| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kumi Sasaki, Hideki Shimura, Masako Itaya, Ryota Tanaka, Hideo Mori, Yoshikuni Mizuno, Kenneth S Kosik, Shigeki Tanaka, Nobutaka Hattor. Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains. FEBS letters. vol 583. issue 13. 2009-09-09. PMID:19527721. |
phosphorylated tau (p-tau) is the principal component of neurofibrillary tangles, a pathological hallmark, and likely plays a neurotoxic role in tauopathies including alzheimer's disease (ad), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd). |
2009-09-09 |
2023-08-12 |
Not clear |
| I Mateo, J L Vázquez-Higuera, P Sánchez-Juan, E Rodríguez-Rodríguez, J Infante, I García-Gorostiaga, J Berciano, O Combarro. Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk. Acta neurologica Scandinavica. vol 120. issue 2. 2009-09-07. PMID:19154537. |
epistasis between tau phosphorylation regulating genes (cdk5r1 and gsk-3beta) and alzheimer's disease risk. |
2009-09-07 |
2023-08-12 |
Not clear |
| I Mateo, J L Vázquez-Higuera, P Sánchez-Juan, E Rodríguez-Rodríguez, J Infante, I García-Gorostiaga, J Berciano, O Combarro. Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk. Acta neurologica Scandinavica. vol 120. issue 2. 2009-09-07. PMID:19154537. |
glycogen synthase kinase-3beta (gsk-3beta) and cyclin-dependent kinase 5 (cdk5) have been implicated as two major protein kinases involved in the abnormal hyperphosphorylation of tau in alzheimer's disease (ad) brain, and the development of neurofibrillary tangles. |
2009-09-07 |
2023-08-12 |
Not clear |
| Orly Reiner, Anat Shmueli, Tamar Sapi. Neuronal migration and neurodegeneration: 2 sides of the same coin. Cerebral cortex (New York, N.Y. : 1991). vol 19 Suppl 1. 2009-09-02. PMID:19346270. |
the involvement of amyloid beta precursor protein, presenilin-1, and tau in the pathogenesis of alzheimer's disease is well established. |
2009-09-02 |
2023-08-12 |
human |
| A J Mitchel. CSF phosphorylated tau in the diagnosis and prognosis of mild cognitive impairment and Alzheimer's disease: a meta-analysis of 51 studies. Journal of neurology, neurosurgery, and psychiatry. vol 80. issue 9. 2009-09-02. PMID:19465413. |
csf phosphorylated tau in the diagnosis and prognosis of mild cognitive impairment and alzheimer's disease: a meta-analysis of 51 studies. |
2009-09-02 |
2023-08-12 |
Not clear |
| A J Mitchel. CSF phosphorylated tau in the diagnosis and prognosis of mild cognitive impairment and Alzheimer's disease: a meta-analysis of 51 studies. Journal of neurology, neurosurgery, and psychiatry. vol 80. issue 9. 2009-09-02. PMID:19465413. |
to evaluate the accuracy and clinical utility of phosphorylated tau (p-tau) for the diagnosis and prognosis of alzheimer's disease (ad) and mild cognitive impairment (mci). |
2009-09-02 |
2023-08-12 |
Not clear |
| Karen Koopman, Nathalie Le Bastard, Jean-Jacques Martin, Guy Nagels, Peter P De Deyn, Sebastiaan Engelborgh. Improved discrimination of autopsy-confirmed Alzheimer's disease (AD) from non-AD dementias using CSF P-tau(181P). Neurochemistry international. vol 55. issue 4. 2009-09-02. PMID:19524111. |
to establish diagnostic accuracy (acc) and optimal cut-off levels of csf tau phosphorylated at threonine 181 (p-tau(181p)) for discriminating alzheimer's disease (ad) from non-ad dementias in autopsy-confirmed dementia patients, csf levels of beta-amyloid peptide (abeta(1-42)), total tau protein (t-tau) and p-tau(181p) from patients with definite ad (n=95) and non-ad dementias (n=50) were determined with single-parameter elisa kits. |
2009-09-02 |
2023-08-12 |
Not clear |
| Ram Fridlich, Francois Delalande, Céline Jaillard, Jun Lu, Laetitia Poidevin, Thérèse Cronin, Ludivine Perrocheau, Géraldine Millet-Puel, Marie-Laure Niepon, Olivier Poch, Arne Holmgren, Alain Van Dorsselaer, Jose-Alain Sahel, Thierry Léveillar. The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina. Molecular & cellular proteomics : MCP. vol 8. issue 6. 2009-09-01. PMID:19279044. |
we demonstrate that the level of phosphorylation of tau is increased in the retina of the nxnl1(-/-) mice as it is hyperphosphorylated in the brain of patients suffering from alzheimer disease, presumably in some cases through oxidative stress. |
2009-09-01 |
2023-08-12 |
mouse |
| Rodrigo A Quintanilla, Tori A Matthews-Roberson, Philip J Dolan, Gail V W Johnso. Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease. The Journal of biological chemistry. vol 284. issue 28. 2009-09-01. PMID:19389700. |
caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of alzheimer disease. |
2009-09-01 |
2023-08-12 |
Not clear |
| Lan Chen, Yan Wei, Xueqing Wang, Rongqiao H. D-Ribosylated Tau forms globular aggregates with high cytotoxicity. Cellular and molecular life sciences : CMLS. vol 66. issue 15. 2009-09-01. PMID:19517062. |
although the glycation of tau that is involved in paired helical filament formation in alzheimer's disease has been widely studied, little attention has been paid to the role of d-ribose in the glycation of tau. |
2009-09-01 |
2023-08-12 |
Not clear |
| Marta Barrachina, Isidre Ferre. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. Journal of neuropathology and experimental neurology. vol 68. issue 8. 2009-09-01. PMID:19606065. |
dna methylation was analyzed in selected regions of mapt, app, and psen1 in the frontal cortex and hippocampus of controls (n=26) and those with alzheimer disease at stages i to ii (n=17); alzheimer disease at stages iii to iv (n=15); alzheimer disease at stages v to vi (n=12); argyrophilic grain disease (n=10); frontotemporal lobar degeneration linked to tau mutations (n=6); frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions (n=4); frontotemporal lobar degeneration with motor neuron disease (n=3); pick disease (n=3); parkinson disease (n=8); dementia with lewy bodies, pure form (n=5); and dementia with lewy bodies, common form (n=15). |
2009-09-01 |
2023-08-12 |
human |
| Heinz-Georg Jahnke, Andrée Rothermel, Ina Sternberger, Till G A Mack, Randy G Kurz, Oliver Pänke, Frank Striggow, Andrea A Robitzk. An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells. Lab on a chip. vol 9. issue 10. 2009-08-28. PMID:19417909. |
tauopathies such as alzheimer's disease (ad) belong to the group of neurodegenerative diseases that are characterised by hyperphosphorylation of the protein tau. |
2009-08-28 |
2023-08-12 |
human |
| Katy A Chalmers, Gordon K Wilcock, Harry V Vinters, Elaine K Perry, Robert Perry, Clive G Ballard, Seth Lov. Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer's disease. Journal of neurology. vol 256. issue 5. 2009-08-21. PMID:19240967. |
cholinesterase inhibitors may increase phosphorylated tau in alzheimer's disease. |
2009-08-21 |
2023-08-12 |
Not clear |
| Selina Wray, Wendy Nobl. Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 31. 2009-08-21. PMID:19657019. |
linking amyloid and tau pathology in alzheimer's disease: the role of membrane cholesterol in abeta-mediated tau toxicity. |
2009-08-21 |
2023-08-12 |
Not clear |
| Eva Kontsekova, Natalia Ivanovova, Martina Handzusova, Michal Nova. Chaperone-like antibodies in neurodegenerative tauopathies: implication for immunotherapy. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19214739. |
alzheimer's disease (ad) belongs to the category of neurodegenerative tauopathies, which are characterized by intracellular and extracellular accumulation of misfolded tau. |
2009-08-19 |
2023-08-12 |
Not clear |
| Branislav Kovacech, Norbert Zilka, Michal Nova. New age of neuroproteomics in Alzheimer's disease research. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19225878. |
functional neuroproteomics was employed to generate the first transgenic rat model of ad by expressing a truncated misordered form of tau, "alzheimer's tau". |
2009-08-19 |
2023-08-12 |
rat |
| Branislav Kovacech, Norbert Zilka, Michal Nova. New age of neuroproteomics in Alzheimer's disease research. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19225878. |
the rat model showed that alzheimer's tau toxic gain of function is responsible for the induction of abnormal tau cascade and is the driving force in the development of neurofibrillary degeneration. |
2009-08-19 |
2023-08-12 |
rat |
| Branislav Kovacech, Norbert Zilka, Michal Nova. New age of neuroproteomics in Alzheimer's disease research. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19225878. |
interaction neuroproteomics revealed links to a new group of proteins interacting with alzheimer's tau (tau interactome) under normal and pathological conditions, which would provide novel drug targets and novel biomarkers for treatment of ad and other tauopathies. |
2009-08-19 |
2023-08-12 |
rat |
| Peter Filipcik, Martin Cente, Gabriela Krajciova, Ivo Vanicky, Michal Nova. Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19263214. |
transition of protein tau from physiologically unfolded to misfolded state represent enigmatic step in the pathogenesis of tauopathies including alzheimer's disease (ad). |
2009-08-19 |
2023-08-12 |
human |
| Martin Cente, Stanislava Mandakova, Peter Filipci. Memantine prevents sensitivity to excitotoxic cell death of rat cortical neurons expressing human truncated tau protein. Cellular and molecular neurobiology. vol 29. issue 6-7. 2009-08-19. PMID:19291393. |
in order to understand integral mechanisms of misfolded tau driven neurodegeneration, we have investigated the role of human truncated tau protein, derived from alzheimer's disease, in rat cortical neurons under the conditions of excitotoxic stress induced by glutamate. |
2009-08-19 |
2023-08-12 |
human |