| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oyinkan Sofola, Fiona Kerr, Iain Rogers, Richard Killick, Hrvoje Augustin, Carina Gandy, Marcus J Allen, John Hardy, Simon Lovestone, Linda Partridg. Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. PLoS genetics. vol 6. issue 9. 2011-01-04. PMID:20824130. |
abeta peptide accumulation is thought to be the primary event in the pathogenesis of alzheimer's disease (ad), with downstream neurotoxic effects including the hyperphosphorylation of tau protein. |
2011-01-04 |
2023-08-12 |
drosophila_melanogaster |
| K Bhaskar, G A Hobbs, S-H Yen, G Le. Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy. Neuropathology and applied neurobiology. vol 36. issue 6. 2011-01-03. PMID:20609109. |
tau protein is a prominent component of paired helical filaments in alzheimer's disease (ad) and other tauopathies. |
2011-01-03 |
2023-08-12 |
mouse |
| Tetsuya Kimura, Tetsuya Fukuda, Naruhiko Sahara, Shunji Yamashita, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Boyoung Lee, Ioannis Sotiropoulos, Sumihiro Maeda, Akihiko Takashim. Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss. The Journal of biological chemistry. vol 285. issue 49. 2010-12-30. PMID:20921222. |
neurofibrillary tangles (nfts), which consist of highly phosphorylated tau, are hallmarks of neurodegenerative diseases including alzheimer disease (ad). |
2010-12-30 |
2023-08-12 |
mouse |
| Ayisha Siddiqua, Martin Margitta. Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20921227. |
three- and four-repeat tau coassemble into heterogeneous filaments: an implication for alzheimer disease. |
2010-12-30 |
2023-08-12 |
human |
| Ayisha Siddiqua, Martin Margitta. Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20921227. |
tau filaments are the pathological hallmark of numerous neurodegenerative diseases including alzheimer disease, pick disease, and progressive supranuclear palsy. |
2010-12-30 |
2023-08-12 |
human |
| Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Marcos J Guerrero-Muoz, George R Jackson, Rakez Kaye. Preparation and characterization of neurotoxic tau oligomers. Biochemistry. vol 49. issue 47. 2010-12-30. PMID:21047142. |
tau aggregation is a pathological hallmark of alzheimer's disease, parkinson's disease, and many other neurodegenerative disorders known as tauopathies. |
2010-12-30 |
2023-08-12 |
Not clear |
| Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Marcos J Guerrero-Muoz, George R Jackson, Rakez Kaye. Preparation and characterization of neurotoxic tau oligomers. Biochemistry. vol 49. issue 47. 2010-12-30. PMID:21047142. |
recently, tau oligomers have emerged as the pathogenic species in tauopathies and a possible mediator of amyloid-β toxicity in alzheimer's disease. |
2010-12-30 |
2023-08-12 |
Not clear |
| Meredith N Braskie, Andrea D Klunder, Kiralee M Hayashi, Hillary Protas, Vladimir Kepe, Karen J Miller, S-C Huang, Jorge R Barrio, Linda M Ercoli, Prabha Siddarth, Nagichettiar Satyamurthy, Jie Liu, Arthur W Toga, Susan Y Bookheimer, Gary W Small, Paul M Thompso. Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease. Neurobiology of aging. vol 31. issue 10. 2010-12-23. PMID:19004525. |
amyloid plaques and tau neurofibrillary tangles, the pathological hallmarks of alzheimer's disease (ad), begin accumulating in the healthy human brain decades before clinical dementia symptoms can be detected. |
2010-12-23 |
2023-08-12 |
human |
| Masood Kamali-Moghaddam, Frida Ekholm Pettersson, Di Wu, Hillevi Englund, Spyros Darmanis, Anna Lord, Gholamreza Tavoosidana, Dag Sehlin, Sigrun Gustafsdottir, Lars N G Nilsson, Lars Lannfelt, Ulf Landegre. Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease. BMC neuroscience. vol 11. 2010-12-23. PMID:20923550. |
for instance, insoluble aggregates of phosphorylated tau and of aβ peptides are cornerstones in the pathology of alzheimer's disease. |
2010-12-23 |
2023-08-12 |
Not clear |
| Sergey Larionov, Przemyslaw Wielgat, Yiner Wang, Dietmar Rudolf Thal, Harald Neuman. Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer. Journal of neuroscience methods. vol 192. issue 1. 2010-12-21. PMID:20655329. |
spatially pathogenic forms of tau detected in alzheimer's disease brain tissue by fluorescence lifetime-based förster resonance energy transfer. |
2010-12-21 |
2023-08-12 |
human |
| Sergey Larionov, Przemyslaw Wielgat, Yiner Wang, Dietmar Rudolf Thal, Harald Neuman. Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer. Journal of neuroscience methods. vol 192. issue 1. 2010-12-21. PMID:20655329. |
in tauopathies including alzheimer's disease (ad) tau molecules have lost their normal spatial distance to each other and appear in oligomeric or aggregated forms. |
2010-12-21 |
2023-08-12 |
human |
| Johan Sundelöf, Johan Sundström, Oskar Hansson, Maria Eriksdotter-Jönhagen, Vilmantas Giedraitis, Anders Larsson, Malin Degerman-Gunnarsson, Martin Ingelsson, Lennart Minthon, Kaj Blennow, Lena Kilander, Hans Basun, Lars Lannfel. Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controls. Journal of Alzheimer's disease : JAD. vol 21. issue 2. 2010-12-20. PMID:20555147. |
cystatin c levels are positively correlated with both abeta42 and tau levels in cerebrospinal fluid in persons with alzheimer's disease, mild cognitive impairment, and healthy controls. |
2010-12-20 |
2023-08-12 |
human |
| Jeroen J J van Eijk, Bart van Everbroeck, W Farid Abdo, Berry P H Kremer, Marcel M Verbee. CSF neurofilament proteins levels are elevated in sporadic Creutzfeldt-Jakob disease. Journal of Alzheimer's disease : JAD. vol 21. issue 2. 2010-12-20. PMID:20555148. |
in this study we investigated the cerebrospinal fluid (csf) levels of neurofilament light (nfl) and heavy chain (nfhp35), total tau (t-tau), and glial fibrillary acidic protein (gfap) to detect disease specific profiles in sporadic creutzfeldt jakob disease (scjd) patients and alzheimer's disease (ad) patients. |
2010-12-20 |
2023-08-12 |
Not clear |
| M Morawski, G Brückner, C Jäger, G Seeger, T Arend. Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20497908. |
neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in alzheimer's disease. |
2010-12-16 |
2023-08-12 |
Not clear |
| Maartje I Kester, Leo Boelaarts, Femke H Bouwman, Raymond L Vogels, Erwin R Groot, Evert J van Elk, Marinus A Blankenstein, Wiesje M van der Flier, Philip Schelten. Diagnostic impact of CSF biomarkers in a local hospital memory clinic. Dementia and geriatric cognitive disorders. vol 29. issue 6. 2010-12-08. PMID:20523047. |
csf biomarkers amyloid-beta 1-42 (abeta42), total tau (tau) and tau phosphorylated at threonine 181 (ptau-181) are useful diagnostic markers for alzheimer's disease (ad). |
2010-12-08 |
2023-08-12 |
Not clear |
| Rhagavendran L Narayanan, Ulrich H N Dürr, Stefan Bibow, Jacek Biernat, Eckhard Mandelkow, Markus Zweckstette. Automatic assignment of the intrinsically disordered protein Tau with 441-residues. Journal of the American Chemical Society. vol 132. issue 34. 2010-12-08. PMID:20687558. |
here we demonstrate that the resonance assignment of 441-residue tau and its smaller isoforms, htau24 (383 residues) and htau23 (352 residues), three prototypes of intrinsically disordered proteins, which bind to microtubules and play a key role in alzheimer disease, can be obtained within 5 days by a combination of seven-dimensional nmr spectra with optimized methods for automatic assignment. |
2010-12-08 |
2023-08-12 |
Not clear |
| Miguel Díaz-Hernández, Alberto Gómez-Ramos, Alicia Rubio, Rosa Gómez-Villafuertes, José R Naranjo, M Teresa Miras-Portugal, Jesús Avil. Tissue-nonspecific alkaline phosphatase promotes the neurotoxicity effect of extracellular tau. The Journal of biological chemistry. vol 285. issue 42. 2010-12-07. PMID:20634292. |
there is solid evidence indicating that hyperphosphorylated tau protein, the main component of intracellular neurofibrillary tangles present in the brain of alzheimer disease patients, plays a key role in progression of this disease. |
2010-12-07 |
2023-08-12 |
Not clear |
| Ricardo B Maccioni, Gonzalo Farías, Inelia Morales, Leonardo Navarret. The revitalized tau hypothesis on Alzheimer's disease. Archives of medical research. vol 41. issue 3. 2010-12-06. PMID:20682182. |
the revitalized tau hypothesis on alzheimer's disease. |
2010-12-06 |
2023-08-12 |
Not clear |
| Zuzana Stozicka, Norbert Zilka, Petr Novak, Branislav Kovacech, Ondrej Bugos, Michal Nova. Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease. Journal of neuroinflammation. vol 7. 2010-12-06. PMID:20937161. |
genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to alzheimer's disease. |
2010-12-06 |
2023-08-12 |
human |
| Stacey Fuller, Megan Steele, Gerald Münc. Activated astroglia during chronic inflammation in Alzheimer's disease--do they neglect their neurosupportive roles? Mutation research. vol 690. issue 1-2. 2010-12-02. PMID:19748514. |
alzheimer's disease (ad) is a neurodegenerative disorder, characterized histopathologically by the extracellular deposition of beta-amyloid peptide in senile plaques, as well as intracellular neurofibrillary tangles (nft) of hyperphosphorylated tau protein, extensive neuronal loss and synaptic changes in the hippocampus and cerebral cortex. |
2010-12-02 |
2023-08-12 |
Not clear |