| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Takahashi, C Uchida, R-W Shin, K Shimazaki, T Uchid. Prolyl isomerase, Pin1: new findings of post-translational modifications and physiological substrates in cancer, asthma and Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 65. issue 3. 2008-04-22. PMID:17965833. |
pin1 has been identified as the molecular partner of tau and amyloid precursor protein (app), the key factors of alzheimer's disease (ad). |
2008-04-22 |
2023-08-12 |
mouse |
| Yasuji Matsuoka, Yan Jouroukhin, Audrey J Gray, Li Ma, Chiho Hirata-Fukae, Hui-Fang Li, Li Feng, Laurent Lecanu, Benjamin R Walker, Emmanuel Planel, Ottavio Arancio, Illana Gozes, Paul S Aise. A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. The Journal of pharmacology and experimental therapeutics. vol 325. issue 1. 2008-04-22. PMID:18199809. |
a neuronal microtubule-interacting agent, napvsipq, reduces tau pathology and enhances cognitive function in a mouse model of alzheimer's disease. |
2008-04-22 |
2023-08-12 |
mouse |
| Yasuji Matsuoka, Yan Jouroukhin, Audrey J Gray, Li Ma, Chiho Hirata-Fukae, Hui-Fang Li, Li Feng, Laurent Lecanu, Benjamin R Walker, Emmanuel Planel, Ottavio Arancio, Illana Gozes, Paul S Aise. A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. The Journal of pharmacology and experimental therapeutics. vol 325. issue 1. 2008-04-22. PMID:18199809. |
neurofibrillary tangles composed of aggregated, hyperphosphorylated tau in an abnormal conformation represent one of the major pathological hallmarks of alzheimer's disease (ad) and other tauopathies. |
2008-04-22 |
2023-08-12 |
mouse |
| Chad A Dickey, John Koren, Yong-Jie Zhang, Ya-Fei Xu, Umesh K Jinwal, Morris J Birnbaum, Bobby Monks, Mei Sun, Jin Q Cheng, Cam Patterson, Rachel M Bailey, Judith Dunmore, Sareh Soresh, Carlos Leon, Dave Morgan, Leonard Petrucell. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18292230. |
a hallmark of the pathology of alzheimer's disease is the accumulation of the microtubule-associated protein tau into fibrillar aggregates. |
2008-04-18 |
2023-08-12 |
mouse |
| Chad A Dickey, John Koren, Yong-Jie Zhang, Ya-Fei Xu, Umesh K Jinwal, Morris J Birnbaum, Bobby Monks, Mei Sun, Jin Q Cheng, Cam Patterson, Rachel M Bailey, Judith Dunmore, Sareh Soresh, Carlos Leon, Dave Morgan, Leonard Petrucell. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18292230. |
hence, akt serves as a major regulator of tau biology by manipulating both tau kinases and protein quality control, providing a link to several common pathways that have demonstrated dysfunction in alzheimer's disease. |
2008-04-18 |
2023-08-12 |
mouse |
| Neeru Gupta, Jessica Fong, Lee C Ang, Yeni H Yüce. Retinal tau pathology in human glaucomas. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie. vol 43. issue 1. 2008-04-17. PMID:18219347. |
the abnormal hyperphosphorylated tau protein at8 disrupts microtubules, interferes with axonal transport, and is associated with neuron injury in neurodegenerative diseases such as alzheimer's disease. |
2008-04-17 |
2023-08-12 |
human |
| Siddhartha Mondragón-Rodríguez, Gustavo Basurto-Islas, Ismael Santa-Maria, Raúl Mena, Lester I Binder, Jesús Avila, Mark A Smith, George Perry, Francisco García-Sierr. Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease. International journal of experimental pathology. vol 89. issue 2. 2008-04-15. PMID:18336525. |
cleavage and conformational changes of tau protein follow phosphorylation during alzheimer's disease. |
2008-04-15 |
2023-08-12 |
mouse |
| Siddhartha Mondragón-Rodríguez, Gustavo Basurto-Islas, Ismael Santa-Maria, Raúl Mena, Lester I Binder, Jesús Avila, Mark A Smith, George Perry, Francisco García-Sierr. Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease. International journal of experimental pathology. vol 89. issue 2. 2008-04-15. PMID:18336525. |
phosphorylation, cleavage and conformational changes in tau protein all play pivotal roles during alzheimer's disease (ad). |
2008-04-15 |
2023-08-12 |
mouse |
| Shinji Higashi, Eizo Iseki, Ryoko Yamamoto, Michiko Minegishi, Hiroaki Hino, Koshiro Fujisawa, Takashi Togo, Omi Katsuse, Hirotake Uchikado, Yoshiko Furukawa, Kenji Kosaka, Heii Ara. Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies. Brain research. vol 1184. 2008-04-08. PMID:17963732. |
concurrence of tdp-43, tau and alpha-synuclein pathology in brains of alzheimer's disease and dementia with lewy bodies. |
2008-04-08 |
2023-08-12 |
Not clear |
| Yi Wen, Emmanuel Planel, Mathieu Herman, Helen Y Figueroa, Lili Wang, Li Liu, Lit-Fui Lau, Wai Haung Yu, Karen E Duf. Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 10. 2008-04-07. PMID:18322105. |
cyclin-dependent kinase 5 (cdk5) and glycogen synthase kinase 3beta (gsk3beta) have been implicated in pathogenic processes associated with alzheimer's disease because both kinases regulate tau hyperphosphorylation and enhance amyloid precursor protein (app) processing leading to an increase in amyloid beta (abeta) production. |
2008-04-07 |
2023-08-12 |
mouse |
| I Mateo, J Llorca, J Infante, E Rodríguez-Rodríguez, J Berciano, O Combarro. Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk. European journal of neurology. vol 15. issue 3. 2008-04-03. PMID:18290843. |
a loss in the regulatory mechanism that controls tau phosphorylation in normal brain is suggested to cause tau hyperphosphorylation in alzheimer's disease (ad) brain and the development of neurofibrillary tangles (nft). |
2008-04-03 |
2023-08-12 |
human |
| Patrice Delobel, Isabelle Lavenir, Graham Fraser, Esther Ingram, Max Holzer, Bernardino Ghetti, Maria Grazia Spillantini, R Anthony Crowther, Michel Goeder. Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy. The American journal of pathology. vol 172. issue 1. 2008-04-02. PMID:18079436. |
recent evidence has suggested that truncation of tau protein at the caspase cleavage site d421 precedes hyperphosphorylation and may be necessary for the assembly of tau into filaments in alzheimer's disease and other tauopathies. |
2008-04-02 |
2023-08-12 |
mouse |
| Xin-Wen Zhou, Heikki Tanila, Jin-Jing Pe. Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction. FEBS letters. vol 582. issue 2. 2008-04-01. PMID:18068129. |
our results suggest that the abeta deposition in senile plaques in alzheimer disease brains might be a primary event that activates p70s6k and phosphorylates tau at s262, resulting in microtubule disruption. |
2008-04-01 |
2023-08-12 |
mouse |
| Ying Liu, Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gon. Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease. FEBS letters. vol 582. issue 2. 2008-04-01. PMID:18174027. |
decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in alzheimer disease. |
2008-04-01 |
2023-08-12 |
human |
| Christopher Exle. Aluminium, tau and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198417. |
aluminium, tau and alzheimer's disease. |
2008-03-25 |
2023-08-12 |
Not clear |
| José Luna-Muñoz, Laura Chávez-Macías, Francisco García-Sierra, Raúl Men. Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho-dependent tau epitopes in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198423. |
earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho-dependent tau epitopes in alzheimer's disease. |
2008-03-25 |
2023-08-12 |
Not clear |
| Cyntia Tremblay, Mireille Pilote, Alix Phivilay, Vincent Emond, David A Bennett, Frédéric Calo. Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198424. |
biochemical characterization of abeta and tau pathologies in mild cognitive impairment and alzheimer's disease. |
2008-03-25 |
2023-08-12 |
human |
| Cyntia Tremblay, Mireille Pilote, Alix Phivilay, Vincent Emond, David A Bennett, Frédéric Calo. Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198424. |
we report a post mortem biochemical analysis of amyloid-beta (abeta) (elisa) and tau (western immunoblots) in the temporo-parietal neocortex of subjects with a clinical diagnosis of mild cognitive impairment (mci, n=12), alzheimer's disease (ad, n=12) or no cognitive impairment (nci, n=12). |
2008-03-25 |
2023-08-12 |
human |
| Inna Khlistunova, Marcus Pickhardt, Jacek Biernat, Yipeng Wang, Eva-Maria Mandelkow, Eckhard Mandelko. Inhibition of tau aggregation in cell models of tauopathy. Current Alzheimer research. vol 4. issue 5. 2008-03-21. PMID:18220518. |
the pathological aggregation of tau into paired helical filaments is a hallmark of several neurodegenerative diseases, including alzheimer's disease. |
2008-03-21 |
2023-08-12 |
Not clear |
| Marcie A Glicksman, Gregory D Cuny, Min Liu, Brittany Dobson, Kenneth Auerbach, Ross L Stein, Kenneth S Kosi. New approaches to the discovery of cdk5 inhibitors. Current Alzheimer research. vol 4. issue 5. 2008-03-21. PMID:18220519. |
among its attractions is the possibility that inhibitors will prevent the pathological phosphorylation of tau and neurofibrillary pathology in both alzheimer's disease and tauopathies. |
2008-03-21 |
2023-08-12 |
Not clear |