| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Fischer, Marco D Mukrasch, Jacek Biernat, Stefan Bibow, Martin Blackledge, Christian Griesinger, Eckhard Mandelkow, Markus Zweckstette. Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. Biochemistry. vol 48. issue 42. 2009-11-24. PMID:19769346. |
for reasons not yet known, tau becomes excessively phosphorylated in alzheimer's brains and as a result no longer binds properly to microtubules. |
2009-11-24 |
2023-08-12 |
Not clear |
| Irène M Riederer, Mariano Schiffrin, Enikö Kövari, Constantin Bouras, Beat M Riedere. Ubiquitination and cysteine nitrosylation during aging and Alzheimer's disease. Brain research bulletin. vol 80. issue 4-5. 2009-11-17. PMID:19427371. |
we identified that the glial fibrillary acidic and tau proteins are more ubiquitinated in brain tissues of alzheimer's patients. |
2009-11-17 |
2023-08-12 |
human |
| Weijiang Dong, John J Albers, Simona Vuleti. Phospholipid transfer protein reduces phosphorylation of tau in human neuronal cells. Journal of neuroscience research. vol 87. issue 14. 2009-11-17. PMID:19472218. |
tau function is regulated by phosphorylation, and abnormal tau phosphorylation in neurons is one of the key processes associated with development of alzheimer's disease and other tauopathies. |
2009-11-17 |
2023-08-12 |
human |
| José Luis Vázquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Ana Pozueta, Jon Infante, José Berciano, Onofre Combarro. Genetic interaction between tau and the apolipoprotein E receptor LRP1 Increases Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 28. issue 2. 2009-11-17. PMID:19684401. |
genetic interaction between tau and the apolipoprotein e receptor lrp1 increases alzheimer's disease risk. |
2009-11-17 |
2023-08-12 |
human |
| José Luis Vázquez-Higuera, Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Ana Pozueta, Jon Infante, José Berciano, Onofre Combarro. Genetic interaction between tau and the apolipoprotein E receptor LRP1 Increases Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 28. issue 2. 2009-11-17. PMID:19684401. |
abnormal tau hyperphosphorylation is one of the central events in the development of neurofibrillary tangles (nfts) in alzheimer's disease (ad), and phosphorylation of tau is accelerated by the increase in the level of neuronal cholesterol. |
2009-11-17 |
2023-08-12 |
human |
| Lars Gerhardsson, Kaj Blennow, Thomas Lundh, Elisabet Londos, Lennart Mintho. Concentrations of metals, beta-amyloid and tau-markers in cerebrospinal fluid in patients with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 28. issue 1. 2009-11-16. PMID:19672066. |
in this study, metal concentrations were related to the levels of well-known alzheimer markers in cerebrospinal fluid (csf), such as amyloid-beta (abeta), total tau (t-tau) and phosphorylated-tau (p-tau). |
2009-11-16 |
2023-08-12 |
Not clear |
| Micha M M Wilhelmus, Sentini C S Grunberg, John G J M Bol, Anne-Marie van Dam, Jeroen J M Hoozemans, Annemieke J M Rozemuller, Benjamin Drukarc. Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain. Brain pathology (Zurich, Switzerland). vol 19. issue 4. 2009-11-04. PMID:18673368. |
alzheimer's disease (ad) is characterized by pathological lesions, in particular senile plaques (sps), cerebral amyloid angiopathy (caa) and neurofibrillary tangles (nfts), predominantly consisting of self-aggregated proteins amyloid beta (abeta) and tau, respectively. |
2009-11-04 |
2023-08-12 |
Not clear |
| W J Jagust, S M Landau, L M Shaw, J Q Trojanowski, R A Koeppe, E M Reiman, N L Foster, R C Petersen, M W Weiner, J C Price, C A Mathi. Relationships between biomarkers in aging and dementia. Neurology. vol 73. issue 15. 2009-11-04. PMID:19822868. |
pet imaging using [(18)f]fluorodeoxyglucose (fdg) and [(11)c]pittsburgh compound b (pib) have been proposed as biomarkers of alzheimer disease (ad), as have csf measures of the 42 amino acid beta-amyloid protein (abeta(1-42)) and total and phosphorylated tau (t-tau and p-tau). |
2009-11-04 |
2023-08-12 |
Not clear |
| P Szaniszlo, P German, G Hajas, D N Saenz, M Kruzel, I Boldog. New insights into clinical trial for Colostrinin in Alzheimer's disease. The journal of nutrition, health & aging. vol 13. issue 3. 2009-11-03. PMID:19262960. |
the pathomechanism of alzheimer's disease (ad) is multifactorial although the most popular hypotheses are centered on the effects of the misfolded, aggregated protein, amyloid beta (abeta) and on tau hyperphosphorylation. |
2009-11-03 |
2023-08-12 |
Not clear |
| b' Johanna Palmio, Jaana Suhonen, Tapani Ker\\xc3\\xa4nen, Janne Hulkkonen, Jukka Peltola, Tuula Pirttil\\xc3\\xa. Cerebrospinal fluid tau as a marker of neuronal damage after epileptic seizure. Seizure. vol 18. issue 7. 2009-11-02. PMID:19428269.' |
cerebrospinal fluid (csf) total tau (t-tau) and phosphorylated tau (p-tau) measurements have been suggested for the diagnosis of alzheimer's disease, and t-tau may also be a marker of axonal damage and neuronal degeneration. |
2009-11-02 |
2023-08-12 |
Not clear |
| Ineka T Whiteman, Othon L Gervasio, Karen M Cullen, Gilles J Guillemin, Erica V Jeong, Paul K Witting, Shane T Antao, Laurie S Minamide, James R Bamburg, Claire Goldsbur. Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 41. 2009-10-30. PMID:19828813. |
in alzheimer's disease (ad), rod-like cofilin aggregates (cofilin-actin rods) and thread-like inclusions containing phosphorylated microtubule-associated protein (pmap) tau form in the brain (neuropil threads), and the extent of their presence correlates with cognitive decline and disease progression. |
2009-10-30 |
2023-08-12 |
Not clear |
| Anna Kowalsk. [The genetics of dementias. Part 1: Molecular basis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)]. Postepy higieny i medycyny doswiadczalnej (Online). vol 63. 2009-10-27. PMID:19535823. |
in contrast to alzheimer's disease(ad), there are neither senile plaques nor neurofibrillary tangles in the brains of ftd patients.frontotemporal dementias are tauopathies, a group of disorders caused by aberrant metabolism of tau protein, a family of proteins associated with microtubules (mapt: macro-tubule-associated tau protein). |
2009-10-27 |
2023-08-12 |
human |
| Mohammad A Khanfar, Bilal Abu Asal, Mudit Mudit, Amal Kaddoumi, Khalid A El Saye. The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling. Bioorganic & medicinal chemistry. vol 17. issue 16. 2009-10-27. PMID:19616957. |
the gsk-3beta inhibitory activity of pmhs entitles them to be potential leads for the treatment of cancer, alzheimer's disease, bipolar disorders, stroke, different tau pathologies, and type-2 diabetes. |
2009-10-27 |
2023-08-12 |
mouse |
| Tetyana Duka, Valeriy Duka, Jeffrey N Joyce, Anita Sidh. Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 9. 2009-10-23. PMID:19369384. |
we have shown in the parkinsonism-inducing neurotoxin mpp(+)/mptp model that alpha-synuclein (alpha-syn), a presynaptic protein causal in parkinson's disease (pd), contributes to hyperphosphorylation of tau (p-tau), a protein normally linked to tauopathies, such as alzheimer's disease (ad). |
2009-10-23 |
2023-08-12 |
mouse |
| Kensuke Yotsumoto, Taro Saito, Akiko Asada, Takayuki Oikawa, Taeko Kimura, Chiyoko Uchida, Koichi Ishiguro, Takafumi Uchida, Masato Hasegawa, Shin-Ichi Hisanag. Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant Tau. The Journal of biological chemistry. vol 284. issue 25. 2009-10-20. PMID:19401603. |
neurodegenerative tauopathies, including alzheimer disease, are characterized by abnormal hyperphosphorylation of the microtubule-associated protein tau. |
2009-10-20 |
2023-08-12 |
mouse |
| Alessandra Bulbarelli, Elena Lonati, Emanuela Cazzaniga, Maria Gregori, Massimo Masserin. Pin1 affects Tau phosphorylation in response to Abeta oligomers. Molecular and cellular neurosciences. vol 42. issue 1. 2009-10-20. PMID:19520166. |
this evidence highlights the role of pin1 as tau phosphorylation modulator during alzheimer onset. |
2009-10-20 |
2023-08-12 |
Not clear |
| Estelle Leclerc, Emmanuel Sturchler, Stefan W Vetter, Claus W Heizman. Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease. Reviews in the neurosciences. vol 20. issue 2. 2009-10-20. PMID:19774788. |
hallmarks of alzheimer's disease (ad) include the accumulation of amyloid beta peptide (abeta), hyperphosphorylation of tau protein, and increased inflammatory activity in the hippocampus and cerebral cortex. |
2009-10-20 |
2023-08-12 |
Not clear |
| Maria Sen Mun Wai, Yong Liang, Chun Shi, Eric Y P Cho, Hsiang-Fu Kung, David T Ye. Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer's disease patients. Biogerontology. vol 10. issue 4. 2009-10-15. PMID:18946722. |
co-localization of hyperphosphorylated tau and caspases in the brainstem of alzheimer's disease patients. |
2009-10-15 |
2023-08-12 |
Not clear |
| Maria Sen Mun Wai, Yong Liang, Chun Shi, Eric Y P Cho, Hsiang-Fu Kung, David T Ye. Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer's disease patients. Biogerontology. vol 10. issue 4. 2009-10-15. PMID:18946722. |
hyperphosphorylation of microtubule associated protein tau had limited studies in alzheimer's disease (ad) brainstem. |
2009-10-15 |
2023-08-12 |
Not clear |
| Lars M Ittner, Yazi D Ke, Jürgen Göt. Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. The Journal of biological chemistry. vol 284. issue 31. 2009-10-14. PMID:19491104. |
phosphorylated tau interacts with c-jun n-terminal kinase-interacting protein 1 (jip1) in alzheimer disease. |
2009-10-14 |
2023-08-12 |
mouse |