| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arjune Sen, Maria Thom, Lillian Martinian, Brian Harding, J Helen Cross, Margareta Nikolic, Sanjay M Sisodiy. Pathological tau tangles localize to focal cortical dysplasia in older patients. Epilepsia. vol 48. issue 8. 2007-09-13. PMID:17441989. |
for example, the proteins cyclin dependent kinase 5 (cdk5) and glycogen synthase kinase 3 beta (gsk3beta), which are essential to normal cortical development, can hyperphosphorylate tau and might contribute to the pathogenesis of alzheimer's disease. |
2007-09-13 |
2023-08-12 |
human |
| Sashi Kesavapany, Ya-Li Zheng, Niranjana Amin, Harish C Pan. Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5. Biotechnology journal. vol 2. issue 8. 2007-09-11. PMID:17526058. |
p25 levels have been found to be elevated in alzheimer's disease (ad) brain and overexpression of p25 in a transgenic mouse results in the formation of phosphorylated tau, neurofibrillary tangles and cognitive deficits that are pathological hallmarks of ad. |
2007-09-11 |
2023-08-12 |
mouse |
| Ayodeji A Asuni, Allal Boutajangout, David Quartermain, Einar M Sigurdsso. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 34. 2007-09-11. PMID:17715348. |
this type of treatment has not been assessed in models that develop neuronal tau aggregates as observed in frontotemporal dementia and alzheimer's disease. |
2007-09-11 |
2023-08-12 |
mouse |
| Peter J Crouch, Anthony R White, Ashley I Bus. The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease. The FEBS journal. vol 274. issue 15. 2007-09-10. PMID:17617225. |
here, we discuss reports that show a loss of metal homeostasis is also an important event in alzheimer's disease, and we identify how metal dyshomeostasis may contribute to development of the amyloid-beta, tau and oxidative stress biology of alzheimer's disease. |
2007-09-10 |
2023-08-12 |
Not clear |
| Jin Zhong, Wei-Hua Le. Lithium: a novel treatment for Alzheimer's disease? Expert opinion on drug safety. vol 6. issue 4. 2007-09-10. PMID:17688381. |
ongoing clinical trials are evaluating lithium's abilities to lower tau and beta-amyloid levels in cerebrospinal fluid in alzheimer's patients. |
2007-09-10 |
2023-08-12 |
Not clear |
| Tara M Caffrey, Richard Wade-Martin. Functional MAPT haplotypes: bridging the gap between genotype and neuropathology. Neurobiology of disease. vol 27. issue 1. 2007-09-06. PMID:17555970. |
the microtubule-associated protein tau (mapt) locus has long been associated with sporadic neurodegenerative disease, notably progressive supranuclear palsy and corticobasal degeneration, and more recently with alzheimer's disease and parkinson's disease. |
2007-09-06 |
2023-08-12 |
Not clear |
| S Yoshida, M Maeda, S Kaku, H Ikeya, K Yamada, S Nakaik. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16855914. |
it has been pointed out that hyperphosphorylation of microtubule-associated protein tau caused by stress might participate in the early stages of alzheimer's disease pathogenesis. |
2007-09-05 |
2023-08-12 |
mouse |
| R Schliebs, T Arend. The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:17039298. |
impaired cortical cholinergic neurotransmission may also contribute to beta-amyloid plaque pathology and increase phosphorylation of tau protein the main component of neurofibrillar tangles in alzheimer's disease. |
2007-09-05 |
2023-08-12 |
Not clear |
| R Schliebs, T Arend. The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:17039298. |
understanding the molecular mechanisms underlying the interrelationship between cortical cholinergic dysfunction, beta-amyloid formation and deposition, and tau pathology in alzheimer's disease, would allow to derive potential treatment strategies to pharmacologically intervene in the disease-causing signaling cascade. |
2007-09-05 |
2023-08-12 |
Not clear |
| Angela L Guillozet-Bongaarts, Kelly E Glajch, Emilie G Libson, Michael E Cahill, Eileen Bigio, Robert W Berry, Lester I Binde. Phosphorylation and cleavage of tau in non-AD tauopathies. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17357802. |
many of the tau alterations that are characteristic of alzheimer's disease have also been identified in psp and cbd. |
2007-08-31 |
2023-08-12 |
Not clear |
| Bin Li, Muhammad Omar Chohan, Inge Grundke-Iqbal, Khalid Iqba. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17372746. |
disruption of microtubule network by alzheimer abnormally hyperphosphorylated tau. |
2007-08-31 |
2023-08-12 |
mouse |
| Bin Li, Muhammad Omar Chohan, Inge Grundke-Iqbal, Khalid Iqba. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17372746. |
hyperphosphorylated tau has long been proposed as the key molecule disrupting normal neuronal microtubule dynamics and leading to neurofibrillary degeneration in alzheimer disease. |
2007-08-31 |
2023-08-12 |
mouse |
| Bin Li, Muhammad Omar Chohan, Inge Grundke-Iqbal, Khalid Iqba. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17372746. |
whereas recombinant human brain tau promoted assembly and bundling of microtubules, abnormally hyperphosphorylated tau isolated from alzheimer disease brain cytosol (ad p-tau) inhibited the assembly and disrupted preformed microtubule network by sequestering normal brain tau and map2. |
2007-08-31 |
2023-08-12 |
mouse |
| Toshiki Uchihar. Silver diagnosis in neuropathology: principles, practice and revised interpretation. Acta neuropathologica. vol 113. issue 5. 2007-08-31. PMID:17401570. |
deposits containing both 3r and 4r tau (neurofibrillary tangles of alzheimer type) are gal+/cs+. |
2007-08-31 |
2023-08-12 |
Not clear |
| Jun-Hua Peng, Chang-E Zhang, Wei Wei, Xiao-Ping Hong, Xi-Ping Pan, Jian-Zhi Wan. Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats. Neuropharmacology. vol 52. issue 7. 2007-08-31. PMID:17434540. |
tau hyperphosphorylation and memory deficit are characteristic alterations of alzheimer's disease (ad), and glycogen synthase kinase-3 (gsk-3) plays a crucial role in these ad-like changes. |
2007-08-31 |
2023-08-12 |
rat |
| Katsunori Fujio, Mahito Sato, Takefumi Uemura, Takashi Sato, Reiko Sato-Harada, Akihiro Harad. 14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice. Neuroreport. vol 18. issue 10. 2007-08-31. PMID:17558294. |
tau is an axonal microtubule-associated protein, whose dysfunction causes neurodegenerative diseases such as alzheimer's disease and other tauopathies. |
2007-08-31 |
2023-08-12 |
mouse |
| Matthew R Reynolds, Robert W Berry, Lester I Binde. Nitration in neurodegeneration: deciphering the "Hows" "nYs". Biochemistry. vol 46. issue 25. 2007-08-29. PMID:17542619. |
these proteins include mn superoxide dismutase and neurofilament light subunit in amyotrophic lateral sclerosis, alpha-synuclein and tyrosine hydroxylase in parkinson's disease, and tau in alzheimer's disease. |
2007-08-29 |
2023-08-12 |
Not clear |
| Pravir Kumar, Rashmi K Ambasta, Vimal Veereshwarayya, Kenneth M Rosen, Ken S Kosik, Hamid Band, Ruben Mestril, Cam Patterson, Henry W Querfurt. CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. Human molecular genetics. vol 16. issue 7. 2007-08-28. PMID:17317785. |
chip is increasingly implicated in the biology of polyglutamine expansion disorders, parkinson's disease and tau protein in alzheimer's disease. |
2007-08-28 |
2023-08-12 |
Not clear |
| Wanjoo Chun, Gail V W Johnso. The role of tau phosphorylation and cleavage in neuronal cell death. Frontiers in bioscience : a journal and virtual library. vol 12. 2007-08-23. PMID:17127334. |
the microtubule-associated protein tau is the primary component of the intracellular filamentous deposits found in alzheimer's disease (ad) brain and also in a family of neurodegenerative diseases called 'tauopathies', where tau pathology is the primary, defining characteristic with little or no amyloid-beta (abeta) pathology. |
2007-08-23 |
2023-08-12 |
Not clear |
| S B Shim, H J Lim, K R Chae, C K Kim, D Y Hwang, S W Jee, S H Lee, J S Sin, Y H Leem, S H Lee, J S Cho, H H Lee, S Y Choi, Y K Ki. Tau overexpression in transgenic mice induces glycogen synthase kinase 3beta and beta-catenin phosphorylation. Neuroscience. vol 146. issue 2. 2007-08-15. PMID:17337327. |
the abnormal phosphorylations of tau, gsk3beta, and beta-catenin have been shown to perform a crucial function in the neuropathology of alzheimer's disease (ad). |
2007-08-15 |
2023-08-12 |
mouse |