| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jormay Lim, Martin Balastik, Tae Ho Lee, Kazuhiro Nakamura, Yih-Cherng Liou, Anyang Sun, Greg Finn, Lucia Pastorino, Virginia M-Y Lee, Kun Ping L. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. The Journal of clinical investigation. vol 118. issue 5. 2008-07-01. PMID:18431510. |
tau pathology is a hallmark of many neurodegenerative diseases including alzheimer disease (ad) and frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2008-07-01 |
2023-08-12 |
mouse |
| Sachio Matsushita, Tomohiro Miyakawa, Hitoshi Maesato, Toshifumi Matsui, Akira Yokoyama, Hiroyuki Arai, Susumu Higuchi, Haruo Kashim. Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathy. Alcoholism, clinical and experimental research. vol 32. issue 6. 2008-07-01. PMID:18445112. |
we also examined csf total tau in nonalcohol dependent patients with alzheimer's disease (ad) as a disease control. |
2008-07-01 |
2023-08-12 |
Not clear |
| Ovidiu C Andronesi, Martin von Bergen, Jacek Biernat, Karsten Seidel, Christian Griesinger, Eckhard Mandelkow, Marc Baldu. Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy. Journal of the American Chemical Society. vol 130. issue 18. 2008-06-23. PMID:18386894. |
the polymerization of the microtubule-associated protein tau into paired helical filaments (phfs) represents one of the hallmarks of alzheimer's disease. |
2008-06-23 |
2023-08-12 |
Not clear |
| Ovidiu C Andronesi, Martin von Bergen, Jacek Biernat, Karsten Seidel, Christian Griesinger, Eckhard Mandelkow, Marc Baldu. Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy. Journal of the American Chemical Society. vol 130. issue 18. 2008-06-23. PMID:18386894. |
we employed solid-state nuclear magnetic resonance (nmr) to investigate the structure and dynamics of phfs formed in vitro by the three-repeat-domain (k19) of protein tau, representing the core of alzheimer phfs. |
2008-06-23 |
2023-08-12 |
Not clear |
| Gustavo Basurto-Islas, Jose Luna-Muñoz, Angela L Guillozet-Bongaarts, Lester I Binder, Raul Mena, Francisco García-Sierr. Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 67. issue 5. 2008-06-20. PMID:18431250. |
accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in alzheimer disease. |
2008-06-20 |
2023-08-12 |
Not clear |
| Gustavo Basurto-Islas, Jose Luna-Muñoz, Angela L Guillozet-Bongaarts, Lester I Binder, Raul Mena, Francisco García-Sierr. Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 67. issue 5. 2008-06-20. PMID:18431250. |
truncations of tau protein at aspartic acid421 (d421) and glutamic acid391 (e391) residues are associated with neurofibrillary tangles (nfts) in the brains of alzheimer disease (ad) patients. |
2008-06-20 |
2023-08-12 |
Not clear |
| Ismael Santa-Mara, Gabriel Santpere, Michael J MacDonald, Elena Gomez de Barreda, Felix Hernandez, Francisco J Moreno, Isidro Ferrer, Jesús Avil. Coenzyme q induces tau aggregation, tau filaments, and Hirano bodies. Journal of neuropathology and experimental neurology. vol 67. issue 5. 2008-06-20. PMID:18431254. |
tau aggregation is a common feature of tauopathies such as alzheimer disease (ad). |
2008-06-20 |
2023-08-12 |
Not clear |
| Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Jon Infante, Carlos Fernández-Viadero, Nicolás Peña, José Berciano, Onofre Combarro. 14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 25. issue 4. 2008-06-17. PMID:18319590. |
14-3-3 zeta and tau genes interactively decrease alzheimer's disease risk. |
2008-06-17 |
2023-08-12 |
human |
| Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Jon Infante, Carlos Fernández-Viadero, Nicolás Peña, José Berciano, Onofre Combarro. 14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 25. issue 4. 2008-06-17. PMID:18319590. |
abnormal tau hyperphosphorylation has been suggested as being one of the central events in the development of neurofibrillary tangles, which are one of the characteristic neuropathological lesions found in alzheimer's disease (ad) brains. |
2008-06-17 |
2023-08-12 |
human |
| Jie Zhou, Juan Chen, Youmei Fen. Effect of truncated-ApoE4 overexpression on tau phosphorylation in cultured N2a cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 3. 2008-06-16. PMID:16961266. |
it was concluded that in vitro overexpression of truncated-apoe4 (delta272-299) can result in tau hyperphosphorylation in n2a cells by activating gsk-3, suggesting truncated-apoe4 (delta272-299) might contribute the pathogenesis of alzheimer disease. |
2008-06-16 |
2023-08-12 |
Not clear |
| Z Wei, M S Song, D MacTavish, J H Jhamandas, S Ka. Role of calpain and caspase in beta-amyloid-induced cell death in rat primary septal cultured neurons. Neuropharmacology. vol 54. issue 4. 2008-06-12. PMID:18222494. |
the invariant characteristic features associated with alzheimer's disease (ad) brain include the presence of extracellular neuritic plaques composed of amyloid beta (abeta) peptide, intracellular neurofibrillary tangles containing hyper-phosphorylated tau protein and the loss of basal forebrain cholinergic neurons. |
2008-06-12 |
2023-08-12 |
rat |
| John C Steele, Patrick L McGee. The ALS/PDC syndrome of Guam and the cycad hypothesis. Neurology. vol 70. issue 21. 2008-06-12. PMID:18490618. |
this includes induction of neurofibrillary tangles with a tau isoform distribution similar to that of alzheimer disease and association of the lesions with tdp-43 and lrrk2. |
2008-06-12 |
2023-08-12 |
Not clear |
| Leslie M Kleva. Alzheimer's disease as copper deficiency. Medical hypotheses. vol 70. issue 4. 2008-06-10. PMID:17928161. |
decreased cognition and increased tau in cerebrospinal fluid in alzheimer's disease also are associated with low copper status. |
2008-06-10 |
2023-08-12 |
Not clear |
| She Chen, Bin Li, Inge Grundke-Iqbal, Khalid Iqba. I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. The Journal of biological chemistry. vol 283. issue 16. 2008-06-10. PMID:18245083. |
in alzheimer disease (ad) brain, the level of i (1)(pp2a), a 249-amino acid long endogenous inhibitor of protein phosphatase 2a (pp2a), is increased, the activity of the phosphatase is decreased, and the microtubule-associated protein tau is abnormally hyperphosphorylated. |
2008-06-10 |
2023-08-12 |
Not clear |
| Tadanori Hamano, Tania F Gendron, Ena Causevic, Shu-Hui Yen, Wen-Lang Lin, Ciro Isidoro, Michael Deture, Li-wen K. Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression. The European journal of neuroscience. vol 27. issue 5. 2008-06-03. PMID:18294209. |
the intracellular assembly of tau aggregates is a pathological hallmark shared by alzheimer's disease and other neurodegenerative disorders known collectively as tauopathies. |
2008-06-03 |
2023-08-12 |
human |
| Kayoko Okuyama, Chisato Nishiura, Fumie Mizushima, Katsuhiko Minoura, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishid. Linkage-dependent contribution of repeat peptides to self-aggregation of three- or four-repeat microtubule-binding domains in tau protein. The FEBS journal. vol 275. issue 7. 2008-06-03. PMID:18312411. |
although one of the priorities in alzheimer's research is to clarify the filament formation mechanism for the tau protein, it is still unclear how it is transformed from a normal structure in a neuron. |
2008-06-03 |
2023-08-12 |
Not clear |
| Tamar Amit, Yael Avramovich-Tirosh, Moussa B H Youdim, Silvia Mande. Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 5. 2008-05-28. PMID:18048580. |
dysregulation of brain iron homeostasis is central to early neuropathological events in alzheimer's disease (ad), including oxidative stress, inflammatory processes, amyloid deposition, tau phosphorylation, and neuronal cell cycle regulatory failure, leading to apoptosis. |
2008-05-28 |
2023-08-12 |
Not clear |
| Martyna Songin, Henryk Jeśko, Grzegorz Czapski, Agata Adamczyk, Robert P Strosznajde. GSK-3beta and oxidative stress in aged brain. Role of poly(ADP- -ribose) polymerase-1. Folia neuropathologica. vol 45. issue 4. 2008-05-20. PMID:18176896. |
in alzheimer's disease it is responsible for hyperphosphorylation of tau. |
2008-05-20 |
2023-08-12 |
rat |
| Mirko Bibl, Brit Mollenhauer, Hermann Esselmann, Michael Schneider, Piotr Lewczuk, Volker Welge, Martin Gross, Peter Falkai, Johannes Kornhuber, Jens Wiltfan. Cerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review. Dementia and geriatric cognitive disorders. vol 25. issue 3. 2008-05-20. PMID:18270488. |
the study evaluated the patterns of cerebrospinal fluid (csf), amyloid-beta (abeta) peptides, total tau and phospho-tau among alzheimer's disease (ad) and vascular dementias (vad). |
2008-05-20 |
2023-08-12 |
Not clear |
| T Engel, P Goñi-Oliver, E Gómez de Barreda, J J Lucas, F Hernández, J Avil. Lithium, a potential protective drug in Alzheimer's disease. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322403. |
since a main tau kinase is glycogen synthase kinase 3 (gsk-3), the use of specific gsk-3 inhibitors, like lithium, could be a potential therapy in alzheimer's disease. |
2008-05-15 |
2023-08-12 |
Not clear |