| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tohru Hasegaw. Prolonged stress will induce Alzheimer's disease in elderly people by increased release of homocysteic acid. Medical hypotheses. vol 69. issue 5. 2007-12-13. PMID:17499446. |
finally, the aggregated alpha-synuclein induces tau pathology, which induces cell death, leading to alzheimer's pathology. |
2007-12-13 |
2023-08-12 |
Not clear |
| Ravindran Kumaran, Ann Kingsbury, Ian Coulter, Tammaryn Lashley, David Williams, Rohan de Silva, David Mann, Tamas Revesz, Andrew Lees, Rina Bandopadhya. DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders. Neurobiology of disease. vol 28. issue 1. 2007-12-12. PMID:17719794. |
this study examines dj-1 immunoreactivity (dj-1 ir) in a variety of neurodegenerative disorders, alzheimer's disease (ad), frontotemporal lobar degeneration (ftld) with pick bodies, ftld with mapt mutations, progressive supranuclear palsy (psp) and corticobasal degeneration (cbd), in which hyperphosphorylated tau inclusions are the major pathological signature. |
2007-12-12 |
2023-08-12 |
Not clear |
| Inna Vulih-Shultzman, Albert Pinhasov, Shmuel Mandel, Nikolaos Grigoriadis, Olga Touloumi, Zipora Pittel, Illana Goze. Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. The Journal of pharmacology and experimental therapeutics. vol 323. issue 2. 2007-12-06. PMID:17720885. |
increased tau hyperphosphorylation is known to cause memory impairments in neurodegenerative diseases associated with tauopathies, including the most prevalent alzheimer's disease. |
2007-12-06 |
2023-08-12 |
mouse |
| Nicolette S Honson, Jordan R Jensen, Michael V Darby, Jeff Kure. Potent inhibition of tau fibrillization with a multivalent ligand. Biochemical and biophysical research communications. vol 363. issue 1. 2007-12-06. PMID:17854770. |
small-molecule inhibitors of tau fibrillization are under investigation as tools for interrogating the tau aggregation pathway and as potential therapeutic agents for alzheimer's disease. |
2007-12-06 |
2023-08-12 |
Not clear |
| Enrico Magnani, Juan Fan, Laura Gasparini, Matthew Golding, Meredith Williams, Giampietro Schiavo, Michel Goedert, Linda A Amos, Maria Grazia Spillantin. Interaction of tau protein with the dynactin complex. The EMBO journal. vol 26. issue 21. 2007-11-30. PMID:17932487. |
mutations in tau cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), and tau aggregates are present in alzheimer's disease and other tauopathies. |
2007-11-30 |
2023-08-12 |
mouse |
| Marcus Pickhardt, Gregor Larbig, Inna Khlistunova, Atilla Coksezen, Bernd Meyer, Eva-Maria Mandelkow, Boris Schmidt, Eckhard Mandelko. Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. Biochemistry. vol 46. issue 35. 2007-11-27. PMID:17685560. |
one of the key pathological features of alzheimer's disease is the aggregation of tau protein. |
2007-11-27 |
2023-08-12 |
Not clear |
| Marcus Pickhardt, Gregor Larbig, Inna Khlistunova, Atilla Coksezen, Bernd Meyer, Eva-Maria Mandelkow, Boris Schmidt, Eckhard Mandelko. Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. Biochemistry. vol 46. issue 35. 2007-11-27. PMID:17685560. |
on the basis of an initial screen of 200000 compounds [pickhardt, m., gazova, z., von bergen, m., khlistunova, i., wang, y., hascher, a., mandelkow, e. m., biernat, j., and mandelkow, e. (2005) anthraquinones inhibit tau aggregation and dissolve alzheimer's paired helical filaments in vitro and in cells, j. biol. |
2007-11-27 |
2023-08-12 |
Not clear |
| Marcus Pickhardt, Gregor Larbig, Inna Khlistunova, Atilla Coksezen, Bernd Meyer, Eva-Maria Mandelkow, Boris Schmidt, Eckhard Mandelko. Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. Biochemistry. vol 46. issue 35. 2007-11-27. PMID:17685560. |
280, 3628-3635], we performed an in silico screen and predicted a new phenylthiazolyl-hydrazide (pth) compound as a possible hit [larbig, g., pickhardt, m., lloyd, d. g., schmidt, b., and mandelkow, e. (2007) screening for inhibitors of tau protein aggregation into alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping. |
2007-11-27 |
2023-08-12 |
Not clear |
| M Degerman Gunnarsson, L Kilander, H Basun, L Lannfel. Reduction of phosphorylated tau during memantine treatment of Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 24. issue 4. 2007-11-27. PMID:17700020. |
reduction of phosphorylated tau during memantine treatment of alzheimer's disease. |
2007-11-27 |
2023-08-12 |
rat |
| Mark Doran, Daniel G du Plessis, Eric J Ghadiali, David M A Mann, Stuart Pickering-Brown, Andrew J Larne. Familial early-onset dementia with tau intron 10 + 16 mutation with clinical features similar to those of Alzheimer disease. Archives of neurology. vol 64. issue 10. 2007-11-20. PMID:17923640. |
familial early-onset dementia with tau intron 10 + 16 mutation with clinical features similar to those of alzheimer disease. |
2007-11-20 |
2023-08-12 |
Not clear |
| Katharina Buerger, Irina Alafuzoff, Michael Ewers, Tuula Pirttilä, Raymond Zinkowski, Harald Hampe. No correlation between CSF tau protein phosphorylated at threonine 181 with neocortical neurofibrillary pathology in Alzheimer's disease. Brain : a journal of neurology. vol 130. issue Pt 10. 2007-11-13. PMID:17615094. |
no correlation between csf tau protein phosphorylated at threonine 181 with neocortical neurofibrillary pathology in alzheimer's disease. |
2007-11-13 |
2023-08-12 |
Not clear |
| Kiren K Ubhi, Hassan Shaibah, Tracey A Newman, David Shepherd, Amritpal Mudhe. A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies. Invertebrate neuroscience : IN. vol 7. issue 3. 2007-11-13. PMID:17636367. |
hyperphosphorylation and aggregation of tau into tangles is a feature of disorders such as alzheimer's disease and other tauopathies. |
2007-11-13 |
2023-08-12 |
human |
| J R Walto. An aluminum-based rat model for Alzheimer's disease exhibits oxidative damage, inhibition of PP2A activity, hyperphosphorylated tau, and granulovacuolar degeneration. Journal of inorganic biochemistry. vol 101. issue 9. 2007-11-13. PMID:17662457. |
an aluminum-based rat model for alzheimer's disease exhibits oxidative damage, inhibition of pp2a activity, hyperphosphorylated tau, and granulovacuolar degeneration. |
2007-11-13 |
2023-08-12 |
human |
| J R Walto. An aluminum-based rat model for Alzheimer's disease exhibits oxidative damage, inhibition of PP2A activity, hyperphosphorylated tau, and granulovacuolar degeneration. Journal of inorganic biochemistry. vol 101. issue 9. 2007-11-13. PMID:17662457. |
in alzheimer's disease (ad), oxidative damage leads to the formation of amyloid plaques while low pp2a activity results in hyperphosphorylated tau that polymerizes to form neurofibrillary tangles. |
2007-11-13 |
2023-08-12 |
human |
| F Hernández, J Avil. Tauopathies. Cellular and molecular life sciences : CMLS. vol 64. issue 17. 2007-11-09. PMID:17604998. |
in several neurodegenerative diseases, as for example alzheimer's disease, tau metabolism is altered. |
2007-11-09 |
2023-08-12 |
Not clear |
| Sebastiaan Engelborghs, Kristel Sleegers, Patrick Cras, Nathalie Brouwers, Sally Serneels, Evelyn De Leenheir, Jean-Jacques Martin, Eugeen Vanmechelen, Christine Van Broeckhoven, Peter Paul De Dey. No association of CSF biomarkers with APOEepsilon4, plaque and tangle burden in definite Alzheimer's disease. Brain : a journal of neurology. vol 130. issue Pt 9. 2007-11-01. PMID:17586559. |
the csf biomarkers beta-amyloid peptide (abeta(1-42)), total tau protein (t-tau) and tau phosphorylated at threonine 181 (p-tau(181p)) were determined in autopsy-confirmed alzheimer's disease patients in order to study possible associations with the epsilon4 allele of apoe and density and spread of plaques (sp) and tangles (nft). |
2007-11-01 |
2023-08-12 |
Not clear |
| J A P van de Nes, S Konermann, R Nafe, D F Swaa. Beta-protein/A4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of Alzheimer's disease patients. Acta neuropathologica. vol 111. issue 2. 2007-10-30. PMID:16456666. |
beta-protein/a4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of alzheimer's disease patients. |
2007-10-30 |
2023-08-12 |
human |
| Johannes Attems, Magdalena Quass, Kurt A Jellinge. Tau and alpha-synuclein brainstem pathology in Alzheimer disease: relation with extrapyramidal signs. Acta neuropathologica. vol 113. issue 1. 2007-10-26. PMID:17031655. |
tau and alpha-synuclein brainstem pathology in alzheimer disease: relation with extrapyramidal signs. |
2007-10-26 |
2023-08-12 |
human |
| Sarita Lagalwar, Robert W Berry, Lester I Binde. Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer's disease and tauopathies to granulovacuolar degeneration bodies. Acta neuropathologica. vol 113. issue 1. 2007-10-26. PMID:17089132. |
alzheimer's disease (ad), progressive supranuclear palsy (psp), corticobasal degeneration (cbd) and pick's disease (pid) all present with pathological lesions containing hyperphosphorylated filamentous tau protein; however, the location and type of lesion varies. |
2007-10-26 |
2023-08-12 |
Not clear |
| Salvatore Spina, Jill R Murrell, Hirotaka Yoshida, Bernardino Ghetti, Niamh Bermingham, Brian Sweeney, Stephen R Dlouhy, R Anthony Crowther, Michel Goedert, Catherine Keohan. The novel Tau mutation G335S: clinical, neuropathological and molecular characterization. Acta neuropathologica. vol 113. issue 4. 2007-10-26. PMID:17186252. |
the pattern of pathological tau bands was like that of alzheimer disease. |
2007-10-26 |
2023-08-12 |
Not clear |