| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antero Salminen, Johanna Ojala, Kai Kaarniranta, Mikko Hiltunen, Hilkka Soinine. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Progress in neurobiology. vol 93. issue 1. 2011-05-06. PMID:21056617. |
alzheimer's disease is a tauopathy which involves the deposition of microtubule-associated tau proteins into neurofibrillary tangles. |
2011-05-06 |
2023-08-12 |
Not clear |
| Antero Salminen, Johanna Ojala, Kai Kaarniranta, Mikko Hiltunen, Hilkka Soinine. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Progress in neurobiology. vol 93. issue 1. 2011-05-06. PMID:21056617. |
we will review the role of hsp90 chaperone network in the regulation of tau biology and pathology in alzheimer's disease. |
2011-05-06 |
2023-08-12 |
Not clear |
| Monika Zilkova, Norbert Zilka, Andrej Kovac, Branislav Kovacech, Rostislav Skrabana, Michaela Skrabanova, Michal Nova. Hyperphosphorylated truncated protein tau induces caspase-3 independent apoptosis-like pathway in the Alzheimer's disease cellular model. Journal of Alzheimer's disease : JAD. vol 23. issue 1. 2011-05-05. PMID:20966551. |
hyperphosphorylated truncated protein tau induces caspase-3 independent apoptosis-like pathway in the alzheimer's disease cellular model. |
2011-05-05 |
2023-08-12 |
human |
| Koichi Ando, Kengo Uemura, Akira Kuzuya, Masato Maesako, Megumi Asada-Utsugi, Masakazu Kubota, Nobuhisa Aoyagi, Katsuji Yoshioka, Katsuya Okawa, Haruhisa Inoue, Jun Kawamata, Shun Shimohama, Tetsuaki Arai, Ryosuke Takahashi, Ayae Kinoshit. N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21177868. |
the dissociation of n-cadherin-mediated synaptic contact by aβ may underlie the pathological basis of neurodegeneration such as neuronal death, synaptic loss, and tau phosphorylation in alzheimer disease brain. |
2011-05-04 |
2023-08-12 |
human |
| Zhaoxu Zhang, Ruiping Zhao, Jiping Qi, Shirong Wen, Ying Tang, Desheng Wan. Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons. Journal of neuroscience research. vol 89. issue 3. 2011-05-03. PMID:21259330. |
recently, tau hyperphosphorylation by glycogen synthase kinase-3β (gsk-3β) activation has been emphasized as one of the pathogenic mechanisms of alzheimer's disease (ad). |
2011-05-03 |
2023-08-12 |
Not clear |
| Wanjoo Chun, Geoffrey S Waldo, Gail V W Johnso. Split GFP complementation assay for quantitative measurement of tau aggregation in situ. Methods in molecular biology (Clifton, N.J.). vol 670. 2011-05-02. PMID:20967587. |
a primary pathological hallmark of alzheimer disease brain is the presence of neurofibrillary tangles, which are highly aggregated and insoluble accumulations of the microtubule-associated protein tau. |
2011-05-02 |
2023-08-12 |
Not clear |
| Dewen Yang, Zhiyong Xie, Diane Stephenson, Daniel Morton, Carol D Hicks, Tracy M Brown, Renuka Sriram, Sharon O'Neill, David Raunig, Thomas Boca. Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). NeuroImage. vol 54. issue 4. 2011-05-02. PMID:21035554. |
volumetric mri and mrs provide sensitive measures of alzheimer's disease neuropathology in inducible tau transgenic mice (rtg4510). |
2011-05-02 |
2023-08-12 |
mouse |
| Dewen Yang, Zhiyong Xie, Diane Stephenson, Daniel Morton, Carol D Hicks, Tracy M Brown, Renuka Sriram, Sharon O'Neill, David Raunig, Thomas Boca. Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). NeuroImage. vol 54. issue 4. 2011-05-02. PMID:21035554. |
the purpose of this study was to determine if in vivo high resolution 3d mri and localized (1)h mr spectroscopy (mrs) can detect brain findings resembling alzheimer's disease in a transgenic mouse model of tau pathology. |
2011-05-02 |
2023-08-12 |
mouse |
| Michael S Wolf. Alzheimer's Disease Drug Discovery--11th International Conference--Targeting Pathological Tau. 27-28 September 2010, Jersey City, NJ, USA. IDrugs : the investigational drugs journal. vol 13. issue 12. 2011-05-02. PMID:21154135. |
alzheimer's disease drug discovery--11th international conference--targeting pathological tau. |
2011-05-02 |
2023-08-12 |
Not clear |
| Michael S Wolf. Alzheimer's Disease Drug Discovery--11th International Conference--Targeting Pathological Tau. 27-28 September 2010, Jersey City, NJ, USA. IDrugs : the investigational drugs journal. vol 13. issue 12. 2011-05-02. PMID:21154135. |
this conference report highlights selected presentations on targeting pathological tau for the prevention or treatment of alzheimer's disease. |
2011-05-02 |
2023-08-12 |
Not clear |
| Lian-Feng Lin, Huan-Min Lu. Screening of treatment targets for Alzheimer's disease from the molecular mechanisms of impairment by β-amyloid aggregation and tau hyperphosphorylation. Neuroscience bulletin. vol 27. issue 1. 2011-05-02. PMID:21270904. |
screening of treatment targets for alzheimer's disease from the molecular mechanisms of impairment by β-amyloid aggregation and tau hyperphosphorylation. |
2011-05-02 |
2023-08-12 |
Not clear |
| Lian-Feng Lin, Huan-Min Lu. Screening of treatment targets for Alzheimer's disease from the molecular mechanisms of impairment by β-amyloid aggregation and tau hyperphosphorylation. Neuroscience bulletin. vol 27. issue 1. 2011-05-02. PMID:21270904. |
β-amyloid (aβ) over-expression and tau hyperphosphorylation are considered to be the central events in the pathogenesis of alzheimer's disease (ad). |
2011-05-02 |
2023-08-12 |
Not clear |
| Xiao-Ping Hong, Cai-Xia Peng, Wei Wei, Qing Tian, Ying-Hua Liu, Fu-Yuan Cao, Qun Wang, Jian-Zhi Wan. Relationship of adult neurogenesis with tau phosphorylation and GSK-3β activity in subventricular zone. Neurochemical research. vol 36. issue 2. 2011-04-29. PMID:21061060. |
altered neurogenesis has been reported in alzheimer disease (ad), the most common neurodegenerative disorder characterized with hyperphosphorylated tau and accumulation of β-amyloid (aβ). |
2011-04-29 |
2023-08-12 |
mouse |
| Anindita Bose, François Mouton-Liger, Claire Paquet, Pierre Mazot, Marc Vigny, Françoise Gray, Jacques Hugo. Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 21. issue 2. 2011-04-28. PMID:21029237. |
modulation of tau phosphorylation by the kinase pkr: implications in alzheimer's disease. |
2011-04-28 |
2023-08-12 |
Not clear |
| Tobias Bittner, Martin Fuhrmann, Steffen Burgold, Simon M Ochs, Nadine Hoffmann, Gerda Mitteregger, Hans Kretzschmar, Frank M LaFerla, Jochen Herm. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PloS one. vol 5. issue 11. 2011-04-27. PMID:21103384. |
the pathology of alzheimer's disease (ad) is characterized by the accumulation of amyloid-β (aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss. |
2011-04-27 |
2023-08-12 |
mouse |
| Claire Thornton, Nicola J Bright, Magdalena Sastre, Phillip J Muckett, David Carlin. AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. The Biochemical journal. vol 434. issue 3. 2011-04-25. PMID:21204788. |
hyperphosphorylation of tau is a hallmark of alzheimer's disease and other tauopathies. |
2011-04-25 |
2023-08-12 |
mouse |
| Anne Gauthier-Kemper, Carina Weissmann, Nataliya Golovyashkina, Zsofia Sebö-Lemke, Gerard Drewes, Volker Gerke, Jürgen J Heinisch, Roland Brand. The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner. The Journal of cell biology. vol 192. issue 4. 2011-04-25. PMID:21339331. |
changes of the microtubule-associated protein tau are central in alzheimer's disease (ad) and frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2011-04-25 |
2023-08-12 |
Not clear |
| Anders M Fjell, Kristine B Walhovd, Christine Fennema-Notestine, Linda K McEvoy, Donald J Hagler, Dominic Holland, Kaj Blennow, James B Brewer, Anders M Dal. Brain atrophy in healthy aging is related to CSF levels of Aβ1-42. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 9. 2011-04-21. PMID:20051356. |
reduced levels of beta-amyloid(1-42) (abeta1-42) and increased levels of tau proteins in the cerebrospinal fluid (csf) are found in alzheimer's disease (ad), likely reflecting abeta deposition in plaques and neuronal and axonal damage. |
2011-04-21 |
2023-08-12 |
Not clear |
| Xi Li, Ying Liu, Xin Zhang, Haifeng Yuan, Qiankun Qua. [Effect of ginsenoside Rg1 on expressions of phosphory protein tau and N-methyl-D-aspartate receptor subunits NR1 and NR2B in rat brain slice model of Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 35. issue 24. 2011-04-12. PMID:21438403. |
[effect of ginsenoside rg1 on expressions of phosphory protein tau and n-methyl-d-aspartate receptor subunits nr1 and nr2b in rat brain slice model of alzheimer's disease]. |
2011-04-12 |
2023-08-12 |
rat |
| Xi Li, Ying Liu, Xin Zhang, Haifeng Yuan, Qiankun Qua. [Effect of ginsenoside Rg1 on expressions of phosphory protein tau and N-methyl-D-aspartate receptor subunits NR1 and NR2B in rat brain slice model of Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 35. issue 24. 2011-04-12. PMID:21438403. |
to investigate the effect of ginsenoside rg1 on the expressions of phosphory protein tau (p-tau), n-methyl-d-aspartate receptor subunit 1 (nr1) and n-methyl-d-aspartate receptor subunit 2b(nr2b) in rat brain slice model of alzheimer's disease. |
2011-04-12 |
2023-08-12 |
rat |