| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Giaccone, M Mangieri, R Capobianco, L Limido, J J Hauw, S Haïk, P Fociani, O Bugiani, F Tagliavin. Tauopathy in human and experimental variant Creutzfeldt-Jakob disease. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17560687. |
cerebral accumulation of hyperphosphorylated tau (phospho-tau) occurs in several neurodegenerative conditions including alzheimer disease. |
2009-01-23 |
2023-08-12 |
mouse |
| G Giaccone, M Mangieri, R Capobianco, L Limido, J J Hauw, S Haïk, P Fociani, O Bugiani, F Tagliavin. Tauopathy in human and experimental variant Creutzfeldt-Jakob disease. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17560687. |
these findings suggest that the abnormal forms of prp associated with vcjd trigger a tauopathy, and provide a paradigm for the early stages of tau pathology associated with cerebral amyloidoses, including alzheimer disease. |
2009-01-23 |
2023-08-12 |
mouse |
| Ramona Bravo, Muriel Arimon, Juan José Valle-Delgado, Raquel García, Núria Durany, Susanna Castel, Montserrat Cruz, Salvador Ventura, Xavier Fernàndez-Busquet. Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity. The Journal of biological chemistry. vol 283. issue 47. 2009-01-22. PMID:18819917. |
the histopathological hallmarks of alzheimer disease are the self-aggregation of the amyloid beta peptide (abeta) in extracellular amyloid fibrils and the formation of intraneuronal tau filaments, but a convincing mechanism connecting both processes has yet to be provided. |
2009-01-22 |
2023-08-12 |
Not clear |
| Ramona Bravo, Muriel Arimon, Juan José Valle-Delgado, Raquel García, Núria Durany, Susanna Castel, Montserrat Cruz, Salvador Ventura, Xavier Fernàndez-Busquet. Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity. The Journal of biological chemistry. vol 283. issue 47. 2009-01-22. PMID:18819917. |
in vitro assays indicate that such transient, local ca(2+) increases can have a direct effect in promoting the formation of tau filaments similar to those isolated from alzheimer disease brains. |
2009-01-22 |
2023-08-12 |
Not clear |
| C Haense, K Buerger, E Kalbe, A Drzezga, S J Teipel, P Markiewicz, K Herholz, W D Heiss, H Hampe. CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's disease. European journal of neurology. vol 15. issue 11. 2009-01-21. PMID:18803648. |
csf total and phosphorylated tau protein, regional glucose metabolism and dementia severity in alzheimer's disease. |
2009-01-21 |
2023-08-12 |
Not clear |
| C Haense, K Buerger, E Kalbe, A Drzezga, S J Teipel, P Markiewicz, K Herholz, W D Heiss, H Hampe. CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's disease. European journal of neurology. vol 15. issue 11. 2009-01-21. PMID:18803648. |
we investigated associations between severity of cognitive impairment, cerebrospinal fluid (csf) concentrations of total-tau (t-tau) protein and tau phosphorylated at threonin 181 (p-tau(181)) and regional glucose metabolism measured with 18f-fluorodeoxyglucose-positron emission tomography (18f-fdg-pet) in patients with probable alzheimer's disease (ad). |
2009-01-21 |
2023-08-12 |
Not clear |
| Scott A Small, Karen Duf. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron. vol 60. issue 4. 2009-01-16. PMID:19038212. |
linking abeta and tau in late-onset alzheimer's disease: a dual pathway hypothesis. |
2009-01-16 |
2023-08-12 |
Not clear |
| Scott A Small, Karen Duf. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron. vol 60. issue 4. 2009-01-16. PMID:19038212. |
alzheimer's disease is characterized by abnormal elevation of abeta peptide and abnormal hyperphosphorylation of the tau protein. |
2009-01-16 |
2023-08-12 |
Not clear |
| Scott A Small, Karen Duf. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron. vol 60. issue 4. 2009-01-16. PMID:19038212. |
the "amyloid hypothesis," which is based on molecular defects observed in autosomal-dominant early-onset alzheimer's disease (eoad), suggests a serial model of causality, whereby elevation of abeta drives other disease features including tau hyperphosphorylation. |
2009-01-16 |
2023-08-12 |
Not clear |
| N Sahara, S Maeda, A Takashim. Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration. Current Alzheimer research. vol 5. issue 6. 2009-01-16. PMID:19075586. |
intracellular accumulation of filamentous tau proteins is a defining feature of neurodegenerative diseases, including alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, pick's disease, and frontotemporal dementia with parkinsonism linked to chromosome 17, all known collectively as tauopathies. |
2009-01-16 |
2023-08-12 |
human |
| Gary W Small, Prabha Siddarth, Alison C Burggren, Vladimir Kepe, Linda M Ercoli, Karen J Miller, Helen Lavretsky, Paul M Thompson, Greg M Cole, S C Huang, Michael E Phelps, Susan Y Bookheimer, Jorge R Barri. Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia. Archives of general psychiatry. vol 66. issue 1. 2009-01-16. PMID:19124691. |
amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of alzheimer disease that accumulate in the brains of people without dementia years before they develop dementia. |
2009-01-16 |
2023-08-12 |
Not clear |
| Breno S O Diniz, Jony A Pinto Júnior, Orestes Vicente Forlenz. Do CSF total tau, phosphorylated tau, and beta-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 9. issue 3. 2009-01-14. PMID:17886169. |
do csf total tau, phosphorylated tau, and beta-amyloid 42 help to predict progression of mild cognitive impairment to alzheimer's disease? |
2009-01-14 |
2023-08-12 |
human |
| Sadasivam Jeganathan, Antje Hascher, Subashchandrabose Chinnathambi, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelko. Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. The Journal of biological chemistry. vol 283. issue 46. 2009-01-07. PMID:18725412. |
tau, a neuronal microtubule-associated protein that aggregates in alzheimer disease is a natively unfolded protein. |
2009-01-07 |
2023-08-12 |
Not clear |
| M A Smach, B Charfeddine, T Lammouchi, H Dridi, L Ben Othman, S Bennamou, K Lime. [Interest of CSF beta-amyloid1-42 and t-tau protein level determinations for the diagnosis of Alzheimer's disease]. Annales de biologie clinique. vol 66. issue 5. 2009-01-05. PMID:18957342. |
in order to clarify the importance of beta amyloid protein dosage (abeta1-42) and protein tau (t-tau) in such pathology, we have rigorously studied three well recruited populations that match in age: healthy controls (n = 32), alzheimer patients (n = 87) and non alzheimer dementia (n = 31) patients. |
2009-01-05 |
2023-08-12 |
Not clear |
| Masafumi Inoue, Akiyoshi Hirata, Kazuki Tainaka, Takashi Morii, Takashi Konn. Charge-pairing mechanism of phosphorylation effect upon amyloid fibrillation of human tau core peptide. Biochemistry. vol 47. issue 45. 2008-12-31. PMID:18922026. |
phosphorylation of a fibrillogenic protein, human tau, is believed to play crucial roles in the pathogenesis of alzheimer's disease. |
2008-12-31 |
2023-08-12 |
human |
| Sadasivam Jeganathan, Martin von Bergen, Eva-Maria Mandelkow, Eckhard Mandelko. The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments. Biochemistry. vol 47. issue 40. 2008-12-30. PMID:18783251. |
the abnormal aggregation of the microtubule-associated protein tau into paired helical filaments (phfs) is one of the hallmarks of alzheimer disease (ad). |
2008-12-30 |
2023-08-12 |
Not clear |
| Ioannis Sotiropoulos, Caterina Catania, Therese Riedemann, Jonathan P Fry, Kieran C Breen, Theologos M Michaelidis, Osborne F X Almeid. Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau. Journal of neurochemistry. vol 107. issue 2. 2008-12-24. PMID:18691381. |
glucocorticoids trigger alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau. |
2008-12-24 |
2023-08-12 |
human |
| Ioannis Sotiropoulos, Caterina Catania, Therese Riedemann, Jonathan P Fry, Kieran C Breen, Theologos M Michaelidis, Osborne F X Almeid. Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau. Journal of neurochemistry. vol 107. issue 2. 2008-12-24. PMID:18691381. |
amyloid precursor protein (app) mis-processing and aberrant tau hyperphosphorylation are causally related to the pathogenesis and neurodegenerative processes that characterize alzheimer's disease (ad). |
2008-12-24 |
2023-08-12 |
human |
| Timothy D Vaden, Sally A N Gowers, Tjalling S J A de Boer, Jeffrey D Steill, Jos Oomens, Lavina C Snoe. Conformational preferences of an amyloidogenic peptide: IR spectroscopy of Ac-VQIVYK-NHMe. Journal of the American Chemical Society. vol 130. issue 44. 2008-12-24. PMID:18844349. |
the (306)vqivyk(311) sequence in the tau peptide is essential for the formation of intracellular amyloid fibrils related to alzheimer's disease, where it forms interdigitating cross-beta-structures. |
2008-12-24 |
2023-08-12 |
Not clear |
| John B J Kwok, Clement T Loy, Gillian Hamilton, Edmond Lau, Marianne Hallupp, Julie Williams, Michael J Owen, G Anthony Broe, Nelson Tang, Linda Lam, John F Powell, Simon Lovestone, Peter R Schofiel. Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease. Annals of neurology. vol 64. issue 4. 2008-12-24. PMID:18991351. |
glycogen synthase kinase-3beta and tau genes interact in alzheimer's disease. |
2008-12-24 |
2023-08-12 |
Not clear |