| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Smita Majumder, Arlan Richardson, Randy Strong, Salvatore Odd. Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PloS one. vol 6. issue 9. 2012-01-26. PMID:21980451. |
while soluble aβ and tau represent toxic species in alzheimer's disease (ad) pathogenesis, there is well documented evidence that plaques and tangles also are detrimental to normal brain function. |
2012-01-26 |
2023-08-12 |
mouse |
| Tomohiro Onishi, Hiroki Iwashita, Yumiko Uno, Jun Kunitomo, Morihisa Saitoh, Eiji Kimura, Hisashi Fujita, Noriko Uchiyama, Masakuni Kori, Masayuki Takizaw. A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease. Journal of neurochemistry. vol 119. issue 6. 2012-01-26. PMID:21992552. |
a novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(s )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of alzheimer's disease. |
2012-01-26 |
2023-08-12 |
mouse |
| P Hemachandra Redd. Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease. Brain research. vol 1415. 2012-01-24. PMID:21872849. |
abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in alzheimer's disease. |
2012-01-24 |
2023-08-12 |
mouse |
| P Hemachandra Redd. Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease. Brain research. vol 1415. 2012-01-24. PMID:21872849. |
growing evidence suggests that amyloid beta (aβ) and tau pathologies are strongly associated with mitochondrial dysfunction and neuronal damage in alzheimer's disease (ad). |
2012-01-24 |
2023-08-12 |
mouse |
| Laurel Vana, Nicholas M Kanaan, Isabella C Ugwu, Joanne Wuu, Elliott J Mufson, Lester I Binde. Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. The American journal of pathology. vol 179. issue 5. 2012-01-24. PMID:21945902. |
progression of tau pathology in cholinergic basal forebrain neurons in mild cognitive impairment and alzheimer's disease. |
2012-01-24 |
2023-08-12 |
human |
| Laurel Vana, Nicholas M Kanaan, Isabella C Ugwu, Joanne Wuu, Elliott J Mufson, Lester I Binde. Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. The American journal of pathology. vol 179. issue 5. 2012-01-24. PMID:21945902. |
tau is a microtubule-associated protein that forms neurofibrillary tangles (nfts) in the selective vulnerable long projection neurons of the cholinergic basal forebrain (cbf) in alzheimer's disease (ad). |
2012-01-24 |
2023-08-12 |
human |
| Kellen Voss, John Koren, Chad A Dicke. The earliest tau dysfunction in Alzheimer's disease? Tau phosphorylated at s422 as a toxic seed. The American journal of pathology. vol 179. issue 5. 2012-01-24. PMID:21964186. |
the earliest tau dysfunction in alzheimer's disease? |
2012-01-24 |
2023-08-12 |
Not clear |
| Annamaria Lanzillotta, Ilenia Sarnico, Marina Benarese, Caterina Branca, Cristina Baiguera, Birgit Hutter-Paier, Manfred Windisch, Pierfranco Spano, Bruno Pietro Imbimbo, Marina Pizz. The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease. Journal of molecular neuroscience : MN. vol 45. issue 1. 2012-01-23. PMID:21181298. |
the γ-secretase modulator chf5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of alzheimer's disease. |
2012-01-23 |
2023-08-12 |
mouse |
| Annamaria Lanzillotta, Ilenia Sarnico, Marina Benarese, Caterina Branca, Cristina Baiguera, Birgit Hutter-Paier, Manfred Windisch, Pierfranco Spano, Bruno Pietro Imbimbo, Marina Pizz. The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease. Journal of molecular neuroscience : MN. vol 45. issue 1. 2012-01-23. PMID:21181298. |
the relationship between β-amyloid (aβ) and tau is not fully understood, though it is proposed that in the pathogenesis of alzheimer's disease (ad) aβ accumulation precedes and promotes tau hyperphosphorylation via activation of glycogen synthase kinase-3beta (gsk-3β). |
2012-01-23 |
2023-08-12 |
mouse |
| Katherine J Kopeikina, George A Carlson, Rose Pitstick, Adam E Ludvigson, Alan Peters, Jennifer I Luebke, Robert M Koffie, Matthew P Frosch, Bradley T Hyman, Tara L Spires-Jone. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. The American journal of pathology. vol 179. issue 4. 2012-01-23. PMID:21854751. |
tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human alzheimer's disease brain. |
2012-01-23 |
2023-08-12 |
mouse |
| Katherine J Kopeikina, George A Carlson, Rose Pitstick, Adam E Ludvigson, Alan Peters, Jennifer I Luebke, Robert M Koffie, Matthew P Frosch, Bradley T Hyman, Tara L Spires-Jone. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. The American journal of pathology. vol 179. issue 4. 2012-01-23. PMID:21854751. |
neurofibrillary tangles (nft), intracellular inclusions of abnormal fibrillar forms of microtubule associated protein tau, accumulate in alzheimer's disease (ad) and other tauopathies and are believed to cause neuronal dysfunction, but the mechanism of tau-mediated toxicity are uncertain. |
2012-01-23 |
2023-08-12 |
mouse |
| Stefan Bibow, Valéry Ozenne, Jacek Biernat, Martin Blackledge, Eckhard Mandelkow, Markus Zweckstette. Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. Journal of the American Chemical Society. vol 133. issue 40. 2012-01-23. PMID:21910444. |
the intrinsically disordered protein tau becomes excessively phosphorylated and aggregates into neurofibrillary tangles in alzheimer's disease. |
2012-01-23 |
2023-08-12 |
Not clear |
| Stefan Bibow, Valéry Ozenne, Jacek Biernat, Martin Blackledge, Eckhard Mandelkow, Markus Zweckstette. Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. Journal of the American Chemical Society. vol 133. issue 40. 2012-01-23. PMID:21910444. |
to obtain insight into the structural consequences of phosphorylation, we characterized a mutant protein of tau in which epitopes recognized by alzheimer diagnostic antibodies were mimicked by mutation to glutamic acid [at8 (s199e, s202e, t205e), at100 (t212e and s214e), and phf1 (s396e and s404e)]. |
2012-01-23 |
2023-08-12 |
Not clear |
| Fumitaka Kawakami, Minori Suzuki, Naoki Shimada, Go Kagiya, Etsuro Ohta, Kei Tamura, Hiroko Maruyama, Takafumi Ichikaw. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. The FEBS journal. vol 278. issue 24. 2012-01-23. PMID:21985244. |
hyperphosphorylation of tau protein (tau) causes neurodegenerative diseases such as alzheimer's disease (ad). |
2012-01-23 |
2023-08-12 |
mouse |
| Ragnhild Eide Skogseth, Tormod Fladby, Ezra Mulugeta, Dag Aarslan. [Biomarkers in spinal fluid of patients with dementia]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 131. issue 22. 2012-01-23. PMID:22085948. |
we wanted to assess whether biomarkers abeta42, tau and p-tau could differentiate between alzheimer's disease and other dementia illnesses. |
2012-01-23 |
2023-08-12 |
Not clear |
| Yasmina Talmat-Amar, Yoan Arribat, Christelle Redt-Clouet, Sébastien Feuillette, Anne-Laure Bougé, Magalie Lecourtois, Marie-Laure Parmentie. Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila. Human molecular genetics. vol 20. issue 19. 2012-01-20. PMID:21705366. |
the microtubule-associated protein tau is found in large amount in axons of neurons and is involved in human neurodegenerative diseases called tauopathies, which include alzheimer's disease. |
2012-01-20 |
2023-08-12 |
human |
| Ludovic Martin, Amandine Magnaudeix, Cornelia M Wilson, Catherine Yardin, Faraj Terr. The new indirubin derivative inhibitors of glycogen synthase kinase-3, 6-BIDECO and 6-BIMYEO, prevent tau phosphorylation and apoptosis induced by the inhibition of protein phosphatase-2A by okadaic acid in cultured neurons. Journal of neuroscience research. vol 89. issue 11. 2012-01-20. PMID:21826701. |
alterations in glycogen synthase kinase-3β (gsk3β) and protein phosphatase-2a (pp2a) have been proposed to be involved in the abnormal tau phosphorylation and aggregation linked to alzheimer's disease (ad). |
2012-01-20 |
2023-08-12 |
Not clear |
| Anna Nogalska, Carla D'Agostino, W King Engel, Valerie Askana. Novel demonstration of conformationally modified tau in sporadic inclusion-body myositis muscle fibers. Neuroscience letters. vol 503. issue 3. 2012-01-20. PMID:21896314. |
its muscle fiber molecular phenotype has close similarities to alzheimer disease (ad) brain, including intra-muscle-fiber accumulations of (a) aβ42 and its oligomers, and (b) large, squiggly or linear, clusters of paired-helical filaments (phfs) that are immunoreactive with various antibodies directed against several epitopes of phosphorylated tau (p-tau), and thereby strongly resembling neurofibrillary tangles of ad brain. |
2012-01-20 |
2023-08-12 |
Not clear |
| N Zilka, M Zilkova, Z Kazmerova, M Sarissky, V Cigankova, M Nova. Mesenchymal stem cells rescue the Alzheimer's disease cell model from cell death induced by misfolded truncated tau. Neuroscience. vol 193. 2012-01-18. PMID:21763758. |
mesenchymal stem cells rescue the alzheimer's disease cell model from cell death induced by misfolded truncated tau. |
2012-01-18 |
2023-08-12 |
human |
| N Zilka, M Zilkova, Z Kazmerova, M Sarissky, V Cigankova, M Nova. Mesenchymal stem cells rescue the Alzheimer's disease cell model from cell death induced by misfolded truncated tau. Neuroscience. vol 193. 2012-01-18. PMID:21763758. |
we have developed a stably transfected human cell model for alzheimer's disease with doxycycline-inducible expression of human misfolded truncated tau protein (at tau). |
2012-01-18 |
2023-08-12 |
human |