| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Koren, Umesh K Jinwal, Daniel C Lee, Jeffrey R Jones, Cody L Shults, Amelia G Johnson, Laura J Anderson, Chad A Dicke. Chaperone signalling complexes in Alzheimer's disease. Journal of cellular and molecular medicine. vol 13. issue 4. 2009-07-08. PMID:19449461. |
in the case of alzheimer's disease (ad), a number of studies have recently emerged describing the impact that these chaperones have on the proteotoxic effects of tau and amyloid- beta accumulation. |
2009-07-08 |
2023-08-12 |
Not clear |
| Mark P Mattson, Uri Asher. No more brain tangles with DeltaNp73. Trends in biochemical sciences. vol 34. issue 1. 2009-07-01. PMID:19008105. |
in alzheimer's disease (ad), neurons suffer dysfunction and death associated with aberrant tau phosphorylation and subsequent neurofibrillary tangles. |
2009-07-01 |
2023-08-12 |
mouse |
| Jens Thorsten Stieler, Torsten Bullmann, Franziska Kohl, Brian M Barnes, Thomas Arend. PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 3. 2009-07-01. PMID:19184336. |
in alzheimer's disease and related disorders, hyperphosphorylation of tau is associated with an increased activity of cyclin dependent kinase 5 (cdk5). |
2009-07-01 |
2023-08-12 |
Not clear |
| Koichi Wakabayashi, Kunikazu Tanji, Fumiaki Mor. [Pathology of basal ganglia in neurodegenerative diseases]. Brain and nerve = Shinkei kenkyu no shinpo. vol 61. issue 4. 2009-07-01. PMID:19378813. |
tau protein in neurofibrillary tangles and beta-amyloid in senile plaques are associated with alzheimer's disease. |
2009-07-01 |
2023-08-12 |
Not clear |
| Dong Han, Hamid Y Qureshi, Yifan Lu, Hemant K Paude. Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitro. The Journal of biological chemistry. vol 284. issue 20. 2009-06-30. PMID:19304664. |
in alzheimer disease (ad), frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) and other tauopathies, tau accumulates and forms paired helical filaments (phfs) in the brain. |
2009-06-30 |
2023-08-12 |
Not clear |
| A Phivilay, C Julien, C Tremblay, L Berthiaume, P Julien, Y Giguère, F Calo. High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-beta and tau pathologies in the 3xTg-AD model of Alzheimer's disease. Neuroscience. vol 159. issue 1. 2009-06-25. PMID:19135506. |
high dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-beta and tau pathologies in the 3xtg-ad model of alzheimer's disease. |
2009-06-25 |
2023-08-12 |
mouse |
| Yi-Yu Chou, Natasha Leporé, Christina Avedissian, Sarah K Madsen, Neelroop Parikshak, Xue Hua, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Arthur W Toga, Paul M Thompso. Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controls. NeuroImage. vol 46. issue 2. 2009-06-24. PMID:19236926. |
mapping correlations between ventricular expansion and csf amyloid and tau biomarkers in 240 subjects with alzheimer's disease, mild cognitive impairment and elderly controls. |
2009-06-24 |
2023-08-12 |
human |
| Francesc X Guix, Gerard Ill-Raga, Ramona Bravo, Tadashi Nakaya, Gianni de Fabritiis, Mireia Coma, Gian Pietro Miscione, Jordi Villà-Freixa, Toshiharu Suzuki, Xavier Fernàndez-Busquets, Miguel A Valverde, Bart de Strooper, Francisco J Muño. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19251756. |
alzheimer's disease neuropathology is characterized by neuronal death, amyloid beta-peptide deposits and neurofibrillary tangles composed of paired helical filaments of tau protein. |
2009-06-24 |
2023-08-12 |
mouse |
| Francesc X Guix, Gerard Ill-Raga, Ramona Bravo, Tadashi Nakaya, Gianni de Fabritiis, Mireia Coma, Gian Pietro Miscione, Jordi Villà-Freixa, Toshiharu Suzuki, Xavier Fernàndez-Busquets, Miguel A Valverde, Bart de Strooper, Francisco J Muño. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19251756. |
transmission electron microscopy (tem) and atomic force microscopy studies have demonstrated that nitro-triosephosphate isomerase binds tau monomers and induces tau aggregation to form paired helical filaments, the characteristic intracellular hallmark of alzheimer's disease brains. |
2009-06-24 |
2023-08-12 |
mouse |
| Francesc X Guix, Gerard Ill-Raga, Ramona Bravo, Tadashi Nakaya, Gianni de Fabritiis, Mireia Coma, Gian Pietro Miscione, Jordi Villà-Freixa, Toshiharu Suzuki, Xavier Fernàndez-Busquets, Miguel A Valverde, Bart de Strooper, Francisco J Muño. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19251756. |
our results link oxidative stress, the main etiopathogenic mechanism in sporadic alzheimer's disease, via the production of peroxynitrite and nitrotyrosination of triosephosphate isomerase, to amyloid beta-peptide-induced toxicity and tau pathology. |
2009-06-24 |
2023-08-12 |
mouse |
| G Lace, G M Savva, G Forster, R de Silva, C Brayne, F E Matthews, J J Barclay, L Dakin, P G Ince, S B Wharto. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19321462. |
deposits of abnormally phosphorylated tau protein are found in numerous neurodegenerative disorders; the 'tauopathies', which include alzheimer's and pick's diseases, but tau pathology is also found in the ageing brain. |
2009-06-24 |
2023-08-12 |
Not clear |
| G Lace, G M Savva, G Forster, R de Silva, C Brayne, F E Matthews, J J Barclay, L Dakin, P G Ince, S B Wharto. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain : a journal of neurology. vol 132. issue Pt 5. 2009-06-24. PMID:19321462. |
in this population sample, which includes the full ageing spectrum from individuals with no cognitive impairment to those with dementia satisfying clinico-pathology criteria for alzheimer's disease, we have demonstrated a high prevalence at death of tau pathology. |
2009-06-24 |
2023-08-12 |
Not clear |
| Wolfgang Härtig, Andreas Reichenbach, Cornelia Voigt, Johannes Boltze, Larysa Bulavina, Martin U Schuhmann, Johannes Seeger, Gerald F Schusser, Christiane Freytag, Jens Grosch. Triple fluorescence labelling of neuronal, glial and vascular markers revealing pathological alterations in various animal models. Journal of chemical neuroanatomy. vol 37. issue 2. 2009-06-22. PMID:19028564. |
moreover, the versatility of the method is verified by its application to sections from old triple transgenic mice with age-dependent beta-amyloidosis and tau hyperphosphorylation in the hippocampus, modelling neuropathological alterations in alzheimer's disease. |
2009-06-22 |
2023-08-12 |
mouse |
| Antonella Caccamo, Abraham Fisher, Frank M LaFerl. M1 agonists as a potential disease-modifying therapy for Alzheimer's disease. Current Alzheimer research. vol 6. issue 2. 2009-06-22. PMID:19355845. |
stimulation of muscarinic acetylcholine receptors and in particular the m1 subtype has been shown to have a beneficial effect in restoring cognition in patients with alzheimer's disease and in attenuating abeta and tau pathology in different animal models. |
2009-06-22 |
2023-08-12 |
Not clear |
| Makoto Higuch. Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease. Current Alzheimer research. vol 6. issue 2. 2009-06-22. PMID:19355848. |
microglial overactivation, which is secondary to abnormalities of amyloid-beta peptide (abeta) and tau proteins in the pathogenic cascade leading to onset of alzheimer's disease (ad), accelerates tau pathology, according to our recent observations using mouse models of tauopathies, and this positive feedback results in formation of a vicious cycle between upstream and downstream processes, potentially hampering effective suppression of the entire cascade by anti-amyloid treatments. |
2009-06-22 |
2023-08-12 |
mouse |
| Karim Belarbi, Katharina Schindowski, Sylvie Burnouf, Raphaëlle Caillierez, Marie-Eve Grosjean, Dominique Demeyer, Malika Hamdane, Nicolas Sergeant, David Blum, Luc Bué. Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease. Current Alzheimer research. vol 6. issue 2. 2009-06-22. PMID:19355850. |
early tau pathology involving the septo-hippocampal pathway in a tau transgenic model: relevance to alzheimer's disease. |
2009-06-22 |
2023-08-12 |
mouse |
| Qipeng Zhang, Xiaoguang Zhang, Anyang Su. Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models. Acta neuropathologica. vol 117. issue 6. 2009-06-18. PMID:19190923. |
truncated tau at d421 is associated with neurodegeneration and tangle formation in the brain of alzheimer transgenic models. |
2009-06-18 |
2023-08-12 |
mouse |
| Qipeng Zhang, Xiaoguang Zhang, Anyang Su. Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models. Acta neuropathologica. vol 117. issue 6. 2009-06-18. PMID:19190923. |
in addition to tau hyperphosphorylation, tau truncation is also detected in alzheimer's disease (ad) patients. |
2009-06-18 |
2023-08-12 |
mouse |
| Zivar Salehi, Farhad Mashayekhi, Mohammad Naj. Insulin like growth factor-1 and insulin like growth factor binding proteins in the cerebrospinal fluid and serum from patients with Alzheimer's disease. BioFactors (Oxford, England). vol 33. issue 2. 2009-06-18. PMID:19346585. |
alzheimer's disease (ad) is an age-dependent dementia characterized by progressive loss of cognitive functions and by characteristic pathological changes in the brain: the formation of aggregates extracellularly by beta-amyloid (ab) peptide and intracellularly by tau proteins. |
2009-06-18 |
2023-08-12 |
human |
| Bethany L Veo, Les A Krushe. Translation initiation of the human tau mRNA through an internal ribosomal entry site. Journal of Alzheimer's disease : JAD. vol 16. issue 2. 2009-06-17. PMID:19221416. |
neurofibrillary tangles are a pathological phenotype in alzheimer's disease (ad) and are caused by the hyperphosphorylation of the microtubule associated protein tau. |
2009-06-17 |
2023-08-12 |
mouse |