| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanne Wegmann, Jonas Schöler, Christian A Bippes, Eckhard Mandelkow, Daniel J Mulle. Competing interactions stabilize pro- and anti-aggregant conformations of human Tau. The Journal of biological chemistry. vol 286. issue 23. 2011-08-05. PMID:21498513. |
aggregation of tau into amyloid-like fibrils is a key process in neurodegenerative diseases such as alzheimer. |
2011-08-05 |
2023-08-12 |
human |
| Elisa A Waxman, Benoit I Giasso. Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613474. |
intracytoplasmic proteinaceous inclusions, primarily composed of tau or α-synuclein (α-syn), are predominant pathological features of alzheimer's disease (ad) and parkinson's disease (pd), respectively. |
2011-08-04 |
2023-08-12 |
Not clear |
| Matthew J Winton, Edward B Lee, Eveline Sun, Margaret M Wong, Susan Leight, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613482. |
intraneuronal app, not free aβ peptides in 3xtg-ad mice: implications for tau versus aβ-mediated alzheimer neurodegeneration. |
2011-08-04 |
2023-08-12 |
mouse |
| Matthew J Winton, Edward B Lee, Eveline Sun, Margaret M Wong, Susan Leight, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613482. |
alzheimer's disease (ad) is characterized by the accumulation of intraneuronal tau and extracellular amyloid-β (aβ) peptide. |
2011-08-04 |
2023-08-12 |
mouse |
| Ioannis Sotiropoulos, Caterina Catania, Lucilia G Pinto, Rui Silva, G Elizabeth Pollerberg, Akihiko Takashima, Nuno Sousa, Osborne F X Almeid. Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613497. |
stress acts cumulatively to precipitate alzheimer's disease-like tau pathology and cognitive deficits. |
2011-08-04 |
2023-08-12 |
rat |
| Jens T Stieler, Torsten Bullmann, Franziska Kohl, Øivind Tøien, Martina K Brückner, Wolfgang Härtig, Brian M Barnes, Thomas Arend. The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PloS one. vol 6. issue 1. 2011-08-02. PMID:21267079. |
abnormal phosphorylation and aggregation of tau protein are hallmarks of a variety of neurological disorders, including alzheimer's disease (ad). |
2011-08-02 |
2023-08-12 |
Not clear |
| Robert A Whittington, László Virág, François Marcouiller, Marie-Amélie Papon, Noura B El Khoury, Carl Julien, Françoise Morin, Charles W Emala, Emmanuel Plane. Propofol directly increases tau phosphorylation. PloS one. vol 6. issue 1. 2011-08-02. PMID:21304998. |
in alzheimer's disease (ad) and other tauopathies, the microtubule-associated protein tau can undergo aberrant hyperphosphorylation potentially leading to the development of neurofibrillary pathology. |
2011-08-02 |
2023-08-12 |
mouse |
| Trine Veje Axelsen, Arne Holm, Gunna Christiansen, Svend Birkelun. Identification of the shortest Aβ-peptide generating highly specific antibodies against the C-terminal end of amyloid-β42. Vaccine. vol 29. issue 17. 2011-08-02. PMID:21371581. |
alzheimer's disease (ad) is characterized by neurofibrillary tangles, consisting of hyperphosphorylated tau protein and senile plaques, which are consisting mainly of amyloid-β (aβ). |
2011-08-02 |
2023-08-12 |
mouse |
| Jonathan Wills, Joel Credle, Thomas Haggerty, Jae-Hoon Lee, Adam W Oaks, Anita Sidh. Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease. PloS one. vol 6. issue 3. 2011-08-02. PMID:21445308. |
this was accompanied by increases in hyperphosphorylated tau [p-tau], phosphorylated at ser202, ser262 and ser396/404, which are the same toxic sites also seen in alzheimer's disease. |
2011-08-02 |
2023-08-12 |
mouse |
| Jean-Daniel Abraham, Sophie Calvayrac-Pawlowski, Sandra Cobo, Nicolas Salvetat, Guillaume Vicat, Laurence Molina, Jacques Touchon, Bernard-François Michel, Franck Molina, Jean-Michel Verdier, Jeannette Fareh, Chantal Mourton-Gille. Combined measurement of PEDF, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between alzheimer's disease and other dementias. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. vol 16. issue 2. 2011-08-01. PMID:21323605. |
combined measurement of pedf, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between alzheimer's disease and other dementias. |
2011-08-01 |
2023-08-12 |
Not clear |
| Todd J Cohen, Jing L Guo, David E Hurtado, Linda K Kwong, Ian P Mills, John Q Trojanowski, Virginia M Y Le. The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nature communications. vol 2. 2011-08-01. PMID:21427723. |
phosphorylation regulates tau-microtubule interactions and hyperphosphorylation contributes to the aberrant formation of insoluble tau aggregates in alzheimer's disease (ad) and related tauopathies. |
2011-08-01 |
2023-08-12 |
mouse |
| Christopher P Corbo, Alejandra del C Alons. Therapeutic targets in Alzheimer's disease and related tauopathies. Progress in molecular biology and translational science. vol 98. 2011-07-27. PMID:21199770. |
alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. |
2011-07-27 |
2023-08-12 |
Not clear |
| Valerio Leon. The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease. Clinical chemistry and laboratory medicine. vol 49. issue 3. 2011-07-27. PMID:21388338. |
the effect of apolipoprotein e (apoe) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in alzheimer's disease. |
2011-07-27 |
2023-08-12 |
Not clear |
| Henry Brodaty, Monique M B Breteler, Steven T Dekosky, Pascale Dorenlot, Laura Fratiglioni, Christoph Hock, Paul-Ariel Kenigsberg, Philip Scheltens, Bart De Stroope. The world of dementia beyond 2020. Journal of the American Geriatrics Society. vol 59. issue 5. 2011-07-26. PMID:21488846. |
counterpoised against dire projections of the tripling of the prevalence of dementia over the next 40 years are major developments in diagnostic biomarkers, neuroimaging, the molecular biology of alzheimer's disease (ad), epidemiology of risk and protective factors, and drug treatments-mainly targeting the amyloid pathway, tau protein, and immunotherapy-that may have the potential to modify the progression of ad. |
2011-07-26 |
2023-08-12 |
Not clear |
| José Luis Vázquez-Higuera, Ana Martínez-García, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Ignacio Mateo, Ana Pozueta, Ana Frank, Fernando Valdivieso, José Berciano, María J Bullido, Onofre Combarro. Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort. Neurobiology of aging. vol 32. issue 3. 2011-07-19. PMID:20096481. |
neurofibrillary tangles, one of the characteristic neuropathological lesions found in alzheimer's disease (ad) brains, are composed of abnormally hyperphosphorylated tau protein. |
2011-07-19 |
2023-08-12 |
human |
| Tetsuo Fukushima, Asako Nakamura, Noboru Iwakami, Yasushi Nakada, Hiroshi Hattori, Satoru Hoki, Hidetoshi Yamaguchi, Masaya Nakagawa, Nobuo Terashima, Hirokazu Narit. T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments associated with neuronal degeneration in P301L tau transgenic mice. Biochemical and biophysical research communications. vol 407. issue 4. 2011-07-19. PMID:21439944. |
tau pathology is implicated in mechanisms of neurodegenerative tauopathies, including alzheimer's disease (ad) and hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
2011-07-19 |
2023-08-12 |
mouse |
| Rakez Kaye. Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease. Human vaccines. vol 6. issue 11. 2011-07-15. PMID:20980799. |
the aggregation and accumulation of the microtubule-associated protein (tau) is a pathological hallmark of alzheimer's disease (ad) and many neurodegenerative diseases. |
2011-07-15 |
2023-08-12 |
mouse |
| Ismael Santa-Maria, Félix Hernández, Joaquín Del Rio, Francisco J Moreno, Jesús Avil. Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Molecular neurodegeneration. vol 2. 2011-07-14. PMID:17822548. |
tramiprosate, a drug of potential interest for the treatment of alzheimer's disease, promotes an abnormal aggregation of tau. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ismael Santa-Maria, Félix Hernández, Joaquín Del Rio, Francisco J Moreno, Jesús Avil. Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Molecular neurodegeneration. vol 2. 2011-07-14. PMID:17822548. |
alzheimer's disease (ad) is characterized by the presence of two histopathological hallmarks; the senile plaques, or extracellular deposits mainly composed of amyloid-beta peptide (abeta), and the neurofibrillary tangles, or intraneuronal inclusions composed of hyperphosphorylated tau protein.since abeta aggregates are found in the pathological cases, several strategies are under way to develop drugs that interact with abeta to reduce its assembly. |
2011-07-14 |
2023-08-12 |
Not clear |
| Yao Zhang, Qing Tian, Qi Zhang, Xinwen Zhou, Shijie Liu, Jian-Zhi Wan. Hyperphosphorylation of microtubule-associated tau protein plays dual role in neurodegeneration and neuroprotection. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 16. issue 4. 2011-07-14. PMID:19410438. |
in the brain of alzheimer's disease (ad) patients, tau protein is abnormally hyperphosphorylated and thus become incompetent in promoting microtubule assemble and maintaining the stability of the microtubules. |
2011-07-14 |
2023-08-12 |
Not clear |