| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John B J Kwok, Clement T Loy, Gillian Hamilton, Edmond Lau, Marianne Hallupp, Julie Williams, Michael J Owen, G Anthony Broe, Nelson Tang, Linda Lam, John F Powell, Simon Lovestone, Peter R Schofiel. Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease. Annals of neurology. vol 64. issue 4. 2008-12-24. PMID:18991351. |
we examined the epistatic effect between haplotypes of glycogen synthase kinase-3beta (gsk3b) gene and microtubule-associated protein tau (mapt) gene in alzheimer's disease (ad). |
2008-12-24 |
2023-08-12 |
Not clear |
| Austin Huang, Collin M Stult. The effect of a DeltaK280 mutation on the unfolded state of a microtubule-binding repeat in Tau. PLoS computational biology. vol 4. issue 8. 2008-12-18. PMID:18725924. |
tau is a natively unfolded protein that forms intracellular aggregates in the brains of patients with alzheimer's disease. |
2008-12-18 |
2023-08-12 |
Not clear |
| Einar M Sigurdsso. Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies. Journal of Alzheimer's disease : JAD. vol 15. issue 2. 2008-12-16. PMID:18953105. |
immunotherapy targeting pathological tau protein in alzheimer's disease and related tauopathies. |
2008-12-16 |
2023-08-12 |
mouse |
| Xin-Wen Zhou, Jan-Ake Gustafsson, Heikki Tanila, Cecilia Bjorkdahl, Rong Liu, Bengt Winblad, Jin-Jing Pe. Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A. Neurobiology of disease. vol 31. issue 3. 2008-12-15. PMID:18586097. |
the down-regulation of protein phosphatase 2a (pp2a) activity is thought to play an important role in the formation of tau hyperphosphorylation in the alzheimer's disease (ad) brain. |
2008-12-15 |
2023-08-12 |
mouse |
| Carolyn A Rankin, Qian Sun, T Chris Gambli. Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures. Neurobiology of disease. vol 31. issue 3. 2008-12-15. PMID:18588978. |
hyperphosphorylated tau protein is a major component of neurofibrillary tangles, a prominent intracellular hallmark of alzheimer's disease. |
2008-12-15 |
2023-08-12 |
Not clear |
| Carolyn A Rankin, Qian Sun, T Chris Gambli. Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures. Neurobiology of disease. vol 31. issue 3. 2008-12-15. PMID:18588978. |
both hyperphosphorylated tau and neurofibrillary tangles have been shown to correlate with dementia in alzheimer's disease, but the relationship between hyperphosphorylation and tangle formation is not clear. |
2008-12-15 |
2023-08-12 |
Not clear |
| Carolyn A Rankin, Qian Sun, T Chris Gambli. Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures. Neurobiology of disease. vol 31. issue 3. 2008-12-15. PMID:18588978. |
these tangle-like structures are optically visible and are similar to those formed by polymerization of gsk-3beta phosphorylated tau monomer and to those isolated from alzheimer's disease tissue. |
2008-12-15 |
2023-08-12 |
Not clear |
| V Corsetti, G Amadoro, A Gentile, S Capsoni, M T Ciotti, M T Cencioni, A Atlante, N Canu, T T Rohn, A Cattaneo, P Calissan. Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models. Molecular and cellular neurosciences. vol 38. issue 3. 2008-12-09. PMID:18511295. |
identification of a caspase-derived n-terminal tau fragment in cellular and animal alzheimer's disease models. |
2008-12-09 |
2023-08-12 |
mouse |
| V Corsetti, G Amadoro, A Gentile, S Capsoni, M T Ciotti, M T Cencioni, A Atlante, N Canu, T T Rohn, A Cattaneo, P Calissan. Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models. Molecular and cellular neurosciences. vol 38. issue 3. 2008-12-09. PMID:18511295. |
biochemical modifications of tau proteins have been proposed to be among the earliest neurobiological changes in alzheimer's disease (ad) and correlate better with cognitive symptoms than do beta-amyloid plaques. |
2008-12-09 |
2023-08-12 |
mouse |
| Mar Pérez, María Asunción Morán, Isidre Ferrer, Jesús Avila, Pilar Gómez-Ramo. Phosphorylated tau in neuritic plaques of APP(sw)/Tau (vlw) transgenic mice and Alzheimer disease. Acta neuropathologica. vol 116. issue 4. 2008-12-09. PMID:18679696. |
phosphorylated tau in neuritic plaques of app(sw)/tau (vlw) transgenic mice and alzheimer disease. |
2008-12-09 |
2023-08-12 |
mouse |
| Mar Pérez, María Asunción Morán, Isidre Ferrer, Jesús Avila, Pilar Gómez-Ramo. Phosphorylated tau in neuritic plaques of APP(sw)/Tau (vlw) transgenic mice and Alzheimer disease. Acta neuropathologica. vol 116. issue 4. 2008-12-09. PMID:18679696. |
to validate these transgenic mice as models of alzheimer disease pathology, in the present study we analyze tau phosphorylation at 12e8 and at-8 epitopes in amyloid plaques. |
2008-12-09 |
2023-08-12 |
mouse |
| Tori A Matthews-Roberson, Rodrigo A Quintanilla, Huiping Ding, Gail V W Johnso. Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death. Brain research. vol 1234. 2008-12-08. PMID:18718455. |
the purpose of this study was to understand if, and in what manner, the presence of asp421 cleaved tau in neurons, which is generated by caspase cleavage, might facilitate neuronal death in alzheimer's disease (ad). |
2008-12-08 |
2023-08-12 |
Not clear |
| Irina Alafuzoff, Thomas Arzberger, Safa Al-Sarraj, Istvan Bodi, Nenad Bogdanovic, Heiko Braak, Orso Bugiani, Kelly Del-Tredici, Isidro Ferrer, Ellen Gelpi, Giorgio Giaccone, Manuel B Graeber, Paul Ince, Wouter Kamphorst, Andrew King, Penelope Korkolopoulou, Gábor G Kovács, Sergey Larionov, David Meyronet, Camelia Monoranu, Piero Parchi, Efstratios Patsouris, Wolfgang Roggendorf, Danielle Seilhean, Fabrizio Tagliavini, Christine Stadelmann, Nathalie Streichenberger, Dietmar R Thal, Stephen B Wharton, Hans Kretzschma. Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium. Brain pathology (Zurich, Switzerland). vol 18. issue 4. 2008-12-04. PMID:18371174. |
consequently, in order to reach a diagnosis of alzheimer's disease (ad), the presence of hyperphosphorylated tau (hp-tau) and beta-amyloid protein in brain tissue must be unequivocal. |
2008-12-04 |
2023-08-12 |
Not clear |
| Tania F Gendron, Sharon McCartney, Ena Causevic, Li-Wen Ko, Shu-Hui Ye. Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau. Neuroscience letters. vol 443. issue 2. 2008-12-02. PMID:18672021. |
tau dysfunction is well known for its involvement in certain neurodegenerative diseases, such as alzheimer's disease. |
2008-12-02 |
2023-08-12 |
human |
| Natalia Ivanovova, Martina Handzusova, Jozef Hanes, Eva Kontsekova, Michal Nova. High-yield purification of fetal tau preserving its structure and phosphorylation pattern. Journal of immunological methods. vol 339. issue 1. 2008-12-02. PMID:18713639. |
the fetal type of tau phosphorylation always re-appears during pathogenesis of alzheimer's disease and related tauopathies. |
2008-12-02 |
2023-08-12 |
Not clear |
| José Luna-Muñoz, Janneth Peralta-Ramirez, Laura Chávez-Macías, Charles R Harrington, Claude M Wischik, Raúl Men. Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints. Acta neuropathologica. vol 116. issue 5. 2008-12-02. PMID:18810470. |
in recent years, we have used a variety of tau immunological markers combined with the dye thiazin red (tr), an accurate marker to differentiate the fibrillar from the nonfibrillar state of both amyloid-beta and tau in alzheimer's disease (ad). |
2008-12-02 |
2023-08-12 |
Not clear |
| Efstratios Mylonas, Antje Hascher, Pau Bernadó, Martin Blackledge, Eckhard Mandelkow, Dmitri I Svergu. Domain conformation of tau protein studied by solution small-angle X-ray scattering. Biochemistry. vol 47. issue 39. 2008-12-01. PMID:18771286. |
tau is one of the two main proteins involved in the pathology of alzheimer's disease via formation of beta-sheet rich intracellular aggregates named paired helical filaments (phfs). |
2008-12-01 |
2023-08-12 |
Not clear |
| Debra Toiber, Amit Berson, David Greenberg, Naomi Melamed-Book, Sophia Diamant, Hermona Sore. N-acetylcholinesterase-induced apoptosis in Alzheimer's disease. PloS one. vol 3. issue 9. 2008-11-25. PMID:18769671. |
alzheimer's disease (ad) involves loss of cholinergic neurons and tau protein hyper-phosphorylation. |
2008-11-25 |
2023-08-12 |
Not clear |
| Cindy Johne, Dorthe Matenia, Xiao-Yu Li, Thomas Timm, Kiruthiga Balusamy, Eva-Maria Mandelko. Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton. Molecular biology of the cell. vol 19. issue 4. 2008-11-24. PMID:18216281. |
because hyperphosphorylation of tau at mark target sites is a hallmark of alzheimer neurodegeneration, we searched for upstream regulators by the yeast two-hybrid approach and identified two new interaction partners of markk, the regulatory sprouty-related protein with evh-1 domain1 (spred1) and the testis-specific protein kinase (tesk1). |
2008-11-24 |
2023-08-12 |
Not clear |
| Barbara A J Schaffer, Lars Bertram, Bruce L Miller, Kristina Mullin, Sandra Weintraub, Nancy Johnson, Eileen H Bigio, Marsel Mesulam, Martina Wiedau-Pazos, George R Jackson, Jeffrey L Cummings, Rita M Cantor, Allan I Levey, Rudolph E Tanzi, Daniel H Geschwin. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Archives of neurology. vol 65. issue 10. 2008-11-18. PMID:18852354. |
deposits of abnormally hyperphosphorylated tau are a hallmark of several dementias, including alzheimer disease (ad), and about 10% of familial frontotemporal dementia (ftd) cases are caused by mutations in the tau gene. |
2008-11-18 |
2023-08-12 |
Not clear |