| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanna Rosenmann, Zeev Meiner, Valeria Geylis, Oded Abramsky, Michael Steinit. Detection of circulating antibodies against tau protein in its unphosphorylated and in its neurofibrillary tangles-related phosphorylated state in Alzheimer's disease and healthy subjects. Neuroscience letters. vol 410. issue 2. 2007-01-23. PMID:17095156. |
we describe here the detection of circulating abs against unphosphorylated and pathologically phosphorylated tau protein in sera of 17 aged subjects: nine alzheimer's disease (ad) patients and eight healthy individuals. |
2007-01-23 |
2023-08-12 |
human |
| Buffie J Clodfelder-Miller, Anna A Zmijewska, Gail V W Johnson, Richard S Jop. Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes. vol 55. issue 12. 2007-01-16. PMID:17130475. |
one of the hallmark pathological characteristics of alzheimer's disease is the presence of neurofibrillary tangles containing hyperphosphorylated tau, a microtubule-associated protein. |
2007-01-16 |
2023-08-12 |
mouse |
| Buffie J Clodfelder-Miller, Anna A Zmijewska, Gail V W Johnson, Richard S Jop. Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes. vol 55. issue 12. 2007-01-16. PMID:17130475. |
these results show that insulin deficiency causes rapid and large increases in tau phosphorylation, a condition that could prime tau for the neuropathology of alzheimer's disease, thereby contributing to the increased susceptibility to alzheimer's disease caused by diabetes. |
2007-01-16 |
2023-08-12 |
mouse |
| J Attems, K A Jellinge. Olfactory tau pathology in Alzheimer disease and mild cognitive impairment. Clinical neuropathology. vol 25. issue 6. 2007-01-05. PMID:17140156. |
olfactory tau pathology in alzheimer disease and mild cognitive impairment. |
2007-01-05 |
2023-08-12 |
human |
| J Attems, K A Jellinge. Olfactory tau pathology in Alzheimer disease and mild cognitive impairment. Clinical neuropathology. vol 25. issue 6. 2007-01-05. PMID:17140156. |
to examine the occurrence of tau pathology in the olfactory system in aged subjects and its relation to the severity of alzheimer disease (ad) pathology. |
2007-01-05 |
2023-08-12 |
human |
| Piotr Lewczuk, Georg Beck, Oliver Ganslandt, Hermann Esselmann, Florian Deisenhammer, Axel Regeniter, Hela-Felicitas Petereit, Hayrettin Tumani, Andreas Gerritzen, Patrick Oschmann, Johannes Schröder, Peter Schönknecht, Klaus Zimmermann, Harald Hampel, Katharina Bürger, Markus Otto, Sabine Haustein, Karin Herzog, Rainer Dannenberg, Ulrich Wurster, Mirko Bibl, Juan Manuel Maler, Udo Reubach, Johannes Kornhuber, Jens Wiltfan. International quality control survey of neurochemical dementia diagnostics. Neuroscience letters. vol 409. issue 1. 2007-01-04. PMID:17045397. |
therefore, in this study, 14 laboratories in germany, austria, and switzerland were given aliquots of a human cerebrospinal fluid (csf) sample, and were asked to measure alzheimer's disease (ad) biomarkers (amyloid beta (abeta) peptides, total tau protein, and phosphorylated tau protein (p-tau(181p))) according to their routine protocols. |
2007-01-04 |
2023-08-12 |
human |
| V Haroutunian, P Davies, C Vianna, J D Buxbaum, D P Purohi. Tau protein abnormalities associated with the progression of alzheimer disease type dementia. Neurobiology of aging. vol 28. issue 1. 2006-12-28. PMID:16343696. |
tau protein abnormalities associated with the progression of alzheimer disease type dementia. |
2006-12-28 |
2023-08-12 |
human |
| Gary W Small, Vladimir Kepe, Linda M Ercoli, Prabha Siddarth, Susan Y Bookheimer, Karen J Miller, Helen Lavretsky, Alison C Burggren, Greg M Cole, Harry V Vinters, Paul M Thompson, S-C Huang, N Satyamurthy, Michael E Phelps, Jorge R Barri. PET of brain amyloid and tau in mild cognitive impairment. The New England journal of medicine. vol 355. issue 25. 2006-12-28. PMID:17182990. |
amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of alzheimer's disease that accumulate in the cortical regions of the brain in persons with mild cognitive impairment who are at risk for alzheimer's disease. |
2006-12-28 |
2023-08-12 |
Not clear |
| Diana Poppek, Susi Keck, Gennady Ermak, Tobias Jung, Alexandra Stolzing, Oliver Ullrich, Kelvin J A Davies, Tilman Grun. Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. The Biochemical journal. vol 400. issue 3. 2006-12-27. PMID:16939415. |
hyperphosphorylated tau proteins accumulate in the paired helical filaments of neurofibrillary tangles seen in such tauopathies as alzheimer's disease. |
2006-12-27 |
2023-08-12 |
human |
| James A R Nicoll, Edward Barton, Delphine Boche, Jim W Neal, Isidro Ferrer, Petrina Thompson, Christina Vlachouli, David Wilkinson, Antony Bayer, Dora Games, Peter Seubert, Dale Schenk, Clive Holme. Abeta species removal after abeta42 immunization. Journal of neuropathology and experimental neurology. vol 65. issue 11. 2006-12-27. PMID:17086100. |
however, if it is to be used for treatment of established alzheimer disease, then the residual tau pathology and cerebral amyloid angiopathy require further study. |
2006-12-27 |
2023-08-12 |
Not clear |
| Masato Hasegaw. Biochemistry and molecular biology of tauopathies. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 26. issue 5. 2006-12-26. PMID:17080729. |
filamentous tau deposits in neurons or glial cells are the hallmark lesions of neurodegenerative tauopathies, such as alzheimer's disease, pick's disease, corticobasal degeneration and progressive supranuclear palsy. |
2006-12-26 |
2023-08-12 |
Not clear |
| Masato Hasegaw. Biochemistry and molecular biology of tauopathies. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 26. issue 5. 2006-12-26. PMID:17080729. |
biochemical analyses of sarkosyl-insoluble tau from brains with tauopathies have revealed that tau deposits in different diseases consisted of different tau isoforms (i.e., all six tau isoforms occur in alzheimer's disease, four repeat tau isoforms occur in corticobasal degeneration or progressive supranuclear palsy, and three repeat tau isoforms occur in pick's disease). |
2006-12-26 |
2023-08-12 |
Not clear |
| Amitabha Sengupta, Michal Novak, Inge Grundke-Iqbal, Khalid Iqba. Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level. FEBS letters. vol 580. issue 25. 2006-12-20. PMID:17045592. |
microtubule associated protein tau, which is expressed in six alternatively spliced molecular isoforms in human brain, is abnormally hyperphosphorylated in alzheimer disease and related tauopathies. |
2006-12-20 |
2023-08-12 |
human |
| M von Bergen, S Barghorn, S Jeganathan, E-M Mandelkow, E Mandelko. Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments. Neuro-degenerative diseases. vol 3. issue 4-5. 2006-12-12. PMID:17047358. |
the abnormal aggregation of the microtubule-associated protein tau into paired helical filaments is one the hallmarks of alzheimer's disease. |
2006-12-12 |
2023-08-12 |
Not clear |
| T Timm, D Matenia, X-Y Li, B Griesshaber, E-M Mandelko. Signaling from MARK to tau: regulation, cytoskeletal crosstalk, and pathological phosphorylation. Neuro-degenerative diseases. vol 3. issue 4-5. 2006-12-12. PMID:17047359. |
the hyperphosphorylation of tau is an early step in the degeneration of neurons in alzheimer's disease and other tauopathies. |
2006-12-12 |
2023-08-12 |
Not clear |
| Stefan Kins, Nadine Lauther, Anita Szodorai, Konrad Beyreuthe. Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease. Neuro-degenerative diseases. vol 3. issue 4-5. 2006-12-12. PMID:17047360. |
thus, changes in app and tau expression may cause perturbed axonal transport and changes in app processing, contributing to cognitive decline and neurodegeneration in alzheimer's disease. |
2006-12-12 |
2023-08-12 |
Not clear |
| Jaya Padmanabhan, Monique Levy, Dennis W Dickson, Huntington Potte. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain : a journal of neurology. vol 129. issue Pt 11. 2006-12-11. PMID:16987932. |
alpha1-antichymotrypsin, an inflammatory protein overexpressed in alzheimer's disease brain, induces tau phosphorylation in neurons. |
2006-12-11 |
2023-08-12 |
mouse |
| Jaya Padmanabhan, Monique Levy, Dennis W Dickson, Huntington Potte. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain : a journal of neurology. vol 129. issue Pt 11. 2006-12-11. PMID:16987932. |
as was previously found for alzheimer's disease, brains from patients with non-alzheimer's tauopathies exhibited an enhanced expression of act, which correlated with the level of tau hyperphosphorylation. |
2006-12-11 |
2023-08-12 |
mouse |
| Jaya Padmanabhan, Monique Levy, Dennis W Dickson, Huntington Potte. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain : a journal of neurology. vol 129. issue Pt 11. 2006-12-11. PMID:16987932. |
this result was further confirmed by the finding that addition of purified act induced the same alzheimer's disease-related tau hyperphosphorylation in cortical neurons cultured in vitro. |
2006-12-11 |
2023-08-12 |
mouse |
| Katharina Buerger, Michael Ewers, Tuula Pirttilä, Raymond Zinkowski, Irina Alafuzoff, Stefan J Teipel, John DeBernardis, Daniel Kerkman, Cheryl McCulloch, Hilkka Soininen, Harald Hampe. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain : a journal of neurology. vol 129. issue Pt 11. 2006-12-11. PMID:17012293. |
csf phosphorylated tau protein correlates with neocortical neurofibrillary pathology in alzheimer's disease. |
2006-12-11 |
2023-08-12 |
Not clear |