All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Marina Célestine, Muriel Jacquier-Sarlin, Eve Borel, Fanny Petit, Jean-Baptiste Perot, Anne-Sophie Hérard, Luc Bousset, Alain Buisson, Marc Dhenai. Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation. Acta neuropathologica communications. vol 11. issue 1. 2023-04-22. PMID:37087498. alzheimer's disease (ad) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (aß) peptides or tau proteins. 2023-04-22 2023-08-14 Not clear
Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. the associations between age and cortical volume or thickness were partially mediated via tau in regions with early alzheimer's disease pathology, i.e., early tau and/or amyloid-beta pathology (subiculum/brodmann area 35/precuneus/posterior cingulate). 2023-04-21 2023-08-14 Not clear
Anika Wuestefeld, Alexa Pichet Binette, David Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L Barnes, David A Bennett, Julie A Schneider, Laura E M Wisse, Oskar Hansso. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023-04-21. PMID:37082959. these results have implications for our understanding of the spreading of tau outside the medial temporal lobe, also in the context of alzheimer's disease. 2023-04-21 2023-08-14 Not clear
Lan-Ting Zhou, Dan Liu, Hui-Cong Kang, Lu Lu, He-Zhou Huang, Wen-Qing Ai, Yang Zhou, Man-Fei Deng, Hao Li, Zhi-Qiang Liu, Wei-Feng Zhang, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Jun Jia, Avijite Kumer Sarkar, Saldin Sharaydeh, Jie Wang, Heng-Ye Man, Marcel Schilling, Lars Bertram, Youming Lu, Ziyuan Guo, Ling-Qiang Zh. Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease. Science advances. vol 9. issue 16. 2023-04-21. PMID:37083538. tau pathology epigenetically remodels the neuron-glial cross-talk in alzheimer's disease. 2023-04-21 2023-08-14 mouse
Lan-Ting Zhou, Dan Liu, Hui-Cong Kang, Lu Lu, He-Zhou Huang, Wen-Qing Ai, Yang Zhou, Man-Fei Deng, Hao Li, Zhi-Qiang Liu, Wei-Feng Zhang, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Jun Jia, Avijite Kumer Sarkar, Saldin Sharaydeh, Jie Wang, Heng-Ye Man, Marcel Schilling, Lars Bertram, Youming Lu, Ziyuan Guo, Ling-Qiang Zh. Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease. Science advances. vol 9. issue 16. 2023-04-21. PMID:37083538. how neurons manipulate the neuron-astrocyte interaction under pathological conditions, such as hyperphosphorylated tau, a pathological hallmark in alzheimer's disease (ad), remains elusive. 2023-04-21 2023-08-14 mouse
Riheb Jabeur, Caroline Corbel, Pascal Loyer, Annabelle Le Parc, Adélaide Le Grand, Arnaud Comte, Stéphane Bach, Gwenaëlle André-Leroux, Olivier Sire, Hedi Ben Mansour, Véronique Le Till. Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25. Biochemistry. 2023-04-19. PMID:37074084. tamoxifen, the gold standard drug for endocrine therapy for breast cancer, modulates the phosphorylation status of the tau protein in alzheimer's disease by inhibiting cdk5 kinase activity. 2023-04-19 2023-08-14 Not clear
Subashchandrabose Chinnathambi, Tushar Dubey, Madhura Chandrasheka. Photo-Excited Toluidine Blue Disaggregates the Repeat Tau and Modulates End-Binding Protein EB1, Cytoskeletal Structure in Neuronal Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 57. issue 2. 2023-04-19. PMID:37074918. alzheimer's disease is a progressive neurological disorder characterized by the intracellular accumulation of tau protein aggregates. 2023-04-19 2023-08-14 Not clear
Solomiia Boyko, Witold K Surewic. Domain-specific modulatory effects of phosphomimetic substitutions on liquid-liquid phase separation of tau protein. The Journal of biological chemistry. 2023-04-19. PMID:37075845. aggregation of tau is one of the major pathogenic events in alzheimer's disease and several other neurodegenerative disorders. 2023-04-19 2023-08-14 Not clear
Solomiia Boyko, Witold K Surewic. Domain-specific modulatory effects of phosphomimetic substitutions on liquid-liquid phase separation of tau protein. The Journal of biological chemistry. 2023-04-19. PMID:37075845. while hyperphosphorylation is a key feature of tau isolated from brains of patients with alzheimer's disease and other tauopathies, the mechanistic role of phosphorylation in tau liquid-liquid phase separation (llps) remains largely unexplored. 2023-04-19 2023-08-14 Not clear
Fang Du, Qing Yu, Russell H Swerdlow, Clarissa L Waite. Glucocorticoid-driven mitochondrial damage stimulates Tau pathology. Brain : a journal of neurology. 2023-04-18. PMID:37070763. finally, we demonstrate that mito-apocynin and the glucocorticoid receptor antagonist mifepristone rescue tau pathology in cytoplasmic hybrid cells, an ex vivo alzheimer's disease model wherein endogenous mitochondria are replaced with mitochondria from alzheimer's subjects. 2023-04-18 2023-08-14 mouse
Fang Du, Qing Yu, Russell H Swerdlow, Clarissa L Waite. Glucocorticoid-driven mitochondrial damage stimulates Tau pathology. Brain : a journal of neurology. 2023-04-18. PMID:37070763. our data also link glucocorticoids to mitochondrial dysfunction and tau pathology in the context of alzheimer's disease, and suggest that mitochondria are promising therapeutic targets for mitigating stress- and tau-related brain damage. 2023-04-18 2023-08-14 mouse
Gautam Kumar Baboo, Raghav Prasad, Pranav Mahajan, Veeky Bath. Tracking the Progression and Influence of Beta-Amyloid Plaques Using Percolation Centrality and Collective Influence Algorithm: A Study Using PET Images. Annals of neurosciences. vol 29. issue 4. 2023-04-17. PMID:37064283. the aberrant accumulation of beta-amyloid plaques and tau protein tangles in alzheimer's disease causes disruption in brain networks. 2023-04-17 2023-08-14 Not clear
Bhawna Randhi, Sai Dheeraj Gutlapalli, Jingxiong Pu, Maheen F Zaidi, Maithily Patel, Lakshmi Malvika Atluri, Natalie A Gonzalez, Navya Sakhamuri, Sreekartthik Athiyaman, Pousette Hami. Sleep Disorders in Mild Cognitive Impairment. Cureus. vol 15. issue 3. 2023-04-17. PMID:37065281. in the initial stages of alzheimer's disease, a-beta lipoprotein and tau deposits were linked to lower slow-wave activity in non-rapid eye movement sleep. 2023-04-17 2023-08-14 Not clear
Jianqiao Tian, Sheela Kumari Raghavan Pillai, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease. Neurology. 2023-04-17. PMID:37068958. white matter degeneration pathways associated with tau deposition in alzheimer disease. 2023-04-17 2023-08-14 human
Dalia Jomepour, Sara Sheikhlary, Esmaeil Heydari, Mohammad Hossein Majles Ar. Inhibitory Impacts of Fulvic Acid-Coated Iron Oxide Nanoparticles on the Amyloid Fibril Aggregations. IEEE transactions on nanobioscience. vol PP. 2023-04-14. PMID:37058385. alzheimer's disease is considered as multi-factor diseases, the main hallmarks of which are extracellular amyloid-beta and intracellular tau protein aggregations, leading to neural death. 2023-04-14 2023-08-14 chicken
Connor Langworth-Green, Saisha Patel, Zane Jaunmuktane, Edwin Jabbari, Huw Morris, Maria Thom, Andrew Lees, John Hardy, Michael Zandi, Karen Duf. Chronic effects of inflammation on tauopathies. The Lancet. Neurology. vol 22. issue 5. 2023-04-14. PMID:37059510. the detrimental role that chronic inflammation plays in the pathogenesis of alzheimer's disease is increasingly recognised; however, it is largely ascribed to the accumulation of amyloid β, leaving the effect of chronic inflammation on tau pathology and neurofibrillary tangle-related pathways greatly overlooked. 2023-04-14 2023-08-14 Not clear
Dongqin Wu, Nana Yu, Yang Gao, Rui Xiong, Luping Liu, Huiyang Lei, Sen Jin, Jiale Liu, Yingzhou Liu, Jiazhao Xie, Enjie Liu, Qiuzhi Zhou, Yanchao Liu, Shihong Li, Linyu Wei, Jingru Lv, Huilin Yu, Wenbo Zeng, Qiang Zhou, Fuqiang Xu, Min-Hua Luo, Yao Zhang, Ying Yang, Jian-Zhi Wan. Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation. Molecular neurodegeneration. vol 18. issue 1. 2023-04-14. PMID:37060096. abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with alzheimer's disease (ad). 2023-04-14 2023-08-14 Not clear
Juyong Kim, Pilju Choi, Young-Tae Park, Taejung Kim, Jungyeob Ham, Jin-Chul Ki. The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer's Disease-like Mouse Model. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047798. the cannabinoids, cbda and thca, rescue memory deficits and reduce amyloid-beta and tau pathology in an alzheimer's disease-like mouse model. 2023-04-13 2023-08-14 mouse
Robin Ziyue Zhou, Davide Liborio Vetrano, Giulia Grande, Frida Duell, Linus Jönsson, Erika J Laukka, Claudia Fredolini, Bengt Winblad, Lars Tjernberg, Sophia Schedin-Weis. A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-04-12. PMID:37042462. a glycan epitope correlates with tau in serum and predicts progression to alzheimer's disease in combination with apoe4 allele status. 2023-04-12 2023-08-14 Not clear
Tony S Eteläinen, M Catarina Silva, Johanna K Uhari-Väänänen, Francesca De Lorenzo, Maria H Jäntti, Hengjing Cui, Marta Chavero-Pieres, Tommi Kilpeläinen, Christina Mechtler, Reinis Svarcbahs, Erin Seppälä, Juha R Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika H Julku, Henri J Huttunen, Stephen J Haggarty, Timo T Myöhäne. A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy. Science translational medicine. vol 15. issue 691. 2023-04-12. PMID:37043557. protein phosphatase 2a (pp2a) is a major tau dephosphorylating phosphatase, and a decrease in its activity has been demonstrated in tauopathies, including alzheimer's disease. 2023-04-12 2023-08-14 mouse