| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eckhard Mandelkow, Martin von Bergen, Jacek Biernat, Eva-Maria Mandelko. Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493042. |
in the paired helical filaments of alzheimer's disease, small segments of tau adopt a beta-conformation and interact with other tau molecules. |
2007-06-26 |
2023-08-12 |
Not clear |
| Jürgen Götz, Natasha Deters, Amy Doldissen, Laita Bokhari, Yazi Ke, Andreas Wiesner, Nicole Schonrock, Lars M Ittne. A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493043. |
since then, much has been learned about the role of tau in alzheimer's disease and related disorders. |
2007-06-26 |
2023-08-12 |
mouse |
| Jürgen Götz, Natasha Deters, Amy Doldissen, Laita Bokhari, Yazi Ke, Andreas Wiesner, Nicole Schonrock, Lars M Ittne. A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493043. |
they have been instrumental for dissecting the cross-talk between tau and the second hallmark lesion of alzheimer's disease, the abeta peptide-containing amyloid plaque. |
2007-06-26 |
2023-08-12 |
mouse |
| Jürgen Götz, Natasha Deters, Amy Doldissen, Laita Bokhari, Yazi Ke, Andreas Wiesner, Nicole Schonrock, Lars M Ittne. A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493043. |
we discuss how the tau models have been used to unravel the pathophysiology of alzheimer's disease, to search for disease modifiers and to develop novel treatment strategies. |
2007-06-26 |
2023-08-12 |
mouse |
| Jürgen Götz, Natasha Deters, Amy Doldissen, Laita Bokhari, Yazi Ke, Andreas Wiesner, Nicole Schonrock, Lars M Ittne. A decade of tau transgenic animal models and beyond. Brain pathology (Zurich, Switzerland). vol 17. issue 1. 2007-06-26. PMID:17493043. |
while tau has received less attention than abeta, it is rapidly acquiring a more prominent position and the emerging view is one of a synergistic action of abeta and tau in alzheimer's disease. |
2007-06-26 |
2023-08-12 |
mouse |
| Lingjun Zuo, Christopher H van Dyck, Xingguang Luo, Henry R Kranzler, Bao-zhu Yang, Joel Gelernte. Variation at APOE and STH loci and Alzheimer's disease. Behavioral and brain functions : BBF. vol 2. 2007-06-20. PMID:16603077. |
the apolipoprotein e (apoe) and tau proteins play important roles in the pathological development of alzheimer's disease (ad). |
2007-06-20 |
2023-08-12 |
Not clear |
| Natália Csóková, Rostislav Skrabana, L'ubica Urbániková, Branislav Kovácech, Alexander Popov, Jozef Sevcík, Michal Nová. Preparation, crystallization and preliminary X-ray analysis of the Fab fragment of monoclonal antibody MN423, revealing the structural aspects of Alzheimer's paired helical filaments. Protein and peptide letters. vol 13. issue 9. 2007-06-20. PMID:17100650. |
monoclonal antibody (mab) mn423 recognizes alzheimer's disease specific conformation of tau protein assembled into paired helical filaments (phf). |
2007-06-20 |
2023-08-12 |
Not clear |
| Binbin Wang, Feng Jin, Ze Yang, Zeping Lu, Chenguang Zheng, Li Wan. HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese. Dementia and geriatric cognitive disorders. vol 23. issue 5. 2007-06-20. PMID:17356275. |
human hspg2 participates in the formation of amyloid and tau aggregation in alzheimer's disease (ad). |
2007-06-20 |
2023-08-12 |
human |
| Peter Schönknecht, Johannes Pantel, Elmar Kaiser, Philipp Thomann, Johannes Schröde. Increased tau protein differentiates mild cognitive impairment from geriatric depression and predicts conversion to dementia. Neuroscience letters. vol 416. issue 1. 2007-06-19. PMID:17331644. |
significantly increased cerebrospinal fluid (csf) total tau (t-tau) and phosphorylated at threonine 181 tau (p-tau) levels were frequently found in patients with mild cognitive impairment (mci) who have an increased risk of developing alzheimer's disease (ad). |
2007-06-19 |
2023-08-12 |
human |
| Hong-Lian Li, Hai-Hong Wang, Shi-Jie Liu, Yan-Qiu Deng, Yong-Jie Zhang, Qing Tian, Xiao-Chuan Wang, Xiao-Qian Chen, Ying Yang, Jia-Yu Zhang, Qun Wang, Huaxi Xu, Francesca-Fang Liao, Jian-Zhi Wan. Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 9. 2007-06-13. PMID:17360687. |
phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in alzheimer's neurodegeneration. |
2007-06-13 |
2023-08-12 |
mouse |
| Hong-Lian Li, Hai-Hong Wang, Shi-Jie Liu, Yan-Qiu Deng, Yong-Jie Zhang, Qing Tian, Xiao-Chuan Wang, Xiao-Qian Chen, Ying Yang, Jia-Yu Zhang, Qun Wang, Huaxi Xu, Francesca-Fang Liao, Jian-Zhi Wan. Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 9. 2007-06-13. PMID:17360687. |
hyperphosphorylated tau is the major protein subunit of neurofibrillary tangles in alzheimer's disease (ad) and related tauopathies. |
2007-06-13 |
2023-08-12 |
mouse |
| Elzbieta Mikiciuk-Olasik, Paweł Szymański, Elzbieta Zure. Diagnostics and therapy of Alzheimer's disease. Indian journal of experimental biology. vol 45. issue 4. 2007-06-13. PMID:17477302. |
in brain of alzheimer's patient's one ascertained presence of neuritic plaques containing the beta-amyloid peptide and protein tau. |
2007-06-13 |
2023-08-12 |
Not clear |
| Thierry S M Reijn, Marcel Olde Rikkert, Wieneke J A van Geel, Danielle de Jong, Marcel M Verbee. Diagnostic accuracy of ELISA and xMAP technology for analysis of amyloid beta(42) and tau proteins. Clinical chemistry. vol 53. issue 5. 2007-06-12. PMID:17395712. |
cerebrospinal fluid (csf) concentrations of amyloid beta(42) (abeta(42)) peptides and tau proteins may serve as biomarkers for alzheimer disease (ad). |
2007-06-12 |
2023-08-12 |
Not clear |
| Robert Adalbert, Jonathan Gilley, Michael P Colema. Abeta, tau and ApoE4 in Alzheimer's disease: the axonal connection. Trends in molecular medicine. vol 13. issue 4. 2007-06-11. PMID:17344096. |
abeta, tau and apoe4 in alzheimer's disease: the axonal connection. |
2007-06-11 |
2023-08-12 |
mouse |
| Robert Adalbert, Jonathan Gilley, Michael P Colema. Abeta, tau and ApoE4 in Alzheimer's disease: the axonal connection. Trends in molecular medicine. vol 13. issue 4. 2007-06-11. PMID:17344096. |
mutations in amyloid precursor protein (app), tau and apolipoprotein e4 (apoe4) lead to alzheimer's disease (ad) or related pathologies. |
2007-06-11 |
2023-08-12 |
mouse |
| Hiroyuki Ara. [From neuropathology to biomarker development in Alzheimer research]. Rinsho shinkeigaku = Clinical neurology. vol 46. issue 11. 2007-06-11. PMID:17432224. |
recent advances in our understanding of neurobiology of alzheimer's disease (ad) demonstrate that ad starts with accumulation of amyloid beta-protein (abeta) followed by abnormal phosphorylation of tau protein and a massive neuron death in vulnerable brain areas. |
2007-06-11 |
2023-08-12 |
mouse |
| Michael R Sawaya, Shilpa Sambashivan, Rebecca Nelson, Magdalena I Ivanova, Stuart A Sievers, Marcin I Apostol, Michael J Thompson, Melinda Balbirnie, Jed J W Wiltzius, Heather T McFarlane, Anders Ø Madsen, Christian Riekel, David Eisenber. Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature. vol 447. issue 7143. 2007-06-07. PMID:17468747. |
these include segments from the alzheimer's amyloid-beta and tau proteins, the prp prion protein, insulin, islet amyloid polypeptide (iapp), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. |
2007-06-07 |
2023-08-12 |
Not clear |
| Qing-Guo Ren, Xiao-Mei Liao, Xiao-Qian Chen, Gong-Ping Liu, Jian-Zhi Wan. Effects of tau phosphorylation on proteasome activity. FEBS letters. vol 581. issue 7. 2007-06-06. PMID:17376439. |
dysfunction of proteasome contributes to the accumulation of the abnormally hyperphosphorylated tau in alzheimer's disease. |
2007-06-06 |
2023-08-12 |
Not clear |
| Tong Li, Hemant K Paude. 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9. Neuroscience letters. vol 414. issue 3. 2007-06-05. PMID:17317006. |
hyperphosphorylated tau is the prominent component of paired helical filaments, which are the major component of neurofibrillary tangles associated with alzheimer's disease (ad). |
2007-06-05 |
2023-08-12 |
cattle |
| Li-Wen Ko, Jayanarayan G Kulathingal, Shu-Hui C Ye. Cytosine beta-D-arabinofuranoside used as a paradigm modifier to increase production of tau aggregates in a cellular model of tauopathy. Neurochemical research. vol 32. issue 4-5. 2007-05-29. PMID:17151917. |
intraneuronal deposition of filamentous tau is a hallmark of alzheimer's disease (ad) and related tauopathies. |
2007-05-29 |
2023-08-12 |
Not clear |