All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
V Corsetti, G Amadoro, A Gentile, S Capsoni, M T Ciotti, M T Cencioni, A Atlante, N Canu, T T Rohn, A Cattaneo, P Calissan. Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models. Molecular and cellular neurosciences. vol 38. issue 3. 2008-12-09. PMID:18511295. biochemical modifications of tau proteins have been proposed to be among the earliest neurobiological changes in alzheimer's disease (ad) and correlate better with cognitive symptoms than do beta-amyloid plaques. 2008-12-09 2023-08-12 mouse
Mar Pérez, María Asunción Morán, Isidre Ferrer, Jesús Avila, Pilar Gómez-Ramo. Phosphorylated tau in neuritic plaques of APP(sw)/Tau (vlw) transgenic mice and Alzheimer disease. Acta neuropathologica. vol 116. issue 4. 2008-12-09. PMID:18679696. phosphorylated tau in neuritic plaques of app(sw)/tau (vlw) transgenic mice and alzheimer disease. 2008-12-09 2023-08-12 mouse
Mar Pérez, María Asunción Morán, Isidre Ferrer, Jesús Avila, Pilar Gómez-Ramo. Phosphorylated tau in neuritic plaques of APP(sw)/Tau (vlw) transgenic mice and Alzheimer disease. Acta neuropathologica. vol 116. issue 4. 2008-12-09. PMID:18679696. to validate these transgenic mice as models of alzheimer disease pathology, in the present study we analyze tau phosphorylation at 12e8 and at-8 epitopes in amyloid plaques. 2008-12-09 2023-08-12 mouse
Tori A Matthews-Roberson, Rodrigo A Quintanilla, Huiping Ding, Gail V W Johnso. Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death. Brain research. vol 1234. 2008-12-08. PMID:18718455. the purpose of this study was to understand if, and in what manner, the presence of asp421 cleaved tau in neurons, which is generated by caspase cleavage, might facilitate neuronal death in alzheimer's disease (ad). 2008-12-08 2023-08-12 Not clear
Irina Alafuzoff, Thomas Arzberger, Safa Al-Sarraj, Istvan Bodi, Nenad Bogdanovic, Heiko Braak, Orso Bugiani, Kelly Del-Tredici, Isidro Ferrer, Ellen Gelpi, Giorgio Giaccone, Manuel B Graeber, Paul Ince, Wouter Kamphorst, Andrew King, Penelope Korkolopoulou, Gábor G Kovács, Sergey Larionov, David Meyronet, Camelia Monoranu, Piero Parchi, Efstratios Patsouris, Wolfgang Roggendorf, Danielle Seilhean, Fabrizio Tagliavini, Christine Stadelmann, Nathalie Streichenberger, Dietmar R Thal, Stephen B Wharton, Hans Kretzschma. Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium. Brain pathology (Zurich, Switzerland). vol 18. issue 4. 2008-12-04. PMID:18371174. consequently, in order to reach a diagnosis of alzheimer's disease (ad), the presence of hyperphosphorylated tau (hp-tau) and beta-amyloid protein in brain tissue must be unequivocal. 2008-12-04 2023-08-12 Not clear
Tania F Gendron, Sharon McCartney, Ena Causevic, Li-Wen Ko, Shu-Hui Ye. Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau. Neuroscience letters. vol 443. issue 2. 2008-12-02. PMID:18672021. tau dysfunction is well known for its involvement in certain neurodegenerative diseases, such as alzheimer's disease. 2008-12-02 2023-08-12 human
Natalia Ivanovova, Martina Handzusova, Jozef Hanes, Eva Kontsekova, Michal Nova. High-yield purification of fetal tau preserving its structure and phosphorylation pattern. Journal of immunological methods. vol 339. issue 1. 2008-12-02. PMID:18713639. the fetal type of tau phosphorylation always re-appears during pathogenesis of alzheimer's disease and related tauopathies. 2008-12-02 2023-08-12 Not clear
José Luna-Muñoz, Janneth Peralta-Ramirez, Laura Chávez-Macías, Charles R Harrington, Claude M Wischik, Raúl Men. Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints. Acta neuropathologica. vol 116. issue 5. 2008-12-02. PMID:18810470. in recent years, we have used a variety of tau immunological markers combined with the dye thiazin red (tr), an accurate marker to differentiate the fibrillar from the nonfibrillar state of both amyloid-beta and tau in alzheimer's disease (ad). 2008-12-02 2023-08-12 Not clear
Efstratios Mylonas, Antje Hascher, Pau Bernadó, Martin Blackledge, Eckhard Mandelkow, Dmitri I Svergu. Domain conformation of tau protein studied by solution small-angle X-ray scattering. Biochemistry. vol 47. issue 39. 2008-12-01. PMID:18771286. tau is one of the two main proteins involved in the pathology of alzheimer's disease via formation of beta-sheet rich intracellular aggregates named paired helical filaments (phfs). 2008-12-01 2023-08-12 Not clear
Debra Toiber, Amit Berson, David Greenberg, Naomi Melamed-Book, Sophia Diamant, Hermona Sore. N-acetylcholinesterase-induced apoptosis in Alzheimer's disease. PloS one. vol 3. issue 9. 2008-11-25. PMID:18769671. alzheimer's disease (ad) involves loss of cholinergic neurons and tau protein hyper-phosphorylation. 2008-11-25 2023-08-12 Not clear
Cindy Johne, Dorthe Matenia, Xiao-Yu Li, Thomas Timm, Kiruthiga Balusamy, Eva-Maria Mandelko. Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton. Molecular biology of the cell. vol 19. issue 4. 2008-11-24. PMID:18216281. because hyperphosphorylation of tau at mark target sites is a hallmark of alzheimer neurodegeneration, we searched for upstream regulators by the yeast two-hybrid approach and identified two new interaction partners of markk, the regulatory sprouty-related protein with evh-1 domain1 (spred1) and the testis-specific protein kinase (tesk1). 2008-11-24 2023-08-12 Not clear
Barbara A J Schaffer, Lars Bertram, Bruce L Miller, Kristina Mullin, Sandra Weintraub, Nancy Johnson, Eileen H Bigio, Marsel Mesulam, Martina Wiedau-Pazos, George R Jackson, Jeffrey L Cummings, Rita M Cantor, Allan I Levey, Rudolph E Tanzi, Daniel H Geschwin. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Archives of neurology. vol 65. issue 10. 2008-11-18. PMID:18852354. deposits of abnormally hyperphosphorylated tau are a hallmark of several dementias, including alzheimer disease (ad), and about 10% of familial frontotemporal dementia (ftd) cases are caused by mutations in the tau gene. 2008-11-18 2023-08-12 Not clear
R Ceravolo, D Borghetti, L Kiferle, G Tognoni, A Giorgetti, D Neglia, N Sassi, D Frosini, C Rossi, L Petrozzi, G Siciliano, L Murr. CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease. Brain research bulletin. vol 76. issue 1-2. 2008-11-17. PMID:18395614. csf phosporylated tau protein levels correlate with cerebral glucose metabolism assessed with pet in alzheimer's disease. 2008-11-17 2023-08-12 Not clear
Claire Goldsbury, Ineka T Whiteman, Erica V Jeong, Yun-An Li. Oxidative stress increases levels of endogenous amyloid-beta peptides secreted from primary chick brain neurons. Aging cell. vol 7. issue 5. 2008-11-17. PMID:18691184. oxidative damage is associated with alzheimer's disease and mild cognitive impairment, but its relationship to the development of neuropathological lesions involving accumulation of amyloid-beta (abeta) peptides and hyperphosphorylated tau protein remains poorly understood. 2008-11-17 2023-08-12 chicken
Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. the brain lesions associated with alzheimer's disease are caused by extracellular accumulation of abeta peptide and intracellular accumulation of tau protein. 2008-11-14 2023-08-12 mouse
Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. mutations of app, the precursor of abeta peptide, cause autosomal dominant familial alzheimer disease, suggesting that a cascade of reactions link abeta overproduction, tau pathology and the clinical phenotype. 2008-11-14 2023-08-12 mouse
Jean-Noël Octave, Nathalie Pierro. [Alzheimer's disease: cellular and molecular aspects]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819686. phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of alzheimer's disease. 2008-11-14 2023-08-12 Not clear
Françoise Forette, Jean-Jacques Hau. [Alzheimer's disease: from brain lesions to new drugs]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819689. alzheimer's disease is characterized by two main lesions: amyloid plaques and neurofibrillary tangles composed of aggregated a beta peptides and hyperphosphorylated tau. 2008-11-14 2023-08-12 Not clear
Steven J Greco, Sraboni Sarkar, Jane M Johnston, Xiongwei Zhu, Bo Su, Gemma Casadesus, J Wesson Ashford, Mark A Smith, Nikolaos Tezapsidi. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochemical and biophysical research communications. vol 376. issue 3. 2008-11-13. PMID:18801339. leptin reduces alzheimer's disease-related tau phosphorylation in neuronal cells. 2008-11-13 2023-08-12 human
Steven J Greco, Sraboni Sarkar, Jane M Johnston, Xiongwei Zhu, Bo Su, Gemma Casadesus, J Wesson Ashford, Mark A Smith, Nikolaos Tezapsidi. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochemical and biophysical research communications. vol 376. issue 3. 2008-11-13. PMID:18801339. a central role for amp-dependent kinase as a mediator of leptin's action is demonstrated by the ability of 5-aminoimidazole-4-carboxyamide ribonucleoside (aicar) to decrease tau phosphorylation, and by blocking leptin in the presence of compound c. thus, leptin, which ameliorates both amyloid beta and tau-related pathological pathways, holds promise as a novel therapeutic for alzheimer's disease. 2008-11-13 2023-08-12 human