| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gang Li, Nga Bien-Ly, Yaisa Andrews-Zwilling, Qin Xu, Aubrey Bernardo, Karen Ring, Brian Halabisky, Changhui Deng, Robert W Mahley, Yadong Huan. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell stem cell. vol 5. issue 6. 2010-06-04. PMID:19951691. |
tau phosphorylation, an alzheimer's disease characteristic, and levels of neurotoxic apoe fragments were both elevated in apoe4-ki hippocampal neurons concomitant with decreased gabaergic interneuron survival. |
2010-06-04 |
2023-08-12 |
mouse |
| Stefan Spulber, Marianne Schultzber. Connection between inflammatory processes and transmittor function-Modulatory effects of interleukin-1. Progress in neurobiology. vol 90. issue 2. 2010-05-26. PMID:19853010. |
its role in neurodegeneration is not fully elucidated, but there is evidence for involvement in both amyloidosis and tau pathology, major neuropathological hallmarks of alzheimer's disease. |
2010-05-26 |
2023-08-12 |
mouse |
| Nina Mohorko, Grega Repovs, Mara Popović, Gabor G Kovacs, Mara Bresjana. Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples. Journal of neuropathology and experimental neurology. vol 69. issue 4. 2010-05-21. PMID:20448485. |
the study aimed to characterize curcumin (ccm) (fluorescent yellow curry pigment) labeling of neuronal fibrillar tau inclusions (ftis) in representative cases of 3 main tauopathies: alzheimer disease (ad), progressive supranuclear palsy, and pick disease. |
2010-05-21 |
2023-08-12 |
human |
| Edward C Lauterbach, Jeff Victoroff, Kerry L Coburn, Samuel D Shillcutt, Suzanne M Doonan, Mario F Mende. Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data. The Journal of neuropsychiatry and clinical neurosciences. vol 22. issue 1. 2010-05-20. PMID:20160205. |
effects on the metabolism of the neurodegenerative disease pathogenic proteins alpha-synuclein, beta-amyloid, and tau, including tau phosphorylation, are particularly addressed, with application to alzheimer's and parkinson's diseases. |
2010-05-20 |
2023-08-12 |
Not clear |
| Antonella Caccamo, Smita Majumder, Arlan Richardson, Randy Strong, Salvatore Odd. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. The Journal of biological chemistry. vol 285. issue 17. 2010-05-20. PMID:20178983. |
accumulation of amyloid-beta (abeta) and tau is an invariant feature of alzheimer disease (ad). |
2010-05-20 |
2023-08-12 |
Not clear |
| James Y Garbern, Manuela Neumann, John Q Trojanowski, Virginia M-Y Lee, Gerald Feldman, Joy W Norris, Michael J Friez, Charles E Schwartz, Roger Stevenson, Anders A F Sim. A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition. Brain : a journal of neurology. vol 133. issue Pt 5. 2010-05-17. PMID:20395263. |
the striking tau deposition in our subjects reveals a probable interaction between sodium/proton exchangers and cytoskeletal elements involved in vesicular transport, and raises the possibility that abnormalities of vesicular targeting may play an important role in more common disorders such as alzheimer's disease and autism spectrum disorders. |
2010-05-17 |
2023-08-12 |
human |
| Chisato Nishiura, Kengo Takeuchi, Katsuhiko Minoura, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishid. Importance of Tyr310 residue in the third repeat of microtubule binding domain for filament formation of tau protein. Journal of biochemistry. vol 147. issue 3. 2010-05-14. PMID:19897570. |
the inhibition of tau fibrillation is a potential therapeutic target for alzheimer's and other neurodegenerative diseases. |
2010-05-14 |
2023-08-12 |
Not clear |
| Pierre Krolak-Salmo. [What use of biological markers for the diagnosis of Alzheimer's disease and associated disorders?]. Psychologie & neuropsychiatrie du vieillissement. vol 8. issue 1. 2010-05-11. PMID:20215096. |
tau, phospho-tau and amyloid, is now over 85% for alzheimer's disease (ad) diagnosis at the dementia and mci stages. |
2010-05-11 |
2023-08-12 |
Not clear |
| Dylan W Peterson, D Michael Ando, Daryl A Taketa, Hongjun Zhou, Fredrick W Dahlquist, John Le. No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133653. |
here, we have compared the steady-state kinetic parameters of cdk5/p35 and cdk5/p25 towards both histone h1, the best known substrate for both enzymes, and the microtubule-associated protein, tau, a physiological substrate whose in vivo phosphorylation is relevant to alzheimer's disease. |
2010-05-10 |
2023-08-12 |
Not clear |
| Marie-Odile Habert, Leonardo Cruz de Souza, Foudil Lamari, Nelle Daragon, Serge Desarnaud, Claude Jardel, Bruno Dubois, Marie Sarazi. Brain perfusion SPECT correlates with CSF biomarkers in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 37. issue 3. 2010-05-05. PMID:19820929. |
our aim was to study the correlations between cerebrospinal fluid (csf) biomarker levels such as beta-amyloid 42 (abeta(42)), total and phosphorylated tau protein (t-tau and p-tau) and brain perfusion spect in alzheimer's disease (ad) using a voxel-based methodology. |
2010-05-05 |
2023-08-12 |
Not clear |
| Marie-Dominique Piercecchi-Marti, Andre Maues De Paula, Gilles Gavaudan, Christophe Bartoli, Anne-Laure Pelissier-Alicot, Georges Leonetti, Jean-François Pellissie. Interpretation of neuropathological lesions: its limitations in medico-legal experts' reports. Forensic science international. vol 194. issue 1-3. 2010-05-05. PMID:19879077. |
the most frequent is alzheimer's disease, which results from an abnormal structural conformation of tubulin-associated protein (tau) and beta-amyloid protein that, respectively, aggregate in certain neurons as intracellular neurofibrillary tangles (nfts) and in the extracellular environment as senile plaques. |
2010-05-05 |
2023-08-12 |
Not clear |
| Vincenzina Nicolia, Andrea Fuso, Rosaria A Cavallaro, Andrea Di Luzio, Sigfrido Scarp. B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A. Journal of Alzheimer's disease : JAD. vol 19. issue 3. 2010-05-05. PMID:20157245. |
neurofibrillary tangles (nfts), composed of intracellular filamentous aggregates of hyperphosphorylated protein tau, are one of the pathological hallmarks of alzheimer's disease (ad). |
2010-05-05 |
2023-08-12 |
Not clear |
| Emilio Di Maria, Sergio Cammarata, Maria Isola Parodi, Roberta Borghi, Luisa Benussi, Marialaura Galli, Daniela Galimberti, Roberta Ghidoni, Davide Gonella, Cristina Novello, Valeria Pollero, Lucia Perroni, Patrizio Odetti, Elio Scarpini, Giuliano Binetti, Massimo Tabato. The H1 haplotype of the tau gene (MAPT) is associated with mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 19. issue 3. 2010-05-05. PMID:20157246. |
these results firstly suggest that the risk of mild cognitive impairment is influenced by tau protein gene variations and that mild cognitive impairment shares a common genetic background with alzheimer's disease. |
2010-05-05 |
2023-08-12 |
Not clear |
| Gurdeep Marwarha, Bhanu Dasari, Jaya R P Prasanthi, Jared Schommer, Othman Ghrib. Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. Journal of Alzheimer's disease : JAD. vol 19. issue 3. 2010-05-05. PMID:20157255. |
accumulation of amyloid-beta (abeta) peptide and deposition of hyperphosphorylated tau protein are two major pathological hallmarks of alzheimer's disease (ad). |
2010-05-05 |
2023-08-12 |
mouse |
| Bart De Stroope. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiological reviews. vol 90. issue 2. 2010-05-04. PMID:20393191. |
alzheimer disease is characterized by the accumulation of abnormally folded protein fragments, i.e., amyloid beta peptide (abeta) and tau that precipitate in amyloid plaques and neuronal tangles, respectively. |
2010-05-04 |
2023-08-12 |
Not clear |
| Eric Siemers, Ronald B DeMattos, Patrick C May, Robert A Dea. Role of biochemical Alzheimer's disease biomarkers as end points in clinical trials. Biomarkers in medicine. vol 4. issue 1. 2010-05-03. PMID:20387304. |
amyloid-beta (abeta) peptides, and total and phosphorylated tau are potential biomarkers for use in the development of treatments for alzheimer's disease. |
2010-05-03 |
2023-08-12 |
Not clear |
| Eric Siemers, Ronald B DeMattos, Patrick C May, Robert A Dea. Role of biochemical Alzheimer's disease biomarkers as end points in clinical trials. Biomarkers in medicine. vol 4. issue 1. 2010-05-03. PMID:20387304. |
abeta(1-41) forms extracellular amyloid plaques, while tau and phospho-tau form intracellular neurofibrillary tangles in the brains of alzheimer's disease patients. |
2010-05-03 |
2023-08-12 |
Not clear |
| Marco A Meraz-Ríos, Karla I Lira-De León, Victoria Campos-Peña, Martha A De Anda-Hernández, Raúl Mena-Lópe. Tau oligomers and aggregation in Alzheimer's disease. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:19943854. |
tau oligomers and aggregation in alzheimer's disease. |
2010-04-30 |
2023-08-12 |
Not clear |
| Marco A Meraz-Ríos, Karla I Lira-De León, Victoria Campos-Peña, Martha A De Anda-Hernández, Raúl Mena-Lópe. Tau oligomers and aggregation in Alzheimer's disease. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:19943854. |
these aggregates of tau protein are the main components in many diseases such as alzheimer's disease (ad). |
2010-04-30 |
2023-08-12 |
Not clear |
| Zafira Castaño, Phillip R Gordon-Weeks, Robert M Kypt. The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth. Journal of neurochemistry. vol 113. issue 1. 2010-04-30. PMID:20067585. |
a genetic polymorphism that leads to an increase in the ratio of gsk-3beta1 to gsk-3beta2 interacts with tau haplotypes to modify disease risk in parkinson's and alzheimer's disease. |
2010-04-30 |
2023-08-12 |
rat |