| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D R Howlett, J C Richardso. The pathology of APP transgenic mice: a model of Alzheimer's disease or simply overexpression of APP? Histology and histopathology. vol 24. issue 1. 2009-02-20. PMID:19012248. |
alzheimer's disease (ad) is characterized by a number of pathological features, notably extracellular senile plaques composed of the beta-amyloid protein (abeta) and neurofibrillary tangles (nft's), which are intracellular inclusions of hyperphosphorylated tau protein. |
2009-02-20 |
2023-08-12 |
mouse |
| Roland Brandt, Aikaterini Gergou, Irene Wacker, Thomas Fath, Harald Hutte. A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17590239. |
a caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of alzheimer's disease-like modified tau. |
2009-02-19 |
2023-08-12 |
human |
| Roland Brandt, Aikaterini Gergou, Irene Wacker, Thomas Fath, Harald Hutte. A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17590239. |
the microtubule-associated tau proteins become functionally and structurally altered in alzheimer's disease (ad). |
2009-02-19 |
2023-08-12 |
human |
| Franziska Denk, Richard Wade-Martin. Knock-out and transgenic mouse models of tauopathies. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17590238. |
tauopathies, characterized by the dysfunction and aggregation of the microtubule-associated protein tau (mapt), represent some of the most devastating neurodegenerative disorders afflicting the elderly, including alzheimer's disease and progressive supranuclear palsy. |
2009-02-19 |
2023-08-12 |
mouse |
| B Borroni, F Gardoni, L Parnetti, L Magno, M Malinverno, E Saggese, P Calabresi, M G Spillantini, A Padovani, M Di Luc. Pattern of Tau forms in CSF is altered in progressive supranuclear palsy. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17709155. |
cerebrospinal fluid (csf) total tau levels vary widely in neurodegenerative disorders, thus being not useful in their discrimination over alzheimer disease. |
2009-02-19 |
2023-08-12 |
human |
| B Borroni, F Gardoni, L Parnetti, L Magno, M Malinverno, E Saggese, P Calabresi, M G Spillantini, A Padovani, M Di Luc. Pattern of Tau forms in CSF is altered in progressive supranuclear palsy. Neurobiology of aging. vol 30. issue 1. 2009-02-19. PMID:17709155. |
tau ratio 33 kda/55 kda was significantly decreased in patients with psp (0.46+/-0.16) when compared to controls, including healthy subjects (1.16+/-0.46, p=0.002) and alzheimer disease (1.38+/-0.68, p<0.001), and when compared to frontotemporal dementia (0.98+/-0.30, p=0.008) or corticobasal degeneration syndrome (0.98+/-0.48, p=0.02). |
2009-02-19 |
2023-08-12 |
human |
| Henny Wati, Takeshi Kawarabayashi, Etsuro Matsubara, Ayumi Kasai, Takae Hirasawa, Takeo Kubota, Yasuo Harigaya, Mikio Shoji, Shuichiro Maed. Transthyretin accelerates vascular Abeta deposition in a mouse model of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 19. issue 1. 2009-02-19. PMID:18429966. |
it was reported that the lack of neurodegeneration in a transgenic mouse model of alzheimer's disease (ad) (tg2576 mouse) was associated with increased ttr level in the hippocampus, and that chronic infusion of anti-ttr antibody into the hippocampus of tg2576 mice led to increased local abeta deposits, tau hyperphosphorylation and apoptosis. |
2009-02-19 |
2023-08-12 |
mouse |
| Heng-Liang Yeh, Shih-Jen Tsa. Lithium may be useful in the prevention of Alzheimer's disease in individuals at risk of presenile familial Alzheimer's disease. Medical hypotheses. vol 71. issue 6. 2009-02-19. PMID:18760542. |
presenile familial ad (fad) and sporadic alzheimer's disease (sad) have identical brain lesions, containing senile plaques with beta-amyloid (abeta) peptide and neurofibrillary tangles formed by hyperphosphorylation of a microtubule-associated protein known as tau. |
2009-02-19 |
2023-08-12 |
Not clear |
| Clayton A Wiley, Brian J Lopresti, Sriram Venneti, Julie Price, William E Klunk, Steven T DeKosky, Chester A Mathi. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Archives of neurology. vol 66. issue 1. 2009-02-19. PMID:19139300. |
alzheimer disease (ad) is defined neuropathologically by the presence of neurofibrillary tangles and plaques associated with tau and beta-amyloid protein deposition. |
2009-02-19 |
2023-08-12 |
Not clear |
| Peter J Crouch, Lin Wai Hung, Paul A Adlard, Mikhalina Cortes, Varsha Lal, Gulay Filiz, Keyla A Perez, Milawaty Nurjono, Aphrodite Caragounis, Tai Du, Katrina Laughton, Irene Volitakis, Ashley I Bush, Qiao-Xin Li, Colin L Masters, Roberto Cappai, Robert A Cherny, Paul S Donnelly, Anthony R White, Kevin J Barnha. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 2. 2009-02-13. PMID:19122148. |
cognitive decline in alzheimer's disease (ad) involves pathological accumulation of synaptotoxic amyloid-beta (abeta) oligomers and hyperphosphorylated tau. |
2009-02-13 |
2023-08-12 |
mouse |
| Natasha Deters, Lars M Ittner, Jürgen Göt. Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and biophysical research communications. vol 379. issue 2. 2009-02-13. PMID:19126401. |
disturbance of this balance causes hyperphosphorylation of tau and neurofibrillary tangle formation in alzheimer's disease brain. |
2009-02-13 |
2023-08-12 |
mouse |
| b' Gorana Mandi\\xc4\\x87, Ivanka Markovi\\xc4\\x87, Marija Ostoji\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Sonja Misirli\\xc4\\x87-Denci\\xc4\\x87, Tatjana Zivanovi\\xc4\\x87-Radni\\xc4\\x87, Rodoljub Stefanovi\\xc4\\x87, Marko Bumbasirevi\\xc4\\x87, Elka Stefanova, Vladimir Kosti\\xc4\\x8. [Cerebrospinal fluid amyloid beta and tau protein: biomarkers for Alzheimer\'s disease]. Vojnosanitetski pregled. vol 65. issue 12. 2009-02-11. PMID:19160984.' |
[cerebrospinal fluid amyloid beta and tau protein: biomarkers for alzheimer's disease]. |
2009-02-11 |
2023-08-12 |
Not clear |
| b' Gorana Mandi\\xc4\\x87, Ivanka Markovi\\xc4\\x87, Marija Ostoji\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Sonja Misirli\\xc4\\x87-Denci\\xc4\\x87, Tatjana Zivanovi\\xc4\\x87-Radni\\xc4\\x87, Rodoljub Stefanovi\\xc4\\x87, Marko Bumbasirevi\\xc4\\x87, Elka Stefanova, Vladimir Kosti\\xc4\\x8. [Cerebrospinal fluid amyloid beta and tau protein: biomarkers for Alzheimer\'s disease]. Vojnosanitetski pregled. vol 65. issue 12. 2009-02-11. PMID:19160984.' |
introduction of acetylcholine esterase inhibitors as a symptomatic treatment of alzheimer's disease (ad) has additionally highlighted the importance of diagnostic markers in cerebrospinal fluid (csf) for early ad diagnosis: low level of 42 amino acid form of amyloid-beta peptide (abeta42), and levels of tau protein (t-tau) and phosphorylated tau protein (p-tau). |
2009-02-11 |
2023-08-12 |
Not clear |
| Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Jon Infante, José Luis Vázquez-Higuera, Inés García-Gorostiaga, José Berciano, Onofre Combarro. Synergistic effect of heme oxygenase-1 and tau genetic variants on Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 26. issue 4. 2009-02-09. PMID:18841019. |
synergistic effect of heme oxygenase-1 and tau genetic variants on alzheimer's disease risk. |
2009-02-09 |
2023-08-12 |
human |
| Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Jon Infante, José Luis Vázquez-Higuera, Inés García-Gorostiaga, José Berciano, Onofre Combarro. Synergistic effect of heme oxygenase-1 and tau genetic variants on Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 26. issue 4. 2009-02-09. PMID:18841019. |
in alzheimer's disease (ad) brain, accumulation of hyperphosphorylated tau in nft is associated with the induction of heme oxygenase-1 (ho-1), a potent antioxidant that downregulates the production of tau. |
2009-02-09 |
2023-08-12 |
human |
| Ditte Zerlang Christensen, Sophie Luise Kraus, Antonius Flohr, Marie-Caroline Cotel, Oliver Wirths, Thomas A Baye. Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice. Acta neuropathologica. vol 116. issue 6. 2009-02-03. PMID:18974993. |
the accumulation of beta-amyloid (a beta) plaques and neurofibrillary tangles consisting of hyperphosphorylated tau protein are pathological features of alzheimer's disease (ad) commonly modeled in mice using known human familial mutations; however, the loss of neurons also found to occur in ad is rarely observed in such models. |
2009-02-03 |
2023-08-12 |
mouse |
| Chad Dickey, Clara Kraft, Umesh Jinwal, John Koren, Amelia Johnson, Laura Anderson, Lori Lebson, Daniel Lee, Dennis Dickson, Rohan de Silva, Lester I Binder, David Morgan, Jada Lewi. Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. The American journal of pathology. vol 174. issue 1. 2009-02-03. PMID:19074615. |
moreover, we show that the active production of small amounts of abnormal tau protein facilitates dysfunction and accumulation of otherwise normal tau, a significant implication for the pathogenesis of patients with alzheimer's disease. |
2009-02-03 |
2023-08-12 |
mouse |
| Shreyasi Chatterjee, Tzu-Kang Sang, George M Lawless, George R Jackso. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Human molecular genetics. vol 18. issue 1. 2009-01-30. PMID:18930955. |
hyperphosphorylation of tau at multiple sites has been implicated in the formation of neurofibrillary tangles in alzheimer's disease; however, the relationship between toxicity and phosphorylation of tau has not been clearly elucidated. |
2009-01-30 |
2023-08-12 |
drosophila_melanogaster |
| Da-yu Yu, Li Tong, Gao-jie Song, Wei-lin Lin, Lai-qun Zhang, Wei Bai, He Gong, Yan-xia Yin, Qun We. Tau binds both subunits of calcineurin, and binding is impaired by calmodulin. Biochimica et biophysica acta. vol 1783. issue 12. 2009-01-27. PMID:18639592. |
they shed some light on how the interactions might control the phosphorylation state of tau under physiological conditions, and provide new insights into the treatment of tauopathies such as alzheimer's disease. |
2009-01-27 |
2023-08-12 |
Not clear |
| Emmanuel Planel, Pavan Krishnamurthy, Tomohiro Miyasaka, Li Liu, Mathieu Herman, Asok Kumar, Alexis Bretteville, Helen Y Figueroa, Wai Haung Yu, Robert A Whittington, Peter Davies, Akihiko Takashima, Ralph A Nixon, Karen E Duf. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 48. 2009-01-26. PMID:19036972. |
in alzheimer's disease, tau is hyperphosphorylated, which is thought to detach it from microtubules (mts), induce mt destabilization, and promote aggregation. |
2009-01-26 |
2023-08-12 |
mouse |