| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karelle Leroy, Kunie Ando, Céline Héraud, Zehra Yilmaz, Michèle Authelet, Jean-Marie Boeynaems, Luc Buée, Robert De Decker, Jean-Pierre Brio. Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110614. |
neurofibrillary tangles (nfts) made of phosphorylated tau proteins are a key lesion of alzheimer's disease and other neurodegenerative diseases, and previous studies have indicated that lithium can decrease tau phosphorylation in tau transgenic models. |
2010-04-06 |
2023-08-12 |
mouse |
| Matthew A Tremblay, Christopher M Acker, Peter Davie. Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110615. |
tau phosphorylated at tyrosine 394 is found in alzheimer's disease tangles and can be a product of the abl-related kinase, arg. |
2010-04-06 |
2023-08-12 |
Not clear |
| Matthew A Tremblay, Christopher M Acker, Peter Davie. Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110615. |
tau is a microtubule-associated protein and a main component of neurofibrillary tangles, one of the pathologic hallmarks of alzheimer's disease. |
2010-04-06 |
2023-08-12 |
Not clear |
| Matthew A Tremblay, Christopher M Acker, Peter Davie. Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110615. |
proteomic analyses show that tau phosphorylated at tyrosine 394 (y394) exists within phf samples taken from alzheimer's disease brains. |
2010-04-06 |
2023-08-12 |
Not clear |
| Matthew A Tremblay, Christopher M Acker, Peter Davie. Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110615. |
given the reported role of arg in oxidative stress response and neural development, the ability to phosphorylate tau at y394 implicates arg as a potential player in the pathogenesis of alzheimer's disease and other tauopathies. |
2010-04-06 |
2023-08-12 |
Not clear |
| Yang-Yang Yin, Hao Liu, Xiao-Bin Cong, Zhao Liu, Qun Wang, Jian-Zhi Wang, Ling-Qiang Zh. Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110616. |
tau hyperphosphorylation and memory deficit are characteristic alterations of alzheimer's disease (ad). |
2010-04-06 |
2023-08-12 |
rat |
| Isidre Ferre. Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease. Journal of bioenergetics and biomembranes. vol 41. issue 5. 2010-04-02. PMID:19798558. |
beta-amyloid (abeta) deposition, in the form of plaques and amyloid angiopathy, and hyper-phosphorylated tau deposition forming neurofibrillary tangles, dystrophic neurites around beta-amyloid plaques and neuropil threads, are neuropathological hallmarks of alzheimer's disease (ad) that accumulate in the brain with disease progression. |
2010-04-02 |
2023-08-12 |
Not clear |
| Haruo Hanyu, Tomohiko Sat. [Alzheimer's disease]. Nihon rinsho. Japanese journal of clinical medicine. vol 68. issue 2. 2010-03-26. PMID:20158105. |
the insulin resistance and peripheral hyperinsulinemia have been known to promote the neurodegeneration in alzheimer's disease (ad), such as beta amyloid (abeta) deposits and increase of tau hyperphosphorylation. |
2010-03-26 |
2023-08-12 |
Not clear |
| José Luis Vázquez-Higuera, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Ignacio Mateo, Ana Pozueta, Ana Frank, Isabel Sastre, Fernando Valdivieso, José Berciano, María J Bullido, Onofre Combarro. DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort. BMC medical genetics. vol 10. 2010-03-25. PMID:19995442. |
as dual-specificity tyrosine phosphorylation-regulated kinase 1a (dyrk1a) has been implicated in the abnormal hyperphosphorylation of tau in alzheimer's disease (ad) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for ad. |
2010-03-25 |
2023-08-12 |
Not clear |
| John C Morris, Catherine M Roe, Chengjie Xiong, Anne M Fagan, Alison M Goate, David M Holtzman, Mark A Mintu. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Annals of neurology. vol 67. issue 1. 2010-03-25. PMID:20186853. |
apoe predicts amyloid-beta but not tau alzheimer pathology in cognitively normal aging. |
2010-03-25 |
2023-08-12 |
Not clear |
| Anne M Fagan, Mark A Mintun, Aarti R Shah, Patricia Aldea, Catherine M Roe, Robert H Mach, Daniel Marcus, John C Morris, David M Holtzma. Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease. EMBO molecular medicine. vol 1. issue 8-9. 2010-03-10. PMID:20049742. |
cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of alzheimer's disease. |
2010-03-10 |
2023-08-12 |
human |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
western blotting revealed that mehg exposure increased tau phosphorylation at thr-205, ser-396 and ser-422 in the cerebral cortex, consistent with the phosphorylation patterns noted in alzheimer's disease and frontotemporal dementia. |
2010-03-09 |
2023-08-12 |
mouse |
| Jason A Bailey, Debomoy K Lahir. A novel effect of rivastigmine on pre-synaptic proteins and neuronal viability in a neurodegeneration model of fetal rat primary cortical cultures and its implication in Alzheimer's disease. Journal of neurochemistry. vol 112. issue 4. 2010-03-08. PMID:19912467. |
alzheimer's disease (ad) is characterized by deposition of amyloid-beta peptide plaque, disrupted amyloid-beta-precursor protein (app) metabolism, hyperphosphorylation of tau leading to neurofibrillary tangles and associated neurotoxicity. |
2010-03-08 |
2023-08-12 |
rat |
| Anders M Fjell, Kristine B Walhovd, Christine Fennema-Notestine, Linda K McEvoy, Donald J Hagler, Dominic Holland, James B Brewer, Anders M Dal. CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147537. |
brain atrophy and altered csf levels of amyloid beta (abeta(42)) and the microtubule-associated protein tau are potent biomarkers of alzheimer's disease (ad)-related pathology. |
2010-03-05 |
2023-08-12 |
human |
| Cees Mulder, Nicolaas A Verwey, Wiesje M van der Flier, Femke H Bouwman, Astrid Kok, Evert J van Elk, Philip Scheltens, Marinus A Blankenstei. Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clinical chemistry. vol 56. issue 2. 2010-03-04. PMID:19833838. |
amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of alzheimer disease. |
2010-03-04 |
2023-08-12 |
Not clear |
| Cees Mulder, Nicolaas A Verwey, Wiesje M van der Flier, Femke H Bouwman, Astrid Kok, Evert J van Elk, Philip Scheltens, Marinus A Blankenstei. Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clinical chemistry. vol 56. issue 2. 2010-03-04. PMID:19833838. |
to improve ante mortem diagnostic accuracy of alzheimer disease (ad), measurement of the biomarkers amyloid-beta(1-42) (abeta42), total tau (tau), and tau phosphorylated at threonine(181) (ptau) in cerebrospinal fluid (csf) has been proposed. |
2010-03-04 |
2023-08-12 |
Not clear |
| Guo-Qing Zheng, Xiu-Min Wang, Yan Wang, Xiao-Tong Wan. Tau as a potential novel therapeutic target in ischemic stroke. Journal of cellular biochemistry. vol 109. issue 1. 2010-03-02. PMID:19921714. |
based on the "ischemia-reperfusion theory" of alzheimer's disease, some previous studies have focused on the relationship of tau and alzheimer lesions in experimental brain ischemia. |
2010-03-02 |
2023-08-12 |
Not clear |
| Alexei Surguchev, Andrei Surgucho. Conformational diseases: looking into the eyes. Brain research bulletin. vol 81. issue 1. 2010-03-01. PMID:19808079. |
in alzheimer's disease with the deposition of amyloid-beta and tau, in scrapie and bovine spongiform encephalopathy with the accumulation of prion protein, in parkinson's disease with the deposition of alpha-synuclein. |
2010-03-01 |
2023-08-12 |
cattle |
| Ryszard Pluta, Marzena Ułamek, Mirosław Jabłońsk. Alzheimer's mechanisms in ischemic brain degeneration. Anatomical record (Hoboken, N.J. : 2007). vol 292. issue 12. 2010-02-26. PMID:19943340. |
generation and deposition of beta-amyloid peptide and tau protein pathology are important key players involved in mechanisms in ischemic neurodegeneration as well as in alzheimer's disease. |
2010-02-26 |
2023-08-12 |
Not clear |
| David O Azorsa, RiLee H Robeson, Danielle Frost, Bessie Meec hoovet, Gillian R Brautigam, Chad Dickey, Christian Beaudry, Gargi D Basu, David R Holz, Joseph A Hernandez, Kristen M Bisanz, Leslie Gwinn, Andrew Grover, Joseph Rogers, Eric M Reiman, Michael Hutton, Dietrich A Stephan, Spyro Mousses, Travis Dunckle. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. BMC genomics. vol 11. 2010-02-26. PMID:20067632. |
high-content sirna screening of the kinome identifies kinases involved in alzheimer's disease-related tau hyperphosphorylation. |
2010-02-26 |
2023-08-12 |
Not clear |