| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiang Yu, Yin Luo, Paul Dinkel, Jie Zheng, Guanghong Wei, Martin Margittai, Ruth Nussinov, Buyong M. Cross-seeding and conformational selection between three- and four-repeat human Tau proteins. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22393063. |
in alzheimer's disease and frontotemporal dementias, the microtubule-associated protein tau forms intracellular paired helical filaments. |
2012-07-02 |
2023-08-12 |
human |
| Jean-Marie Sontag, Viyada Nunbhakdi-Craig, Charles L White, Shelley Halpain, Estelle Sonta. The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22403409. |
significantly, down-regulation of pp2a/bα and deregulation of fyn-tau protein interactions have been linked to enhanced tau phosphorylation in alzheimer disease. |
2012-07-02 |
2023-08-12 |
human |
| Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Jose Sarmiento, Juan Troncoso, George R Jackson, Rakez Kaye. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 5. 2012-06-29. PMID:22253473. |
identification of oligomers at early stages of tau aggregation in alzheimer's disease. |
2012-06-29 |
2023-08-12 |
human |
| Xiao-Chuan Wang, Jing Zhang, Xian Yu, Liu Han, Zhen-Tao Zhou, Yao Zhang, Jian-Zhi Wan. Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 1. 2012-06-28. PMID:15719129. |
hyperphosphorylated microtubule-associated protein tau is the major protein component of neurofibrillary tangles in the brain of patients with alzheimer's disease (ad). |
2012-06-28 |
2023-08-12 |
rat |
| Nicole Schonrock, Miriam Matamales, Lars M Ittner, Jürgen Göt. MicroRNA networks surrounding APP and amyloid-β metabolism--implications for Alzheimer's disease. Experimental neurology. vol 235. issue 2. 2012-06-28. PMID:22119426. |
their profiles are significantly altered in neurodegenerative diseases such as alzheimer's disease (ad) that is characterized by both amyloid-β (aβ) and tau deposition in brain. |
2012-06-28 |
2023-08-12 |
Not clear |
| Stefani N Thomas, Kristen E Funk, Yunhu Wan, Zhongping Liao, Peter Davies, Jeff Kuret, Austin J Yan. Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach. Acta neuropathologica. vol 123. issue 1. 2012-06-25. PMID:22033876. |
in sporadic alzheimer's disease (ad), neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. |
2012-06-25 |
2023-08-12 |
Not clear |
| Juan F Reyes, Changiz Geula, Laurel Vana, Lester I Binde. Selective tau tyrosine nitration in non-AD tauopathies. Acta neuropathologica. vol 123. issue 1. 2012-06-25. PMID:22057784. |
previously, we reported the characterization of two novel antibodies that react with tau nitrated at tyrosine 197 (tau-ny197) and tyrosine 394 (tau-ny394) in alzheimer's disease (ad). |
2012-06-25 |
2023-08-12 |
Not clear |
| Szabolcs Farkas, Katalin Nagy, Miklós Palkovits, Gábor G Kovács, Zhisheng Jia, Sean Donohue, Vic Pike, Christer Halldin, Domokos Máthé, Tibor Harkany, Balázs Gulyás, László Csib. [¹²⁵I]SD-7015 reveals fine modalities of CB₁ cannabinoid receptor density in the prefrontal cortex during progression of Alzheimer's disease. Neurochemistry international. vol 60. issue 3. 2012-06-25. PMID:22222721. |
in the present study we used a novel selective cb₁r radioligand to investigate regional variations in cb₁r ligand binding as a factor of progressive braak tau pathology in the frontal cortex of alzheimer's disease (ad) patients. |
2012-06-25 |
2023-08-12 |
human |
| Qian Chen, Zhou Zhou, Lei Zhang, Yuan Wang, Yan-wen Zhang, Min Zhong, Shang-cheng Xu, Chun-hai Chen, Li Li, Zheng-ping Y. Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF. Neurochemistry international. vol 60. issue 3. 2012-06-25. PMID:22226842. |
tau protein, a microtubule-associated protein involved in a number of neurological disorders such as alzheimer's disease (ad), may undergo modifications under both physiological and pathological conditions. |
2012-06-25 |
2023-08-12 |
rat |
| Maria Grazia Spillantini, Mariangela Iovino, Romina Vuon. Release of growth factors by neuronal precursor cells as a treatment for diseases with tau pathology. Archives italiennes de biologie. vol 149. issue 2. 2012-06-21. PMID:21701993. |
the intraneuronal accumulation of the microtubule associated protein tau in a hyperphosphorylated state and the extracellular deposit of ßamyloid protein constitute the defining neuropathological signature of alzheimer's disease, the most common type of dementia in ageing homo sapiens.there is accumulating evidence suggesting that transplantation of embryonic and adult derived neuronal precursor cells (npcs) has a major role for cell based repair strategies in models of acute and chronic injury. |
2012-06-21 |
2023-08-12 |
mouse |
| Ikuko Aib. [Corticobasal syndrome: recent advances and future directions]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 4. 2012-06-21. PMID:22481519. |
the most frequent causes of cbs are cbd, followed by alzheimer's disease, progressive supranuclear palsy, frontotemporal lobar degeneration with tdp-43 pathology (sporadic and familial), pick's disease, lewy body disease, frontotemporal lobar degeneration with fused in sarcoma-positive inclusions, creutzfeldt-jakob disease, and mutations in the microtubule-associated protein tau (mapt) and progranulin (grn) genes. |
2012-06-21 |
2023-08-12 |
Not clear |
| Tohru Matsuki, Mariam Zaka, Rita Guerreiro, Marcel P van der Brug, Jonathan A Cooper, Mark R Cookson, John A Hardy, Brian W Howel. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. PloS one. vol 7. issue 2. 2012-06-18. PMID:22355340. |
hyperphosphorylation of the microtubule binding protein tau is a feature of a number of neurodegenerative diseases, including alzheimer's disease. |
2012-06-18 |
2023-08-12 |
mouse |
| Suk Ling Ma, Nelson Leung Sang Tang, Cindy Woon Chi Tam, Victor Wing Cheong Lui, Linda Chiu Wa Lam, Helen Fung Kum Chiu, Jane Ann Driver, Lucia Pastorino, Kun Ping L. A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:20580132. |
alzheimer's disease (ad), the most common form of dementia, is characterized by the presence of neurofibrillary tangles composed of tau and senile plaques of amyloid-beta peptides (aβ) derived from amyloid precursor protein (app). |
2012-06-15 |
2023-08-12 |
Not clear |
| S Sakura Minami, Thomas G Clifford, Hyang-Sook Hoe, Yasuji Matsuoka, G William Rebec. Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21741124. |
to determine the effect of fyn on both aβ and tau pathologies, we crossed homozygous alzheimer's disease triple transgenic (3×tg) mice harboring mutations in amyloid precursor protein, presenilin-1, and tau with wild-type or fyn knockout mice to generate fyn(+/+)3×tg(+/-) or fyn(+/-)3×tg(+/-) mice. |
2012-06-15 |
2023-08-12 |
mouse |
| Nicholas M Kanaan, Gerardo Morfini, Gustavo Pigino, Nichole E LaPointe, Athena Andreadis, Yuyu Song, Ellen Leitman, Lester I Binder, Scott T Brad. Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21794954. |
alzheimer's disease (ad) and other tauopathies are characterized by fibrillar inclusions composed of the microtubule-associated protein, tau. |
2012-06-15 |
2023-08-12 |
Not clear |
| Olivia Sheppard, Florian Plattner, Anna Rubin, Amy Slender, Jacqueline M Linehan, Sebastian Brandner, Victor L J Tybulewicz, Elizabeth M C Fisher, Frances K Wisema. Altered regulation of tau phosphorylation in a mouse model of down syndrome aging. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21843906. |
here, using the unique transchromosomic tc1 mouse model of ds we investigate the influence of trisomy of hsa21 on the protein tau, which is hyperphosphorylated in alzheimer's disease. |
2012-06-15 |
2023-08-12 |
mouse |
| Giuseppina Amadoro, Veronica Corsetti, Anna Atlante, Fulvio Florenzano, Simona Capsoni, Rossana Bussani, Delio Mercanti, Pietro Calissan. Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:21958963. |
structural and functional mitochondrial alterations play an early, precipitating role in synaptic failure of alzheimer's disease (ad) pathogenesis and an aggravated mitochondrial impairment has been described in triple app/ps/tau transgenic mice carrying both plaques and tangles, if compared with mice overexpressing tau or amyloid precursor protein (app) alone. |
2012-06-15 |
2023-08-12 |
mouse |
| Panagiotis Alexopoulos, Liang-Hao Guo, Amalia Tsolakidou, Martina Kratzer, Timo Grimmer, Christine Westerteicher, Meizi Jiang, Hideaki Bujo, Janine Diehl-Schmid, Alexander Kurz, Robert Perneczk. Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 28. issue 3. 2012-06-15. PMID:22045485. |
interrelations between csf soluble aβppβ, amyloid-β 1-42, sorl1, and tau levels in alzheimer's disease. |
2012-06-15 |
2023-08-12 |
Not clear |
| Alexis M Stranahan, Bronwen Martin, Stuart Maudsle. Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22329653. |
treadmill exercise has also been shown to ameliorate the accumulation of phosphorylated tau, an essential component of neurofibrillary tangles in alzheimer's models. |
2012-06-14 |
2023-08-12 |
mouse |
| Eun Ji Gong, Hee Ra Park, Mi Eun Kim, Shunfu Piao, Eunjin Lee, Dong-Gyu Jo, Hae Young Chung, Nam-Chul Ha, Mark P Mattson, Jaewon Le. Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Neurobiology of disease. vol 44. issue 2. 2012-06-11. PMID:21782947. |
alzheimer's disease (ad) is the major form of age-related dementia and is characterized by progressive cognitive impairment, the accumulation of extracellular amyloid β-peptide (aβ), and intracellular hyperphosphorylated tau aggregates in affected brain regions. |
2012-06-11 |
2023-08-12 |
mouse |