All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Eva Kontsekova, Natalia Ivanovova, Martina Handzusova, Michal Nova. Chaperone-like antibodies in neurodegenerative tauopathies: implication for immunotherapy. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19214739. alzheimer's disease (ad) belongs to the category of neurodegenerative tauopathies, which are characterized by intracellular and extracellular accumulation of misfolded tau. 2009-08-19 2023-08-12 Not clear
Branislav Kovacech, Norbert Zilka, Michal Nova. New age of neuroproteomics in Alzheimer's disease research. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19225878. functional neuroproteomics was employed to generate the first transgenic rat model of ad by expressing a truncated misordered form of tau, "alzheimer's tau". 2009-08-19 2023-08-12 rat
Branislav Kovacech, Norbert Zilka, Michal Nova. New age of neuroproteomics in Alzheimer's disease research. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19225878. the rat model showed that alzheimer's tau toxic gain of function is responsible for the induction of abnormal tau cascade and is the driving force in the development of neurofibrillary degeneration. 2009-08-19 2023-08-12 rat
Branislav Kovacech, Norbert Zilka, Michal Nova. New age of neuroproteomics in Alzheimer's disease research. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19225878. interaction neuroproteomics revealed links to a new group of proteins interacting with alzheimer's tau (tau interactome) under normal and pathological conditions, which would provide novel drug targets and novel biomarkers for treatment of ad and other tauopathies. 2009-08-19 2023-08-12 rat
Peter Filipcik, Martin Cente, Gabriela Krajciova, Ivo Vanicky, Michal Nova. Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19263214. transition of protein tau from physiologically unfolded to misfolded state represent enigmatic step in the pathogenesis of tauopathies including alzheimer's disease (ad). 2009-08-19 2023-08-12 human
Martin Cente, Stanislava Mandakova, Peter Filipci. Memantine prevents sensitivity to excitotoxic cell death of rat cortical neurons expressing human truncated tau protein. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19291393. in order to understand integral mechanisms of misfolded tau driven neurodegeneration, we have investigated the role of human truncated tau protein, derived from alzheimer's disease, in rat cortical neurons under the conditions of excitotoxic stress induced by glutamate. 2009-08-19 2023-08-12 human
Emmanuel Planel, Alexis Bretteville, Li Liu, Laszlo Virag, Angela L Du, Wai Haung Yu, Dennis W Dickson, Robert A Whittington, Karen E Duf. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 8. 2009-08-18. PMID:19279139. alzheimer's disease and other tauopathies are characterized by the presence of intracellular neurofibrillary tangles composed of hyperphosphorylated, insoluble tau. 2009-08-18 2023-08-12 mouse
Emmanuel Planel, Alexis Bretteville, Li Liu, Laszlo Virag, Angela L Du, Wai Haung Yu, Dennis W Dickson, Robert A Whittington, Karen E Duf. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 8. 2009-08-18. PMID:19279139. general anesthesia has been shown to be associated with increased risk of alzheimer's disease, and we have previously demonstrated that anesthesia induces hypothermia, which leads to overt tau hyperphosphorylation in the brain of mice regardless of the anesthetic used. 2009-08-18 2023-08-12 mouse
Philipp Gorlovoy, Sergey Larionov, Thao Thi Hien Pham, Harald Neuman. Accumulation of tau induced in neurites by microglial proinflammatory mediators. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 8. 2009-08-18. PMID:19289607. aggregated fibrillary microtubule-associated protein tau is the major component of neurofibrillary tangles in alzheimer's disease. 2009-08-18 2023-08-12 human
F Deisenhammer, R Egg, G Giovannoni, B Hemmer, A Petzold, F Sellebjerg, C Teunissen, H Tuman. EFNS guidelines on disease-specific CSF investigations. European journal of neurology. vol 16. issue 6. 2009-08-17. PMID:19475759. high tau protein in combination with low amyloid beta levels has a high sensitivity (80%) and specificity (90%) for alzheimer's disease (ad) against normal aging and can predict conversion of mild cognitive impairment to ad. 2009-08-17 2023-08-12 Not clear
Sönke Arlt, Stefanie Brassen, Holger Jahn, Florian Wilke, Martin Eichenlaub, Ivayla Apostolova, Fabian Wenzel, Frank Thiele, Stewart Young, Ralph Bucher. Association between FDG uptake, CSF biomarkers and cognitive performance in patients with probable Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 36. issue 7. 2009-08-13. PMID:19219430. brain imaging of fdg uptake and cerebrospinal fluid (csf) concentration of amyloid-beta 1-42 (abeta(1-42)) or tau proteins are promising biomarkers in the diagnosis of alzheimer's disease (ad). 2009-08-13 2023-08-12 Not clear
Elin S Blom, Vilmantas Giedraitis, Henrik Zetterberg, Hiroaki Fukumoto, Kaj Blennow, Bradley T Hyman, Michael C Irizarry, Lars-Olof Wahlund, Lars Lannfelt, Martin Ingelsso. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. Dementia and geriatric cognitive disorders. vol 27. issue 5. 2009-08-12. PMID:19420940. rapid progression from mild cognitive impairment to alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the apoe epsilon4/epsilon4 genotype. 2009-08-12 2023-08-12 human
Elin S Blom, Vilmantas Giedraitis, Henrik Zetterberg, Hiroaki Fukumoto, Kaj Blennow, Bradley T Hyman, Michael C Irizarry, Lars-Olof Wahlund, Lars Lannfelt, Martin Ingelsso. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. Dementia and geriatric cognitive disorders. vol 27. issue 5. 2009-08-12. PMID:19420940. increased cerebrospinal fluid (csf) tau, decreased csf amyloid-beta42 (abeta42) and the apolipoprotein e gene (apoe) epsilon4 allele predict progression from mild cognitive impairment (mci) to alzheimer's disease (ad). 2009-08-12 2023-08-12 human
Ruth Vukovich, Robert Perneczky, Alexander Drzezga, Hans Förstl, Alexander Kurz, Matthias Riemenschneide. Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 27. issue 5. 2009-08-12. PMID:19439965. brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in alzheimer's disease. 2009-08-12 2023-08-12 Not clear
Ruth Vukovich, Robert Perneczky, Alexander Drzezga, Hans Förstl, Alexander Kurz, Matthias Riemenschneide. Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 27. issue 5. 2009-08-12. PMID:19439965. the cerebrospinal fluid (csf) proteins beta-amyloid 42 (abeta42) and tau are believed to indirectly reflect some core pathological features of alzheimer's disease (ad). 2009-08-12 2023-08-12 Not clear
Inés García-Gorostiaga, Pascual Sánchez-Juan, Ignacio Mateo, Eloy Rodríguez-Rodríguez, Coro Sánchez-Quintana, Soraya Curiel del Olmo, José Luis Vázquez-Higuera, José Berciano, Onofre Combarros, Jon Infant. Glycogen synthase kinase-3 beta and tau genes interact in Parkinson's and Alzheimer's diseases. Annals of neurology. vol 65. issue 6. 2009-08-12. PMID:19557862. glycogen synthase kinase-3 beta and tau genes interact in parkinson's and alzheimer's diseases. 2009-08-12 2023-08-12 Not clear
Da-yu Yu, Nan Qiao, Ping Liu, Qun We. Different regulation modes of calcineurin regulatory subunit on its catalytic subunit with RII peptide and tau as substrates. Protein and peptide letters. vol 16. issue 2. 2009-08-10. PMID:19200040. the findings shed some light on the role of cnb in controlling phosphorylation of tau in vivo and the pathogenesis of tauopathies such as alzheimer's disease. 2009-08-10 2023-08-12 Not clear
Mariko Tsukane, Takashi Yamauch. Ca2+/calmodulin-dependent protein kinase II mediates apoptosis of P19 cells expressing human tau during neural differentiation with retinoic acid treatment. Journal of enzyme inhibition and medicinal chemistry. vol 24. issue 2. 2009-08-04. PMID:18830878. the involvement of tau phosphorylation in apoptosis resembling alzheimer's disease (ad) was investigated using a cell model of p19 cells stably expressing human tau441 (tau/p19 cells). 2009-08-04 2023-08-12 human
Tapan K Khan, Thomas J Nelson, Vishal A Verma, Paul A Wender, Daniel L Alko. A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts. Neurobiology of disease. vol 34. issue 2. 2009-08-04. PMID:19233276. pkc signaling is critical for the non-toxic degradation of amyloid precursor protein (app) and inhibition of gsk3beta, which controls phosphorylation of tau protein in alzheimer's disease (ad). 2009-08-04 2023-08-12 Not clear
Donna M Wilcock, Nastaran Gharkholonarehe, William E Van Nostrand, Judianne Davis, Michael P Vitek, Carol A Colto. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 25. 2009-08-04. PMID:19553436. amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of alzheimer's disease. 2009-08-04 2023-08-12 mouse