| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B J Balin, D M Appel. Transglutaminase-catalyzed formation of Alzheimer-like insoluble complexes from recombinant tau. Methods in molecular medicine. vol 32. 2012-10-02. PMID:21318534. |
here we discuss important aspects of tgase and in vitro experimental approaches that address its ability to catalyze the tau protein into insoluble complexes exhibiting biophysical and immuno-logical properties similar to those of the alzheimer phfs and nfts. |
2012-10-02 |
2023-08-12 |
human |
| Annica Sjölander, Malin E Andersson, Henrik Zetterberg, Lennart Minthon, Nenad Bogdanovic, Kaj Blenno. Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk. Molecular medicine reports. vol 2. issue 6. 2012-10-02. PMID:21475932. |
cyclin-dependent kinase 5 (cdk5) has been identified as one of the kinases that phosphorylates tau at several alzheimer's disease (ad)-associated sites. |
2012-10-02 |
2023-08-12 |
Not clear |
| Anne Eckert, Karen Schmitt, Jürgen Göt. Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity. Alzheimer's research & therapy. vol 3. issue 2. 2012-10-02. PMID:21545753. |
the pathology of alzheimer's disease (ad) is characterized by amyloid plaques (aggregates of amyloid-β (aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by mitochondrial dysfunction, but the mechanisms underlying this dysfunction are poorly understood. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jose F Abisambra, Umesh K Jinwal, Amirthaa Suntharalingam, Karthik Arulselvam, Sarah Brady, Matthew Cockman, Ying Jin, Bo Zhang, Chad A Dicke. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau. Journal of molecular biology. vol 421. issue 4-5. 2012-10-02. PMID:22343013. |
tau reductions facilitated by dnaja1 were dependent on the integrity of lysines known to be poly-ubiquitinated in human alzheimer's brain. |
2012-10-02 |
2023-08-12 |
human |
| M Shoji, M Kana. Cerebrospinal fluid Aβ40 and Aβ42: Natural course and clinical usefulness. Journal of Alzheimer's disease : JAD. vol 3. issue 3. 2012-10-02. PMID:22387626. |
combination assays of csf tau and aβ ratio provided further efficient diagnostic sensitivity (81%) reliability of the assay may prompt worldwide usage of these csf biomarkers for alzheimer's patients. |
2012-10-02 |
2023-08-12 |
Not clear |
| Sabine Liebscher, Melanie Meyer-Luehman. A Peephole into the Brain: Neuropathological Features of Alzheimer's Disease Revealed by in vivo Two-Photon Imaging. Frontiers in psychiatry. vol 3. 2012-10-02. PMID:22485096. |
alzheimer's disease (ad) is a protein conformational disorder characterized by two major neuropathological features: extracellular accumulations of amyloid-β peptides in the form of plaques and intracellular tangles, consisting of hyperphosphorylated tau proteins. |
2012-10-02 |
2023-08-12 |
mouse |
| Akihiko Takashim. GSK-3β and memory formation. Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22536172. |
in alzheimer's disease (ad), tau hyperphosphorylation and neurofibrillary tangle (nft) formation are strongly associated with dementia, a characteristic and early feature of this disease. |
2012-10-02 |
2023-08-12 |
mouse |
| Almudena Fuster-Matanzo, María Llorens-Martín, Jerónimo Jurado-Arjona, Jesús Avila, Félix Hernánde. Tau protein and adult hippocampal neurogenesis. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22787440. |
tau metabolism has attracted much attention because of its role in neurodegenerative disorders called tauopathies, mainly alzheimer disease. |
2012-10-02 |
2023-08-12 |
Not clear |
| Evangelyn Dominguez, Ting-Yu Chin, Chih-Ping Chen, Tzong-Yuan W. Management of moderate to severe Alzheimer's disease: focus on memantine. Taiwanese journal of obstetrics & gynecology. vol 50. issue 4. 2012-10-01. PMID:22212311. |
aside from nmda receptor antagonism, numerous studies have reported that memantine can also affect dopamine receptors, block excessive calcium influx and production of reactive oxygen species (ros) induced by aβ oligomers, and inhibit the internal ribosome entry site (ires), thus preventing the expression of the amyloid precursor and tau proteins which are considered as early indicators of alzheimer's. |
2012-10-01 |
2023-08-12 |
Not clear |
| Axel Regeniter, Jens Kuhle, Thomas Baumann, Marc Sollberger, Markus Herdener, Ursula Kunze, Michael C Camuso, Andreas U Monsc. Biomarkers of dementia: comparison of electrochemiluminescence results and reference ranges with conventional ELISA. Methods (San Diego, Calif.). vol 56. issue 4. 2012-10-01. PMID:22503775. |
innogenetics tau, innogenetics p-tau(181) and msd t-tau differentiated the alzheimer's (n=44) and minimal impairment group (mci, n=39) from normal controls (n=37), but the mci group was not statistically different from the normal controls. |
2012-10-01 |
2023-08-12 |
Not clear |
| Rodrigo A Quintanilla, Philip J Dolan, Youngnam N Jin, Gail V W Johnso. Truncated tau and Aβ cooperatively impair mitochondria in primary neurons. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21450370. |
mitochondrial dysfunction is likely a significant contributing factor to alzheimer disease pathogenesis, and both amyloid peptide (aβ) and pathological forms of tau may contribute to this impairment. |
2012-09-28 |
2023-08-12 |
Not clear |
| Rodrigo A Quintanilla, Philip J Dolan, Youngnam N Jin, Gail V W Johnso. Truncated tau and Aβ cooperatively impair mitochondria in primary neurons. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21450370. |
cleavage of tau at asp421 occurs early in alzheimer disease, and asp421-cleaved tau likely negatively impacts neuronal function. |
2012-09-28 |
2023-08-12 |
Not clear |
| Rodrigo A Quintanilla, Philip J Dolan, Youngnam N Jin, Gail V W Johnso. Truncated tau and Aβ cooperatively impair mitochondria in primary neurons. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21450370. |
these new findings show that asp421-cleaved tau and aβ cooperate to impair mitochondria, which likely contributes to the neuronal dysfunction in alzheimer disease. |
2012-09-28 |
2023-08-12 |
Not clear |
| Paola Gamba, Gabriella Testa, Barbara Sottero, Simona Gargiulo, Giuseppe Poli, Gabriella Leonarduzz. The link between altered cholesterol metabolism and Alzheimer's disease. Annals of the New York Academy of Sciences. vol 1259. 2012-09-27. PMID:22758637. |
alzheimer's disease (ad), the most common form of dementia, is characterized by the progressive loss of neurons and synapses, and by extracellular deposits of amyloid-β (aβ) as senile plaques, aβ deposits in the cerebral blood vessels, and intracellular inclusions of hyperphosphorylated tau in the form of neurofibrillary tangles. |
2012-09-27 |
2023-08-12 |
Not clear |
| Buyong Ma, Ruth Nussino. Selective molecular recognition in amyloid growth and transmission and cross-species barriers. Journal of molecular biology. vol 421. issue 2-3. 2012-09-25. PMID:22119878. |
on the other hand, the tau protein repeats with the characteristic u-turn shape can cross-seed alzheimer's amyloid β and, similarly, the islet amyloid polypeptide. |
2012-09-25 |
2023-08-12 |
Not clear |
| Gayathri Ramachandran, Jayant B Udgaonka. Evidence for the existence of a secondary pathway for fibril growth during the aggregation of tau. Journal of molecular biology. vol 421. issue 2-3. 2012-09-25. PMID:22281439. |
amyloid fibril formation by tau, a microtubule-associated protein whose aggregation to form neurofibrillary tangles is implicated in alzheimer's disease and other tauopathies, in the presence of inducers such as heparin and fatty acid micelles, has always been traditionally described by a ligand-induced ndp model. |
2012-09-25 |
2023-08-12 |
Not clear |
| Guangyu Li, Fei Cai, Wei Yan, Cairong Li, Jianghua Wan. A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. Toxicological sciences : an official journal of the Society of Toxicology. vol 127. issue 2. 2012-09-24. PMID:22430071. |
moreover, mclr was found to induce tau hyperphosphorylation, spatial memory impairment, neuronal degenerative changes, and apoptosis, suggesting that this cyanotoxin may contribute to alzheimer's disease in humans. |
2012-09-24 |
2023-08-12 |
rat |
| Ann Van der Jeugd, Katja Hochgräfe, Tariq Ahmed, Jochen M Decker, Astrid Sydow, Anne Hofmann, Dan Wu, Lars Messing, Detlef Balschun, Rudi D'Hooge, Eva-Maria Mandelko. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta neuropathologica. vol 123. issue 6. 2012-09-24. PMID:22532069. |
neurofibrillary lesions of abnormal tau are hallmarks of alzheimer disease and frontotemporal dementias. |
2012-09-24 |
2023-08-12 |
mouse |
| Jessica S Damoiseaux, William W Seeley, Juan Zhou, William R Shirer, Giovanni Coppola, Anna Karydas, Howard J Rosen, Bruce L Miller, Joel H Kramer, Michael D Greiciu. Gender modulates the APOE ε4 effect in healthy older adults: convergent evidence from functional brain connectivity and spinal fluid tau levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 24. 2012-09-24. PMID:22699906. |
an additional analysis in an independent sample of healthy elderly using an independent marker of alzheimer's disease, i.e., spinal fluid levels of tau, provided corresponding evidence for this gender-by-apoe interaction. |
2012-09-24 |
2023-08-12 |
human |
| Tara Vanderweyde, Haung Yu, Megan Varnum, Liqun Liu-Yesucevitz, Allison Citro, Tsuneya Ikezu, Karen Duff, Benjamin Wolozi. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 24. 2012-09-24. PMID:22699908. |
we examined the relationship between sg proteins and neuropathology in brain tissue from p301l tau transgenic mice, as well as in cases of alzheimer's disease and ftdp-17. |
2012-09-24 |
2023-08-12 |
mouse |