| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pengxu We. Ultra-Early Screening of Cognitive Decline Due to Alzheimer's Pathology. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37239094. |
alzheimer's pathology can be assessed and defined via aβ and tau biomarkers. |
2023-05-27 |
2023-08-14 |
Not clear |
| Tatyana Shulyatnikova, Melvin R Hayde. Why Are Perivascular Spaces Important? Medicina (Kaunas, Lithuania). vol 59. issue 5. 2023-05-27. PMID:37241149. |
metabolic waste includes misfolded proteins of amyloid beta and tau that are known to accumulate in late-onset alzheimer's disease (load) within the interstitial fluid that is delivered to the subarachnoid space and eventually the cerebral spinal fluid (csf). |
2023-05-27 |
2023-08-14 |
Not clear |
| Hidekazu Hiroak. Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges. Biophysics and physicobiology. vol 20. issue 1. 2023-05-26. PMID:37234855. |
there are two major hypotheses for the pathogenesis of alzheimer's dementia: the β-amyloid (aβ) hypothesis and the tau hypothesis. |
2023-05-26 |
2023-08-14 |
Not clear |
| Richard A Hartz, Vijay T Ahuja, Guanglin Luo, Ling Chen, Prasanna Sivaprakasam, Hong Xiao, Carol M Krause, Wendy J Clarke, Songmei Xu, John S Tokarski, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R Burton, John E Macor, Gene M Dubowchi. Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. Journal of medicinal chemistry. 2023-05-26. PMID:37235865. |
there is considerable evidence indicating that gsk-3β in the central nervous system plays a role in the production of abnormal, hyperphosphorylated, microtubule-associated tau protein found in neurofibrillary tangles associated with alzheimer's disease. |
2023-05-26 |
2023-08-14 |
Not clear |
| Gregory E Merz, Matthew J Chalkley, Sophia K Tan, Eric Tse, Joanne Lee, Stanley B Prusiner, Nick A Paras, William F DeGrado, Daniel R Southwort. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nature communications. vol 14. issue 1. 2023-05-26. PMID:37236970. |
stacked binding of a pet ligand to alzheimer's tau paired helical filaments. |
2023-05-26 |
2023-08-14 |
Not clear |
| Gregory E Merz, Matthew J Chalkley, Sophia K Tan, Eric Tse, Joanne Lee, Stanley B Prusiner, Nick A Paras, William F DeGrado, Daniel R Southwort. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nature communications. vol 14. issue 1. 2023-05-26. PMID:37236970. |
accumulation of filamentous aggregates of tau protein in the brain is a pathological hallmark of alzheimer's disease (ad) and many other neurodegenerative tauopathies. |
2023-05-26 |
2023-08-14 |
Not clear |
| Isobel Leak. Oligomeric tau might spread trans-synaptically in Alzheimer disease. Nature reviews. Neuroscience. 2023-05-26. PMID:37237104. |
oligomeric tau might spread trans-synaptically in alzheimer disease. |
2023-05-26 |
2023-08-14 |
Not clear |
| Jingshan Chen, Xue Zhao, Wenyan Zhang, Tianxiang Zhang, Siting Wu, Jinghao Shao, Fu-Dong Sh. Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment. Alzheimer's research & therapy. vol 15. issue 1. 2023-05-26. PMID:37237388. |
plasma amyloid-β (aβ) peptides and tau proteins are promising biomarkers of alzheimer's disease (ad), not only for predicting aβ and tau pathology but also for differentiating ad from other neurodegenerative diseases. |
2023-05-26 |
2023-08-14 |
Not clear |
| Yingfei Chen, Leshuang Wu, Jun Liu, Li Ma, Wenli Zhan. Adenine nucleotide translocase: Current knowledge in post-translational modifications, regulations and pathological implications for human diseases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 6. 2023-05-25. PMID:37224026. |
ant impairment leads to bioenergetic failure and mitochondrial dysfunction, contributing to pathogenesis of diseases, such as diabetes (deficiency), heart disease (deficiency), parkinson's disease (reduction), sengers syndrome (decrease), cancer (isoform shifting), alzheimer's disease (coaggregation with tau), progressive external opthalmoplegia (mutation), and fascioscapulohumeral muscular dystrophy (overexpression). |
2023-05-25 |
2023-08-14 |
human |
| Antoinette O'Connor, David M Cash, Teresa Poole, Pawel J Markiewicz, Maggie R Fraser, Ian B Malone, Jieqing Jiao, Philip S J Weston, Shaney Flores, Russ Hornbeck, Eric McDade, Michael Schöll, Brian A Gordon, Randall J Bateman, Tammie L S Benzinger, Nick C Fo. Tau accumulation in autosomal dominant Alzheimer's disease: a longitudinal [ Alzheimer's research & therapy. vol 15. issue 1. 2023-05-25. PMID:37231491. |
tau accumulation in autosomal dominant alzheimer's disease: a longitudinal [ cortical tau accumulation is a key pathological event that partly defines alzheimer's disease (ad) onset and is associated with cognitive decline and future disease progression. |
2023-05-25 |
2023-08-14 |
human |
| Bakhtiarzadeh Fatemeh, Shahpasand Koorosh, Shojaei Amir, Fathollahi Yaghoub, Mirnajafi-Zadeh Java. Intra-hippocampal cis-P tau microinjection induces long-term changes in behavior and synaptic plasticity in mice. Behavioral and brain functions : BBF. vol 19. issue 1. 2023-05-25. PMID:37231523. |
alzheimer's disease is accompanied by an abnormal high accumulation of cis-p tau. |
2023-05-25 |
2023-08-14 |
mouse |
| Mari Aksnes, Trine H Edwin, Ingvild Saltvedt, Rannveig S Eldholm, Farrukh A Chaudhry, Nathalie B Halaas, Marius Myrstad, Leiv O Watne, Anne-Brita Knapsko. Sex-specific associations of matrix metalloproteinases in Alzheimer's disease. Biology of sex differences. vol 14. issue 1. 2023-05-24. PMID:37221606. |
alzheimer's disease (ad) can be characterised in vivo by biomarkers reflecting amyloid-β (aβ) and tau pathology. |
2023-05-24 |
2023-08-14 |
Not clear |
| Liding Zhang, Ying Su, Xiaohan Liang, Kai Cao, Qingming Luo, Haiming Lu. Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay. Nano research. vol 16. issue 5. 2023-05-24. PMID:37223429. |
ultrasensitive and point-of-care detection of plasma phosphorylated tau in alzheimer's disease using colorimetric and surface-enhanced raman scattering dual-readout lateral flow assay. |
2023-05-24 |
2023-08-14 |
Not clear |
| Daniel J Panyard, Justin McKetney, Yuetiva K Deming, Autumn R Morrow, Gilda E Ennis, Erin M Jonaitis, Carol A Van Hulle, Chengran Yang, Yun Ju Sung, Muhammad Ali, Gwendlyn Kollmorgen, Ivonne Suridjan, Anna Bayfield, Barbara B Bendlin, Henrik Zetterberg, Kaj Blennow, Carlos Cruchaga, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Joshua J Coon, Corinne D Engelma. Large-scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-05-23. PMID:37218097. |
a hallmark of alzheimer's disease (ad) is the aggregation of proteins (amyloid beta [a] and hyperphosphorylated tau [t]) in the brain, making cerebrospinal fluid (csf) proteins of particular interest. |
2023-05-23 |
2023-08-14 |
Not clear |
| Kathrin Jahreis, Alina Brüge, Saskia Borsdorf, Franziska E Müller, Weilun Sun, Shaobo Jia, Dong Min Kang, Nicolette Boesen, Seulgi Shin, Sungsu Lim, Anastasia Koroleva, Grzegorz Satała, Andrzej J Bojarski, Elena Rakuša, Anne Fink, Gabriele Doblhammer-Reiter, Yun Kyung Kim, Alexander Dityatev, Evgeni Ponimaskin, Josephine Labu. Amisulpride as a potential disease-modifying drug in the treatment of tauopathies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-05-23. PMID:37218673. |
hyperphosphorylation and aggregation of the microtubule-associated protein tau cause the development of tauopathies, such as alzheimer's disease and frontotemporal dementia (ftd). |
2023-05-23 |
2023-08-14 |
Not clear |
| Subashchandrabose Chinnathambi, Rashmi Da. Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis. Cell & bioscience. vol 13. issue 1. 2023-05-23. PMID:37221563. |
tau protein forms neurofibrillary tangles and becomes deposited in the brain during alzheimer's disease (ad). |
2023-05-23 |
2023-08-14 |
Not clear |
| Yu Hirota, Yasufumi Sakakibara, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M Iijim. Alzheimer's Disease-Related Phospho-Tau181 Signals Are Localized to Demyelinated Axons of Parvalbumin-Positive GABAergic Interneurons in an App Knock-In Mouse Model of Amyloid-β Pathology. Journal of Alzheimer's disease : JAD. 2023-05-22. PMID:37212118. |
the tau protein phosphorylated at thr181 (p-tau181) in cerebrospinal fluid and blood is a sensitive biomarker for alzheimer's disease (ad). |
2023-05-22 |
2023-08-14 |
mouse |
| Antonio Terracciano, Keenan Walker, Yang An, Martina Luchetti, Yannick Stephan, Abhay R Moghekar, Angelina R Sutin, Luigi Ferrucci, Susan M Resnic. The association between personality and plasma biomarkers of astrogliosis and neuronal injury. Neurobiology of aging. vol 128. 2023-05-21. PMID:37210782. |
personality traits have been associated with the risk of dementia and alzheimer's disease neuropathology, including amyloid and tau. |
2023-05-21 |
2023-08-14 |
human |
| Luisa Diomede, Elisa R Zanier, Federico Moro, Gloria Vegliante, Laura Colombo, Luca Russo, Alfredo Cagnotto, Carmina Natale, Federica Marta Xodo, Ada De Luigi, Michele Mosconi, Marten Beeg, Marcella Catania, Giacomina Rossi, Fabrizio Tagliavini, Giuseppe Di Fede, Mario Salmon. Aβ1-6 Molecular psychiatry. 2023-05-17. PMID:37198260. |
aβ1-6 alzheimer's disease (ad), the leading cause of dementia in older adults, is a double proteinopathy characterized by amyloid-β (aβ) and tau pathology. |
2023-05-17 |
2023-08-14 |
Not clear |
| Laia Montoliu-Gaya, Andréa L Benedet, Cécile Tissot, Agathe Vrillon, Nicholas J Ashton, Wagner S Brum, Juan Lantero-Rodriguez, Jenna Stevenson, Johanna Nilsson, Mathias Sauer, Nesrine Rahmouni, Gunnar Brinkmalm, Firoza Z Lussier, Tharick A Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, Claire Paquet, Johan Gobom, Pedro Rosa-Neto, Kaj Blenno. Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies. Nature aging. 2023-05-17. PMID:37198279. |
blood phosphorylated tau (p-tau) biomarkers, at differing sites, demonstrate high accuracy to detect alzheimer's disease (ad). |
2023-05-17 |
2023-08-14 |
human |