| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luc Buée, André Delacourt. [Tauopathy and Alzheimer disease: a full degenerating process]. Psychologie & neuropsychiatrie du vieillissement. vol 4. issue 4. 2007-03-13. PMID:17194646. |
in the present work, the role of tau pathology as both diagnostic marker and therapeutic target is highlighted in alzheimer disease and related disorders. |
2007-03-13 |
2023-08-12 |
Not clear |
| Martin Cente, Peter Filipcik, Miroslava Pevalova, Michal Nova. Expression of a truncated tau protein induces oxidative stress in a rodent model of tauopathy. The European journal of neuroscience. vol 24. issue 4. 2007-03-06. PMID:16930434. |
truncation of tau protein and oxidative stress have been implicated as important pathogenetic events in tauopathies including alzheimer's disease (ad). |
2007-03-06 |
2023-08-12 |
human |
| Noriyuki Matsukawa, Kosei Ojik. [Function of HCNP/HCNP precursor in memory formation]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 26. issue 5-6. 2007-03-06. PMID:17240848. |
hcnp and its precursor can be a candidate for the key molecules elucidating the underlying association among abeta, phosphorylated tau, degeneration of dendritic spine and decrease of acetylcholine in alzheimer brain. |
2007-03-06 |
2023-08-12 |
rat |
| Y Zhang, H-L Li, D-L Wang, S-J Liu, J-Z Wan. A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 10. 2007-03-02. PMID:16465464. |
a transitory activation of protein kinase-a induces a sustained tau hyperphosphorylation at multiple sites in n2a cells-imply a new mechanism in alzheimer pathology. |
2007-03-02 |
2023-08-12 |
Not clear |
| Y Zhang, H-L Li, D-L Wang, S-J Liu, J-Z Wan. A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 10. 2007-03-02. PMID:16465464. |
it is suggested that only transitory activation of pka in early stage of alzheimer disease may result in a sustained tau hyperphosphorylation at multiple sites, implying a new mechanism to alzheimer-like tau hyperphosphorylation. |
2007-03-02 |
2023-08-12 |
Not clear |
| Chun Lai Nie, Xing Sheng Wang, Ying Liu, Sarah Perrett, Rong Qiao H. Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells. BMC neuroscience. vol 8. 2007-02-28. PMID:17241479. |
the microtubule associated protein tau is the principle component of neurofibrillar tangles, which are a characteristic marker in the pathology of alzheimer's disease; similar lesions are also observed after chronic alcohol abuse. |
2007-02-28 |
2023-08-12 |
Not clear |
| Rostislav Skrabana, Michaela Skrabanova-Khuebachova, Peter Kontsek, Michal Nova. Alzheimer's-disease-associated conformation of intrinsically disordered tau protein studied by intrinsically disordered protein liquid-phase competitive enzyme-linked immunosorbent assay. Analytical biochemistry. vol 359. issue 2. 2007-02-27. PMID:17081491. |
tau protein, the major constituent of paired helical filaments in alzheimer's disease, belongs to the intrinsically disordered proteins (idps). |
2007-02-27 |
2023-08-12 |
Not clear |
| Evan Elliott, Irith Ginzbur. The role of neurotrophins and insulin on tau pathology in Alzheimer's disease. Reviews in the neurosciences. vol 17. issue 6. 2007-02-27. PMID:17283608. |
the role of neurotrophins and insulin on tau pathology in alzheimer's disease. |
2007-02-27 |
2023-08-12 |
Not clear |
| Evan Elliott, Irith Ginzbur. The role of neurotrophins and insulin on tau pathology in Alzheimer's disease. Reviews in the neurosciences. vol 17. issue 6. 2007-02-27. PMID:17283608. |
alterations in the structure and function of tau protein is the primary pathology of a variety of neurodegenerative diseases, including alzheimer's disease (ad). |
2007-02-27 |
2023-08-12 |
Not clear |
| Hugo Vanderstichele, Karen De Vreese, Kaj Blennow, Niels Andreasen, Christian Sindic, Adrian Ivanoiu, Harald Hampel, Katharina Bürger, Lucilla Parnetti, Alessia Lanari, Allesandro Padovani, Monica DiLuca, Miriam Bläser, Annika Ohrfelt Olsson, Hans Pottel, Frank Hulstaert, Eugeen Vanmechele. Analytical performance and clinical utility of the INNOTEST PHOSPHO-TAU181P assay for discrimination between Alzheimer's disease and dementia with Lewy bodies. Clinical chemistry and laboratory medicine. vol 44. issue 12. 2007-02-26. PMID:17163825. |
total tau (t-tau) and beta-amyloid((1-42)) (abeta(1-42)) levels in cerebrospinal fluid (csf) can differentiate alzheimer's disease (ad) from normal aging or depressive pseudo-dementia. |
2007-02-26 |
2023-08-12 |
Not clear |
| K Leroy, Z Yilmaz, J-P Brio. Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration. Neuropathology and applied neurobiology. vol 33. issue 1. 2007-02-26. PMID:17239007. |
the somatodendritic accumulation of hyperphosphorylated tau proteins is an early event preceding the appearance of neurofibrillary tangles (nft) in alzheimer's disease (ad) and might be necessary for their formation. |
2007-02-26 |
2023-08-12 |
Not clear |
| Odity Mukherjee, John S K Kauwe, Kevin Mayo, John C Morris, Alison M Goat. Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease. BMC genetics. vol 8. 2007-02-26. PMID:17266761. |
a prominent hypothesis for the aetiopathology of alzheimer's disease is that in the presence of a beta-amyloid load, individuals expressing a pathogenic form of tau protein (mapt) are at increased risk for developing the disease. |
2007-02-26 |
2023-08-12 |
Not clear |
| Ian W Jones, Adam Westmacott, Elcie Chan, Roy W Jones, Kelly Dineley, Michael J O'Neill, Susan Wonnacot. Alpha7 nicotinic acetylcholine receptor expression in Alzheimer's disease: receptor densities in brain regions of the APP(SWE) mouse model and in human peripheral blood lymphocytes. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192639. |
the brains of people with alzheimer's disease (ad) display several characteristic pathological features, including deposits (plaques) of beta-amyloid 1-42 (abeta1-42), intraneuronal accumulations (tangles) of hyperphosphorylated tau, degeneration of the basal forebrain cholinergic pathway, and gliosis. |
2007-02-23 |
2023-08-12 |
mouse |
| E N Kapaki, G P Paraskevas, N G Tzerakis, C Sfagos, A Seretis, E Kararizou, D Vassilopoulo. Cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease. European journal of neurology. vol 14. issue 2. 2007-02-23. PMID:17250725. |
cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from alzheimer's disease. |
2007-02-23 |
2023-08-12 |
Not clear |
| E N Kapaki, G P Paraskevas, N G Tzerakis, C Sfagos, A Seretis, E Kararizou, D Vassilopoulo. Cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease. European journal of neurology. vol 14. issue 2. 2007-02-23. PMID:17250725. |
the aim of the present study was the quantitation of total tau protein (tau(t)), tau phosphorylated at threonine 181 (tau(p-181)) and beta-amyloid(1-42) (abeta42) in the cerebrospinal fluid (csf) of patients with idiopathic normal pressure hydrocephalus (inph), alzheimer's disease (ad) and controls. |
2007-02-23 |
2023-08-12 |
Not clear |
| Mariko Tsukane, Chihiro Yoshizaki, Takashi Yamauch. Development and specific induction of apoptosis of cultured cell models overexpressing human tau during neural differentiation: Implication in Alzheimer's disease. Analytical biochemistry. vol 360. issue 1. 2007-02-22. PMID:17113559. |
development and specific induction of apoptosis of cultured cell models overexpressing human tau during neural differentiation: implication in alzheimer's disease. |
2007-02-22 |
2023-08-12 |
human |
| Soma Sengupta, Peleg M Horowitz, Stanislav L Karsten, George R Jackson, Daniel H Geschwind, Yifan Fu, Robert W Berry, Lester I Binde. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. vol 45. issue 50. 2007-02-21. PMID:17154549. |
tau, a microtubule associated protein, aggregates into intracellular paired helical filaments (phfs) by an unknown mechanism in alzheimer's disease (ad) and other tauopathies. |
2007-02-21 |
2023-08-12 |
human |
| Stephen I Deutsch, Richard B Rosse, Lynn H Deutsc. Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16504486. |
faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in alzheimer's disease. |
2007-02-20 |
2023-08-12 |
Not clear |
| Stephen I Deutsch, Richard B Rosse, Lynn H Deutsc. Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16504486. |
hyperphosphorylated tau protein is the basic structural component of the neurofibrillary tangle, a histopathological hallmark of alzheimer's disease. |
2007-02-20 |
2023-08-12 |
Not clear |
| Stephen I Deutsch, Richard B Rosse, Lynn H Deutsc. Faulty regulation of tau phosphorylation by the reelin signal transduction pathway is a potential mechanism of pathogenesis and therapeutic target in Alzheimer's disease. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 8. 2007-02-20. PMID:16504486. |
ultimately, inhibition of tau phosphorylation may be an important therapeutic target in alzheimer's disease and other neuropsychiatric disorders. |
2007-02-20 |
2023-08-12 |
Not clear |