| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kunie Ando, Karelle Leroy, Céline Heraud, Anna Kabova, Zehra Yilmaz, Michèle Authelet, Valèrie Suain, Robert De Decker, Jean-Pierre Brio. Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model. Biochemical Society transactions. vol 38. issue 4. 2010-11-12. PMID:20658993. |
we have reported previously a tau transgenic mouse model (tg30tau) overexpressing human 4r1n double-mutant tau (p301s and g272v) and that develops ad (alzheimer's disease)-like nfts (neurofibrillary tangles) in an age-dependent manner. |
2010-11-12 |
2023-08-12 |
mouse |
| Isabelle Landrieu, Arnaud Leroy, Caroline Smet-Nocca, Isabelle Huvent, Laziza Amniai, Malika Hamdane, Nathalie Sibille, Luc Buée, Jean-Michel Wieruszeski, Guy Lippen. NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease. Biochemical Society transactions. vol 38. issue 4. 2010-11-12. PMID:20658994. |
nmr spectroscopy of the neuronal tau protein: normal function and implication in alzheimer's disease. |
2010-11-12 |
2023-08-12 |
Not clear |
| Amy M Pooler, Diane P Hange. Functional implications of the association of tau with the plasma membrane. Biochemical Society transactions. vol 38. issue 4. 2010-11-12. PMID:20658995. |
thus it is possible that the hyperphosphoryation of tau may contribute to the pathogenesis of alzheimer's disease by promoting the formation of neurofibrillary tangles from cytosolic tau, and also by inhibiting additional tau functions through disruption of its targeting to the plasma membrane. |
2010-11-12 |
2023-08-12 |
Not clear |
| Valerio Leoni, Alina Solomon, Miia Kivipelt. Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment. Biochemical Society transactions. vol 38. issue 4. 2010-11-12. PMID:20658997. |
in csf (cerebrospinal fluid) collected form from patients with cognitive impairment (alzheimer's disease and patients with mild cognitive impairment) the levels of apoe, tau, p-tau (hyperphosphorylated tau) were significantly increased, together with 24ohc, compared with controls. |
2010-11-12 |
2023-08-12 |
Not clear |
| Valerio Leoni, Alina Solomon, Miia Kivipelt. Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment. Biochemical Society transactions. vol 38. issue 4. 2010-11-12. PMID:20658997. |
the csf tau levels are considered to be related to the neurodegenerative process in alzheimer's disease. |
2010-11-12 |
2023-08-12 |
Not clear |
| Ville Leinonen, Anne M Koivisto, Sakari Savolainen, Jaana Rummukainen, Juuso N Tamminen, Tomi Tillgren, Sannakaisa Vainikka, Okko T Pyykkö, Juhani Mölsä, Mikael Fraunberg, Tuula Pirttilä, Juha E Jääskeläinen, Hilkka Soininen, Jaakko Rinne, Irina Alafuzof. Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease. Annals of neurology. vol 68. issue 4. 2010-11-12. PMID:20976765. |
amyloid and tau proteins in cortical brain biopsy and alzheimer's disease. |
2010-11-12 |
2023-08-12 |
Not clear |
| W Noble, D P Hanger, J-M Gall. Transgenic mouse models of tauopathy in drug discovery. CNS & neurological disorders drug targets. vol 9. issue 4. 2010-11-09. PMID:20522014. |
tauopathies, including alzheimer's disease, are neurodegenerative diseases characterized by the deposition of hyperphosphorylated tau protein in the central nervous system, and are the major cause of dementia in later life. |
2010-11-09 |
2023-08-12 |
mouse |
| Kenneth I Shulma. Lithium for older adults with bipolar disorder: Should it still be considered a first-line agent? Drugs & aging. vol 27. issue 8. 2010-11-08. PMID:20658789. |
its action of inhibiting the enzyme glycogen synthase kinase-3 may be responsible in part for a decrease in the induction of amyloid beta peptide and hyperphosphorylated tau protein, which have been implicated in the development of alzheimer's disease. |
2010-11-08 |
2023-08-12 |
Not clear |
| Akihiko Takashim. [Drug development for tauopathy and Alzheimer's disease]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 30. issue 4. 2010-11-04. PMID:20857696. |
neurofibrillary tangles (nfts), which consist of a fibrillar aggregate of hyperphosphorylated tau, are commonly seen in aging brains and those with alzheimer's disease. |
2010-11-04 |
2023-08-12 |
mouse |
| Yaisa Andrews-Zwilling, Nga Bien-Ly, Qin Xu, Gang Li, Aubrey Bernardo, Seo Yeon Yoon, Daniel Zwilling, Tonya Xue Yan, Ligong Chen, Yadong Huan. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 41. 2010-11-04. PMID:20943911. |
consequently, reducing tau and enhancing gaba signaling are potential strategies to treat or prevent apoe4-related alzheimer's disease. |
2010-11-04 |
2023-08-12 |
mouse |
| Kurt R Brunden, Bin Zhang, Jenna Carroll, Yuemang Yao, Justin S Potuzak, Anne-Marie L Hogan, Michiyo Iba, Michael J James, Sharon X Xie, Carlo Ballatore, Amos B Smith, Virginia M-Y Lee, John Q Trojanowsk. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 41. 2010-11-04. PMID:20943926. |
neurons in the brains of those with alzheimer's disease (ad) and many frontotemporal dementias (ftds) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. |
2010-11-04 |
2023-08-12 |
mouse |
| Jürgen Götz, Amadeus Gladbach, Luis Pennanen, Janet van Eersel, Andreas Schild, Della David, Lars M Ittne. Animal models reveal role for tau phosphorylation in human disease. Biochimica et biophysica acta. vol 1802. issue 10. 2010-11-02. PMID:19751831. |
this includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of alzheimer's disease patients. |
2010-11-02 |
2023-08-12 |
mouse |
| Tomasz Jaworski, Ilse Dewachter, Claire Marie Seymour, Peter Borghgraef, Herman Devijver, Sebastian Kügler, Fred Van Leuve. Alzheimer's disease: old problem, new views from transgenic and viral models. Biochimica et biophysica acta. vol 1802. issue 10. 2010-11-02. PMID:20332023. |
these are compounded on and exacerbating the underlying amyloid and tau pathology that remain the basis of the pathological definition of alzheimer's disease. |
2010-11-02 |
2023-08-12 |
mouse |
| Hai-Hong Wang, Hong-Lian Li, Rong Liu, Yao Zhang, Kai Liao, Qun Wang, Jian-Zhi Wang, Shi-Jie Li. Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors. Journal of Alzheimer's disease : JAD. vol 21. issue 1. 2010-11-02. PMID:20413892. |
the formation of neurofibrillary tangles, mainly composed of hyperphosphorylated tau protein, is a hallmark in the brain of human tauopathies, including alzheimer's disease (ad). |
2010-11-02 |
2023-08-12 |
mouse |
| C Köhler, P Bista, J Götz, H Schröde. Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain research. vol 1347. 2010-11-02. PMID:20513372. |
to test the suitability of the pr5 model as a model of alzheimer's disease concerning the cholinergic innervation of the telencephalon, we determined the expression of the human tau transgene and the presence of neurofibrillary changes in the basal nucleus of meynert, the septal nuclei and the diagonal band of broca, sources of cholinergic innervation of the cerebral cortex and hippocampus. |
2010-11-02 |
2023-08-12 |
mouse |
| Keith A Vossel, Kai Zhang, Jens Brodbeck, Aaron C Daub, Punita Sharma, Steven Finkbeiner, Bianxiao Cui, Lennart Muck. Tau reduction prevents Abeta-induced defects in axonal transport. Science (New York, N.Y.). vol 330. issue 6001. 2010-11-02. PMID:20829454. |
amyloid-β (aβ) peptides, derived from the amyloid precursor protein, and the microtubule-associated protein tau are key pathogenic factors in alzheimer's disease (ad). |
2010-11-02 |
2023-08-12 |
Not clear |
| Chang-Jun Lin, Han-Chang Huang, Zhao-Feng Jian. Cu(II) interaction with amyloid-beta peptide: a review of neuroactive mechanisms in AD brains. Brain research bulletin. vol 82. issue 5-6. 2010-11-01. PMID:20598459. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the dys-homeostasis of biometal metabolism, the extracellular accumulation of neurotoxic amyloid-beta (abeta) peptide, the intracellular accumulation of hyperphosphorylated tau and the loss of synapses. |
2010-11-01 |
2023-08-12 |
Not clear |
| Michael Demars, Yuan-Shih Hu, Archana Gadadhar, Orly Lazaro. Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20209626. |
interestingly, levels of hyperphosphorylated tau, the cytotoxic precursor of the alzheimer's disease hallmark neurofibrillary tangles, are particularly high in the neurogenic niches. |
2010-10-26 |
2023-08-12 |
mouse |
| Michael Demars, Yuan-Shih Hu, Archana Gadadhar, Orly Lazaro. Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20209626. |
finally, hyperphosphorylation of the microtubule-associated protein tau, a critical player in cell proliferation, neuronal maturation, and axonal transport, is a major contributor to impaired neurogenesis in alzheimer's disease. |
2010-10-26 |
2023-08-12 |
mouse |
| Alejandra D Alonso, John Di Clerico, Bin Li, Christopher P Corbo, Maria E Alaniz, Inge Grundke-Iqbal, Khalid Iqba. Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20663882. |
abnormal hyperphosphorylation of the microtubule-associated protein tau is a hallmark of alzheimer disease and related diseases called tauopathies. |
2010-10-26 |
2023-08-12 |
Not clear |