| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruifeng Zhang, Miao Zeng, Xiaolu Zhang, Yujia Zheng, Nuan Lv, Luming Wang, Jiali Gan, Yawen Li, Xijuan Jiang, Lin Yan. Therapeutic Candidates for Alzheimer's Disease: Saponins. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445682. |
these studies suggest that saponins have the potential to ameliorate alzheimer's disease by reducing amyloid beta peptide deposition, inhibiting tau phosphorylation, modulating oxidative stress, reducing inflammation, and antiapoptosis. |
2023-07-14 |
2023-08-14 |
Not clear |
| Constantin Kondak, Michael Leith, Thomas C Baddeley, Renato X Santos, Charles R Harrington, Claude M Wischik, Gernot Riedel, Jochen Klei. Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445987. |
tau protein aggregations are important contributors to the etiology of alzheimer's disease (ad). |
2023-07-14 |
2023-08-14 |
mouse |
| Amina U Syed, Christopher Liang, Krystal K Patel, Rommani Mondal, Vallabhi M Kamalia, Taylor R Moran, Shamiha T Ahmed, Jogeshwar Mukherje. Comparison of Monoamine Oxidase-A, Aβ Plaques, Tau, and Translocator Protein Levels in Postmortem Human Alzheimer's Disease Brain. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445985. |
comparison of monoamine oxidase-a, aβ plaques, tau, and translocator protein levels in postmortem human alzheimer's disease brain. |
2023-07-14 |
2023-08-14 |
human |
| Qian Zhang, Yaping Ya. The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer's disease: a narrative review. Neural regeneration research. vol 18. issue 12. 2023-07-14. PMID:37449593. |
although the pathological mechanisms underlying alzheimer's disease are complex and remain unclear, previous research has identified two widely accepted pathological characteristics: extracellular neuritic plaques containing amyloid beta peptide, and intracellular neurofibrillary tangles containing tau. |
2023-07-14 |
2023-08-14 |
Not clear |
| Yijun Chen, Yang Y. Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation. Journal of neuroinflammation. vol 20. issue 1. 2023-07-14. PMID:37452321. |
tau and neuroinflammation in alzheimer's disease: interplay mechanisms and clinical translation. |
2023-07-14 |
2023-08-14 |
Not clear |
| Xi Xiong, Haijun He, Qianqian Ye, Shuangjie Qian, Shuoting Zhou, Feifei Feng, Evandro F Fang, Chenglong Xi. Alzheimer's disease diagnostic accuracy by fluid and neuroimaging ATN framework. CNS neuroscience & therapeutics. 2023-07-13. PMID:37438991. |
the atn's different modalities (fluids and neuroimaging) for each of the aβ (a), tau (t), and neurodegeneration (n) elements are used for the biological diagnosis of alzheimer's disease (ad). |
2023-07-13 |
2023-08-14 |
Not clear |
| Kanta Horie, Gemma Salvadó, Nicolas R Barthélemy, Shorena Janelidze, Yan Li, Yingxin He, Benjamin Saef, Charles D Chen, Hong Jiang, Olof Strandberg, Alexa Pichet Binette, Sebastian Palmqvist, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Brian A Gordon, Tammie L S Benzinger, David M Holtzman, John C Morris, Niklas Mattsson-Carlgren, Erik Stomrud, Rik Ossenkoppele, Suzanne E Schindler, Oskar Hansson, Randall J Batema. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer's disease. Nature medicine. 2023-07-13. PMID:37443334. |
csf mtbr-tau243 is a specific biomarker of tau tangle pathology in alzheimer's disease. |
2023-07-13 |
2023-08-14 |
Not clear |
| Kanta Horie, Gemma Salvadó, Nicolas R Barthélemy, Shorena Janelidze, Yan Li, Yingxin He, Benjamin Saef, Charles D Chen, Hong Jiang, Olof Strandberg, Alexa Pichet Binette, Sebastian Palmqvist, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Brian A Gordon, Tammie L S Benzinger, David M Holtzman, John C Morris, Niklas Mattsson-Carlgren, Erik Stomrud, Rik Ossenkoppele, Suzanne E Schindler, Oskar Hansson, Randall J Batema. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer's disease. Nature medicine. 2023-07-13. PMID:37443334. |
aggregated insoluble tau is one of two defining features of alzheimer's disease. |
2023-07-13 |
2023-08-14 |
Not clear |
| Kanta Horie, Gemma Salvadó, Nicolas R Barthélemy, Shorena Janelidze, Yan Li, Yingxin He, Benjamin Saef, Charles D Chen, Hong Jiang, Olof Strandberg, Alexa Pichet Binette, Sebastian Palmqvist, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Brian A Gordon, Tammie L S Benzinger, David M Holtzman, John C Morris, Niklas Mattsson-Carlgren, Erik Stomrud, Rik Ossenkoppele, Suzanne E Schindler, Oskar Hansson, Randall J Batema. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer's disease. Nature medicine. 2023-07-13. PMID:37443334. |
we show that the microtubule-binding region (mtbr) of tau containing the residue 243 (mtbr-tau243) is a new cerebrospinal fluid (csf) biomarker specific for insoluble tau aggregates and compared it to multiple other phosphorylated tau measures (p-tau181, p-tau205, p-tau217 and p-tau231) in two independent cohorts (biofinder-2, n = 448; and knight alzheimer disease research center, n = 219). |
2023-07-13 |
2023-08-14 |
Not clear |
| Prapti H Mody, Kelsey N Marvin, DiAnna L Hynds, Laura K Hanso. Cytomegalovirus infection induces Alzheimer's disease-associated alterations in tau. Journal of neurovirology. 2023-07-12. PMID:37436577. |
cytomegalovirus infection induces alzheimer's disease-associated alterations in tau. |
2023-07-12 |
2023-08-14 |
mouse |
| Prapti H Mody, Kelsey N Marvin, DiAnna L Hynds, Laura K Hanso. Cytomegalovirus infection induces Alzheimer's disease-associated alterations in tau. Journal of neurovirology. 2023-07-12. PMID:37436577. |
alzheimer's disease (ad) manifests with loss of neurons correlated with intercellular deposition of amyloid (amyloid plaques) and intracellular neurofibrillary tangles of hyperphosphorylated tau. |
2023-07-12 |
2023-08-14 |
mouse |
| Helena Østergaard Rasmussen, Janni Nielsen, Angela de Poli, Daniel Otzen, Jan Skov Pederse. Tau Fibrillation Induced by Heparin or a Lysophospholipid Show Different Initial Oligomer Formation. Journal of molecular biology. 2023-07-12. PMID:37437877. |
the protein tau is involved in several neurogenerative diseases such as alzheimer's disease, where tau content and fibrillation have been linked to disease progression. |
2023-07-12 |
2023-08-14 |
Not clear |
| Leon M Aksman, Neil P Oxtoby, Marzia A Scelsi, Peter A Wijeratne, Alexandra L Young, Isadora Lopes Alves, Lyduine E Collij, Jacob W Vogel, Frederik Barkhof, Daniel C Alexander, Andre Altman. A data-driven study of Alzheimer's disease related amyloid and tau pathology progression. Brain : a journal of neurology. 2023-07-11. PMID:37433038. |
a data-driven study of alzheimer's disease related amyloid and tau pathology progression. |
2023-07-11 |
2023-08-14 |
Not clear |
| Leon M Aksman, Neil P Oxtoby, Marzia A Scelsi, Peter A Wijeratne, Alexandra L Young, Isadora Lopes Alves, Lyduine E Collij, Jacob W Vogel, Frederik Barkhof, Daniel C Alexander, Andre Altman. A data-driven study of Alzheimer's disease related amyloid and tau pathology progression. Brain : a journal of neurology. 2023-07-11. PMID:37433038. |
amyloid-beta is thought to facilitate the spread of tau throughout the neocortex in alzheimer's disease, though how this occurs is not well understood. |
2023-07-11 |
2023-08-14 |
Not clear |
| Leon M Aksman, Neil P Oxtoby, Marzia A Scelsi, Peter A Wijeratne, Alexandra L Young, Isadora Lopes Alves, Lyduine E Collij, Jacob W Vogel, Frederik Barkhof, Daniel C Alexander, Andre Altman. A data-driven study of Alzheimer's disease related amyloid and tau pathology progression. Brain : a journal of neurology. 2023-07-11. PMID:37433038. |
the rate of longitudinal amyloid-beta and tau accumulation (both measured via pet) within this group did not differ from normal aging, supporting the distinction of primary age-related tauopathy from alzheimer's disease. |
2023-07-11 |
2023-08-14 |
Not clear |
| Danko Jeremic, Juan D Navarro-López, Lydia Jiménez-Día. Efficacy and Safety of Anti-Amyloid-β Monoclonal Antibodies in Current Alzheimer's Disease Phase III Clinical Trials: A Systematic Review and Interactive Web App-based Meta-Analysis. Ageing research reviews. 2023-07-09. PMID:37423541. |
secondary and tertiary outcomes included biomarkers of aβ and tau pathology, adverse events, and performance on alzheimer's disease cooperative study - activities of daily living scale. |
2023-07-09 |
2023-08-14 |
Not clear |
| Karthivashan Govindarajan, Satyabrata Ka. Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of alzheimer's disease. Journal of nanobiotechnology. vol 21. issue 1. 2023-07-09. PMID:37424018. |
evidence suggests that increased level/aggregation of β-amyloid (aβ) peptide, together with enhanced phosphorylation/aggregation of tau protein, play a critical role in the development of alzheimer's disease (ad), the leading cause of dementia in the elderly. |
2023-07-09 |
2023-08-14 |
mouse |
| Shudan Gao, Yun Wang, Tao Ma, Junying Zhan. The Late Stage of Abnormal Aging: Dementia. Advances in experimental medicine and biology. vol 1419. 2023-07-07. PMID:37418213. |
currently, many related mechanisms of the pathogenesis of alzheimer's disease have been proposed, such as beta-amyloid (a) theory, tau protein theory, and nerve and blood vessel theory. |
2023-07-07 |
2023-08-14 |
Not clear |
| Lu Wang, Yingjuan Wei, Zhenzhou Sun, Lin-Hua Jiang, Yaling Yin, Panpan Zheng, Yun Fu, Hongwei Wang, Changzheng Li, Jian-Zhi Wan. DpdtpA, A Multi-Metal Ion Chelator, Attenuates Tau Phosphorylation and Microglial Inflammatory Response via Regulating the PI3K/AKT/GSK-3β Signal Pathways. Neuroscience. 2023-07-07. PMID:37419407. |
tau protein hyperphosphorylation and formation of intracellular neurofibrillary tangles (nfts) are one of the histopathological hallmarks of alzheimer's disease (ad) and positively correlated with the severity of ad symptoms. |
2023-07-07 |
2023-08-14 |
human |
| Shunsuke Koga, Aya Murakami, Alexandra I Soto-Beasley, Ronald L Walton, Matthew C Baker, Monica Castanedes-Casey, Keith A Josephs, Owen A Ross, Dennis W Dickso. Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies. Acta neuropathologica communications. vol 11. issue 1. 2023-07-06. PMID:37415197. |
her amnestic symptoms that were suggestive of alzheimer's type dementia are best explained by diffuse agd and medial temporal tdp-43 proteinopathy, and her motor symptoms were likely explained by neuronal loss and gliosis due to tau pathology in the substantia nigra. |
2023-07-06 |
2023-08-14 |
Not clear |