| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Ceravolo, D Borghetti, L Kiferle, G Tognoni, A Giorgetti, D Neglia, N Sassi, D Frosini, C Rossi, L Petrozzi, G Siciliano, L Murr. CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease. Brain research bulletin. vol 76. issue 1-2. 2008-11-17. PMID:18395614. |
csf phosporylated tau protein levels correlate with cerebral glucose metabolism assessed with pet in alzheimer's disease. |
2008-11-17 |
2023-08-12 |
Not clear |
| Claire Goldsbury, Ineka T Whiteman, Erica V Jeong, Yun-An Li. Oxidative stress increases levels of endogenous amyloid-beta peptides secreted from primary chick brain neurons. Aging cell. vol 7. issue 5. 2008-11-17. PMID:18691184. |
oxidative damage is associated with alzheimer's disease and mild cognitive impairment, but its relationship to the development of neuropathological lesions involving accumulation of amyloid-beta (abeta) peptides and hyperphosphorylated tau protein remains poorly understood. |
2008-11-17 |
2023-08-12 |
chicken |
| Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. |
the brain lesions associated with alzheimer's disease are caused by extracellular accumulation of abeta peptide and intracellular accumulation of tau protein. |
2008-11-14 |
2023-08-12 |
mouse |
| Charles Duyckaerts, Claire Perruchini, Thibaud Lebouvier, Marie-Claude Potie. [The lesions of Alzheimer's disease: which therapeutic perspectives?]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819685. |
mutations of app, the precursor of abeta peptide, cause autosomal dominant familial alzheimer disease, suggesting that a cascade of reactions link abeta overproduction, tau pathology and the clinical phenotype. |
2008-11-14 |
2023-08-12 |
mouse |
| Jean-Noël Octave, Nathalie Pierro. [Alzheimer's disease: cellular and molecular aspects]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819686. |
phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of alzheimer's disease. |
2008-11-14 |
2023-08-12 |
Not clear |
| Françoise Forette, Jean-Jacques Hau. [Alzheimer's disease: from brain lesions to new drugs]. Bulletin de l'Academie nationale de medecine. vol 192. issue 2. 2008-11-14. PMID:18819689. |
alzheimer's disease is characterized by two main lesions: amyloid plaques and neurofibrillary tangles composed of aggregated a beta peptides and hyperphosphorylated tau. |
2008-11-14 |
2023-08-12 |
Not clear |
| Steven J Greco, Sraboni Sarkar, Jane M Johnston, Xiongwei Zhu, Bo Su, Gemma Casadesus, J Wesson Ashford, Mark A Smith, Nikolaos Tezapsidi. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochemical and biophysical research communications. vol 376. issue 3. 2008-11-13. PMID:18801339. |
leptin reduces alzheimer's disease-related tau phosphorylation in neuronal cells. |
2008-11-13 |
2023-08-12 |
human |
| Steven J Greco, Sraboni Sarkar, Jane M Johnston, Xiongwei Zhu, Bo Su, Gemma Casadesus, J Wesson Ashford, Mark A Smith, Nikolaos Tezapsidi. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochemical and biophysical research communications. vol 376. issue 3. 2008-11-13. PMID:18801339. |
a central role for amp-dependent kinase as a mediator of leptin's action is demonstrated by the ability of 5-aminoimidazole-4-carboxyamide ribonucleoside (aicar) to decrease tau phosphorylation, and by blocking leptin in the presence of compound c. thus, leptin, which ameliorates both amyloid beta and tau-related pathological pathways, holds promise as a novel therapeutic for alzheimer's disease. |
2008-11-13 |
2023-08-12 |
human |
| Geneviève Leuba, Claude Walzer, André Vernay, Béatrice Carnal, Rudolf Kraftsik, Françoise Piotton, Pascale Marin, Constantin Bouras, Armand Savio. Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction. Neurobiology of disease. vol 30. issue 3. 2008-11-07. PMID:18424056. |
we observed a significant decrease in presynaptic synaptophysin and an increase in postsynaptic density protein psd-95, positively correlated with beta amyloid and phosphorylated tau proteins in alzheimer cases. |
2008-11-07 |
2023-08-12 |
Not clear |
| Juan F Reyes, Matthew R Reynolds, Peleg M Horowitz, Yifan Fu, Angela L Guillozet-Bongaarts, Robert Berry, Lester I Binde. A possible link between astrocyte activation and tau nitration in Alzheimer's disease. Neurobiology of disease. vol 31. issue 2. 2008-11-07. PMID:18562203. |
a possible link between astrocyte activation and tau nitration in alzheimer's disease. |
2008-11-07 |
2023-08-12 |
Not clear |
| Juan F Reyes, Matthew R Reynolds, Peleg M Horowitz, Yifan Fu, Angela L Guillozet-Bongaarts, Robert Berry, Lester I Binde. A possible link between astrocyte activation and tau nitration in Alzheimer's disease. Neurobiology of disease. vol 31. issue 2. 2008-11-07. PMID:18562203. |
alzheimer's disease (ad) pathology has been characterized, in part, by the self-assembly of the tau molecule into neurofibrillary tangles (nft). |
2008-11-07 |
2023-08-12 |
Not clear |
| Susanna Pietropaolo, Joram Feldon, Benjamin K Ye. Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease. Behavioral neuroscience. vol 122. issue 4. 2008-11-05. PMID:18729626. |
the triple-transgenic mouse line (3 x tg-ad) harboring ps1m146v, appswe, and taup301l transgenes represents the only transgenic model for alzheimer's disease (ad) to date capturing both beta-amyloid and tau neuropathology. |
2008-11-05 |
2023-08-12 |
mouse |
| Octavio Mercado-Gómez, Karla Hernández-Fonseca, Alexa Villavicencio-Queijeiro, Lourdes Massieu, Jesús Chimal-Monroy, Clorinda Aria. Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation. Neurochemical research. vol 33. issue 8. 2008-11-03. PMID:18461448. |
glycogen synthase kinase gsk-3beta has been identified as one of the major candidates mediating tau hyperphosphorylation at the same sites as those present in tau protein in brain from alzheimer's disease (ad) patients. |
2008-11-03 |
2023-08-12 |
rat |
| Huiping Ding, Philip J Dolan, Gail V W Johnso. Histone deacetylase 6 interacts with the microtubule-associated protein tau. Journal of neurochemistry. vol 106. issue 5. 2008-11-03. PMID:18636984. |
here, we provide in vitro and in vivo evidence that hdac6 interacts with tau, a microtubule-associated protein that forms neurofibrillary tangles in alzheimer's disease. |
2008-11-03 |
2023-08-12 |
Not clear |
| Khalid Iqbal, Alejandra del C Alonso, Inge Grundke-Iqba. Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly. Journal of Alzheimer's disease : JAD. vol 14. issue 4. 2008-11-03. PMID:18688085. |
neurofibrillary degeneration of abnormally hyperphosphorylated tau, a hallmark of alzheimer's disease (ad) and related tauopathies, occurs both as cytosolic aggregated/oligomeric protein (ad p-tau) and as neurofibrillary tangles. |
2008-11-03 |
2023-08-12 |
Not clear |
| Rudy J Castellani, Akihiko Nunomura, Hyoung-gon Lee, George Perry, Mark A Smit. Phosphorylated tau: toxic, protective, or none of the above. Journal of Alzheimer's disease : JAD. vol 14. issue 4. 2008-11-03. PMID:18688087. |
identification of phosphorylated tau as the major protein component of neurofibrillary tangles (nfts) led to the concept that phosphorylated tau was inherently toxic and, as such, intimately involved in alzheimer's disease (ad) pathogenesis. |
2008-11-03 |
2023-08-12 |
Not clear |
| Jin-Jing Pei, Cecilia Björkdahl, Haiyan Zhang, Xinwen Zhou, Bengt Winbla. p70 S6 kinase and tau in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 4. 2008-11-03. PMID:18688088. |
p70 s6 kinase and tau in alzheimer's disease. |
2008-11-03 |
2023-08-12 |
Not clear |
| Jin-Jing Pei, Cecilia Björkdahl, Haiyan Zhang, Xinwen Zhou, Bengt Winbla. p70 S6 kinase and tau in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 4. 2008-11-03. PMID:18688088. |
this article presented evidence that supports both toxic and protective roles of p70s6k activity towards tau in alzheimer's disease (ad) brains. |
2008-11-03 |
2023-08-12 |
Not clear |
| Francisco García-Sierra, Siddhartha Mondragón-Rodríguez, Gustavo Basurto-Isla. Truncation of tau protein and its pathological significance in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 4. 2008-11-03. PMID:18688090. |
truncation of tau protein and its pathological significance in alzheimer's disease. |
2008-11-03 |
2023-08-12 |
mouse |
| Francisco García-Sierra, Siddhartha Mondragón-Rodríguez, Gustavo Basurto-Isla. Truncation of tau protein and its pathological significance in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 4. 2008-11-03. PMID:18688090. |
abnormal posttranslational modifications of tau protein lead it to aggregate into paired helical filaments in alzheimer's disease (ad). |
2008-11-03 |
2023-08-12 |
mouse |