| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bingyu Li, Kening Shi, Chao Ren, Min Kong, Maowen B. Detection of Tau-PET Positivity in Clinically Diagnosed Mild Cognitive Impairment with Multidimensional Features. Journal of Alzheimer's disease : JAD. 2023-06-19. PMID:37334600. |
interest in less expensive and convenient ways to detect tau pathology in alzheimer's disease has increased due to the high cost of tau-pet and the invasiveness of lumbar puncture, which typically slows down the cost and enrollment of clinical trials. |
2023-06-19 |
2023-08-14 |
Not clear |
| Tristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen McFarland, Alejandra Jolie Ruiz, Gabriela P Hery, Patrick Sullivan, David R Borchelt, Stefan Prokop, Paramita Chakrabart. Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy. Acta neuropathologica communications. vol 11. issue 1. 2023-06-19. PMID:37337279. |
in human alzheimer's disease brain tissues, we found no direct correlation between higher burden of phosphorylated tau and apoe4 genotype. |
2023-06-19 |
2023-08-14 |
mouse |
| Tristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen McFarland, Alejandra Jolie Ruiz, Gabriela P Hery, Patrick Sullivan, David R Borchelt, Stefan Prokop, Paramita Chakrabart. Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy. Acta neuropathologica communications. vol 11. issue 1. 2023-06-19. PMID:37337279. |
as expected, there was a strong correlation between phosphorylated tau burden with amyloid deposition in apoe4-positive alzheimer's disease cases. |
2023-06-19 |
2023-08-14 |
mouse |
| Melania Gonzalez-Rodriguez, Sandra Villar-Conde, Veronica Astillero-Lopez, Patricia Villanueva-Anguita, Isabel Ubeda-Banon, Alicia Flores-Cuadrado, Alino Martinez-Marcos, Daniel Saiz-Sanche. Human amygdala involvement in Alzheimer's disease revealed by stereological and dia-PASEF analysis. Brain pathology (Zurich, Switzerland). 2023-06-18. PMID:37331354. |
alzheimer's disease (ad) is characterized by the accumulation of pathological amyloid-β (aβ) and tau proteins. |
2023-06-18 |
2023-08-14 |
human |
| Nibedita Ghosh, Lal Mohan Kund. Cyclic di-peptide in situ inhibited protein-aggregation. Bioorganic & medicinal chemistry letters. 2023-06-18. PMID:37331639. |
protein aggregation diseases like huntington's disease results from the deposition of aggregated huntingtin proteins within the nucleus, transmissible prion encephalopathies occur due to extracellular deposition of pathogenic prion proteins whereas alzheimer's disease from the accumulation of both extracellular β-amyloid and intracellular hyperphosphorylated tau protein aggregates. |
2023-06-18 |
2023-08-14 |
Not clear |
| Margrethe A Olesen, Rodrigo A Quintanill. Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer's Disease. Molecular neurobiology. 2023-06-18. PMID:37332018. |
pathological impact of tau proteolytical process on neuronal and mitochondrial function: a crucial role in alzheimer's disease. |
2023-06-18 |
2023-08-14 |
Not clear |
| Margrethe A Olesen, Rodrigo A Quintanill. Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer's Disease. Molecular neurobiology. 2023-06-18. PMID:37332018. |
research interest has focused on studying the role of post-translational tau modifications in mitochondrial failure, oxidative damage, and synaptic impairment in alzheimer's disease (ad). |
2023-06-18 |
2023-08-14 |
Not clear |
| Yi Yao, Yanmin Chang, Shaomin Li, Jiahui Zhu, Yanqing Wu, Xingjun Jiang, Lulu Li, Ruitian Liu, Rong Ma, Gang L. Complement C3a Receptor Antagonist Alleviates Tau Pathology and Ameliorates Cognitive Deficits in P301S Mice. Brain research bulletin. 2023-06-17. PMID:37330021. |
human tauopathies, including alzheimer's disease (ad), are a major class of neurodegenerative diseases characterized by intracellular deposition of pathological hyperphosphorylated forms of tau protein. |
2023-06-17 |
2023-08-14 |
mouse |
| Yamah Hamsafar, Qian Chen, Alexander D Borowsky, Thomas G Beach, Geidy E Serrano, Lucia I Sue, Charles H Adler, Douglas G Walker, Brittany N Dugge. Biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of Alzheimer's disease. Neuroscience letters. 2023-06-17. PMID:37330193. |
biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of alzheimer's disease. |
2023-06-17 |
2023-08-14 |
human |
| Yamah Hamsafar, Qian Chen, Alexander D Borowsky, Thomas G Beach, Geidy E Serrano, Lucia I Sue, Charles H Adler, Douglas G Walker, Brittany N Dugge. Biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of Alzheimer's disease. Neuroscience letters. 2023-06-17. PMID:37330193. |
hyperphosphorylation of the microtubule-associated protein tau is hypothesized to lead to the development of neurofibrillary tangles in select brain regions during normal aging and in alzheimer's disease (ad). |
2023-06-17 |
2023-08-14 |
human |
| Cory M Nadel, Aye C Thwin, Matthew Callahan, Kanghyun Lee, Emily Connelly, Charles S Craik, Daniel R Southworth, Jason E Gestwick. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT). Journal of molecular biology. 2023-06-17. PMID:37330289. |
hyper-phosphorylated tau accumulates as insoluble fibrils in alzheimer's disease (ad) and related dementias. |
2023-06-17 |
2023-08-14 |
Not clear |
| Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Martin Ingelsson, Jinar Rostami, Maria Lindskog, Anna Erlandsso. Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology. Acta neuropathologica communications. vol 11. issue 1. 2023-06-17. PMID:37330529. |
tau deposits in astrocytes are frequently found in alzheimer's disease (ad) and other tauopathies. |
2023-06-17 |
2023-08-14 |
human |
| Theodore J Zwang, Benjamin Woost, Joshua Bailey, Zachary Hoglund, Douglas S Richardson, Rachel E Bennett, Bradley T Hyma. Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging. Brain communications. vol 5. issue 3. 2023-06-16. PMID:37324243. |
we were able to identify 8103 tau tangles, 132 465 neurons and 299 640 nuclei in tissue samples from three subjects with severe alzheimer's disease (braak v-vi) and 4 tau tangles, 200 447 neurons and 462 715 nuclei in tissue samples from three subjects with no significant tau pathology (braak 0-i). |
2023-06-16 |
2023-08-14 |
human |
| Sopan Nangare, Pravin Pati. Poly(allylamine) coated layer-by-layer assembly decorated 2D carbon backbone for highly sensitive and selective detection of Tau-441 using surface plasmon resonance biosensor. Analytica chimica acta. vol 1271. 2023-06-16. PMID:37328252. |
the determination of clinically significant amounts of tau protein in bodily fluids is a major problem in alzheimer's disease (ad) diagnosis. |
2023-06-16 |
2023-08-14 |
rabbit |
| Mite Mijalkov, Dániel Veréb, Anna Canal-Garcia, Thomas Hinault, Giovanni Volpe, Joana B Pereir. Nonlinear changes in delayed functional network topology in Alzheimer's disease: relationship with amyloid and tau pathology. Alzheimer's research & therapy. vol 15. issue 1. 2023-06-16. PMID:37328909. |
nonlinear changes in delayed functional network topology in alzheimer's disease: relationship with amyloid and tau pathology. |
2023-06-16 |
2023-08-14 |
Not clear |
| Mite Mijalkov, Dániel Veréb, Anna Canal-Garcia, Thomas Hinault, Giovanni Volpe, Joana B Pereir. Nonlinear changes in delayed functional network topology in Alzheimer's disease: relationship with amyloid and tau pathology. Alzheimer's research & therapy. vol 15. issue 1. 2023-06-16. PMID:37328909. |
alzheimer's disease is a neurodegenerative disorder associated with the abnormal deposition of pathological processes, such as amyloid-ß and tau, which produces nonlinear changes in the functional connectivity patterns between different brain regions across the alzheimer's disease continuum. |
2023-06-16 |
2023-08-14 |
Not clear |
| Arthur C Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez-Arias, Nesrine Rahmouni, Firoza Z Lussier, Marie Vermeiren, Gleb Bezgin, Paolo Vitali, Kok Pin Ng, Eduardo R Zimmer, Marie-Christine Guiot, Tharick A Pascoal, Serge Gauthier, Pedro Rosa-Net. The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2023-06-15. PMID:37321820. |
the use of tau pet to stage alzheimer disease according to the braak staging framework. |
2023-06-15 |
2023-08-14 |
Not clear |
| Jiaqian Wan, Yu Zou, Ruiqing Sun, Zhengdong Xu, Jiaxing Tang, Yehong Gong, Guanghong Wei, Qingwen Zhan. Destabilization mechanism of R3-R4 tau protofilament by purpurin: a molecular dynamics study. Physical chemistry chemical physics : PCCP. 2023-06-14. PMID:37314291. |
it has been established that the structure of the tau protofilament in chronic traumatic encephalopathy (cte) is similar to that of alzheimer's disease (ad). |
2023-06-14 |
2023-08-14 |
Not clear |
| Saleha Anwar, Taj Mohammad, Md Khabeer Azhar, Hera Fatima, Afsar Alam, Gulam Mustafa Hasan, Asimul Islam, Punit Kaur, Md Imtaiyaz Hassa. Investigating MARK4 inhibitory potential of Bacopaside II: Targeting Alzheimer's disease. International journal of biological macromolecules. 2023-06-14. PMID:37315665. |
microtubule affinity regulating kinase (mark4) is known to hyperphosphorylate tau protein, which subsequently causes alzheimer's disease (ad). |
2023-06-14 |
2023-08-14 |
Not clear |
| Hao-Lun Sun, Xiu-Qing Yao, Li Lei, Wang-Sheng Jin, Yu-Di Bai, Gui-Hua Zeng, An-Yu Shi, Jun Liang, Li Zhu, Yu-Hui Liu, Yan-Jiang Wang, Xian-Le B. Associations of Blood and Cerebrospinal Fluid Aβ and tau Levels with Renal Function. Molecular neurobiology. 2023-06-13. PMID:37310581. |
amyloid β (aβ) and tau play pivotal roles in the pathogenesis of alzheimer's disease (ad). |
2023-06-13 |
2023-08-14 |
human |