| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kourosh Shahpasand, Isao Uemura, Taro Saito, Tsunaki Asano, Kenji Hata, Keitaro Shibata, Yoko Toyoshima, Masato Hasegawa, Shin-Ichi Hisanag. Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 7. 2012-04-23. PMID:22396417. |
here, we examined the function of human tau phosphorylation at three sites, ser199, ser202, and thr205, which together comprise the at8 sites that mark abnormal phosphorylation in alzheimer's disease. |
2012-04-23 |
2023-08-12 |
mouse |
| Goang-Won Cho, Min-Young Noh, Byung Yong Kang, Il-Whea Ku, Jiseon Park, Yoon-Ho Hong, Myung-Hwa Kim, Seung Hyun Ki. Development of a cellular tau enzyme-linked immunosorbent assay method for screening GSK-3β inhibitors. Assay and drug development technologies. vol 9. issue 5. 2012-04-19. PMID:21561378. |
glycogen synthase kinase-3β (gsk-3β), a serine/threonine kinase also known as tau protein kinase i, has been implicated in the pathogenic conditions of alzheimer's disease. |
2012-04-19 |
2023-08-12 |
human |
| Peng Zhou, Zhuo Chen, Ning Zhao, Dan Liu, Zi-Yuan Guo, Lu Tan, Juan Hu, Qun Wang, Jian-Zhi Wang, Ling-Qiang Zh. Acetyl-L-carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities. Rejuvenation research. vol 14. issue 6. 2012-04-17. PMID:21978079. |
hyperhomocystinemia could induce tau protein hyperphosphorylation, β-amyloid (aβ) accumulation, and memory deficits as seen in alzheimer disease (ad), the most common cause of senile dementia with no effective cure currently. |
2012-04-17 |
2023-08-12 |
rat |
| Tara Spires-Jones, Shira Knaf. Spines, plasticity, and cognition in Alzheimer's model mice. Neural plasticity. vol 2012. 2012-04-17. PMID:22203915. |
the pathological hallmarks of alzheimer's disease (ad)--widespread synaptic and neuronal loss and the pathological accumulation of amyloid-beta peptide (aβ) in senile plaques, as well as hyperphosphorylated tau in neurofibrillary tangles--have been known for many decades, but the links between ad pathology and dementia and effective therapeutic strategies remain elusive. |
2012-04-17 |
2023-08-12 |
mouse |
| Ana Lloret, Mari-Carmen Badia, Esther Giraldo, Gennady Ermak, Maria-Dolores Alonso, Federico V Pallardó, Kelvin J A Davies, Jose Viñ. Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 4. 2012-04-16. PMID:21876249. |
amyloid-β toxicity and tau hyperphosphorylation are linked via rcan1 in alzheimer's disease. |
2012-04-16 |
2023-08-12 |
rat |
| Ana Lloret, Mari-Carmen Badia, Esther Giraldo, Gennady Ermak, Maria-Dolores Alonso, Federico V Pallardó, Kelvin J A Davies, Jose Viñ. Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 4. 2012-04-16. PMID:21876249. |
amyloid-β peptide (aβ) toxicity and tau hyperphosphorylation are hallmarks of alzheimer's disease (ad). |
2012-04-16 |
2023-08-12 |
rat |
| Miryam Carecchio, Chiara Fenoglio, Francesca Cortini, Cristoforo Comi, Luisa Benussi, Roberta Ghidoni, Barbara Borroni, Milena De Riz, Maria Serpente, Claudia Cantoni, Massimo Franceschi, Valentina Albertini, Francesco Monaco, Innocenzo Rainero, Giuliano Binetti, Alessandro Padovani, Nereo Bresolin, Elio Scarpini, Daniela Galimbert. Cerebrospinal fluid biomarkers in Progranulin mutations carriers. Journal of Alzheimer's disease : JAD. vol 27. issue 4. 2012-04-16. PMID:21891865. |
cerebrospinal fluid (csf) biomarkers (aβ₁₋₄₂, total tau, p-181 tau) are currently used to support a clinical diagnosis of alzheimer's disease (ad). |
2012-04-16 |
2023-08-12 |
Not clear |
| Meryem Lebbadi, Carl Julien, Alix Phivilay, Cyntia Tremblay, Vincent Emond, Jing X Kang, Frédéric Calo. Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 27. issue 4. 2012-04-16. PMID:21914946. |
dietary supplementation with n-3 polyunsaturated fatty acids (n-3 pufa) reduces amyloid-β (aβ) and tau pathology and improves cognitive performance in animal models of alzheimer's disease (ad). |
2012-04-16 |
2023-08-12 |
mouse |
| Alix de Calignon, Manuela Polydoro, Marc Suárez-Calvet, Christopher William, David H Adamowicz, Kathy J Kopeikina, Rose Pitstick, Naruhiko Sahara, Karen H Ashe, George A Carlson, Tara L Spires-Jones, Bradley T Hyma. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. vol 73. issue 4. 2012-04-16. PMID:22365544. |
propagation of tau pathology in a model of early alzheimer's disease. |
2012-04-16 |
2023-08-12 |
mouse |
| Bettina Platt, Benjamin Drever, David Koss, Sandra Stoppelkamp, Amar Jyoti, Andrea Plano, Aneli Utan, Georgina Merrick, Duncan Ryan, Valeria Melis, Hong Wan, Marco Mingarelli, Emanuele Porcu, Louise Scrocchi, Andy Welch, Gernot Riede. Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1. PloS one. vol 6. issue 11. 2012-04-10. PMID:22096518. |
late-stage neuropathological hallmarks of alzheimer's disease (ad) are β-amyloid (βa) and hyperphosphorylated tau peptides, aggregated into plaques and tangles, respectively. |
2012-04-10 |
2023-08-12 |
mouse |
| Kazuhiro Ohmi, Hui-Zhi Zhao, Elizabeth F Neufel. Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. PloS one. vol 6. issue 11. 2012-04-10. PMID:22096577. |
we found earlier that neurons in the medial entorhinal cortex (mec) and the dentate gyrus showed a number of secondary defects, including the presence of hyperphosphorylated tau (ptau) detected with antibodies raised against ptau in alzheimer disease brain. |
2012-04-10 |
2023-08-12 |
mouse |
| Masafumi Inoue, Takashi Konno, Kazuki Tainaka, Eiji Nakata, Hiro-O Yoshida, Takashi Mori. Positional effects of phosphorylation on the stability and morphology of tau-related amyloid fibrils. Biochemistry. vol 51. issue 7. 2012-04-10. PMID:22304362. |
hyperphosphorylated forms of tau protein are the main component of paired helical filaments (phfs) of neurofibrillary tangles in the brain of alzheimer's disease patients. |
2012-04-10 |
2023-08-12 |
Not clear |
| Patrick L McGeer, John C Steel. The ALS/PDC syndrome of Guam: potential biomarkers for an enigmatic disorder. Progress in neurobiology. vol 95. issue 4. 2012-04-09. PMID:21527311. |
the most prominent pathological hallmark is the widespread occurrence of neurofibrillary tangles which express the same balance of 3r and 4r tau that is found in alzheimer disease. |
2012-04-09 |
2023-08-12 |
Not clear |
| Stanley I Rapoport, Peter T Nelso. Biomarkers and evolution in Alzheimer disease. Progress in neurobiology. vol 95. issue 4. 2012-04-09. PMID:21801803. |
biomarkers such as reduced glucose metabolism in association neocortex, defects in long white matter tracts, rna neurochemical changes, and high csf levels of total and phosphorylated tau protein, which are helpful to identify mci and preclinical alzheimer disease patients, may also provide insights into what brain changes led to this disease being introduced during hominid evolution. |
2012-04-09 |
2023-08-12 |
Not clear |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
acetylated tau, a novel pathological signature in alzheimer's disease and other tauopathies. |
2012-04-09 |
2023-08-12 |
Not clear |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
the microtubule-binding protein, tau, is the major component of neurofibrillary inclusions characteristic of alzheimer's disease and related neurodegenerative tauopathies. |
2012-04-09 |
2023-08-12 |
Not clear |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
acetylated-tau pathology was compared with the sequential emergence of other tau modifications in the alzheimer's disease hippocampus using monoclonal antibodies to multiple well-characterized tau epitopes. |
2012-04-09 |
2023-08-12 |
Not clear |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
acetylated-tau pathology was largely in intracellular, thioflavin-s-positive tau inclusions in alzheimer's disease, and also thioflavin-s-negative pathology in corticobasal degeneration and progressive supranuclear palsy. |
2012-04-09 |
2023-08-12 |
Not clear |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
acetylated-tau was present throughout all stages of alzheimer's disease pathology, but was more prominently associated with pathological tau epitopes in moderate to severe-stage cases. |
2012-04-09 |
2023-08-12 |
Not clear |
| David J Irwin, Todd J Cohen, Murray Grossman, Steven E Arnold, Sharon X Xie, Virginia M-Y Lee, John Q Trojanowsk. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a journal of neurology. vol 135. issue Pt 3. 2012-04-09. PMID:22366796. |
these temporal and morphological immunohistochemical features suggest acetylation of tau at this epitope is preceded by early modifications, including phosphorylation, and followed by later truncation events and cell death in alzheimer's disease. |
2012-04-09 |
2023-08-12 |
Not clear |