All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Jing L Guo, Virginia M-Y Le. Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. The Journal of biological chemistry. vol 286. issue 17. 2011-07-14. PMID:21372138. neurofibrillary tangles (nfts) in alzheimer disease and related tauopathies are composed of insoluble hyperphosphorylated tau protein, but the mechanisms underlying the conversion of highly soluble tau into insoluble nfts remain elusive. 2011-07-14 2023-08-12 Not clear
Kumar Sambamurti, K S Jagannatha Rao, Miguel A Pappoll. Frontiers in the pathogenesis of Alzheimer's disease. Indian journal of psychiatry. vol 51 Suppl 1. 2011-07-14. PMID:21416019. alzheimer's disease (ad) is characterized by progressive dementia and brain deposits of the amyloid β protein (aβ) as senile plaques and the microtubule-associated protein, tau, as neurofibrillary tangles (nft). 2011-07-14 2023-08-12 mouse
Paul D Dinkel, Ayisha Siddiqua, Huy Huynh, Monil Shah, Martin Margitta. Variations in filament conformation dictate seeding barrier between three- and four-repeat tau. Biochemistry. vol 50. issue 20. 2011-07-14. PMID:21510682. tau filaments are the pathological hallmark of >20 neurodegenerative diseases including alzheimer's disease. 2011-07-14 2023-08-12 Not clear
Christopher Medway, Hui Shi, James Bullock, Holly Black, Kristelle Brown, Baharak Vafadar-Isfahani, Balwir Matharoo-Ball, Graham Ball, Robert Rees, Noor Kalsheker, Kevin Morga. Using In silico LD clumping and meta-analysis of genome-wide datasets as a complementary tool to investigate and validate new candidate biomarkers in Alzheimer's disease. International journal of molecular epidemiology and genetics. vol 1. issue 2. 2011-07-14. PMID:21537386. genes encoding current alzheimer's biomarkers; app (aβ), mapt (tau) and apoe were also included. 2011-07-14 2023-08-12 Not clear
D Larry Sparks, Chuck Ziolkowski, Todd Lawmaster, Timothy Marti. Influence of water quality on cholesterol-induced tau pathology: preliminary data. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21559186. the studies employed the cholesterol-fed rabbit model of alzheimer's disease (ad) to investigate the relationship between ad-like neurofibrillary tangle (nft) neuropathology and tau protein levels as the main component of nft. 2011-07-14 2023-08-12 rabbit
Ann De Vos, Jayamani Anandhakumar, Jeff Van den Brande, Mathias Verduyckt, Vanessa Franssens, Joris Winderickx, Erwin Swinne. Yeast as a model system to study tau biology. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21559193. hyperphosphorylated and aggregated human protein tau constitutes a hallmark of a multitude of neurodegenerative diseases called tauopathies, exemplified by alzheimer's disease. 2011-07-14 2023-08-12 human
Marjelo A Mines, Eleonore Beurel, Richard S Jop. Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21629713. evidence for the involvement of gsk3 in alzheimer's disease pathology and neuronal loss comes from studies of gsk3 overexpression, gsk3 localization studies, multiple relationships between gsk3 and amyloid β-peptide (aβ), interactions between gsk3 and the microtubule-associated tau protein, and gsk3-mediated apoptotic cell death. 2011-07-14 2023-08-12 Not clear
Jari Koistinaho, Tarja Malm, Gundars Goldstein. Glycogen synthase kinase-3β: a mediator of inflammation in Alzheimer's disease? International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21629736. glycogen synthase kinase-3β has been extensively investigated in connection to tau and amyloid β toxicity, whereas reports on the role of this enzyme in neuroinflammation in alzheimer's disease are negligible. 2011-07-14 2023-08-12 Not clear
Herman Moreno, Soonwook Choi, Eunah Yu, Janaina Brusco, Jesus Avila, Jorge E Moreira, Mutsuyuki Sugimori, Rodolfo R Lliná. Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MA. Frontiers in synaptic neuroscience. vol 3. 2011-07-14. PMID:21629767. filamentous tau inclusions are hallmarks of alzheimer's disease and related neurodegenerative tauopathies, but the molecular mechanisms involved in tau-mediated changes in neuronal function and their possible effects on synaptic transmission are unknown. 2011-07-14 2023-08-12 human
Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Audra L Clos, George R Jackson, Rakez Kaye. Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Molecular neurodegeneration. vol 6. 2011-07-14. PMID:21645391. the correlation between neurofibrillary tangles of tau and disease progression in the brains of alzheimer's disease (ad) patients remains an area of contention. 2011-07-14 2023-08-12 mouse
Gurdeep Marwarha, Jaya Rp Prasanthi, Jared Schommer, Bhanu Dasari, Othman Ghrib. Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus. Molecular neurodegeneration. vol 6. issue 1. 2011-07-14. PMID:21651786. evidence shows that the insulin-like growth factor-1 (igf-1) and leptin reduce β-amyloid (aβ) production and tau phosphorylation, two major hallmarks of alzheimer's disease (ad). 2011-07-14 2023-08-12 rabbit
Mikio Shoj. Biomarkers of the dementia. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21660205. csf aβ40, aβ42, total tau, and phosphorylated tau are the most sensitive biomarkers for diagnosis of alzheimer's disease (ad) and prediction of onset of ad from mild cognitive impairment (mci). 2011-07-14 2023-08-12 Not clear
Peter Wostyn, Debby Van Dam, Kurt Audenaert, Peter Paul De Dey. Increased Cerebrospinal Fluid Production as a Possible Mechanism Underlying Caffeine's Protective Effect against Alzheimer's Disease. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21660211. alzheimer's disease (ad), the most common type of dementia among older people, is characterized by the accumulation of β-amyloid (aβ) senile plaques and neurofibrillary tangles composed of hyperphosphorylated tau in the brain. 2011-07-14 2023-08-12 human
Cristina Solé-Padullés, Albert Lladó, David Bartrés-Faz, Juan Fortea, Raquel Sánchez-Valle, Beatriz Bosch, Anna Antonell, José Luis Molinuevo, Lorena Ram. Association between cerebrospinal fluid tau and brain atrophy is not related to clinical severity in the Alzheimer's disease continuum. Psychiatry research. vol 192. issue 3. 2011-07-12. PMID:21546220. association between cerebrospinal fluid tau and brain atrophy is not related to clinical severity in the alzheimer's disease continuum. 2011-07-12 2023-08-12 human
Brittany N Dugger, Michael Tu, Melissa E Murray, Dennis W Dickso. Disease specificity and pathologic progression of tau pathology in brainstem nuclei of Alzheimer's disease and progressive supranuclear palsy. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21236314. disease specificity and pathologic progression of tau pathology in brainstem nuclei of alzheimer's disease and progressive supranuclear palsy. 2011-07-05 2023-08-12 Not clear
Brittany N Dugger, Michael Tu, Melissa E Murray, Dennis W Dickso. Disease specificity and pathologic progression of tau pathology in brainstem nuclei of Alzheimer's disease and progressive supranuclear palsy. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21236314. previous studies have shown tau pathology in the inferior colliculus (ic) and superior colliculus (sc) in alzheimer's disease (ad); however, it has not been compared to other tauopathies, such as progressive supranuclear palsy (psp), or characterized with respect to progression of tau pathology in ad. 2011-07-05 2023-08-12 Not clear
Tibor Hortobágyi, Claire Troakes, Agnes L Nishimura, Caroline Vance, John C van Swieten, Harro Seelaar, Andrew King, Safa Al-Sarraj, Boris Rogelj, Christopher E Sha. Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders. Acta neuropathologica. vol 121. issue 4. 2011-07-01. PMID:21360076. optn-positive inclusions were identified in a few alzheimer's disease (ad) cases but did not co-localise with tau and tdp-43. 2011-07-01 2023-08-12 Not clear
Ming Jin, Nina Shepardson, Ting Yang, Gang Chen, Dominic Walsh, Dennis J Selko. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 14. 2011-07-01. PMID:21421841. soluble amyloid beta-protein dimers isolated from alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration. 2011-07-01 2023-08-12 human
Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagn. 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21436112. 18f-thk523: a novel in vivo tau imaging ligand for alzheimer's disease. 2011-07-01 2023-08-12 mouse
Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagn. 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain : a journal of neurology. vol 134. issue Pt 4. 2011-07-01. PMID:21436112. while considerable effort has focused on developing positron emission tomography β-amyloid imaging radiotracers for the early diagnosis of alzheimer's disease, no radiotracer is available for the non-invasive quantification of tau. 2011-07-01 2023-08-12 mouse