All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Nicholas M Kanaan, Gerardo Morfini, Gustavo Pigino, Nichole E LaPointe, Athena Andreadis, Yuyu Song, Ellen Leitman, Lester I Binder, Scott T Brad. Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21794954. alzheimer's disease (ad) and other tauopathies are characterized by fibrillar inclusions composed of the microtubule-associated protein, tau. 2012-06-15 2023-08-12 Not clear
Olivia Sheppard, Florian Plattner, Anna Rubin, Amy Slender, Jacqueline M Linehan, Sebastian Brandner, Victor L J Tybulewicz, Elizabeth M C Fisher, Frances K Wisema. Altered regulation of tau phosphorylation in a mouse model of down syndrome aging. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21843906. here, using the unique transchromosomic tc1 mouse model of ds we investigate the influence of trisomy of hsa21 on the protein tau, which is hyperphosphorylated in alzheimer's disease. 2012-06-15 2023-08-12 mouse
Giuseppina Amadoro, Veronica Corsetti, Anna Atlante, Fulvio Florenzano, Simona Capsoni, Rossana Bussani, Delio Mercanti, Pietro Calissan. Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21958963. structural and functional mitochondrial alterations play an early, precipitating role in synaptic failure of alzheimer's disease (ad) pathogenesis and an aggravated mitochondrial impairment has been described in triple app/ps/tau transgenic mice carrying both plaques and tangles, if compared with mice overexpressing tau or amyloid precursor protein (app) alone. 2012-06-15 2023-08-12 mouse
Panagiotis Alexopoulos, Liang-Hao Guo, Amalia Tsolakidou, Martina Kratzer, Timo Grimmer, Christine Westerteicher, Meizi Jiang, Hideaki Bujo, Janine Diehl-Schmid, Alexander Kurz, Robert Perneczk. Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 28. issue 3. 2012-06-15. PMID:22045485. interrelations between csf soluble aβppβ, amyloid-β 1-42, sorl1, and tau levels in alzheimer's disease. 2012-06-15 2023-08-12 Not clear
Alexis M Stranahan, Bronwen Martin, Stuart Maudsle. Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22329653. treadmill exercise has also been shown to ameliorate the accumulation of phosphorylated tau, an essential component of neurofibrillary tangles in alzheimer's models. 2012-06-14 2023-08-12 mouse
Eun Ji Gong, Hee Ra Park, Mi Eun Kim, Shunfu Piao, Eunjin Lee, Dong-Gyu Jo, Hae Young Chung, Nam-Chul Ha, Mark P Mattson, Jaewon Le. Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Neurobiology of disease. vol 44. issue 2. 2012-06-11. PMID:21782947. alzheimer's disease (ad) is the major form of age-related dementia and is characterized by progressive cognitive impairment, the accumulation of extracellular amyloid β-peptide (aβ), and intracellular hyperphosphorylated tau aggregates in affected brain regions. 2012-06-11 2023-08-12 mouse
Rhiannon L Killian, Jessica D Flippin, Cheryl M Herrera, Angels Almenar-Queralt, Lawrence S B Goldstei. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PloS one. vol 7. issue 1. 2012-06-11. PMID:22272245. the etiology of sporadic alzheimer disease (ad) is largely unknown, although evidence implicates the pathological hallmark molecules amyloid beta (aβ) and phosphorylated tau. 2012-06-11 2023-08-12 human
Hai-Li Zhu, Sheng-Rong Meng, Jun-Bao Fan, Jie Chen, Yi Lian. Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362. PloS one. vol 6. issue 9. 2012-06-08. PMID:21966400. neurofibrillary tangles, mainly consisted of bundles of filaments formed by the microtubule-associated protein tau, are a hallmark of alzheimer disease. 2012-06-08 2023-08-12 human
Hai-Li Zhu, Sheng-Rong Meng, Jun-Bao Fan, Jie Chen, Yi Lian. Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362. PloS one. vol 6. issue 9. 2012-06-08. PMID:21966400. however, it has not been reported so far whether pb(2+) plays a role in the pathology of alzheimer disease through interaction with human tau protein and thereby mediates tau filament formation. 2012-06-08 2023-08-12 human
Shih-Yuan Chen, Ta-Fu Chen, Liang-Chuan Lai, Jen-Hau Chen, Yu Sun, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Yen-Ching Che. Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. Journal of neuroinflammation. vol 9. 2012-06-06. PMID:22272811. interleukin 6 (il-6) has been related to beta-amyloid aggregation and the appearance of hyperphosphorylated tau in alzheimer's disease (ad) brain. 2012-06-06 2023-08-12 Not clear
Kazuhiro Nakamura, Alex Greenwood, Lester Binder, Eileen H Bigio, Sarah Denial, Linda Nicholson, Xiao Zhen Zhou, Kun Ping L. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell. vol 149. issue 1. 2012-06-04. PMID:22464332. proline isomer-specific antibodies reveal the early pathogenic tau conformation in alzheimer's disease. 2012-06-04 2023-08-12 Not clear
Kazuhiro Nakamura, Alex Greenwood, Lester Binder, Eileen H Bigio, Sarah Denial, Linda Nicholson, Xiao Zhen Zhou, Kun Ping L. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell. vol 149. issue 1. 2012-06-04. PMID:22464332. pin1 converts cis to trans p-tau to prevent alzheimer's tau pathology. 2012-06-04 2023-08-12 Not clear
Hugo Vanderstichele, Mirko Bibl, Sebastiaan Engelborghs, Nathalie Le Bastard, Piotr Lewczuk, Jose Luis Molinuevo, Lucilla Parnetti, Armand Perret-Liaudet, Leslie M Shaw, Charlotte Teunissen, Dirk Wouters, Kaj Blenno. Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 1. 2012-05-31. PMID:22047631. numerous studies show that the cerebrospinal fluid biomarkers total tau (t-tau), tau phosphorylated at threonine 181 (p-tau(181p)), and amyloid-β (1-42) (aβ(1-42)) have high diagnostic accuracy for alzheimer's disease. 2012-05-31 2023-08-12 Not clear
Charles R Harringto. The molecular pathology of Alzheimer's disease. Neuroimaging clinics of North America. vol 22. issue 1. 2012-05-29. PMID:22284730. neurofibrillary pathology in alzheimer's disease consists of paired helical filaments comprising tau protein. 2012-05-29 2023-08-12 Not clear
Vladimir P Skulache. Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases. Journal of Alzheimer's disease : JAD. vol 28. issue 2. 2012-05-24. PMID:21987592. in the second article, the authors identified molecular mechanisms by which amyloid-β-induced mros can mediate hyperphosphorylation of the tau protein, a key event in alzheimer's disease. 2012-05-24 2023-08-12 rat
Y X Shen, A M Sun, S Fang, L J Feng, Q Li, H L Hou, C Liu, H P Wang, J L Shen, J Luo, J N Zho. Hrd1 facilitates tau degradation and promotes neuron survival. Current molecular medicine. vol 12. issue 2. 2012-05-24. PMID:22280354. intraneuronal accumulation of abnormal phosphorylated tau (p-tau) is a molecular pathology in many neurodegenerative tauopathies, including alzheimer's disease (ad) and frontotemporal dementia with parkinsonism-linked to chromosome 17 (ftdp-17). 2012-05-24 2023-08-12 human
Edmond Teng, Vladimir Kepe, Sally A Frautschy, Jie Liu, Nagichettiar Satyamurthy, Fusheng Yang, Ping-Ping Chen, Graham B Cole, Mychica R Jones, Sung-Cheng Huang, Dorothy G Flood, Stephen P Trusko, Gary W Small, Gregory M Cole, Jorge R Barri. [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Neurobiology of disease. vol 43. issue 3. 2012-05-21. PMID:21605674. in vivo detection of alzheimer's disease (ad) neuropathology in living patients using positron emission tomography (pet) in conjunction with high affinity molecular imaging probes for β-amyloid (aβ) and tau has the potential to assist with early diagnosis, evaluation of disease progression, and assessment of therapeutic interventions. 2012-05-21 2023-08-12 mouse
Scott A Yuzwa, Xiaoyang Shan, Matthew S Macauley, Thomas Clark, Yuliya Skorobogatko, Keith Vosseller, David J Vocadl. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nature chemical biology. vol 8. issue 4. 2012-05-21. PMID:22366723. oligomerization of tau is a key process contributing to the progressive death of neurons in alzheimer's disease. 2012-05-21 2023-08-12 mouse
Pavan K Krishnamurthy, Einar M Sigurdsso. Therapeutic applications of antibodies in non-infectious neurodegenerative diseases. New biotechnology. vol 28. issue 5. 2012-05-15. PMID:21473943. neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease, huntington's disease (hd) or amyotrophic lateral sclerosis (als) are all characterised histologically by the presence of deposits of misfolded proteins, tau and amyloid-β, α-synuclein, huntingtin or superoxide dismutase, respectively. 2012-05-15 2023-08-12 Not clear
Maartje I Kester, Nicolaas A Verwey, Evert J van Elk, Marinus A Blankenstein, Philip Scheltens, Wiesje M van der Flie. Progression from MCI to AD: predictive value of CSF Aβ42 is modified by APOE genotype. Neurobiology of aging. vol 32. issue 8. 2012-05-14. PMID:19748159. to study csf biomarkers amyloid-beta 1-42 (aβ42) and total tau (tau) in relation to apoe genotype in their ability to predict progression from mild cognitive impairment (mci) to alzheimer's disease (ad). 2012-05-14 2023-08-12 Not clear