| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Hu, Jeffrey F Waring, Murali Gopalakrishnan, Jinhe L. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. Journal of neurochemistry. vol 106. issue 3. 2008-09-15. PMID:18485099. |
beta-amyloid peptide 1-42 (abeta(1-42)) and hyperphosphorylated tau are associated with neurodegeneration in alzheimer's disease. |
2008-09-15 |
2023-08-12 |
mouse |
| Min Hu, Jeffrey F Waring, Murali Gopalakrishnan, Jinhe L. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. Journal of neurochemistry. vol 106. issue 3. 2008-09-15. PMID:18485099. |
this study provides evidence of nachr mechanisms underlying abeta(1-42) toxicity and tau phosphorylation, which, if translated in vivo, could provide additional basis for the utility of alpha7 nachr ligands in the treatment of alzheimer's disease. |
2008-09-15 |
2023-08-12 |
mouse |
| Mohamed Ali Smach, Bassem Charfeddine, Turkia Lammouchi, Imed Harrabi, Leila Ben Othman, Hedi Dridi, Soufien Bennamou, Khalifa Lime. CSF beta-amyloid 1-42 and tau in Tunisian patients with Alzheimer's disease: the effect of APOE epsilon4 allele. Neuroscience letters. vol 440. issue 2. 2008-09-15. PMID:18555606. |
csf beta-amyloid 1-42 and tau in tunisian patients with alzheimer's disease: the effect of apoe epsilon4 allele. |
2008-09-15 |
2023-08-12 |
human |
| Huiping Ding, Gail V W Johnso. New application of beta-galactosidase complementation to monitor tau self-association. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18498442. |
neurofibrillary tangles composed of hyperphosphorylated and aberrantly cleaved microtubule-associated protein tau are a major neuropathological hallmark of alzheimer's disease. |
2008-09-12 |
2023-08-12 |
human |
| Chun-Hui Yu, Tong Si, Wei-Hui Wu, Jia Hu, Jin-Tang Du, Yu-Fen Zhao, Yan-Mei L. O-GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau. Biochemical and biophysical research communications. vol 375. issue 1. 2008-09-09. PMID:18671940. |
in alzheimer's disease (ad), tau protein is abnormally hyperphosphorylated and aggregated into paired helical filaments (phfs). |
2008-09-09 |
2023-08-12 |
human |
| Chiho Hirata-Fukae, Hui-Fang Li, Hyang-Sook Hoe, Audrey J Gray, S Sakura Minami, Katsuyoshi Hamada, Takako Niikura, Fang Hua, Hiroe Tsukagoshi-Nagai, Yuko Horikoshi-Sakuraba, Mohamed Mughal, G William Rebeck, Frank M LaFerla, Mark P Mattson, Nobuhisa Iwata, Takaomi C Saido, William L Klein, Karen E Duff, Paul S Aisen, Yasuji Matsuok. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain research. vol 1216. 2008-09-08. PMID:18486110. |
females exhibit more extensive amyloid, but not tau, pathology in an alzheimer transgenic model. |
2008-09-08 |
2023-08-12 |
mouse |
| Min Liu, Sungwoon Choi, Gregory D Cuny, Kai Ding, Brittany C Dobson, Marcie A Glicksman, Ken Auerbach, Ross L Stei. Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. Biochemistry. vol 47. issue 32. 2008-09-02. PMID:18636751. |
cdk5/p25 is a member of the family of cyclin-dependent, ser/thr kinases and is thought to play a causal role in alzheimer's disease (ad) due to its ability to phosphorylate the protein tau, and thus promote the latter's aggregation into intraneuronal tangles. |
2008-09-02 |
2023-08-12 |
Not clear |
| Mun'delanji Vestergaard, Kagan Kerman, Do-Kyun Kim, Minh Hiep Ha, Eiichi Tamiy. Detection of Alzheimer's tau protein using localised surface plasmon resonance-based immunochip. Talanta. vol 74. issue 4. 2008-08-26. PMID:18371746. |
detection of alzheimer's tau protein using localised surface plasmon resonance-based immunochip. |
2008-08-26 |
2023-08-12 |
cattle |
| Lewis H Kuller, Oscar L Lope. Dementia: is it time for a change in focus? Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 4. issue 1 Suppl 1. 2008-08-26. PMID:18632006. |
ad and dementia research has matured since the inception of the alzheimer's disease center program from a primary social service problem to clinical-pathologic correlates and better definition of disease to evaluation of measures of cognition, in vivo images of the brain, and then to measures of beta amyloid and tau in vivo and relationship to clinical dementia. |
2008-08-26 |
2023-08-12 |
Not clear |
| Masaki Hattori, Etsuko Sugino, Katsuhiko Minoura, Yasuko In, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishid. Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain. Biochemical and biophysical research communications. vol 374. issue 1. 2008-08-25. PMID:18619417. |
one of the priorities in alzheimer research is to develop a compound that inhibits the filament formation of tau protein. |
2008-08-25 |
2023-08-12 |
Not clear |
| H Zetterberg, U Rüetschi, E Portelius, G Brinkmalm, U Andreasson, K Blennow, A Brinkmal. Clinical proteomics in neurodegenerative disorders. Acta neurologica Scandinavica. vol 118. issue 1. 2008-08-21. PMID:18279484. |
a triplet of biomarkers for alzheimer's disease (ad), total and hyperphosphorylated tau and the 42 amino acid isoform of beta-amyloid, has already been established for early detection of ad before the onset of dementia. |
2008-08-21 |
2023-08-12 |
Not clear |
| Rosa Resende, Elisabete Ferreiro, Cláudia Pereira, Catarina Resende Oliveir. ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation. Journal of neuroscience research. vol 86. issue 9. 2008-08-20. PMID:18335524. |
intracellular neurofibrillary tangles, one of the characteristic hallmarks of alzheimer's disease (ad), are mainly composed of hyperphosphorylated tau. |
2008-08-20 |
2023-08-12 |
Not clear |
| Naruhiko Sahara, Miyuki Murayama, Boyoung Lee, Jung-Mi Park, Sarita Lagalwar, Lester I Binder, Akihiko Takashim. Active c-jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3beta is required for tau aggregation. The European journal of neuroscience. vol 27. issue 11. 2008-08-20. PMID:18540881. |
neurofibrillary tangles (nfts), comprising human intracellular microtubule-associated protein tau, are one of the hallmarks of tauopathies, including alzheimer's disease. |
2008-08-20 |
2023-08-12 |
human |
| Irving E Vega, Edwin E Traverso, Yancy Ferrer-Acosta, Eduardo Matos, Migdalisel Colon, John Gonzalez, Dennis Dickson, Michael Hutton, Jada Lewis, Shu H Ye. A novel calcium-binding protein is associated with tau proteins in tauopathy. Journal of neurochemistry. vol 106. issue 1. 2008-08-19. PMID:18346207. |
finally, the association between tau and the novel calcium-binding protein is conserved in human and enriched in alzheimer's disease brain. |
2008-08-19 |
2023-08-12 |
mouse |
| Thomas Timm, Kiruthiga Balusamy, Xiaoyu Li, Jacek Biernat, Eckhard Mandelkow, Eva-Maria Mandelko. Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2. The Journal of biological chemistry. vol 283. issue 27. 2008-08-19. PMID:18424437. |
because of its role in abnormal phosphorylation of the tau protein in alzheimer disease, we searched for regulatory kinases. |
2008-08-19 |
2023-08-12 |
Not clear |
| Thomas Timm, Kiruthiga Balusamy, Xiaoyu Li, Jacek Biernat, Eckhard Mandelkow, Eva-Maria Mandelko. Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2. The Journal of biological chemistry. vol 283. issue 27. 2008-08-19. PMID:18424437. |
because gsk3beta can also phosphorylate tau at sites outside the repeat domain, the activation of gsk3beta, and concomitant inactivation of mark can shift the pattern of pathological phosphorylation of tau protein in alzheimer disease. |
2008-08-19 |
2023-08-12 |
Not clear |
| Seung Yong Yoon, Jung Eun Choi, Jin Myung Choi, Dong Hou Ki. Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons. Neuroscience letters. vol 437. issue 2. 2008-08-18. PMID:18448253. |
impairment of protein phosphatase 2a (pp2a) activity is implicated in tau hyperphosphorylation and microtubule (mt) instability in alzheimer's disease (ad). |
2008-08-18 |
2023-08-12 |
rat |
| Adam R Cole, Marc P M Soutar, Makoto Rembutsu, Lidy van Aalten, C James Hastie, Hilary McLauchlan, Mark Peggie, Martin Balastik, Kun Ping Lu, Calum Sutherlan. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. The Journal of biological chemistry. vol 283. issue 26. 2008-08-18. PMID:18460467. |
we propose that relative resistance to phosphatases might be a common feature of cdk5 substrates and could contribute to the hyperphosphorylation of crmp2 and tau observed in alzheimer disease. |
2008-08-18 |
2023-08-12 |
mouse |
| C Hugh Reynolds, Claire J Garwood, Selina Wray, Caroline Price, Stuart Kellie, Timothy Perera, Marketa Zvelebil, Alice Yang, Paul W Sheppard, Ian M Varndell, Diane P Hanger, Brian H Anderto. Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. The Journal of biological chemistry. vol 283. issue 26. 2008-08-18. PMID:18467332. |
tau is well known to aggregate to form hyperphosphorylated filamentous deposits in several neurodegenerative diseases (tauopathies) including alzheimer disease. |
2008-08-18 |
2023-08-12 |
Not clear |
| C Hugh Reynolds, Claire J Garwood, Selina Wray, Caroline Price, Stuart Kellie, Timothy Perera, Marketa Zvelebil, Alice Yang, Paul W Sheppard, Ian M Varndell, Diane P Hanger, Brian H Anderto. Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. The Journal of biological chemistry. vol 283. issue 26. 2008-08-18. PMID:18467332. |
after phosphorylation in vitro or in transfected cells, tau showed reduced binding to sh3 domains; no binding was detected with hyperphosphorylated tau isolated from alzheimer brain, but sh3 binding was restored by phosphatase treatment. |
2008-08-18 |
2023-08-12 |
Not clear |