| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuliana M DiMarco, Breanna N Harris, Alena V Savonenko, Paul L Sot. Acute stressors do not impair short-term memory or attention in an aged mouse model of amyloidosis. Frontiers in behavioral neuroscience. vol 17. 2023-05-30. PMID:37250187. |
memory impairment in alzheimer's disease patients is thought to be associated with the accumulation of amyloid-beta peptides and tau proteins. |
2023-05-30 |
2023-08-14 |
mouse |
| Huan-Chun Lin, Kun-Ju Lin, Kuo-Lun Huang, Shih-Hsin Chen, Tsung-Ying Ho, Chin-Chang Huang, Jung-Lung Hsu, Chiung-Chih Chang, Ing-Tsung Hsia. Visual reading for [ Frontiers in neuroscience. vol 17. 2023-05-30. PMID:37250400. |
visual reading for [ tau-targeted positron emission tomography (tau-pet) is a potential tool for the differential diagnosis of alzheimer's disease (ad) and to clarify the distribution of tau deposition. |
2023-05-30 |
2023-08-14 |
Not clear |
| Jaime Fernández Arias, Joseph Therriault, Emilie Thomas, Firoza Z Lussier, Gleb Bezgin, Cécile Tissot, Stijn Servaes, Sulantha S Mathotaarachchi, Dorothée Schoemaker, Jenna Stevenson, Nesrine Rahmouni, Min Su Kang, Vanessa Pallen, Nina Margherita Poltronetti, Yi-Ting Wang, Peter Kunach, Mira Chamoun, Kely M Quispialaya S, Paolo Vitali, Gassan Massarweh, Serge Gauthier, Maria N Rajah, Tharick Pascoal, Pedro Rosa-Net. Verbal memory formation across PET-based Braak stages of tau accumulation in Alzheimer's disease. Brain communications. vol 5. issue 3. 2023-05-30. PMID:37252014. |
verbal memory formation across pet-based braak stages of tau accumulation in alzheimer's disease. |
2023-05-30 |
2023-08-14 |
Not clear |
| Jaime Fernández Arias, Joseph Therriault, Emilie Thomas, Firoza Z Lussier, Gleb Bezgin, Cécile Tissot, Stijn Servaes, Sulantha S Mathotaarachchi, Dorothée Schoemaker, Jenna Stevenson, Nesrine Rahmouni, Min Su Kang, Vanessa Pallen, Nina Margherita Poltronetti, Yi-Ting Wang, Peter Kunach, Mira Chamoun, Kely M Quispialaya S, Paolo Vitali, Gassan Massarweh, Serge Gauthier, Maria N Rajah, Tharick Pascoal, Pedro Rosa-Net. Verbal memory formation across PET-based Braak stages of tau accumulation in Alzheimer's disease. Brain communications. vol 5. issue 3. 2023-05-30. PMID:37252014. |
a classical early sign of typical alzheimer's disease is memory decline, which has been linked to the aggregation of tau in the medial temporal lobe. |
2023-05-30 |
2023-08-14 |
Not clear |
| Jon-Anders Tunold, Manuela M X Tan, Shunsuke Koga, Hanneke Geut, Annemieke J M Rozemuller, Rebecca Valentino, Hiroaki Sekiya, Nicholas B Martin, Michael G Heckman, Jose Bras, Rita Guerreiro, Dennis W Dickson, Mathias Toft, Wilma van de Berg, Owen A Ross, Lasse Pihlstrø. Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease. Brain : a journal of neurology. 2023-05-29. PMID:37247383. |
using summary statistics from parkinson's disease and alzheimer's disease genome wide association studies we calculated polygenic risk scores and investigated the relationship with lewy, amyloid-β, and tau pathology. |
2023-05-29 |
2023-08-14 |
Not clear |
| Jon-Anders Tunold, Manuela M X Tan, Shunsuke Koga, Hanneke Geut, Annemieke J M Rozemuller, Rebecca Valentino, Hiroaki Sekiya, Nicholas B Martin, Michael G Heckman, Jose Bras, Rita Guerreiro, Dennis W Dickson, Mathias Toft, Wilma van de Berg, Owen A Ross, Lasse Pihlstrø. Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease. Brain : a journal of neurology. 2023-05-29. PMID:37247383. |
in an ordinal logistic regression model the alzheimer's disease polygenic risk score was associated with concomitant amyloid-β and tau pathology in both cohorts. |
2023-05-29 |
2023-08-14 |
Not clear |
| Petrice M Cogswell, Emily S Lundt, Terry M Therneau, Carly T Mester, Heather J Wiste, Jonathan Graff-Radford, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Robert I Reid, Scott A Przybelski, David S Knopman, Prashanthi Vemuri, Ronald C Petersen, Clifford R Jac. Evidence against a temporal association between cerebrovascular disease and Alzheimer's disease imaging biomarkers. Nature communications. vol 14. issue 1. 2023-05-29. PMID:37248223. |
we investigate the relationship of disease trajectories of cerebrovascular disease (white matter hyperintensity, wmh, and fractional anisotropy, fa) and alzheimer's disease (amyloid and tau pet) biomarkers in 2406 mayo clinic study of aging and mayo alzheimer's disease research center participants using accelerated failure time models. |
2023-05-29 |
2023-08-14 |
human |
| Bruna Bellaver, Guilherme Povala, Pamela C L Ferreira, João Pedro Ferrari-Souza, Douglas T Leffa, Firoza Z Lussier, Andréa L Benedet, Nicholas J Ashton, Gallen Triana-Baltzer, Hartmuth C Kolb, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar L Lopez, Dana L Tudorascu, Victor L Villemagne, Milos D Ikonomovic, Serge Gauthier, Eduardo R Zimmer, Henrik Zetterberg, Kaj Blennow, Howard J Aizenstein, William E Klunk, Beth E Snitz, Pauline Maki, Rebecca C Thurston, Ann D Cohen, Mary Ganguli, Thomas K Karikari, Pedro Rosa-Neto, Tharick A Pascoa. Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease. Nature medicine. 2023-05-29. PMID:37248300. |
astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical alzheimer's disease. |
2023-05-29 |
2023-08-14 |
Not clear |
| Bruna Bellaver, Guilherme Povala, Pamela C L Ferreira, João Pedro Ferrari-Souza, Douglas T Leffa, Firoza Z Lussier, Andréa L Benedet, Nicholas J Ashton, Gallen Triana-Baltzer, Hartmuth C Kolb, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Nesrine Rahmouni, Oscar L Lopez, Dana L Tudorascu, Victor L Villemagne, Milos D Ikonomovic, Serge Gauthier, Eduardo R Zimmer, Henrik Zetterberg, Kaj Blennow, Howard J Aizenstein, William E Klunk, Beth E Snitz, Pauline Maki, Rebecca C Thurston, Ann D Cohen, Mary Ganguli, Thomas K Karikari, Pedro Rosa-Neto, Tharick A Pascoa. Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease. Nature medicine. 2023-05-29. PMID:37248300. |
an unresolved question for the understanding of alzheimer's disease (ad) pathophysiology is why a significant percentage of amyloid-β (aβ)-positive cognitively unimpaired (cu) individuals do not develop detectable downstream tau pathology and, consequently, clinical deterioration. |
2023-05-29 |
2023-08-14 |
Not clear |
| Brian Sheng Yep Yeo, Jin Hean Koh, Adele Chin Wei Ng, Shaun Loh, Anna See, Dennis Chuen Chai Seow, Song Tar To. The association of obstructive sleep apnea with blood and cerebrospinal fluid biomarkers of Alzheimer's dementia - A systematic review and meta-analysis. Sleep medicine reviews. vol 70. 2023-05-28. PMID:37245474. |
alzheimer's disease (ad) is the most common type of dementia and is characterized by the aggregation of extracellular amyloid-beta and intracellular hyperphosphorylation of tau proteins. |
2023-05-28 |
2023-08-14 |
Not clear |
| Kenneth Maies. Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238686. |
critical insight into and modulation of these complex pathways are required since mtor signaling pathways, such as ampk activation, can improve memory retention in alzheimer's disease (ad) and dm, promote healthy aging, facilitate clearance of β-amyloid (aß) and tau in the brain, and control inflammation, but also may lead to cognitive loss and long-covid syndrome through mechanisms that can include oxidative stress, mitochondrial dysfunction, cytokine release, and apoe-ε4 if pathways such as autophagy and other mechanisms of programmed cell death are left unchecked. |
2023-05-27 |
2023-08-14 |
Not clear |
| Rawan Tarawne. Microvascular Contributions to Alzheimer Disease Pathogenesis: Is Alzheimer Disease Primarily an Endotheliopathy? Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238700. |
alzheimer disease (ad) models are based on the notion that abnormal protein aggregation is the primary event in ad, which begins a decade or longer prior to symptom onset, and culminates in neurodegeneration; however, emerging evidence from animal and clinical studies suggests that reduced blood flow due to capillary loss and endothelial dysfunction are early and primary events in ad pathogenesis, which may precede amyloid and tau aggregation, and contribute to neuronal and synaptic injury via direct and indirect mechanisms. |
2023-05-27 |
2023-08-14 |
Not clear |
| Pengxu We. Ultra-Early Screening of Cognitive Decline Due to Alzheimer's Pathology. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37239094. |
alzheimer's pathology can be assessed and defined via aβ and tau biomarkers. |
2023-05-27 |
2023-08-14 |
Not clear |
| Tatyana Shulyatnikova, Melvin R Hayde. Why Are Perivascular Spaces Important? Medicina (Kaunas, Lithuania). vol 59. issue 5. 2023-05-27. PMID:37241149. |
metabolic waste includes misfolded proteins of amyloid beta and tau that are known to accumulate in late-onset alzheimer's disease (load) within the interstitial fluid that is delivered to the subarachnoid space and eventually the cerebral spinal fluid (csf). |
2023-05-27 |
2023-08-14 |
Not clear |
| Hidekazu Hiroak. Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges. Biophysics and physicobiology. vol 20. issue 1. 2023-05-26. PMID:37234855. |
there are two major hypotheses for the pathogenesis of alzheimer's dementia: the β-amyloid (aβ) hypothesis and the tau hypothesis. |
2023-05-26 |
2023-08-14 |
Not clear |
| Richard A Hartz, Vijay T Ahuja, Guanglin Luo, Ling Chen, Prasanna Sivaprakasam, Hong Xiao, Carol M Krause, Wendy J Clarke, Songmei Xu, John S Tokarski, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R Burton, John E Macor, Gene M Dubowchi. Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. Journal of medicinal chemistry. 2023-05-26. PMID:37235865. |
there is considerable evidence indicating that gsk-3β in the central nervous system plays a role in the production of abnormal, hyperphosphorylated, microtubule-associated tau protein found in neurofibrillary tangles associated with alzheimer's disease. |
2023-05-26 |
2023-08-14 |
Not clear |
| Gregory E Merz, Matthew J Chalkley, Sophia K Tan, Eric Tse, Joanne Lee, Stanley B Prusiner, Nick A Paras, William F DeGrado, Daniel R Southwort. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nature communications. vol 14. issue 1. 2023-05-26. PMID:37236970. |
stacked binding of a pet ligand to alzheimer's tau paired helical filaments. |
2023-05-26 |
2023-08-14 |
Not clear |
| Gregory E Merz, Matthew J Chalkley, Sophia K Tan, Eric Tse, Joanne Lee, Stanley B Prusiner, Nick A Paras, William F DeGrado, Daniel R Southwort. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nature communications. vol 14. issue 1. 2023-05-26. PMID:37236970. |
accumulation of filamentous aggregates of tau protein in the brain is a pathological hallmark of alzheimer's disease (ad) and many other neurodegenerative tauopathies. |
2023-05-26 |
2023-08-14 |
Not clear |
| Isobel Leak. Oligomeric tau might spread trans-synaptically in Alzheimer disease. Nature reviews. Neuroscience. 2023-05-26. PMID:37237104. |
oligomeric tau might spread trans-synaptically in alzheimer disease. |
2023-05-26 |
2023-08-14 |
Not clear |
| Jingshan Chen, Xue Zhao, Wenyan Zhang, Tianxiang Zhang, Siting Wu, Jinghao Shao, Fu-Dong Sh. Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment. Alzheimer's research & therapy. vol 15. issue 1. 2023-05-26. PMID:37237388. |
plasma amyloid-β (aβ) peptides and tau proteins are promising biomarkers of alzheimer's disease (ad), not only for predicting aβ and tau pathology but also for differentiating ad from other neurodegenerative diseases. |
2023-05-26 |
2023-08-14 |
Not clear |