All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Abdenour Belkacemi, Sihem Doggui, Lé Dao, Charles Ramassam. Challenges associated with curcumin therapy in Alzheimer disease. Expert reviews in molecular medicine. vol 13. 2012-02-09. PMID:22051121. in vitro and in vivo studies have demonstrated that curcumin could target pathways involved in the pathophysiology of alzheimer disease (ad), such as the β-amyloid cascade, tau phosphorylation, neuroinflammation or oxidative stress. 2012-02-09 2023-08-12 Not clear
Kristina R Patterson, Sarah M Ward, Benjamin Combs, Kellen Voss, Nicholas M Kanaan, Gerardo Morfini, Scott T Brady, T Chris Gamblin, Lester I Binde. Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry. vol 50. issue 47. 2012-02-07. PMID:22039833. aggregation and accumulation of the microtubule-associated protein tau are associated with cognitive decline and neuronal degeneration in alzheimer's disease and other tauopathies. 2012-02-07 2023-08-12 Not clear
Masashi Kitazawa, David Cheng, Michelle R Tsukamoto, Maya A Koike, Paul D Wes, Vitaly Vasilevko, David H Cribbs, Frank M LaFerl. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 12. 2012-02-07. PMID:22095718. blocking il-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an alzheimer's disease model. 2012-02-07 2023-08-12 mouse
Ai-Wu Xiao, Jing He, Qian Wang, Yi Luo, Yan Sun, Yan-Ping Zhou, Yang Guan, Paul J Lucassen, Jia-Pei Da. The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease. Neuroscience bulletin. vol 27. issue 5. 2012-02-06. PMID:21934724. the origin and development of plaques and phosphorylated tau are associated with axonopathy in alzheimer's disease. 2012-02-06 2023-08-12 Not clear
Ai-Wu Xiao, Jing He, Qian Wang, Yi Luo, Yan Sun, Yan-Ping Zhou, Yang Guan, Paul J Lucassen, Jia-Pei Da. The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease. Neuroscience bulletin. vol 27. issue 5. 2012-02-06. PMID:21934724. the production of neurotoxic β-amyloid and the formation of hyperphosphorylated tau are thought to be critical steps contributing to the neuropathological mechanisms in alzheimer's disease (ad). 2012-02-06 2023-08-12 Not clear
Hirotaka Yoshida, Michel Goeder. Phosphorylation of microtubule-associated protein tau by AMPK-related kinases. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:21985311. microtubule-associated protein tau is abnormally hyperphosphorylated in the intracellular filamentous inclusions seen in neurodegenerative disorders with dementia, such as alzheimer's disease and other tauopathies. 2012-02-06 2023-08-12 rat
Markus Britschgi, Kaspar Rufibach, Sarah L Bauer Huang, Christopher M Clark, Jeffrey A Kaye, Ge Li, Elaine R Peskind, Joseph F Quinn, Douglas R Galasko, Tony Wyss-Cora. Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome. Molecular & cellular proteomics : MCP. vol 10. issue 10. 2012-02-03. PMID:21742799. we found small numbers of signaling proteins that were able to model key pathological markers of alzheimer's disease, including levels of cerebrospinal fluid β-amyloid and tau, and classify disease in independent samples. 2012-02-03 2023-08-12 Not clear
M Obulesu, R Venu, R Somashekha. Tau mediated neurodegeneration: an insight into Alzheimer's disease pathology. Neurochemical research. vol 36. issue 8. 2012-02-01. PMID:21509508. tau mediated neurodegeneration: an insight into alzheimer's disease pathology. 2012-02-01 2023-08-12 Not clear
M Obulesu, R Venu, R Somashekha. Tau mediated neurodegeneration: an insight into Alzheimer's disease pathology. Neurochemical research. vol 36. issue 8. 2012-02-01. PMID:21509508. extracellular accumulations of aβ, hyperphosphorylation of tau and intracellular neurofibrillary tangle formation have been the hallmarks of alzheimer's disease (ad). 2012-02-01 2023-08-12 Not clear
Zheng-Qi Fu, Ying Yang, Jie Song, Qian Jiang, Zan-Chao Lin, Qun Wang, Ling-Qiang Zhu, Jian-Zhi Wang, Qing Tia. LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3β in vivo and in vitro. Journal of Alzheimer's disease : JAD. vol 21. issue 4. 2012-01-31. PMID:21504119. abnormal hyperphosphorylation of microtubule-associated protein tau is involved in the pathogenesis of several neurodegenerative diseases, including alzheimer's disease (ad). 2012-01-31 2023-08-12 rat
Erik D Roberson, Omotola A Hope, Roy C Martin, Dieter Schmid. Geriatric epilepsy: research and clinical directions for the future. Epilepsy & behavior : E&B. vol 22. issue 1. 2012-01-27. PMID:21596624. dr. roberson will discuss his work focusing on the relationship of epilepsy and cognitive impairment, particularly as it relates to alzheimer's disease pathology including tau and its role in epileptiform activity. 2012-01-27 2023-08-12 Not clear
Lidia Blazquez-Llorca, Virginia Garcia-Marin, Paula Merino-Serrais, Jesús Ávila, Javier DeFelip. Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 26. issue 4. 2012-01-26. PMID:21677375. abnormal tau phosphorylation in the thorny excrescences of ca3 hippocampal neurons in patients with alzheimer's disease. 2012-01-26 2023-08-12 Not clear
Smita Majumder, Arlan Richardson, Randy Strong, Salvatore Odd. Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PloS one. vol 6. issue 9. 2012-01-26. PMID:21980451. while soluble aβ and tau represent toxic species in alzheimer's disease (ad) pathogenesis, there is well documented evidence that plaques and tangles also are detrimental to normal brain function. 2012-01-26 2023-08-12 mouse
Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno, Jun Kunitomo, Morihisa Saitoh, Eiji Kimura, Hisashi Fujita, Noriko Uchiyama, Masakuni Kori, Masayuki Takizaw. A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease. Journal of neurochemistry. vol 119. issue 6. 2012-01-26. PMID:21992552. a novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(s )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of alzheimer's disease. 2012-01-26 2023-08-12 mouse
P Hemachandra Redd. Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease. Brain research. vol 1415. 2012-01-24. PMID:21872849. abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in alzheimer's disease. 2012-01-24 2023-08-12 mouse
P Hemachandra Redd. Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease. Brain research. vol 1415. 2012-01-24. PMID:21872849. growing evidence suggests that amyloid beta (aβ) and tau pathologies are strongly associated with mitochondrial dysfunction and neuronal damage in alzheimer's disease (ad). 2012-01-24 2023-08-12 mouse
Laurel Vana, Nicholas M Kanaan, Isabella C Ugwu, Joanne Wuu, Elliott J Mufson, Lester I Binde. Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. The American journal of pathology. vol 179. issue 5. 2012-01-24. PMID:21945902. progression of tau pathology in cholinergic basal forebrain neurons in mild cognitive impairment and alzheimer's disease. 2012-01-24 2023-08-12 human
Laurel Vana, Nicholas M Kanaan, Isabella C Ugwu, Joanne Wuu, Elliott J Mufson, Lester I Binde. Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. The American journal of pathology. vol 179. issue 5. 2012-01-24. PMID:21945902. tau is a microtubule-associated protein that forms neurofibrillary tangles (nfts) in the selective vulnerable long projection neurons of the cholinergic basal forebrain (cbf) in alzheimer's disease (ad). 2012-01-24 2023-08-12 human
Kellen Voss, John Koren, Chad A Dicke. The earliest tau dysfunction in Alzheimer's disease? Tau phosphorylated at s422 as a toxic seed. The American journal of pathology. vol 179. issue 5. 2012-01-24. PMID:21964186. the earliest tau dysfunction in alzheimer's disease? 2012-01-24 2023-08-12 Not clear
Annamaria Lanzillotta, Ilenia Sarnico, Marina Benarese, Caterina Branca, Cristina Baiguera, Birgit Hutter-Paier, Manfred Windisch, Pierfranco Spano, Bruno Pietro Imbimbo, Marina Pizz. The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease. Journal of molecular neuroscience : MN. vol 45. issue 1. 2012-01-23. PMID:21181298. the γ-secretase modulator chf5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of alzheimer's disease. 2012-01-23 2023-08-12 mouse