All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
David E Hurtado, Laura Molina-Porcel, Michiyo Iba, Awo K Aboagye, Steven M Paul, John Q Trojanowski, Virginia M-Y Le. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. The American journal of pathology. vol 177. issue 4. 2011-03-11. PMID:20802182. a{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an alzheimer mouse model. 2011-03-11 2023-08-12 mouse
David E Hurtado, Laura Molina-Porcel, Michiyo Iba, Awo K Aboagye, Steven M Paul, John Q Trojanowski, Virginia M-Y Le. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. The American journal of pathology. vol 177. issue 4. 2011-03-11. PMID:20802182. senile plaques formed by β-amyloid peptides (aβ) and neurofibrillary tangles (nfts) formed by hyperphosphorylated tau, a microtubule-associated protein, are the hallmark lesions of alzheimer's disease (ad) in addition to loss of neurons. 2011-03-11 2023-08-12 mouse
Qi-Hai Gong, Qian Wang, Li-Long Pan, Xin-Hua Liu, Hong Xin, Yi-Zhun Zh. S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-κB pathway in rats. Brain, behavior, and immunity. vol 25. issue 1. 2011-03-10. PMID:20828607. neuroinflammation exacerbates hyperphosphorylated tau and amyloid-β (aβ) generation by generating a plethora of inflammatory mediators and neurotoxic compounds in a transgenic model of alzheimer's disease (ad), and it was reported that hydrogen sulfide (h₂s) attenuates lipopolysaccharide (lps)-induced neuroinflammation both in vitro and in vivo. 2011-03-10 2023-08-12 rat
Dong Liu, Michael Pitta, Jong-Hwan Lee, Balmiki Ray, Debomoy K Lahiri, Katsutoshi Furukawa, Mohamed Mughal, Haiyang Jiang, Julissa Villarreal, Roy G Cutler, Nigel H Greig, Mark P Mattso. The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 22. issue 2. 2011-03-09. PMID:20847430. the katp channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xtgad mouse model of alzheimer's disease. 2011-03-09 2023-08-12 mouse
Juan S Jiméne. Protein-DNA interaction at the origin of neurological diseases: a hypothesis. Journal of Alzheimer's disease : JAD. vol 22. issue 2. 2011-03-09. PMID:20847445. a number of neurodegenerative diseases, including alzheimer's disease, tauopathies, parkinson's disease, and synucleinopathies, polyglutamine diseases, including huntington's disease, amyotrophic lateral sclerosis, and transmissible spongiform encephalopathy, are characterized by the existence of a protein or peptide prone to aggregation specific to the disease: amyloid-β, tau protein, α-synuclein, atrophin 1, androgen receptor, prion protein, copper-zinc superoxide dismutase, α 1a subunit of cav2.1, tata-box binding protein, huntingtin, and ataxins 1, 2, 3, and 7. 2011-03-09 2023-08-12 Not clear
Jun Wang, Ismael Santa-Maria, Lap Ho, Hanna Ksiezak-Reding, Kenjiro Ono, David B Teplow, Giulio Maria Pasinett. Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 22. issue 2. 2011-03-09. PMID:20858961. grape derived polyphenols attenuate tau neuropathology in a mouse model of alzheimer's disease. 2011-03-09 2023-08-12 mouse
Jun Wang, Ismael Santa-Maria, Lap Ho, Hanna Ksiezak-Reding, Kenjiro Ono, David B Teplow, Giulio Maria Pasinett. Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 22. issue 2. 2011-03-09. PMID:20858961. aggregation of microtubule-associated protein tau into insoluble intracellular neurofibrillary tangles is a characteristic hallmark of alzheimer's disease (ad) and other neurodegenerative diseases, including progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, frontotemporal dementias with parkinsonism linked to chromosome 17, and pick's disease. 2011-03-09 2023-08-12 mouse
Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Xiu-Qing Yao, Yao Zhang, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus. vol 20. issue 12. 2011-03-07. PMID:19816983. an increased hippocampal neurogenesis has been observed in alzheimer disease (ad), the most common neurodegenerative disorder characterized with accumulation of β-amyloid (aβ) and hyperphosphorylated tau (p-tau). 2011-03-07 2023-08-12 mouse
Xiaoning B. Alzheimer disease: update on basic mechanisms. The Journal of the American Osteopathic Association. vol 110. issue 9 Suppl 8. 2011-03-07. PMID:20926741. pathologically, alzheimer disease is characterized by progressive synaptic and neuronal loss and the presence of diagnostic amyloid plaques, consisting of fibril b-amyloid peptide aggregates and neurofibrillary tangles containing hyperphosphorylated tau protein filaments. 2011-03-07 2023-08-12 Not clear
Xiaoning B. Alzheimer disease: update on basic mechanisms. The Journal of the American Osteopathic Association. vol 110. issue 9 Suppl 8. 2011-03-07. PMID:20926741. although plaques and tangles were originally considered the mediators of neurotoxicity in alzheimer disease, recent research has underscored the roles of soluble β-amyloid oligomers and tau molecules. 2011-03-07 2023-08-12 Not clear
H N Dawson, V Cantillana, M Jansen, H Wang, M P Vitek, D M Wilcock, J R Lynch, D T Laskowit. Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20434528. loss of tau elicits axonal degeneration in a mouse model of alzheimer's disease. 2011-03-04 2023-08-12 mouse
H N Dawson, V Cantillana, M Jansen, H Wang, M P Vitek, D M Wilcock, J R Lynch, D T Laskowit. Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20434528. plaque associated and neuropil dystrophic neurites and spheroids are prominent features of alzheimer's disease (masliah et al., 1993; terry, 1996; stokin et al., 2005), and our current data suggests that loss of tau function may lead to neurodegeneration. 2011-03-04 2023-08-12 mouse
Alexandra M Nicholson, D Nicole Riherd Methner, Adriana Ferreir. Membrane cholesterol modulates {beta}-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of N-methyl-D-aspartic acid receptors. The Journal of biological chemistry. vol 286. issue 2. 2011-03-02. PMID:21047784. we have previously shown that β-amyloid (aβ) treatment resulted in an age-dependent calpain activation leading to tau cleavage into a neurotoxic 17-kda fragment in a cellular model of alzheimer disease. 2011-03-02 2023-08-12 Not clear
Lars M Ittner, Jürgen Göt. Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease. Nature reviews. Neuroscience. vol 12. issue 2. 2011-03-01. PMID:21193853. amyloid-β and tau--a toxic pas de deux in alzheimer's disease. 2011-03-01 2023-08-12 Not clear
Lars M Ittner, Jürgen Göt. Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease. Nature reviews. Neuroscience. vol 12. issue 2. 2011-03-01. PMID:21193853. amyloid-β and tau are the two hallmark proteins in alzheimer's disease. 2011-03-01 2023-08-12 Not clear
Lars M Ittner, Jürgen Göt. Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease. Nature reviews. Neuroscience. vol 12. issue 2. 2011-03-01. PMID:21193853. although both amyloid-β and tau have been extensively studied individually with regard to their separate modes of toxicity, more recently new light has been shed on their possible interactions and synergistic effects in alzheimer's disease. 2011-03-01 2023-08-12 Not clear
Lars M Ittner, Jürgen Göt. Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease. Nature reviews. Neuroscience. vol 12. issue 2. 2011-03-01. PMID:21193853. here, we review novel findings that have shifted our understanding of the role of tau in the pathogenesis of alzheimer's disease towards being a crucial partner of amyloid-β. 2011-03-01 2023-08-12 Not clear
b' Nahuai Badiola, Marc Su\\xc3\\xa1rez-Calvet, Alberto Lle\\xc3\\xb. Tau phosphorylation and aggregation as a therapeutic target in tauopathies. CNS & neurological disorders drug targets. vol 9. issue 6. 2011-02-28. PMID:20942789.' the obstacles found in amyloid-based therapies in alzheimer's disease, the most common tauopathy, have stimulated the search for alternative targets, including tau. 2011-02-28 2023-08-12 Not clear
Odete A B da Cruz e Silva, Ana Gabriela Henriques, Sara Catarina Timóteo Santos Domingues, Edgar F da Cruz e Silv. Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease. CNS & neurological disorders drug targets. vol 9. issue 6. 2011-02-28. PMID:20942790. individuals with alzheimer's disease (ad) exhibit extracellular senile plaques (sps) of aggregated a beta and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein (nfts), and also an extensive loss in basal forebrain cholinergic neurons that innervate the hippocampus and neocortex. 2011-02-28 2023-08-12 mouse
Y Avramovich-Tirosh, O Bar-Am, T Amit, M B H Youdim, O Weinre. Up-regulation of hypoxia-inducible factor (HIF)-1α and HIF-target genes in cortical neurons by the novel multifunctional iron chelator anti-Alzheimer drug, M30. Current Alzheimer research. vol 7. issue 4. 2011-02-24. PMID:20043814. regarding aspects of relevance to alzheimer's disease (ad), western blotting analysis of glycogen synthase kinase- 3beta (gsk-3beta) signaling pathway revealed that m30 enhanced the levels of phospho-akt (ser473) and phospho- gsk-3beta (ser9) and attenuated tau phosphorylation. 2011-02-24 2023-08-12 rat