012-12-20 |
2023-08-12 |
human |
| Daan van Abel, Omar Abdulhamid, Wiep Scheper, Marie van Dijk, Cees B M Oudejan. STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. Neuroscience letters. vol 528. issue 2. 2012-12-20. PMID:22995177. |
our results show that stox1a induces phosphorylation of the longest human tau isoform at phospho-epitopes typically found in neurofibrillary tangles in alzheimer's disease. |
2012-12-20 |
2023-08-12 |
human |
| Daan van Abel, Omar Abdulhamid, Wiep Scheper, Marie van Dijk, Cees B M Oudejan. STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. Neuroscience letters. vol 528. issue 2. 2012-12-20. PMID:22995177. |
in conclusion, our results show a stox1a-dependent effect on tau phosphorylation found in neurodegenerative diseases such as alzheimer's disease. |
2012-12-20 |
2023-08-12 |
human |
| Suzhen Dong, Yale Duan, Yinghe Hu, Zheng Zha. Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis. Translational neurodegeneration. vol 1. issue 1. 2012-12-20. PMID:23210692. |
alzheimer's disease (ad) is a common neurodegenerative disease characterized clinically by progressive deterioration of memory, and pathologically by histopathological changes including extracellular deposits of amyloid-beta (a-beta) peptides forming senile plaques (sp) and the intracellular neurofibrillary tangles (nft) of hyperphosphorylated tau in the brain. |
2012-12-20 |
2023-08-12 |
Not clear |
| Connie Luk, Yaroslau Compta, Nadia Magdalinou, Maria José Martí, Geshanthi Hondhamuni, Henrik Zetterberg, Kaj Blennow, Radu Constantinescu, Yolande Pijnenburg, Brit Mollenhauer, Claudia Trenkwalder, John Van Swieten, Wan Zheng Chiu, Barbara Borroni, Ana Cámara, Perdita Cheshire, David R Williams, Andrew J Lees, Rohan de Silv. Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three- and four-repeat tau isoforms in tauopathies. Journal of neurochemistry. vol 123. issue 3. 2012-12-19. PMID:22862741. |
characteristic tau isoform composition of the insoluble fibrillar tau inclusions define tauopathies, including alzheimer's disease (ad), progressive supranuclear palsy (psp) and frontotemporal dementia with parkinsonism linked to chromosome 17/frontotemporal lobar degeneration-tau (ftdp-17/ftld-tau). |
2012-12-19 |
2023-08-12 |
Not clear |
| b' Jin Chu, Phillip F Giannopoulos, Carolina Ceballos-Diaz, Todd E Golde, Domenico Pratic\\xc3\\xb. 5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease. Annals of neurology. vol 72. issue 3. 2012-12-14. PMID:23034916.' |
5-lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease. |
2012-12-14 |
2023-08-12 |
mouse |
| Casey Cook, Tania F Gendron, Kristyn Scheffel, Yari Carlomagno, Judy Dunmore, Michael DeTure, Leonard Petrucell. Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation. Human molecular genetics. vol 21. issue 13. 2012-12-13. PMID:22492994. |
the abnormal accumulation of the microtubule-binding protein tau is associated with a number of neurodegenerative conditions, and correlates with cognitive decline in alzheimer's disease. |
2012-12-13 |
2023-08-12 |
Not clear |
| Researchers gain better understanding of mechanism behind tau spreading in the brain and the progression of Alzheimer's disease. American journal of Alzheimer's disease and other dementias. vol 27. issue 5. 2012-12-12. PMID:22991705. |
researchers gain better understanding of mechanism behind tau spreading in the brain and the progression of alzheimer's disease. |
2012-12-12 |
2023-08-12 |
Not clear |
| F-X Gallat, A Laganowsky, K Wood, F Gabel, L van Eijck, J Wuttke, M Moulin, M Härtlein, D Eisenberg, J-P Colletier, G Zaccai, M Wei. Dynamical coupling of intrinsically disordered proteins and their hydration water: comparison with folded soluble and membrane proteins. Biophysical journal. vol 103. issue 1. 2012-12-10. PMID:22828339. |
we investigated the human idp tau, which is involved in the pathogenic processes accompanying alzheimer disease. |
2012-12-10 |
2023-08-12 |
human |
| Ales Bartos, Lenka Fialová, Jana Svarcová, Daniela Ripov. Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament. Journal of neuroimmunology. vol 252. issue 1-2. 2012-12-10. PMID:22948089. |
patients with alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament. |
2012-12-10 |
2023-08-12 |
Not clear |
| Efthimios M C Skoulakis, Amritpal Mudhe. Twice is better: highlights of the second meeting focused on tau biology and pathology. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817708. |
it is an exciting time for tau researchers as it is now generally accepted that abnormal tau species are required to mediate the toxic effects of amyloid β-peptide oligomers in alzheimer's disease. |
2012-12-07 |
2023-08-12 |
Not clear |
| Yipeng Wang, Eckhard Mandelko. Degradation of tau protein by autophagy and proteasomal pathways. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817709. |
tau aggregates are present in several neurodegenerative diseases and correlate with the severity of memory deficit in ad (alzheimer's disease). |
2012-12-07 |
2023-08-12 |
Not clear |
| Jesus Avila, Elena Gomez de Barreda, Almudena Fuster-Matanzo, Diana Simón, María Llorens-Martín, Tobias Engel, Jose J Lucas, Miguel Díaz-Hernández, Félix Hernánde. Looking for novel functions of tau. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817710. |
furthermore, tau can be found in the extracellular space because of the neuronal cell death occurring in neurodegenerative disorders such as alzheimer's disease. |
2012-12-07 |
2023-08-12 |
mouse |
| Jeanna M Wheeler, Chris R Guthrie, Brian C Kraeme. Potential neuroprotective strategies against tauopathy. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817711. |
tauopathies are neurodegenerative diseases, including ad (alzheimer's disease) and ftld-t (tau-positive frontotemporal lobar degeneration), with shared pathology presenting as accumulation of detergent-insoluble hyperphosphorylated tau deposits in the central nervous system. |
2012-12-07 |
2023-08-12 |
caenorhabditis_elegans |
| Kurt R Brunden, Carlo Ballatore, Virginia M-Y Lee, Amos B Smith, John Q Trojanowsk. Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817712. |
neurons within the brains of those with ad (alzheimer's disease) and related neurodegenerative disorders, collectively termed 'tauopathies', contain fibrillar inclusions composed of hyperphosphorylated tau protein. |
2012-12-07 |
2023-08-12 |
mouse |
| Sarah M Ward, Diana S Himmelstein, Jody K Lancia, Lester I Binde. Tau oligomers and tau toxicity in neurodegenerative disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817713. |
ad (alzheimer's disease) is a progressive neurodegenerative disorder characterized by the extracellular accumulation of amyloid β-peptide and the intracellular accumulation of tau. |
2012-12-07 |
2023-08-12 |
squid |
| Michael Niblock, Jean-Marc Gall. Tau alternative splicing in familial and sporadic tauopathies. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817715. |
thus an accurate regulation of tau alternative splicing is critical for the maintenance of neuronal viability, and its alteration might be a contributing factor to alzheimer's disease. |
2012-12-07 |
2023-08-12 |
human |