| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lan Xiao, Xuyu Yang, Vinay Kumar Sharma, Daniel Abebe, Y Peng Lo. Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's Disease male mice. Molecular psychiatry. 2023-06-27. PMID:37369719. |
alzheimer's disease (ad) is a prevalent neurodegenerative disease characterized by tau hyperphosphorylation, aβ1-42 aggregation and cognitive dysfunction. |
2023-06-27 |
2023-08-14 |
mouse |
| Débora E Peretti, Federica Ribaldi, Max Scheffler, Christian Chicherio, Giovanni B Frisoni, Valentina Garibott. Prognostic value of imaging-based ATN profiles in a memory clinic cohort. European journal of nuclear medicine and molecular imaging. 2023-06-26. PMID:37358619. |
the atn model represents a research framework used to classify subjects based on the presence or absence of alzheimer's disease (ad) pathology through biomarkers for amyloid (a), tau (t), and neurodegeneration (n). |
2023-06-26 |
2023-08-14 |
human |
| Masihuz Zaman, Yingxue Fu, Ping-Chung Chen, Huan Sun, Shu Yang, Zhiping Wu, Zhen Wang, Suresh Poudel, Geidy E Serrano, Thomas G Beach, Ling Li, Xusheng Wang, Junmin Pen. Dissecting detergent-insoluble proteome in Alzheimer's disease by TMTc-corrected quantitative mass spectrometry. Molecular & cellular proteomics : MCP. 2023-06-25. PMID:37356496. |
protein aggregation of amyloid-β (aβ) peptides and tau are pathological hallmarks of alzheimer's disease (ad), which are often resistant to detergent extraction and thus enriched in the insoluble proteome. |
2023-06-25 |
2023-08-14 |
human |
| L Iaccarino, S C Burnham, G Dell'Agnello, S A Dowsett, S Epelbau. Diagnostic Biomarkers of Amyloid and Tau Pathology in Alzheimer's Disease: An Overview of Tests for Clinical Practice in the United States and Europe. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357283. |
diagnostic biomarkers of amyloid and tau pathology in alzheimer's disease: an overview of tests for clinical practice in the united states and europe. |
2023-06-25 |
2023-08-14 |
Not clear |
| L Iaccarino, S C Burnham, G Dell'Agnello, S A Dowsett, S Epelbau. Diagnostic Biomarkers of Amyloid and Tau Pathology in Alzheimer's Disease: An Overview of Tests for Clinical Practice in the United States and Europe. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357283. |
amyloid and tau biomarkers for alzheimer's disease are widely recognized diagnostic tools for the identification of alzheimer's disease pathology antemortem and are recommended by the most recent clinical and research guidelines. |
2023-06-25 |
2023-08-14 |
Not clear |
| L Iaccarino, S C Burnham, G Dell'Agnello, S A Dowsett, S Epelbau. Diagnostic Biomarkers of Amyloid and Tau Pathology in Alzheimer's Disease: An Overview of Tests for Clinical Practice in the United States and Europe. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357283. |
all available pet amyloid and tau biomarkers demonstrate high accuracy in identifying amyloid and tau alzheimer's disease pathology, respectively, at autopsy. |
2023-06-25 |
2023-08-14 |
Not clear |
| L Iaccarino, S C Burnham, G Dell'Agnello, S A Dowsett, S Epelbau. Diagnostic Biomarkers of Amyloid and Tau Pathology in Alzheimer's Disease: An Overview of Tests for Clinical Practice in the United States and Europe. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357283. |
overall, we conclude that commercially available pet, cerebrospinal fluid and plasma assays accurately identify alzheimer's disease amyloid and tau pathology. |
2023-06-25 |
2023-08-14 |
Not clear |
| K P Ng, J Y Shen, H J Chiew, A S L Ng, N Kandiah, P Rosa-Neto, S Gauthie. White Matter Hyperintensity as a Vascular Contribution to the AT(N) Framework. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357280. |
the at(n) framework enables the classification of an individual within the biological alzheimer's disease (ad) continuum by pairing the cognitive stage with the biomarker status of amyloid-beta (aβ, a), tau (t) and neurodegeneration (n). |
2023-06-25 |
2023-08-14 |
Not clear |
| Dianne Marquez Lopez, Connor J Maltby, Hannah Warming, Nullin Divecha, Mariana Vargas-Caballero, Mark J Coldwell, Katrin Deinhard. A luminescence-based reporter to study tau secretion reveals overlapping mechanisms for the release of healthy and pathological tau. Frontiers in neuroscience. vol 17. 2023-06-22. PMID:37342467. |
in alzheimer's disease, tau pathology is thought to spread via a prion-like manner along connected neuronal networks. |
2023-06-22 |
2023-08-14 |
Not clear |
| Nathalie Kyalu Ngoie Zola, Clémence Balty, Sébastien Pyr Dit Ruys, Axelle A T Vanparys, Nicolas D G Huyghe, Gaëtan Herinckx, Manuel Johanns, Emilien Boyer, Pascal Kienlen-Campard, Mark H Rider, Didier Vertommen, Bernard J Hanseeu. Specific post-translational modifications of soluble tau protein distinguishes Alzheimer's disease and primary tauopathies. Nature communications. vol 14. issue 1. 2023-06-22. PMID:37349319. |
specific post-translational modifications of soluble tau protein distinguishes alzheimer's disease and primary tauopathies. |
2023-06-22 |
2023-08-14 |
human |
| Nathalie Kyalu Ngoie Zola, Clémence Balty, Sébastien Pyr Dit Ruys, Axelle A T Vanparys, Nicolas D G Huyghe, Gaëtan Herinckx, Manuel Johanns, Emilien Boyer, Pascal Kienlen-Campard, Mark H Rider, Didier Vertommen, Bernard J Hanseeu. Specific post-translational modifications of soluble tau protein distinguishes Alzheimer's disease and primary tauopathies. Nature communications. vol 14. issue 1. 2023-06-22. PMID:37349319. |
we therefore characterized post-translational modifications of both the aggregated and the soluble tau protein obtained from post mortem human brain tissue of patients with alzheimer's disease, cortico-basal degeneration, pick's disease, and frontotemporal lobe degeneration. |
2023-06-22 |
2023-08-14 |
human |
| Klara Zubčić, Dina Franić, Mihaela Pravica, Patrick R Hof, Goran Šimić, Mirta Boba. Effects of heterologous human tau protein expression in yeast models of proteotoxic stress response. CNS neuroscience & therapeutics. 2023-06-21. PMID:37341072. |
the primary histological characteristic of alzheimer's disease is the presence of neurofibrillary tangles, which are large aggregates of tau protein. |
2023-06-21 |
2023-08-14 |
human |
| Klara Zubčić, Dina Franić, Mihaela Pravica, Patrick R Hof, Goran Šimić, Mirta Boba. Effects of heterologous human tau protein expression in yeast models of proteotoxic stress response. CNS neuroscience & therapeutics. 2023-06-21. PMID:37341072. |
aging is the primary risk factor for the development of alzheimer's disease, however, the underlying causes of tau protein aggregation and toxicity are unclear. |
2023-06-21 |
2023-08-14 |
human |
| Anastasie Mate De Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta neuropathologica. 2023-06-21. PMID:37341831. |
insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in alzheimer's disease. |
2023-06-21 |
2023-08-14 |
mouse |
| Anastasie Mate De Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta neuropathologica. 2023-06-21. PMID:37341831. |
we prepared sarkosyl-insoluble and hmw tau from the frontal cortex of alzheimer patients and compared their properties using a variety of biophysical and bioactivity assays. |
2023-06-21 |
2023-08-14 |
mouse |
| Anastasie Mate De Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta neuropathologica. 2023-06-21. PMID:37341831. |
these data suggest that soluble hmw tau has similar properties to fibrillar sarkosyl-insoluble tau with regard to tau seeding potential, but may be equal or even more bioactive with respect to propagation across neural systems and activation of glial responses, both relevant to tau-related alzheimer phenotypes. |
2023-06-21 |
2023-08-14 |
mouse |
| Airi Tarutani, Sofia Lövestam, Xianjun Zhang, Abhay Kotecha, Andrew C Robinson, David M A Mann, Yuko Saito, Shigeo Murayama, Taisuke Tomita, Michel Goedert, Sjors H W Scheres, Masato Hasegaw. Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration. FEBS open bio. 2023-06-20. PMID:37337995. |
cryo-em structures of tau filaments from sh-sy5y cells seeded with brain extracts from cases of alzheimer's disease and corticobasal degeneration. |
2023-06-20 |
2023-08-14 |
human |
| Airi Tarutani, Sofia Lövestam, Xianjun Zhang, Abhay Kotecha, Andrew C Robinson, David M A Mann, Yuko Saito, Shigeo Murayama, Taisuke Tomita, Michel Goedert, Sjors H W Scheres, Masato Hasegaw. Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration. FEBS open bio. 2023-06-20. PMID:37337995. |
here, we report the electron cryo-microscopy structures of tau filaments from undifferentiated seeded sh-sy5y cells, that transiently expressed n-terminally ha-tagged 1n3r or 1n4r human tau, using brain extracts from individuals with alzheimer's disease or corticobasal degeneration. |
2023-06-20 |
2023-08-14 |
human |
| Frédéric St-Onge, Marianne Chapleau, John Cs Breitner, Sylvia Villeneuve, Alexa Pichet Binett. Tau accumulation and its spatial progression across the Alzheimer's disease spectrum. medRxiv : the preprint server for health sciences. 2023-06-19. PMID:37333413. |
tau accumulation and its spatial progression across the alzheimer's disease spectrum. |
2023-06-19 |
2023-08-14 |
Not clear |
| Frédéric St-Onge, Marianne Chapleau, John Cs Breitner, Sylvia Villeneuve, Alexa Pichet Binett. Tau accumulation and its spatial progression across the Alzheimer's disease spectrum. medRxiv : the preprint server for health sciences. 2023-06-19. PMID:37333413. |
the spread of tau abnormality in sporadic alzheimer's disease is believed typically to follow neuropathologically defined braak staging. |
2023-06-19 |
2023-08-14 |
Not clear |