All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Erik D Roberson, Brian Halabisky, Jong W Yoo, Jinghua Yao, Jeannie Chin, Fengrong Yan, Tiffany Wu, Patricia Hamto, Nino Devidze, Gui-Qiu Yu, Jorge J Palop, Jeffrey L Noebels, Lennart Muck. Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 2. 2011-02-22. PMID:21228179. amyloid-β/fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of alzheimer's disease. 2011-02-22 2023-08-12 mouse
Rahul S Desikan, Mert R Sabuncu, Nicholas J Schmansky, Martin Reuter, Howard J Cabral, Christopher P Hess, Michael W Weiner, Alessandro Biffi, Christopher D Anderson, Jonathan Rosand, David H Salat, Thomas L Kemper, Anders M Dale, Reisa A Sperling, Bruce Fisch. Selective disruption of the cerebral neocortex in Alzheimer's disease. PloS one. vol 5. issue 9. 2011-02-18. PMID:20886094. alzheimer's disease (ad) and its transitional state mild cognitive impairment (mci) are characterized by amyloid plaque and tau neurofibrillary tangle (nft) deposition within the cerebral neocortex and neuronal loss within the hippocampal formation. 2011-02-18 2023-08-12 Not clear
Andrew Bottley, Nicola M Phillips, Thomas E Webb, Anne E Willis, Keith A Sprigg. eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease. PloS one. vol 5. issue 9. 2011-02-18. PMID:20927385. inhibition of eif4a selectively and simultaneously modulates the synthesis of proteins involved in alzheimer's disease: reducing a-beta and tau synthesis, while increasing proteins predicted to be neuroprotective. 2011-02-18 2023-08-12 Not clear
Tomás L Falzone, Shermali Gunawardena, David McCleary, Gerald F Reis, Lawrence S B Goldstei. Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Human molecular genetics. vol 19. issue 22. 2011-02-17. PMID:20817925. together with previous work, our results suggest that non-lethal reductions in axonal transport, and perhaps other types of minor axonal stress, are sufficient to induce and/or accelerate abnormal tau behavior characteristic of alzheimer's disease and other neurodegenerative tauopathies. 2011-02-17 2023-08-12 mouse
Yan Cai, Kun Xiong, Xue-Mei Zhang, Huaibin Cai, Xue-Gang Luo, Jia-Chun Feng, Richard W Clough, Robert G Struble, Peter R Patrylo, Yaping Chu, Jeffrey H Kordower, Xiao-Xin Ya. β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation. The European journal of neuroscience. vol 32. issue 7. 2011-02-14. PMID:20726888. alzheimer's disease (ad) is the most common dementia-causing disorder in the elderly; it may be related to multiple risk factors, and is characterized pathologically by cerebral hypometabolism, paravascular β-amyloid peptide (aβ) plaques, neuritic dystrophy, and intra-neuronal aggregation of phosphorylated tau. 2011-02-14 2023-08-12 human
Celine Ullrich, Michael Pirchl, Christian Humpe. Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. Molecular and cellular neurosciences. vol 45. issue 4. 2011-02-07. PMID:20696249. alzheimer's disease (ad) is a chronic brain disorder characterized by cognitive impairment, cholinergic dysfunction, inflammation, tau and beta-amyloid pathology and vascular damage. 2011-02-07 2023-08-12 rat
Anders A F Sim. Encephalopathies: the emerging diabetic complications. Acta diabetologica. vol 47. issue 4. 2011-02-03. PMID:20798963. the pathobiology of accumulation of β-amyloid and tau the hallmarks of alzheimer's disease are discussed based on experimental data. 2011-02-03 2023-08-12 Not clear
Jongyeon Shin, Saet-Byeol Yu, Un Young Yu, Sangmee Ahn Jo, Jung-Hyuck Ah. Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease. BMB reports. vol 43. issue 10. 2011-02-02. PMID:21034535. the swedish mutation (k595n/m596l) of amyloid precursor protein (app-swe) has been known to increase abnormal cleavage of cellular app by beta-secretase (bace), which causes tau protein hyperphosphorylation and early-onset alzheimer's disease (ad). 2011-02-02 2023-08-12 Not clear
Mirsada Caušević, Umbreen Farooq, Simon Lovestone, Richard Killic. β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration. Neuroscience letters. vol 485. issue 3. 2011-01-28. PMID:20826196. β-amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to alzheimer's type neurodegeneration. 2011-01-28 2023-08-12 human
Catherine M Cowan, Torsten Bossing, Anton Page, David Shepherd, Amritpal Mudhe. Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo. Acta neuropathologica. vol 120. issue 5. 2011-01-25. PMID:20617325. it has been hypothesised that tau protein, when hyper-phosphorylated as in alzheimer's disease (ad), does not bind effectively to microtubules and is no longer able to stabilise them; thus microtubules break down, and axonal transport can no longer proceed efficiently in affected brain regions in ad and related tauopathies (tau-microtubule hypothesis). 2011-01-25 2023-08-12 human
Kelly Zhao, Giulia Ippolito, Lulu Wang, Valerie Price, Mi Hwa Kim, Gavin Cornwell, Stephanie Fulenchek, Gail A Breen, Warren J Goux, Santosh R D'Mell. Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. Journal of neuroscience research. vol 88. issue 15. 2011-01-25. PMID:20882568. intracellular aggregation of tau is a pathological hallmark in alzheimer's disease and other tauopathies. 2011-01-25 2023-08-12 Not clear
Kajsa Sämgård, Henrik Zetterberg, Kaj Blennow, Oskar Hansson, Lennart Minthon, Elisabet Londo. Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity. International journal of geriatric psychiatry. vol 25. issue 4. 2011-01-21. PMID:19650161. cerebrospinal fluid total tau as a marker of alzheimer's disease intensity. 2011-01-21 2023-08-12 Not clear
Igor Yakushev, Peter Bartenstein, Thomas Siessmeier, Christoph Hiemke, Armin Scheurich, Johannes Lotz, Andreas Fellgiebel, Matthias J Mülle. Cerebrospinal fluid tau protein levels and 18F-fluorodeoxyglucose positron emission tomography in the differential diagnosis of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 30. issue 3. 2011-01-21. PMID:20847555. cerebrospinal fluid tau protein levels and 18f-fluorodeoxyglucose positron emission tomography in the differential diagnosis of alzheimer's disease. 2011-01-21 2023-08-12 Not clear
Igor Yakushev, Peter Bartenstein, Thomas Siessmeier, Christoph Hiemke, Armin Scheurich, Johannes Lotz, Andreas Fellgiebel, Matthias J Mülle. Cerebrospinal fluid tau protein levels and 18F-fluorodeoxyglucose positron emission tomography in the differential diagnosis of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 30. issue 3. 2011-01-21. PMID:20847555. in this study, we aimed to compare cerebrospinal fluid (csf) levels of total tau (t-tau), phosphorylated tau (p-tau(181)) and positron emission tomography with (18)f-fluorodeoxyglucose (fdg-pet) in the differential diagnosis of alzheimer's disease (ad) under clinical conditions. 2011-01-21 2023-08-12 Not clear
Ke-Wu Zeng, Hyeonseok Ko, Hyun Ok Yang, Xue-Mei Wan. Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells. Neuropharmacology. vol 59. issue 6. 2011-01-20. PMID:20708632. thus, this study promises a great potential agent for alzheimer's disease and other tau pathology-related neuronal degenerative diseases. 2011-01-20 2023-08-12 rat
Brian R Hoover, Miranda N Reed, Jianjun Su, Rachel D Penrod, Linda A Kotilinek, Marianne K Grant, Rose Pitstick, George A Carlson, Lorene M Lanier, Li-Lian Yuan, Karen H Ashe, Dezhi Lia. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. vol 68. issue 6. 2011-01-19. PMID:21172610. the microtubule-associated protein tau accumulates in alzheimer's and other fatal dementias, which manifest when forebrain neurons die. 2011-01-19 2023-08-12 Not clear
Peng Lei, Scott Ayton, David I Finkelstein, Paul A Adlard, Colin L Masters, Ashley I Bus. Tau protein: relevance to Parkinson's disease. The international journal of biochemistry & cell biology. vol 42. issue 11. 2011-01-18. PMID:20678581. in alzheimer's and parkinson's diseases, there is a hyperphosphorylation of tau that leads to the intracellular accumulation of tau in the form of neurofibrillary tangles. 2011-01-18 2023-08-12 Not clear
Philip J Dolan, Gail V W Johnso. The role of tau kinases in Alzheimer's disease. Current opinion in drug discovery & development. vol 13. issue 5. 2011-01-18. PMID:20812151. the role of tau kinases in alzheimer's disease. 2011-01-18 2023-08-12 Not clear
Philip J Dolan, Gail V W Johnso. The role of tau kinases in Alzheimer's disease. Current opinion in drug discovery & development. vol 13. issue 5. 2011-01-18. PMID:20812151. a principal feature of the progression of alzheimer's disease (ad) is the appearance of aberrant phosphorylation of the microtubule-associated protein tau in the brains of affected individuals. 2011-01-18 2023-08-12 Not clear
Kun-Lin Chen, Rey-Yue Yuan, Chaur-Jong Hu, Chung Y Hs. Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20615469. amyloid-beta peptide (aβ) and tau protein are the lead constituents in the pathogenesis of alzheimer's disease (ad). 2011-01-12 2023-08-12 Not clear