| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sachin Patil, Joseph Melrose, Christina Cha. Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. The European journal of neuroscience. vol 26. issue 8. 2008-02-01. PMID:17908174. |
a high-fat diet has been shown to significantly increase the risk of the development of alzheimer's disease (ad), a neurodegenerative disease histochemically characterized by the accumulation of amyloid beta (abeta) protein in senile plaques and hyperphosphorylated tau in neurofibrillary tangles. |
2008-02-01 |
2023-08-12 |
rat |
| Seungyong Yoon, Jungeun Choi, Juhee Haam, Han Choe, DongHou Ki. Reduction of mint-1, mint-2, and APP overexpression in okadaic acid-treated neurons. Neuroreport. vol 18. issue 18. 2008-01-25. PMID:18007179. |
treatment of neurons with okadaic acid, a protein phosphatase-2a inhibitor, has been used to induce tau phosphorylation and neuronal death, and to create a research model of alzheimer's disease. |
2008-01-25 |
2023-08-12 |
Not clear |
| Ling-Feng Jiang, Tian-Ming Yao, Zhi-Liang Zhu, Chong Wang, Liang-Nian J. Impacts of Cd(II) on the conformation and self-aggregation of Alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain. Biochimica et biophysica acta. vol 1774. issue 11. 2008-01-24. PMID:17920001. |
impacts of cd(ii) on the conformation and self-aggregation of alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain. |
2008-01-24 |
2023-08-12 |
Not clear |
| Ling-Feng Jiang, Tian-Ming Yao, Zhi-Liang Zhu, Chong Wang, Liang-Nian J. Impacts of Cd(II) on the conformation and self-aggregation of Alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain. Biochimica et biophysica acta. vol 1774. issue 11. 2008-01-24. PMID:17920001. |
for the first time, we investigated the impacts of cd(ii) on the conformation and self-aggregation of alzheimer's tau peptide r3, corresponding to the third repeat of microtubule-binding domain. |
2008-01-24 |
2023-08-12 |
Not clear |
| Wagner B Dias, Gerald W Har. O-GlcNAc modification in diabetes and Alzheimer's disease. Molecular bioSystems. vol 3. issue 11. 2008-01-24. PMID:17940659. |
with respect to alzheimer's disease, several proteins involved in the etiology of the disease, including tau, neurofilaments, beta-amyloid precursor protein, and synaptosomal proteins are glcnacylated in normal brain. |
2008-01-24 |
2023-08-12 |
Not clear |
| Emmanuel Planel, Yoshitaka Tatebayashi, Tomohiro Miyasaka, Li Liu, Lili Wang, Mathieu Herman, W Haung Yu, Jose A Luchsinger, Brian Wadzinski, Karen E Duff, Akihiko Takashim. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 50. 2008-01-22. PMID:18077675. |
hyperphosphorylated tau is the major component of paired helical filaments in neurofibrillary tangles found in alzheimer's disease (ad) brains, and tau hyperphosphorylation is thought to be a critical event in the pathogenesis of the disease. |
2008-01-22 |
2023-08-12 |
mouse |
| M Ewers, K Buerger, S J Teipel, P Scheltens, J Schröder, R P Zinkowski, F H Bouwman, P Schönknecht, N S M Schoonenboom, N Andreasen, A Wallin, J F DeBernardis, D J Kerkman, B Heindl, K Blennow, H Hampe. Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI. Neurology. vol 69. issue 24. 2008-01-14. PMID:18071141. |
the measurement of hyperphosphorylated tau (p-tau) in csf has been proposed as a biomarker candidate for the prediction of alzheimer disease (ad) in patients with mild cognitive impairment (mci). |
2008-01-14 |
2023-08-12 |
Not clear |
| Wenkai Li, Virginia M-Y Le. Characterization of two VQIXXK motifs for tau fibrillization in vitro. Biochemistry. vol 45. issue 51. 2008-01-11. PMID:17176091. |
tau proteins are building blocks of the filaments that form neurofibrillary tangles of alzheimer's disease (ad) and related neurodegenerative tauopathies. |
2008-01-11 |
2023-08-12 |
human |
| Stéphanie Boutillier, Béatrice Lannes, Luc Buée, André Delacourte, Caroline Rouaux, Michel Mohr, Jean-Pierre Bellocq, François Sellal, Yves Larmet, Anne-Laurence Boutillier, Jean-Philippe Loeffle. Sp3 and sp4 transcription factor levels are increased in brains of patients with Alzheimer's disease. Neuro-degenerative diseases. vol 4. issue 6. 2008-01-09. PMID:17934324. |
alzheimer's disease (ad) is characterized by extracellular abeta peptide deposition originating from amyloid precursor protein cleavage and intracellular neurofibrillary tangles resulting from pathological tau protein aggregation. |
2008-01-09 |
2023-08-12 |
Not clear |
| Jesús Avila, Félix Hernánde. GSK-3 inhibitors for Alzheimer's disease. Expert review of neurotherapeutics. vol 7. issue 11. 2008-01-02. PMID:17997701. |
glycogen synthase kinase (gsk)-3 has been proposed as the link between the two histopathological hallmarks of alzheimer's disease, the extracellular senile plaques made of beta-amyloid and the intracellular neurofibrillary tangles made of hyperphosphorylated tau. |
2008-01-02 |
2023-08-12 |
Not clear |
| Chris Conrad, Jun Zhu, Cintia Conrad, David Schoenfeld, Zhide Fang, Martin Ingelsson, Stefan Stamm, George Church, Bradley T Hyma. Single molecule profiling of tau gene expression in Alzheimer's disease. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17727636. |
single molecule profiling of tau gene expression in alzheimer's disease. |
2007-12-21 |
2023-08-12 |
Not clear |
| Jin-Tang Du, Chun-Hui Yu, Lian-Xiu Zhou, Wei-Hui Wu, Peng Lei, Yong Li, Yu-Fen Zhao, Hiroshi Nakanishi, Yan-Mei L. Phosphorylation modulates the local conformation and self-aggregation ability of a peptide from the fourth tau microtubule-binding repeat. The FEBS journal. vol 274. issue 19. 2007-12-18. PMID:17725643. |
phosphorylation of tau protein modulates both its physiological role and its aggregation into paired helical fragments, as observed in alzheimer's diseased neurons. |
2007-12-18 |
2023-08-12 |
Not clear |
| Tohru Hasegaw. Prolonged stress will induce Alzheimer's disease in elderly people by increased release of homocysteic acid. Medical hypotheses. vol 69. issue 5. 2007-12-13. PMID:17499446. |
finally, the aggregated alpha-synuclein induces tau pathology, which induces cell death, leading to alzheimer's pathology. |
2007-12-13 |
2023-08-12 |
Not clear |
| Ravindran Kumaran, Ann Kingsbury, Ian Coulter, Tammaryn Lashley, David Williams, Rohan de Silva, David Mann, Tamas Revesz, Andrew Lees, Rina Bandopadhya. DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders. Neurobiology of disease. vol 28. issue 1. 2007-12-12. PMID:17719794. |
this study examines dj-1 immunoreactivity (dj-1 ir) in a variety of neurodegenerative disorders, alzheimer's disease (ad), frontotemporal lobar degeneration (ftld) with pick bodies, ftld with mapt mutations, progressive supranuclear palsy (psp) and corticobasal degeneration (cbd), in which hyperphosphorylated tau inclusions are the major pathological signature. |
2007-12-12 |
2023-08-12 |
Not clear |
| Inna Vulih-Shultzman, Albert Pinhasov, Shmuel Mandel, Nikolaos Grigoriadis, Olga Touloumi, Zipora Pittel, Illana Goze. Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. The Journal of pharmacology and experimental therapeutics. vol 323. issue 2. 2007-12-06. PMID:17720885. |
increased tau hyperphosphorylation is known to cause memory impairments in neurodegenerative diseases associated with tauopathies, including the most prevalent alzheimer's disease. |
2007-12-06 |
2023-08-12 |
mouse |
| Nicolette S Honson, Jordan R Jensen, Michael V Darby, Jeff Kure. Potent inhibition of tau fibrillization with a multivalent ligand. Biochemical and biophysical research communications. vol 363. issue 1. 2007-12-06. PMID:17854770. |
small-molecule inhibitors of tau fibrillization are under investigation as tools for interrogating the tau aggregation pathway and as potential therapeutic agents for alzheimer's disease. |
2007-12-06 |
2023-08-12 |
Not clear |
| Enrico Magnani, Juan Fan, Laura Gasparini, Matthew Golding, Meredith Williams, Giampietro Schiavo, Michel Goedert, Linda A Amos, Maria Grazia Spillantin. Interaction of tau protein with the dynactin complex. The EMBO journal. vol 26. issue 21. 2007-11-30. PMID:17932487. |
mutations in tau cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), and tau aggregates are present in alzheimer's disease and other tauopathies. |
2007-11-30 |
2023-08-12 |
mouse |
| Marcus Pickhardt, Gregor Larbig, Inna Khlistunova, Atilla Coksezen, Bernd Meyer, Eva-Maria Mandelkow, Boris Schmidt, Eckhard Mandelko. Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. Biochemistry. vol 46. issue 35. 2007-11-27. PMID:17685560. |
one of the key pathological features of alzheimer's disease is the aggregation of tau protein. |
2007-11-27 |
2023-08-12 |
Not clear |
| Marcus Pickhardt, Gregor Larbig, Inna Khlistunova, Atilla Coksezen, Bernd Meyer, Eva-Maria Mandelkow, Boris Schmidt, Eckhard Mandelko. Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. Biochemistry. vol 46. issue 35. 2007-11-27. PMID:17685560. |
on the basis of an initial screen of 200000 compounds [pickhardt, m., gazova, z., von bergen, m., khlistunova, i., wang, y., hascher, a., mandelkow, e. m., biernat, j., and mandelkow, e. (2005) anthraquinones inhibit tau aggregation and dissolve alzheimer's paired helical filaments in vitro and in cells, j. biol. |
2007-11-27 |
2023-08-12 |
Not clear |
| Marcus Pickhardt, Gregor Larbig, Inna Khlistunova, Atilla Coksezen, Bernd Meyer, Eva-Maria Mandelkow, Boris Schmidt, Eckhard Mandelko. Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. Biochemistry. vol 46. issue 35. 2007-11-27. PMID:17685560. |
280, 3628-3635], we performed an in silico screen and predicted a new phenylthiazolyl-hydrazide (pth) compound as a possible hit [larbig, g., pickhardt, m., lloyd, d. g., schmidt, b., and mandelkow, e. (2007) screening for inhibitors of tau protein aggregation into alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping. |
2007-11-27 |
2023-08-12 |
Not clear |