| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Bonda, R J Castellani, X Zhu, A Nunomura, H-g Lee, G Perry, M A Smit. A novel perspective on tau in Alzheimer's disease. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605042. |
a novel perspective on tau in alzheimer's disease. |
2012-07-19 |
2023-08-12 |
Not clear |
| K Belarbi, S Burnouf, F-J Fernandez-Gomez, J Desmercières, L Troquier, J Brouillette, L Tsambou, M-E Grosjean, R Caillierez, D Demeyer, M Hamdane, K Schindowski, D Blum, L Bué. Loss of medial septum cholinergic neurons in THY-Tau22 mouse model: what links with tau pathology? Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605043. |
alzheimer's disease (ad) is a neurodegenerative disorder histologically defined by the cerebral accumulation of amyloid deposits and neurofibrillary tangles composed of hyperphosphorylated tau proteins. |
2012-07-19 |
2023-08-12 |
mouse |
| E Lonati, M Masserini, A Bulbarell. Pin1: a new outlook in Alzheimer's disease. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605045. |
neurodegenerative diseases termed tauopathies, including alzheimer disease, are characterized by the presence of intraneuronal neurofibrillary tangles (nfts), composed by hyperphosphorylated protein tau. |
2012-07-19 |
2023-08-12 |
Not clear |
| G Farías, A Cornejo, J Jiménez, L Guzmán, R B Maccion. Mechanisms of tau self-aggregation and neurotoxicity. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605046. |
pathological tau protein aggregates can be found in brain of patients with some of the neurodegenerative diseases collectively known as tauopathies, which include alzheimer's disease (ad). |
2012-07-19 |
2023-08-12 |
Not clear |
| A Boutajangout, E M Sigurdsson, P K Krishnamurth. Tau as a therapeutic target for Alzheimer's disease. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21679154. |
tau as a therapeutic target for alzheimer's disease. |
2012-07-19 |
2023-08-12 |
Not clear |
| A Boutajangout, E M Sigurdsson, P K Krishnamurth. Tau as a therapeutic target for Alzheimer's disease. Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21679154. |
neurofibrillary tangles (nfts) are one of the pathological hallmarks of alzheimer's disease (ad) and are primarily composed of aggregates of hyperphosphorylated forms of the microtubule associated protein tau. |
2012-07-19 |
2023-08-12 |
Not clear |
| Mikio Shoj. [Biomarkers for Alzheimer's disease: after Alzheimer's disease neuroimaging initiative studies]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 5. 2012-07-17. PMID:22570063. |
csf aβ42, total tau, and phosphorylated tau181 are the most sensitive biomarkers for diagnosing alzheimer's disease (ad) and predicting the onset of ad in cases with mild cognitive impairment (mci) due to ad. |
2012-07-17 |
2023-08-12 |
Not clear |
| Gema Alvarez, Jesús Aldudo, María Alonso, Soraya Santana, Fernando Valdivies. Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells. Journal of neuroscience research. vol 90. issue 5. 2012-07-16. PMID:22252837. |
although tau is most widely known as a microtubule-associated protein found in a hyperphosphorylated state in the brains of patients with alzheimer's disease (ad), this protein has also been detected at other sites such as the nucleolus. |
2012-07-16 |
2023-08-12 |
human |
| Justin M Nussbaum, Stephan Schilling, Holger Cynis, Antonia Silva, Eric Swanson, Tanaporn Wangsanut, Kaycie Tayler, Brian Wiltgen, Asa Hatami, Raik Rönicke, Klaus Reymann, Birgit Hutter-Paier, Anca Alexandru, Wolfgang Jagla, Sigrid Graubner, Charles G Glabe, Hans-Ulrich Demuth, George S Bloo. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature. vol 485. issue 7400. 2012-07-12. PMID:22660329. |
extracellular plaques of amyloid-β and intraneuronal neurofibrillary tangles made from tau are the histopathological signatures of alzheimer's disease. |
2012-07-12 |
2023-08-12 |
mouse |
| Eric Heuer, Rebecca F Rosen, Amarallys Cintron, Lary C Walke. Nonhuman primate models of Alzheimer-like cerebral proteopathy. Current pharmaceutical design. vol 18. issue 8. 2012-07-09. PMID:22288403. |
the aβ and tau proteins, two key players in the pathogenesis of alzheimer's disease (ad), are highly homologous among primates. |
2012-07-09 |
2023-08-12 |
human |
| Toshiki Uchihara, Makoto Hara, Ayako Nakamura, Katsuiku Hirokaw. Tangle evolution linked to differential 3- and 4-repeat tau isoform deposition: a double immunofluorolabeling study using two monoclonal antibodies. Histochemistry and cell biology. vol 137. issue 2. 2012-07-05. PMID:22116524. |
this novel method revealed that tau immunoreactivity (ir) in the hippocampal pyramidal neurons of alzheimer's disease (ad) brains is heterogeneous in that pretangle neurons exhibit 4r-selective (3r-/4r+) ir, ghost tangles exhibit 3r-selective (3r+/4r-) ir, and neurofibrillary tangles exhibit both 3r and 4r (3r+/4r+) ir. |
2012-07-05 |
2023-08-12 |
human |
| Rodrigo Medeiros, David Baglietto-Vargas, Frank M LaFerl. The role of tau in Alzheimer's disease and related disorders. CNS neuroscience & therapeutics. vol 17. issue 5. 2012-07-03. PMID:20553310. |
the role of tau in alzheimer's disease and related disorders. |
2012-07-03 |
2023-08-12 |
Not clear |
| Rodrigo Medeiros, David Baglietto-Vargas, Frank M LaFerl. The role of tau in Alzheimer's disease and related disorders. CNS neuroscience & therapeutics. vol 17. issue 5. 2012-07-03. PMID:20553310. |
tau, the microtubule-associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in alzheimer's disease (ad) and related tauopathies. |
2012-07-03 |
2023-08-12 |
Not clear |
| Malgorzata Broncel, Eberhard Krause, Dirk Schwarzer, Christian P R Hackenberge. The Alzheimer's disease related tau protein as a new target for chemical protein engineering. Chemistry (Weinheim an der Bergstrasse, Germany). vol 18. issue 9. 2012-07-03. PMID:22231520. |
the alzheimer's disease related tau protein as a new target for chemical protein engineering. |
2012-07-03 |
2023-08-12 |
Not clear |
| Xiang Yu, Yin Luo, Paul Dinkel, Jie Zheng, Guanghong Wei, Martin Margittai, Ruth Nussinov, Buyong M. Cross-seeding and conformational selection between three- and four-repeat human Tau proteins. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22393063. |
in alzheimer's disease and frontotemporal dementias, the microtubule-associated protein tau forms intracellular paired helical filaments. |
2012-07-02 |
2023-08-12 |
human |
| Jean-Marie Sontag, Viyada Nunbhakdi-Craig, Charles L White, Shelley Halpain, Estelle Sonta. The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22403409. |
significantly, down-regulation of pp2a/bα and deregulation of fyn-tau protein interactions have been linked to enhanced tau phosphorylation in alzheimer disease. |
2012-07-02 |
2023-08-12 |
human |
| Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Jose Sarmiento, Juan Troncoso, George R Jackson, Rakez Kaye. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 5. 2012-06-29. PMID:22253473. |
identification of oligomers at early stages of tau aggregation in alzheimer's disease. |
2012-06-29 |
2023-08-12 |
human |
| Xiao-Chuan Wang, Jing Zhang, Xian Yu, Liu Han, Zhen-Tao Zhou, Yao Zhang, Jian-Zhi Wan. Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 1. 2012-06-28. PMID:15719129. |
hyperphosphorylated microtubule-associated protein tau is the major protein component of neurofibrillary tangles in the brain of patients with alzheimer's disease (ad). |
2012-06-28 |
2023-08-12 |
rat |
| Nicole Schonrock, Miriam Matamales, Lars M Ittner, Jürgen Göt. MicroRNA networks surrounding APP and amyloid-β metabolism--implications for Alzheimer's disease. Experimental neurology. vol 235. issue 2. 2012-06-28. PMID:22119426. |
their profiles are significantly altered in neurodegenerative diseases such as alzheimer's disease (ad) that is characterized by both amyloid-β (aβ) and tau deposition in brain. |
2012-06-28 |
2023-08-12 |
Not clear |
| Stefani N Thomas, Kristen E Funk, Yunhu Wan, Zhongping Liao, Peter Davies, Jeff Kuret, Austin J Yan. Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach. Acta neuropathologica. vol 123. issue 1. 2012-06-25. PMID:22033876. |
in sporadic alzheimer's disease (ad), neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. |
2012-06-25 |
2023-08-12 |
Not clear |