| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Johannes Attems, Dietmar R Thal, Kurt A Jellinge. The relationship between subcortical tau pathology and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817721. |
the relationship between subcortical tau pathology and alzheimer's disease. |
2012-12-07 |
2023-08-12 |
Not clear |
| Johannes Attems, Dietmar R Thal, Kurt A Jellinge. The relationship between subcortical tau pathology and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817721. |
the stepwise progression of tau pathology [nfts (neurofibrillary tangles) and nts (neuropil threads)] in ad (alzheimer's disease) is generally assumed to begin in the transentorhinal region (entorhinal stage) from which it progresses to the hippocampus (limbic stage) and to neocortical regions (neocortical stage). |
2012-12-07 |
2023-08-12 |
Not clear |
| Cora O'Neill, Aoife P Kiely, Meghan F Coakley, Sean Manning, Caitriona M Long-Smit. Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817723. |
thus, in ad (alzheimer's disease), soluble oligomers, protofibrils and fibrils of the aβ (amyloid β-peptide) and tau protein accumulate in specific brain regions. |
2012-12-07 |
2023-08-12 |
Not clear |
| Shuai Dong, Lan Chu, Fang Liu, Zhu Xu, Shirong Li, Yifan Zhang, Hao Wang, Lijun Cai, Mingming Da. Roles of the tau gene short tandem repeats in late-onset Alzheimer's disease. The International journal of neuroscience. vol 122. issue 5. 2012-12-06. PMID:22176350. |
roles of the tau gene short tandem repeats in late-onset alzheimer's disease. |
2012-12-06 |
2023-08-12 |
human |
| Shuai Dong, Lan Chu, Fang Liu, Zhu Xu, Shirong Li, Yifan Zhang, Hao Wang, Lijun Cai, Mingming Da. Roles of the tau gene short tandem repeats in late-onset Alzheimer's disease. The International journal of neuroscience. vol 122. issue 5. 2012-12-06. PMID:22176350. |
this study assessed the roles of tau gene short tandem repeats (strs) nested within intron 1 (rs5820604 and rs10675722) and apolipoprotein e (apoe) gene polymorphisms in 70 late-onset alzheimer's disease (ad) subjects, 70 vascular dementia (vd) subjects, and 70 normal controls (ncs) in guizhou han population. |
2012-12-06 |
2023-08-12 |
human |
| Yang Hong-Qi, Sun Zhi-Kun, Chen Sheng-D. Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau. Translational neurodegeneration. vol 1. issue 1. 2012-12-06. PMID:23210837. |
current advances in the treatment of alzheimer's disease: focused on considerations targeting aβ and tau. |
2012-12-06 |
2023-08-12 |
Not clear |
| Sean J Colloby, Shane McParland, John T O'Brien, Johannes Attem. Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias. Brain : a journal of neurology. vol 135. issue Pt 9. 2012-12-05. PMID:22961551. |
we aimed to investigate the influence of nigral neuronal loss as well as nigral (α-synuclein, tau) and striatal (α-synuclein, tau, amyloid β) pathology on striatal uptake in a cohort of autopsy-confirmed alzheimer's disease (n = 4), dementia with lewy bodies (n = 7) and parkinson's disease dementia (n = 12) cases. |
2012-12-05 |
2023-08-12 |
human |
| Siddhartha Mondragón-Rodríguez, Emilie Trillaud-Doppia, Anthony Dudilot, Catherine Bourgeois, Michel Lauzon, Nicole Leclerc, Jannic Boeh. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. The Journal of biological chemistry. vol 287. issue 38. 2012-12-04. PMID:22833681. |
amyloid-β and tau protein are the two most prominent factors in the pathology of alzheimer disease. |
2012-12-04 |
2023-08-12 |
Not clear |
| Gonzalo Farías, Patricio Pérez, Andrea Slachevsky, Ricardo B Maccion. Platelet tau pattern correlates with cognitive status in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22495344. |
platelet tau pattern correlates with cognitive status in alzheimer's disease. |
2012-12-03 |
2023-08-12 |
human |
| Armand Perret-Liaudet, Mathieu Pelpel, Yannick Tholance, Benoit Dumont, Hugo Vanderstichele, Willy Zorzi, Benaissa Elmoualij, Susanna Schraen, Olivier Moreaud, Audrey Gabelle, Eric Thouvenot, Catherine Thomas-Anterion, Jacques Touchon, Pierre Krolak-Salmon, Gabor G Kovacs, Arnaud Coudreuse, Isabelle Quadrio, Sylvain Lehman. Risk of Alzheimer's disease biological misdiagnosis linked to cerebrospinal collection tubes. Journal of Alzheimer's disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22495345. |
tau proteins and amyloid-β (aβ) peptides are the current recognized cerebrospinal fluid (csf) biomarkers used as an aid in the diagnosis of alzheimer's disease (ad). |
2012-12-03 |
2023-08-12 |
Not clear |
| b' Yash B Joshi, Jin Chu, Domenico Pratic\\xc3\\xb. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer\'s disease. Journal of Alzheimer\'s disease : JAD. vol 31. issue 1. 2012-12-03. PMID:22531419.' |
stress hormone leads to memory deficits and altered tau phosphorylation in a model of alzheimer's disease. |
2012-12-03 |
2023-08-12 |
mouse |
| Rodrigo Medeiros, Masashi Kitazawa, Meredith A Chabrier, David Cheng, David Baglietto-Vargas, Andreas Kling, Achim Moeller, Kim N Green, Frank M LaFerl. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. The American journal of pathology. vol 181. issue 2. 2012-11-26. PMID:22688056. |
exacerbated activation of calpain has been implicated as a major component in the signaling cascade that leads to β-amyloid (aβ) production and tau hyperphosphorylation in alzheimer's disease (ad). |
2012-11-26 |
2023-08-12 |
mouse |
| Sebastiaan Engelborghs, Nathalie Le Bastar. The impact of cerebrospinal fluid biomarkers on the diagnosis of Alzheimer's disease. Molecular diagnosis & therapy. vol 16. issue 3. 2012-11-19. PMID:22646065. |
the cerebrospinal fluid (csf) biomarkers β-amyloid(1-42) (aβ(1-42)), total tau protein (t-tau), and tau phosphorylated at threonine 181 (p-tau(181p)) are gradually finding their way into routine clinical practice as an affirmative diagnostic tool for alzheimer's disease (ad). |
2012-11-19 |
2023-08-12 |
Not clear |
| Qi-Rui Ong, Mei-Li Lim, Ching-Ching Chua, Nam Sang Cheung, Boon-Seng Won. Impaired insulin signaling in an animal model of Niemann-Pick Type C disease. Biochemical and biophysical research communications. vol 424. issue 3. 2012-11-19. PMID:22776200. |
studies have shown similarities between the histopathological characteristics of npc and alzheimer's disease (ad) including amyloid and tau pathologies. |
2012-11-19 |
2023-08-12 |
mouse |
| G Nübling, J Levin, B Bader, L Israel, K Bötzel, S Lorenzl, A Gies. Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation. Experimental neurology. vol 237. issue 2. 2012-11-13. PMID:22890115. |
tauopathies such as alzheimer's disease or progressive supranuclear palsy are characterized by pathological deposits of aggregated protein tau. |
2012-11-13 |
2023-08-12 |
Not clear |
| Rostislav Skrabana, Radovan Dvorsky, Jozef Sevcik, Michal Nova. Monoclonal antibody MN423 as a stable mold facilitates structure determination of disordered tau protein. Journal of structural biology. vol 171. issue 1. 2012-11-08. PMID:20184958. |
in this work we compare two "antibody mold structures": (1) x-ray structure of the free form of the alzheimer's disease phf core-specific antibody mn423 and (2) previously solved structure of the complex of mn423 with the phf core c-terminal tau peptide. |
2012-11-08 |
2023-08-12 |
Not clear |
| Sheng-Rong Meng, Ying-Zhu Zhu, Tong Guo, Xiao-Ling Liu, Jie Chen, Yi Lian. Fibril-forming motifs are essential and sufficient for the fibrillization of human Tau. PloS one. vol 7. issue 6. 2012-11-08. PMID:22701727. |
the misfolding of amyloidogenic proteins including human tau protein, human prion protein, and human α-synuclein is involved in neurodegenerative diseases such as alzheimer disease, prion disease, and parkinson disease. |
2012-11-08 |
2023-08-12 |
human |
| Lucilla Parnetti, Davide Chiasserin. Role of CSF biomarkers in the diagnosis of prodromal Alzheimer's disease. Biomarkers in medicine. vol 5. issue 4. 2012-11-07. PMID:21861669. |
alzheimer's disease (ad) core biomarkers (aβ(1-42), total tau and phosphorylated tau) have proven to be useful in the clinical practice to evaluate patients with mild cognitive impairment in order to predict progression to alzheimer's disease. |
2012-11-07 |
2023-08-12 |
Not clear |
| Claire Paquet, François Mouton-Liger, Eliane F Meurs, Pierre Mazot, Constantin Bouras, Laurent Pradier, Françoise Gray, Jacques Hugo. The PKR activator PACT is induced by Aβ: involvement in Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 22. issue 2. 2012-11-06. PMID:21790829. |
the neuropathological hallmarks of alzheimer's disease (ad) include senile plaques made of aβ peptide, neurofibrillary tangles containing hyperphosphorylated tau protein and neuronal loss. |
2012-11-06 |
2023-08-12 |
mouse |
| Francisco García-Sierra, Jose J Jarero-Basulto, Zdena Kristofikova, Emerich Majer, Lester I Binder, Daniela Ripov. Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 22. issue 2. 2012-11-06. PMID:21919991. |
ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in alzheimer's disease. |
2012-11-06 |
2023-08-12 |
Not clear |