| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernando Gonzalez-Ortiz, Bjørn-Eivind Kirsebom, José Contador, Jordan E Tanley, Per Selnes, Berglind Gísladóttir, Lene Pålhaugen, Mathilde Suhr Hemminghyth, Jonas Jarholm, Ragnhild Skogseth, Geir Bråthen, Gøril Grøndtvedt, Atle Bjørnerud, Sandra Tecelao, Knut Waterloo, Dag Aarsland, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Michael Turton, Agnes Hesthamar, Przemyslaw R Kac, Johanna Nilsson, Jose Luchsinger, Kathleen M Hayden, Peter Harrison, Albert Puig-Pijoan, Henrik Zetterberg, Timothy M Hughes, Marc Suárez-Calvet, Thomas K Karikari, Tormod Fladby, Kaj Blenno. Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease. Nature communications. vol 15. issue 1. 2024-04-04. PMID:38575616. |
plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in alzheimer's disease. |
2024-04-04 |
2024-04-07 |
human |
| Heather M Terron, Sagar J Parikh, Samer O Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W Dickson, Paul Saftig, Frank M LaFerla, Shelley Lane, Malcolm A Leissrin. Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-04. PMID:38575959. |
cathepsin d (catd) is a lysosomal protease that degrades both the amyloid-β protein (aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in alzheimer disease (ad), but few studies have examined the role of catd in the development of aβ pathology and tauopathy in vivo. |
2024-04-04 |
2024-04-07 |
Not clear |
| Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilk. Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. Acta neuropathologica communications. vol 12. issue 1. 2024-04-04. PMID:38576010. |
shaping the future of preclinical development of successful disease-modifying drugs against alzheimer's disease: a systematic review of tau propagation models. |
2024-04-04 |
2024-04-07 |
Not clear |
| Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilk. Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. Acta neuropathologica communications. vol 12. issue 1. 2024-04-04. PMID:38576010. |
the transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of alzheimer's disease and related tauopathies. |
2024-04-04 |
2024-04-07 |
Not clear |
| Douglas M Lopes, Jack A Wells, Da Ma, Lauren Wallis, Daniel Park, Sophie K Llewellyn, Zeshan Ahmed, Mark F Lythgoe, Ian F Harriso. Glymphatic inhibition exacerbates tau propagation in an Alzheimer's disease model. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-04. PMID:38576025. |
glymphatic inhibition exacerbates tau propagation in an alzheimer's disease model. |
2024-04-04 |
2024-04-07 |
Not clear |
| Douglas M Lopes, Jack A Wells, Da Ma, Lauren Wallis, Daniel Park, Sophie K Llewellyn, Zeshan Ahmed, Mark F Lythgoe, Ian F Harriso. Glymphatic inhibition exacerbates tau propagation in an Alzheimer's disease model. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-04. PMID:38576025. |
the aggregation and spread of misfolded amyloid structured proteins, such as tau and α-synuclein, are key pathological features associated with neurodegenerative disorders, including alzheimer's and parkinson's disease. |
2024-04-04 |
2024-04-07 |
Not clear |
| Nikki McArthur, Bokyung Kang, Felix G Rivera Moctezuma, Akber T Shaikh, Kathryn Loeffler, Nemil N Bhatt, Madison Kidd, Jennifer M Zupancic, Alec A Desai, Naima Djeddar, Anton Bryksin, Peter M Tessier, Rakez Kayed, Levi B Wood, Ravi S Kan. Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates. Biotechnology progress. 2024-04-03. PMID:38568030. |
alzheimer's disease and other tauopathies are characterized by the misfolding and aggregation of the tau protein into oligomeric and fibrillar structures. |
2024-04-03 |
2024-04-05 |
mouse |
| Komaldeep Kaur, Yogesh A Kulkarni, Sarika Wairka. Exploring the potential of quercetin in Alzheimer's Disease: Pharmacodynamics, Pharmacokinetics, and Nanodelivery systems. Brain research. 2024-04-02. PMID:38565372. |
multiple complex pathways, such as oxidative stress, tau and amyloid-beta (aβ) pathology, and cholinergic dysfunction, are involved in the pathogenesis of alzheimer's disease. |
2024-04-02 |
2024-04-05 |
Not clear |
| Guy C Brown, Michael T Henek. The endotoxin hypothesis of Alzheimer's disease. Molecular neurodegeneration. vol 19. issue 1. 2024-04-02. PMID:38561809. |
we outline the hypothesis here that lps may contribute to the pathophysiology of alzheimer's disease (ad) via peripheral infections or gut dysfunction elevating lps levels in blood and brain, which promotes: amyloid pathology, tau pathology and microglial activation, contributing to the neurodegeneration of ad. |
2024-04-02 |
2024-04-04 |
mouse |
| Cornelis Jan Sta. Hub overload and failure as a final common pathway in neurological brain network disorders. Network neuroscience (Cambridge, Mass.). vol 8. issue 1. 2024-04-02. PMID:38562292. |
in alzheimer's disease, hyperactive hub nodes are directly associated with amyloid-beta and tau pathology. |
2024-04-02 |
2024-04-04 |
Not clear |
| Kun-Ju Lin, Shao-Yi Huang, Kuo-Lun Huang, Chin-Chang Huang, Ing-Tsung Hsia. Human biodistribution and radiation dosimetry for the tau tracer [ EJNMMI radiopharmacy and chemistry. vol 9. issue 1. 2024-04-02. PMID:38563872. |
human biodistribution and radiation dosimetry for the tau tracer [ tau pathology plays a crucial role in neurodegeneration diseases including alzheimer's disease (ad) and non-ad diseases such as progressive supranuclear palsy. |
2024-04-02 |
2024-04-04 |
human |
| Hanaa B Atya, Nadia Mohamed Sharaf, Ragwa Mansour Abdelghany, Sara Nageeb El-Helaly, Heba Tah. Autophagy and exosomes; inter-connected maestros in Alzheimer's disease. Inflammopharmacology. 2024-04-02. PMID:38564092. |
autophagy may affect exosomal processing, but whether autophagy controls the release of aggregated β-amyloid and tau proteins in exosomes of alzheimer disease (ad) is unclear. |
2024-04-02 |
2024-04-04 |
mouse |
| Astrid Wachter, Maya E Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily McGlame, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Rachel Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Grinberg, Methasit Jaisa-Aad, Huan Li, Matthew P Frosch, Markus P Kummer, Sudeshna Das, Tammy Dellovade, Eric H Karran, Xavier Langlois, Janina S Ried, Alberto Serrano-Pozo, Robert V Talanian, Knut Biber, Bradley T Hyma. Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau. Acta neuropathologica. vol 147. issue 1. 2024-04-01. PMID:38557897. |
landscape of brain myeloid cell transcriptome along the spatiotemporal progression of alzheimer's disease reveals distinct sequential responses to aβ and tau. |
2024-04-01 |
2024-04-04 |
human |
| Shatakshi Mishra, B Stany, Anushka Das, Deepankumar Kanagavel, Murali Vijaya. A Comprehensive Review of Membrane Transporters and MicroRNA Regulation in Alzheimer's Disease. Molecular neurobiology. 2024-04-01. PMID:38558361. |
alzheimer's disease (ad) is a distressing neurodegenerative condition characterized by the accumulation of amyloid-beta (aβ) plaques and tau tangles within the brain. |
2024-04-01 |
2024-04-04 |
Not clear |
| Aishwarya Pradeep, Sheelakumari Raghavan, Scott A Przybelski, Gregory Preboske, Christopher G Schwarz, Val J Lowe, David S Knopman, Ronald C Petersen, Clifford R Jack, Jonathan Graff-Radford, Petrice M Cogswell, Prashanthi Vemur. Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer's disease pathology in the population? Research square. 2024-04-01. PMID:38558965. |
we aimed to identify the spatial patterns of wmh using the 4-scale fazekas visual assessment and explore their differential association with age, vascular health, alzheimer's imaging markers, namely amyloid and tau burden, and cognition. |
2024-04-01 |
2024-04-04 |
human |
| Wyatt C Powell, McKinley Nahum, Karl Pankratz, Morgane Herlory, James Greenwood, Darya Poliyenko, Patrick Holland, Ruiheng Jing, Luke Biggerstaff, Michael H B Stowell, Maciej A Walcza. Post-Translational Modifications Control Phase Transitions of Tau. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559065. |
the self-assembly of tau(297-391) into filaments, which mirror the structures observed in alzheimer's disease (ad) brains, raises questions about the role of ad-specific post-translational modifications (ptms) in the formation of paired helical filaments (phfs). |
2024-04-01 |
2024-04-04 |
Not clear |
| Dennis C Chan, ChaeMin Kim, Rachel Y Kang, Madison K Kuhn, Lynne M Beidler, Nanyin Zhang, Elizabeth A Procto. Cytokine expression patterns predict suppression of vulnerable neural circuits in a mouse model of Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559177. |
alzheimer's disease is a neurodegenerative disorder characterized by progressive amyloid plaque accumulation, tau tangle formation, neuroimmune dysregulation, synapse an neuron loss, and changes in neural circuit activation that lead to cognitive decline and dementia. |
2024-04-01 |
2024-04-04 |
mouse |
| Ashish Raj, Justin Toro. Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559176. |
understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of alzheimer's disease. |
2024-04-01 |
2024-04-04 |
human |
| Ashish Raj, Justin Toro. Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559176. |
it is well known that aβ and tau proteins are deposited stereotypically in brain regions to cause alzheimer's disease. |
2024-04-01 |
2024-04-04 |
human |
| Keke Chai, Jian Yang, Ying Tu, Junjie Wu, Kang Fang, Shuo Shi, Tianming Ya. Molecular Deformation Is a Key Factor in Screening Aggregation Inhibitor for Intrinsically Disordered Protein Tau. ACS central science. vol 10. issue 3. 2024-04-01. PMID:38559297. |
direct inhibitor of tau aggregation has been extensively studied as potential therapeutic agents for alzheimer's disease. |
2024-04-01 |
2024-04-04 |
Not clear |