| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Yoshida, M Maeda, S Kaku, H Ikeya, K Yamada, S Nakaik. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16855914. |
it has been pointed out that hyperphosphorylation of microtubule-associated protein tau caused by stress might participate in the early stages of alzheimer's disease pathogenesis. |
2007-09-05 |
2023-08-12 |
mouse |
| R Schliebs, T Arend. The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:17039298. |
impaired cortical cholinergic neurotransmission may also contribute to beta-amyloid plaque pathology and increase phosphorylation of tau protein the main component of neurofibrillar tangles in alzheimer's disease. |
2007-09-05 |
2023-08-12 |
Not clear |
| R Schliebs, T Arend. The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:17039298. |
understanding the molecular mechanisms underlying the interrelationship between cortical cholinergic dysfunction, beta-amyloid formation and deposition, and tau pathology in alzheimer's disease, would allow to derive potential treatment strategies to pharmacologically intervene in the disease-causing signaling cascade. |
2007-09-05 |
2023-08-12 |
Not clear |
| Angela L Guillozet-Bongaarts, Kelly E Glajch, Emilie G Libson, Michael E Cahill, Eileen Bigio, Robert W Berry, Lester I Binde. Phosphorylation and cleavage of tau in non-AD tauopathies. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17357802. |
many of the tau alterations that are characteristic of alzheimer's disease have also been identified in psp and cbd. |
2007-08-31 |
2023-08-12 |
Not clear |
| Bin Li, Muhammad Omar Chohan, Inge Grundke-Iqbal, Khalid Iqba. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17372746. |
disruption of microtubule network by alzheimer abnormally hyperphosphorylated tau. |
2007-08-31 |
2023-08-12 |
mouse |
| Bin Li, Muhammad Omar Chohan, Inge Grundke-Iqbal, Khalid Iqba. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17372746. |
hyperphosphorylated tau has long been proposed as the key molecule disrupting normal neuronal microtubule dynamics and leading to neurofibrillary degeneration in alzheimer disease. |
2007-08-31 |
2023-08-12 |
mouse |
| Bin Li, Muhammad Omar Chohan, Inge Grundke-Iqbal, Khalid Iqba. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17372746. |
whereas recombinant human brain tau promoted assembly and bundling of microtubules, abnormally hyperphosphorylated tau isolated from alzheimer disease brain cytosol (ad p-tau) inhibited the assembly and disrupted preformed microtubule network by sequestering normal brain tau and map2. |
2007-08-31 |
2023-08-12 |
mouse |
| Toshiki Uchihar. Silver diagnosis in neuropathology: principles, practice and revised interpretation. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17401570. |
deposits containing both 3r and 4r tau (neurofibrillary tangles of alzheimer type) are gal+/cs+. |
2007-08-31 |
2023-08-12 |
Not clear |
| Jun-Hua Peng, Chang-E Zhang, Wei Wei, Xiao-Ping Hong, Xi-Ping Pan, Jian-Zhi Wan. Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats. Neuropharmacology. vol 52. issue 7. 2007-08-31. PMID:17434540. |
tau hyperphosphorylation and memory deficit are characteristic alterations of alzheimer's disease (ad), and glycogen synthase kinase-3 (gsk-3) plays a crucial role in these ad-like changes. |
2007-08-31 |
2023-08-12 |
rat |
| Katsunori Fujio, Mahito Sato, Takefumi Uemura, Takashi Sato, Reiko Sato-Harada, Akihiro Harad. 14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice. Neuroreport. vol 18. issue 10. 2007-08-31. PMID:17558294. |
tau is an axonal microtubule-associated protein, whose dysfunction causes neurodegenerative diseases such as alzheimer's disease and other tauopathies. |
2007-08-31 |
2023-08-12 |
mouse |
| Matthew R Reynolds, Robert W Berry, Lester I Binde. Nitration in neurodegeneration: deciphering the "Hows" "nYs". Biochemistry. vol 46. issue 25. 2007-08-29. PMID:17542619. |
these proteins include mn superoxide dismutase and neurofilament light subunit in amyotrophic lateral sclerosis, alpha-synuclein and tyrosine hydroxylase in parkinson's disease, and tau in alzheimer's disease. |
2007-08-29 |
2023-08-12 |
Not clear |
| Pravir Kumar, Rashmi K Ambasta, Vimal Veereshwarayya, Kenneth M Rosen, Ken S Kosik, Hamid Band, Ruben Mestril, Cam Patterson, Henry W Querfurt. CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. Human molecular genetics. vol 16. issue 7. 2007-08-28. PMID:17317785. |
chip is increasingly implicated in the biology of polyglutamine expansion disorders, parkinson's disease and tau protein in alzheimer's disease. |
2007-08-28 |
2023-08-12 |
Not clear |
| Wanjoo Chun, Gail V W Johnso. The role of tau phosphorylation and cleavage in neuronal cell death. Frontiers in bioscience : a journal and virtual library. vol 12. 2007-08-23. PMID:17127334. |
the microtubule-associated protein tau is the primary component of the intracellular filamentous deposits found in alzheimer's disease (ad) brain and also in a family of neurodegenerative diseases called 'tauopathies', where tau pathology is the primary, defining characteristic with little or no amyloid-beta (abeta) pathology. |
2007-08-23 |
2023-08-12 |
Not clear |
| S B Shim, H J Lim, K R Chae, C K Kim, D Y Hwang, S W Jee, S H Lee, J S Sin, Y H Leem, S H Lee, J S Cho, H H Lee, S Y Choi, Y K Ki. Tau overexpression in transgenic mice induces glycogen synthase kinase 3beta and beta-catenin phosphorylation. Neuroscience. vol 146. issue 2. 2007-08-15. PMID:17337327. |
the abnormal phosphorylations of tau, gsk3beta, and beta-catenin have been shown to perform a crucial function in the neuropathology of alzheimer's disease (ad). |
2007-08-15 |
2023-08-12 |
mouse |
| Naomi S Hachiya, Kiyotoshi Kanek. Investigation of laser-microdissected inclusion bodies. Methods in cell biology. vol 82. 2007-08-15. PMID:17586264. |
as a model system for analyzing inclusion bodies associated with various diseases such as alzheimer's disease, parkinson's disease, and prion diseases including bovine spongiform encephalopathy (bse), we applied this novel method to examine brain samples of patients with pick's disease, a type of progressive presenile dementia with intraneuronal lesions denoted as pick bodies (pbs) whose major structural components are tau proteins. |
2007-08-15 |
2023-08-12 |
cattle |
| Kanwar Virdee, Hirotaka Yoshida, Sew Peak-Chew, Michel Goeder. Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily. FEBS letters. vol 581. issue 14. 2007-08-14. PMID:17512525. |
intraneuronal inclusions made of hyperphosphorylated microtubule-associated protein tau are a defining neuropathological characteristic of alzheimer's disease, and of several other neurodegenerative disorders. |
2007-08-14 |
2023-08-12 |
human |
| Carolyn A Rankin, Qian Sun, Truman C Gambli. Tau phosphorylation by GSK-3beta promotes tangle-like filament morphology. Molecular neurodegeneration. vol 2. 2007-08-10. PMID:17598919. |
although the molecular mechanisms responsible for the conversion of disperse tau filaments into tangles of filaments are not known, it is believed that some of the associated changes in tau observed in alzheimer's disease, such as phosphorylation, truncation, ubiquitination, glycosylation or nitration, may play a role. |
2007-08-10 |
2023-08-12 |
Not clear |
| Julia Leschik, Alfred Welzel, Carina Weissmann, Anne Eckert, Roland Brand. Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death. Journal of neurochemistry. vol 101. issue 5. 2007-08-06. PMID:17298384. |
alzheimer's disease (ad) is characterized by massive neuron loss in distinct brain regions, extracellular accumulations of the amyloid precursor protein-fragment amyloid-beta (a beta) and intracellular tau fibrils containing hyperphosphorylated tau. |
2007-08-06 |
2023-08-12 |
Not clear |
| Julia Leschik, Alfred Welzel, Carina Weissmann, Anne Eckert, Roland Brand. Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death. Journal of neurochemistry. vol 101. issue 5. 2007-08-06. PMID:17298384. |
suppression of tau expression or inhibition of tau phosphorylation at disease-relevant sites may provide an effective therapeutic strategy to prevent neurodegeneration in alzheimer's disease. |
2007-08-06 |
2023-08-12 |
Not clear |
| Michael P Mazanetz, Peter M Fische. Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. Nature reviews. Drug discovery. vol 6. issue 6. 2007-08-02. PMID:17541419. |
aggregation of hyperphosphorylated tau is one of the characteristic neuropathological lesions of alzheimer's disease and other neurodegenerative disorders. |
2007-08-02 |
2023-08-12 |
Not clear |