| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karunya K Kandimalla, Olenych G Scott, Smita Fulzele, Michael W Davidson, Joseph F Podusl. Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein. PloS one. vol 4. issue 2. 2009-04-27. PMID:19247480. |
alzheimer's disease (ad) is characterized by significant neurodegeneration in the cortex and hippocampus; intraneuronal tangles of hyperphosphorylated tau protein; and accumulation of beta-amyloid (abeta) proteins 40 and 42 in the brain parenchyma as well as in the cerebral vasculature. |
2009-04-27 |
2023-08-12 |
mouse |
| Qipeng Zhang, Xiaoguang Zhang, Jie Chen, Yanying Miao, Anyang Su. Role of caspase-3 in tau truncation at D421 is restricted in transgenic mouse models for tauopathies. Journal of neurochemistry. vol 109. issue 2. 2009-04-24. PMID:19200347. |
truncated tau is widely detected in alzheimer's disease brain, and caspase-3 has been considered as a major executioner for tau truncation at aspartate421 (d421), according to its capability of cleaving recombinant tau in vitro. |
2009-04-24 |
2023-08-12 |
mouse |
| Marco D Mukrasch, Stefan Bibow, Jegannath Korukottu, Sadasivam Jeganathan, Jacek Biernat, Christian Griesinger, Eckhard Mandelkow, Markus Zweckstette. Structural polymorphism of 441-residue tau at single residue resolution. PLoS biology. vol 7. issue 2. 2009-04-23. PMID:19226187. |
tau belongs to the class of natively unfolded proteins, binds to and stabilizes microtubules, and partially folds into an ordered beta-structure during aggregation to alzheimer paired helical filaments (phfs). |
2009-04-23 |
2023-08-12 |
Not clear |
| Gabriel Santpere, Isidre Ferre. LRRK2 and neurodegeneration. Acta neuropathologica. vol 117. issue 3. 2009-04-22. PMID:19142648. |
likewise, some studies have shown lrrk2 immunoreactivity in hyper-phosphorylated tau inclusions in alzheimer's disease (ad) and other tauopathies, whereas other studies did not find lrrk2 in hyper-phosphorylated tau inclusions. |
2009-04-22 |
2023-08-12 |
Not clear |
| Wenjun Sun, Jianping Ji. The +347 C promoter allele up-regulates MAPT expression and is associated with Alzheimer's disease among the Chinese Han. Neuroscience letters. vol 450. issue 3. 2009-04-20. PMID:19070646. |
the microtubule-associated protein tau has been known to be associated with the pathogenesis of alzheimer's disease (ad). |
2009-04-20 |
2023-08-12 |
human |
| Mario Ezquerra, Jaume Campdelacreu, Carles Gaig, Yaroslau Compta, Esteban Muñoz, Maria Jose Martí, Francesc Valldeoriola, Eduardo Tolos. Lack of association of APOE and tau polymorphisms with dementia in Parkinson's disease. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18930114. |
some apoe or tau gene polymorphisms have been associated with alzheimer's disease (ad), progressive supranuclear palsy (psp) and parkinson's disease (pd). |
2009-04-16 |
2023-08-12 |
Not clear |
| Andreas Fellgiebel, Elzbieta Kojro, Matthias J Müller, Armin Scheurich, Lutz G Schmidt, Falk Fahrenhol. CSF APPs alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of Alzheimer's type. Journal of geriatric psychiatry and neurology. vol 22. issue 1. 2009-04-16. PMID:19073834. |
csf apps alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of alzheimer's type. |
2009-04-16 |
2023-08-12 |
Not clear |
| Andreas Fellgiebel, Elzbieta Kojro, Matthias J Müller, Armin Scheurich, Lutz G Schmidt, Falk Fahrenhol. CSF APPs alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of Alzheimer's type. Journal of geriatric psychiatry and neurology. vol 22. issue 1. 2009-04-16. PMID:19073834. |
we exploratively measured apps alpha, a secreted fragment of the non-amyloidogenic cleavage of amyloid precursor protein via a-secretase, and tau protein phosphorylated at threonine 181 (p tau) in the cerebrospinal fluid of 10 patients with mild cognitive impairment, 20 patients with dementia of alzheimer's type, and 10 controls. |
2009-04-16 |
2023-08-12 |
Not clear |
| Andreas Fellgiebel, Elzbieta Kojro, Matthias J Müller, Armin Scheurich, Lutz G Schmidt, Falk Fahrenhol. CSF APPs alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of Alzheimer's type. Journal of geriatric psychiatry and neurology. vol 22. issue 1. 2009-04-16. PMID:19073834. |
p tau levels were significantly elevated in mild cognitive impairment and in patients with dementia of alzheimer's type, apps alpha levels were significantly reduced in patients with dementia of alzheimer's type compared to the controls. |
2009-04-16 |
2023-08-12 |
Not clear |
| Andreas Fellgiebel, Elzbieta Kojro, Matthias J Müller, Armin Scheurich, Lutz G Schmidt, Falk Fahrenhol. CSF APPs alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of Alzheimer's type. Journal of geriatric psychiatry and neurology. vol 22. issue 1. 2009-04-16. PMID:19073834. |
both, an increase in p tau levels and a decrease in cerebrospinal fluid apps alpha, seem to refer to relevant but functionally different processes in the development of mild cognitive impairment and dementia of alzheimer's type. |
2009-04-16 |
2023-08-12 |
Not clear |
| Stéphanie G Trouche, Ayodeji Asuni, Sylvie Rouland, Thomas Wisniewski, Blas Frangione, Jean-Michel Verdier, Einar M Sigurdsson, Nadine Mestre-Francé. Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives. Vaccine. vol 27. issue 7. 2009-04-16. PMID:19114076. |
while we are continuing to characterize these vaccines in mice, in preparation for studies in old primates and for human trials we assessed their effect in young lemur primates (n=25) that with age develop abeta plaques and tau aggregates as seen in alzheimer's disease. |
2009-04-16 |
2023-08-12 |
mouse |
| Daniel C Carrettiero, Israel Hernandez, Pierre Neveu, Thales Papagiannakopoulos, Kenneth S Kosi. The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 7. 2009-04-16. PMID:19228967. |
tau inclusions are a prominent feature of many neurodegenerative diseases including alzheimer's disease. |
2009-04-16 |
2023-08-12 |
Not clear |
| T Engel, P Goñi-Oliver, P Gomez-Ramos, M A Morán, J J Lucas, J Avila, F Hernánde. Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta. Neuroscience. vol 157. issue 4. 2009-04-15. PMID:18951953. |
glycogen synthase kinase-3beta (gsk-3beta) has been proposed as the main kinase able to phosphorylate tau aberrantly in alzheimer's disease and in related tauopathies. |
2009-04-15 |
2023-08-12 |
mouse |
| Johannes Schröder, Elmar Kaiser, Peter Schönknecht, Aoife Hunt, Philipp A Thomann, Johannes Pantel, Johannes Schröde. [CSF levels of total tau protein in patients with mild cognitive impairment and Alzheimer's disease]. Zeitschrift fur Gerontologie und Geriatrie. vol 41. issue 6. 2009-04-13. PMID:18327693. |
[csf levels of total tau protein in patients with mild cognitive impairment and alzheimer's disease]. |
2009-04-13 |
2023-08-12 |
Not clear |
| Johannes Schröder, Elmar Kaiser, Peter Schönknecht, Aoife Hunt, Philipp A Thomann, Johannes Pantel, Johannes Schröde. [CSF levels of total tau protein in patients with mild cognitive impairment and Alzheimer's disease]. Zeitschrift fur Gerontologie und Geriatrie. vol 41. issue 6. 2009-04-13. PMID:18327693. |
in recent studies, patients diagnosed with alzheimer's disease (ad) showed significantly elevated csf levels of tau protein. |
2009-04-13 |
2023-08-12 |
Not clear |
| Sabrina Ravaglia, Paola Bini, Elena Sinforiani, Diego Franciotta, Elisabetta Zardini, Pietro Tosca, Arrigo Moglia, Alfredo Cost. Cerebrospinal fluid levels of tau phosphorylated at threonine 181 in patients with Alzheimer's disease and vascular dementia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 29. issue 6. 2009-04-09. PMID:19011737. |
cerebrospinal fluid levels of tau phosphorylated at threonine 181 in patients with alzheimer's disease and vascular dementia. |
2009-04-09 |
2023-08-12 |
human |
| Sabrina Ravaglia, Paola Bini, Elena Sinforiani, Diego Franciotta, Elisabetta Zardini, Pietro Tosca, Arrigo Moglia, Alfredo Cost. Cerebrospinal fluid levels of tau phosphorylated at threonine 181 in patients with Alzheimer's disease and vascular dementia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 29. issue 6. 2009-04-09. PMID:19011737. |
in 31 patients with probable alzheimer's disease (ad), 19 with probable vascular dementia (vad) and 20 with possible ad and possible vad, cerebrospinal fluid (csf) tau levels hyperphosphorylated at threonine 181 (ptau) were measured by elisa. |
2009-04-09 |
2023-08-12 |
human |
| Carl Julien, Cyntia Tremblay, Vincent Emond, Meryem Lebbadi, Norman Salem, David A Bennett, Frédéric Calo. Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 68. issue 1. 2009-04-09. PMID:19104446. |
sirtuin 1 reduction parallels the accumulation of tau in alzheimer disease. |
2009-04-09 |
2023-08-12 |
human |
| J Marksteiner, C Humpe. Beta-amyloid expression, release and extracellular deposition in aged rat brain slices. Molecular psychiatry. vol 13. issue 10. 2009-04-08. PMID:17712316. |
alzheimer's disease (ad) is characterized by beta-amyloid plaques, tau pathology, cholinergic cell death and inflammation. |
2009-04-08 |
2023-08-12 |
rat |
| Anne Eckert, Susanne Hauptmann, Isabel Scherping, Jessica Meinhardt, Virginie Rhein, Stefan Dröse, Ulrich Brandt, Marcus Fändrich, Walter E Müller, Jürgen Göt. Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice. Journal of molecular medicine (Berlin, Germany). vol 86. issue 11. 2009-04-08. PMID:18709343. |
we recently provided evidence for a mitochondrial dysfunction in p301l tau transgenic mice, a strain modeling the tau pathology of alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2009-04-08 |
2023-08-12 |
mouse |